Gja1

Functionⁱ

Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization (PubMed:15181016). Plays an essential role in gap junction communication in the ventricles (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

beta-tubulin binding Source: Ensembl
connexin binding
Source: RGD
Inferred from physical interactionⁱ
- 11557558
disordered domain specific binding
Source: CAFA
Inferred from physical interactionⁱ
- 19808665
gap junction channel activity
Source: CAFA
Inferred from direct assayⁱ
- 15284189
PDZ domain binding
Source: CAFA
Inferred from physical interactionⁱ
- 14699011
- 15492000
protein domain specific binding
Source: RGD
Inferred from direct assayⁱ
- 17008717
protein tyrosine kinase binding Source: Ensembl
scaffold protein binding Source: Ensembl
SH3 domain binding
Source: RGD
Inferred from direct assayⁱ
- 14699011
signaling receptor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adult heart development Source: Ensembl
apoptotic process
Source: RGD
Inferred from mutant phenotypeⁱ
- 17107662
ATP transport
Source: RGD
Inferred from mutant phenotypeⁱ
- 16731531
atrial ventricular junction remodeling Source: Ensembl
blood vessel morphogenesis Source: Ensembl
cardiac conduction Source: Ensembl
cell-cell signaling
Source: RGD
Inferred from direct assayⁱ
- 15048573
cell communication
Source: RGD
Inferred from mutant phenotypeⁱ
- 15685554
cell communication by chemical coupling Source: Ensembl
cell communication by electrical coupling Source: Ensembl
cellular response to mechanical stimulus
Source: RGD
Inferred from expression patternⁱ
- 10631100
cellular response to parathyroid hormone stimulus
Source: RGD
Inferred from expression patternⁱ
- 11159864
cellular response to pH Source: Ensembl
chronic inflammatory response
Source: RGD
Inferred from mutant phenotypeⁱ
- 23165424
decidualization
Source: RGD
Inferred from expression patternⁱ
- 8924512
embryonic digit morphogenesis Source: Ensembl
endothelium development
Source: RGD
Inferred from expression patternⁱ
- 10990491
epididymis development
Source: RGD
Inferred from expression patternⁱ
- 12388089
epithelial cell maturation Source: Ensembl
gap junction assembly
Source: UniProtKB
Traceable author statementⁱ
- 15709751
heart development
Source: RGD
Inferred from expression patternⁱ
- 8944820
heart looping Source: Ensembl
in utero embryonic development Source: Ensembl
lens development in camera-type eye Source: Ensembl
milk ejection reflex Source: Ensembl
negative regulation of cardiac muscle cell proliferation
Source: RGD
Inferred from mutant phenotypeⁱ
- 19377854
negative regulation of cell growth
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15181016
negative regulation of cell proliferation
Source: RGD
Inferred from direct assayⁱ
- 12952975
negative regulation of DNA biosynthetic process
Source: RGD
Inferred from direct assayⁱ
- 14702389
negative regulation of endothelial cell proliferation
Source: RGD
Inferred from mutant phenotypeⁱ
- 18172080
negative regulation of gene expression Source: Ensembl
negative regulation of wound healing
Source: RGD
Inferred from mutant phenotypeⁱ
- 18172080
neuron migration Source: Ensembl
neuron projection morphogenesis
Source: RGD
Inferred from mutant phenotypeⁱ
- 16731531
osteoblast differentiation Source: Ensembl
positive regulation of behavioral fear response
Source: RGD
Inferred from mutant phenotypeⁱ
- 22665389
positive regulation of blood vessel diameter
Source: RGD
Inferred from mutant phenotypeⁱ
- 15301736
positive regulation of cell communication by chemical coupling
Source: RGD
Inferred from mutant phenotypeⁱ
- 15678088
positive regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from sequence or structural similarityⁱ
- 27626200
positive regulation of cytosolic calcium ion concentration
Source: RGD
Inferred from mutant phenotypeⁱ
- 22577485
positive regulation of gene expression Source: Ensembl
positive regulation of glomerular filtration
Source: RGD
Inferred from mutant phenotypeⁱ
- 18046320
positive regulation of insulin secretion
Source: RGD
Inferred from mutant phenotypeⁱ
- 24301293
positive regulation of osteoblast differentiation Source: Ensembl
positive regulation of protein catabolic process
Source: RGD
Inferred from direct assayⁱ
- 12952975
positive regulation of striated muscle tissue development Source: Ensembl
positive regulation of vasoconstriction
Source: RGD
Inferred from mutant phenotypeⁱ
- 21414209
protein complex oligomerization
Source: RGD
Inferred from direct assayⁱ
- 11557558
- 15817491
regulation of atrial cardiac muscle cell membrane depolarization Source: Ensembl
regulation of bicellular tight junction assembly
Source: RGD
Inferred from mutant phenotypeⁱ
- 19509333
regulation of bone mineralization Source: Ensembl
regulation of bone remodeling Source: Ensembl
regulation of calcium ion transport
Source: RGD
Inferred from mutant phenotypeⁱ
- 16878174
regulation of transmembrane transporter activity
Source: CAFA
Inferred from mutant phenotypeⁱ
- 15284189
regulation of ventricular cardiac muscle cell membrane depolarization Source: Ensembl
regulation of ventricular cardiac muscle cell membrane repolarization Source: Ensembl
response to estradiol
Source: RGD
Inferred from expression patternⁱ
- 25798059
response to fluid shear stress
Source: RGD
Inferred from expression patternⁱ
- 15558296
response to glucose
Source: RGD
Inferred from expression patternⁱ
- 21567444
response to ischemia
Source: RGD
Inferred from expression patternⁱ
- 24728265
response to lipopolysaccharide
Source: RGD
Inferred from expression patternⁱ
- 10909894
response to peptide hormone
Source: RGD
Inferred from expression patternⁱ
- 12700188
response to pH
Source: RGD
Inferred from direct assayⁱ
- 14699011
response to retinoic acid
Source: RGD
Inferred from expression patternⁱ
- 9570757
skeletal muscle tissue regeneration Source: Ensembl
transmembrane transport
Source: CAFA
Inferred from direct assayⁱ
- 15284189
vascular transport
Source: RGD
Inferred from mutant phenotypeⁱ
- 16878174

