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UniProtKB - P08078 (STRB1_STRGR)
Protein
Inosamine-phosphate amidinotransferase 1
Gene
strB1
Organism
Streptomyces griseus
Status
Functioni
Catalyzes two non-consecutive transamidination reactions. It converts scyllo-inosamine 4-phosphate into N-amidino-scyllo-inosamine 4-phosphate and N1-amidinostreptamine 6-phosphate into streptidine 6-phosphate.
Catalytic activityi
- 1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine = 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithineEC:2.1.4.2
: streptomycin biosynthesis Pathwayi
This protein is involved in the pathway streptomycin biosynthesis, which is part of Antibiotic biosynthesis.View all proteins of this organism that are known to be involved in the pathway streptomycin biosynthesis and in Antibiotic biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 179 | By similarity | 1 | |
Active sitei | 227 | 1 | ||
Active sitei | 332 | Amidino-cysteine intermediate | 1 |
GO - Molecular functioni
- scyllo-inosamine-4-phosphate amidinotransferase activity Source: UniProtKB-EC
GO - Biological processi
- streptomycin biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Transferase |
Biological process | Antibiotic biosynthesis, Streptomycin biosynthesis |
Enzyme and pathway databases
BRENDAi | 2.1.4.2, 6035 |
UniPathwayi | UPA00066 |
Names & Taxonomyi
Protein namesi | Recommended name: Inosamine-phosphate amidinotransferase 1 (EC:2.1.4.2)Alternative name(s): Aminocyclitol amidinotransferase Short name: ADT Inosamine-phosphate amidinotransferase I |
Gene namesi | Name:strB1 Synonyms:AT, strB |
Organismi | Streptomyces griseus |
Taxonomic identifieri | 1911 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Streptomycetales › Streptomycetaceae › Streptomyces › |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000215475 | 2 – 347 | Inosamine-phosphate amidinotransferase 1Add BLAST | 346 |
Interactioni
Subunit structurei
Homodimer.
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P08078 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P08078 |
Family & Domainsi
Sequence similaritiesi
Belongs to the amidinotransferase family.Curated
Family and domain databases
InterProi | View protein in InterPro IPR033195, AmidinoTrfase |
PANTHERi | PTHR10488, PTHR10488, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P08078-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLVSVHNEW DPLEEVIVGT AVGARVPTAD RSVFAVEYAG DYESQEQIPS
60 70 80 90 100
GAYPDRVLKE TEEELHVLAA ELTKLGVTVR RPGPRDHSAL IKTPDWETDG
110 120 130 140 150
FHDYCPRDGL LSVGQTIIET PMALRSRFLE SLAYKDLLLE YFASGSRWLS
160 170 180 190 200
APKPRLTDDS YAPQAPAGER LTDEEPVFDA ANVLRFGTDL LYLVSDSGNE
210 220 230 240 250
LGAKWLQSAV GDTYTVHPCR KLYASTHVDS TIVPLRPGLV LTNPSRVNDE
260 270 280 290 300
NMPDFLRSWE NITCPELVDI GFTGDKPHCS VWIGMNLLVV RPDLAVVDRR
310 320 330 340
QTALIRLLEK HGMNVLPLQL THSRTLGGGF HCATLDVRRT ARETYQF
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 144 – 146 | SGS → ERI in strain: ISP 5236. | 3 | |
Natural varianti | 329 | G → R in strain: ISP 5236. | 1 | |
Natural varianti | 340 – 342 | TAR → RPL in strain: ISP 5236. | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y00459 Genomic DNA Translation: CAA68517.1 X05045 Genomic DNA Translation: CAA28718.1 |
PIRi | B26984 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y00459 Genomic DNA Translation: CAA68517.1 X05045 Genomic DNA Translation: CAA28718.1 |
PIRi | B26984 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1BWD | X-ray | 3.10 | A/B | 2-347 | [»] | |
SMRi | P08078 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Enzyme and pathway databases
UniPathwayi | UPA00066 |
BRENDAi | 2.1.4.2, 6035 |
Miscellaneous databases
EvolutionaryTracei | P08078 |
Family and domain databases
InterProi | View protein in InterPro IPR033195, AmidinoTrfase |
PANTHERi | PTHR10488, PTHR10488, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | STRB1_STRGR | |
Accessioni | P08078Primary (citable) accession number: P08078 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 100 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families