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-RNO-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-RNO-190861 Gap junction assembly R-RNO-190873 Gap junction degradation R-RNO-191647 c-src mediated regulation of Cx43 function and closure of gap junctions R-RNO-196025 Formation of annular gap junctions R-RNO-215126 Transport of connexins along the secretory pathway

Reactomeⁱ

R-RNO-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
R-RNO-190861 Gap junction assembly
R-RNO-190873 Gap junction degradation
R-RNO-191647 c-src mediated regulation of Cx43 function and closure of gap junctions
R-RNO-196025 Formation of annular gap junctions
R-RNO-215126 Transport of connexins along the secretory pathway

Protein family/group databases

TCDBⁱ	1.A.24.1.1 the gap junction-forming connexin (connexin) family

TCDBⁱ

1.A.24.1.1 the gap junction-forming connexin (connexin) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Gap junction alpha-1 protein Alternative name(s): Connexin-43 Short name: Cx43 Gap junction 43 kDa heart protein
Gene namesⁱ	Name:Gja1 Synonyms:Cxn-43
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 20

Organism-specific databases

Rat genome database More...RGDⁱ	2690 Gja1

RGDⁱ

2690 Gja1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	2 – 13	Cytoplasmic1 PublicationAdd BLAST	12
Transmembraneⁱ	14 – 36	HelicalCuratedAdd BLAST	23
Topological domainⁱ	37 – 76	Extracellular1 PublicationAdd BLAST	40
Transmembraneⁱ	77 – 99	HelicalCuratedAdd BLAST	23
Topological domainⁱ	100 – 154	Cytoplasmic1 PublicationAdd BLAST	55
Transmembraneⁱ	155 – 177	HelicalCuratedAdd BLAST	23
Topological domainⁱ	178 – 208	Extracellular1 PublicationAdd BLAST	31
Transmembraneⁱ	209 – 231	HelicalCuratedAdd BLAST	23
Topological domainⁱ	232 – 382	Cytoplasmic1 PublicationAdd BLAST	151

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Endoplasmic reticulum, Gap junction, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	368	S → A: Loss of phosphorylation by PKC/PRKCD. 1 Publication		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed2 Publications
ChainⁱPRO_0000057804	2 – 382	Gap junction alpha-1 proteinAdd BLAST		381

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	5	PhosphoserineCombined sources	1
Disulfide bondⁱ	54 ↔ 192	By similarity
Cross-linkⁱ	144	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Disulfide bondⁱ	187 ↔ 198	By similarity
Cross-linkⁱ	237	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residueⁱ	247	PhosphotyrosineBy similarity	1
Modified residueⁱ	255	PhosphoserineBy similarity	1
Modified residueⁱ	257	PhosphoserineCombined sources	1
Modified residueⁱ	262	PhosphoserineBy similarity	1
Modified residueⁱ	271	S-nitrosocysteineBy similarity	1
Modified residueⁱ	275	PhosphothreonineBy similarity	1
Modified residueⁱ	306	PhosphoserineCombined sources	1
Modified residueⁱ	314	PhosphoserineCombined sources	1
Modified residueⁱ	325	PhosphoserineCombined sources	1
Modified residueⁱ	326	PhosphothreonineCombined sources	1
Modified residueⁱ	328	PhosphoserineCombined sources	1
Modified residueⁱ	330	PhosphoserineCombined sources	1
Modified residueⁱ	365	Phosphoserine1 Publication	1
Modified residueⁱ	368	Phosphoserine; by PKC/PRKCG and PKC/PRKCD1 Publication1 Publication	1
Modified residueⁱ	369	Phosphoserine1 Publication	1
Modified residueⁱ	373	Phosphoserine1 Publication	1

Post-translational modificationⁱ

Contains at least one intramolecular disulfide bond.

Phosphorylation at Ser-325, Ser-328 and Ser-330 by CK1 modulates gap junction assembly. Phosphorylated at Ser-368 by PRKCG; phosphorylation induces disassembly of gap junction plaques and inhibition of gap junction activity (By similarity). Phosphorylation at Ser-368 by PRKCD triggers its internalization into small vesicles leading to proteasome-mediated degradation (PubMed:24500718).By similarity1 Publication

Sumoylated with SUMO1, SUMO2 and SUMO3, which may regulate the level of functional Cx43 gap junctions at the plasma membrane. May be desumoylated by SENP1 or SENP2 (By similarity).By similarity

S-nitrosylation at Cys-271 is enriched at the muscle endothelial gap junction in arteries, it augments channel permeability and may regulate of smooth muscle cell to endothelial cell communication.

Keywords - PTMⁱ

Disulfide bond, Isopeptide bond, Phosphoprotein, S-nitrosylation, Ubl conjugation

Proteomic databases

PaxDbⁱ	P08050
PRIDEⁱ	P08050

PTM databases

iPTMnetⁱ	P08050
PhosphoSitePlusⁱ	P08050

Expressionⁱ

Inductionⁱ

In bladder smooth muscle cells, exhibits night/day variations with low levels during the sleep phase, at circadian time (CT) 4-8 (at protein level). Expression starts to increase around CT12 and forms a plateau during the active phase (CT16-24) (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSRNOG00000000805 Expressed in 10 organ(s), highest expression level in heart
Genevisibleⁱ	P08050 RN

Interactionⁱ

Subunit structureⁱ

A connexon is composed of a hexamer of connexins (PubMed:1371548). Interacts with SGSM3 (By similarity). Interacts with RIC1/CIP150 (By similarity). Interacts with CNST and CSNK1D (By similarity). Interacts (via C-terminus) with TJP1 (PubMed:15492000, PubMed:18636092). Interacts (via C-terminus) with SRC (via SH3 domain) (PubMed:15492000). Interacts (not ubiquitinated) with UBQLN4 (via UBA domain) (PubMed:20127391). Interacts with NOV (PubMed:15181016, PubMed:15213231). Interacts with TMEM65 (By similarity).By similarity6 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Kcnj8	Q63664	4	EBI-476947,EBI-6991142
Sgsm3	Q8VCZ6	4	EBI-476947,EBI-525155	From Mus musculus.
UBQLN4	Q9NRR5	2	EBI-476947,EBI-711226	From Homo sapiens.

GO - Molecular functionⁱ

beta-tubulin binding Source: Ensembl
connexin binding
Source: RGD
Inferred from physical interactionⁱ
- 11557558
disordered domain specific binding
Source: CAFA
Inferred from physical interactionⁱ
- 19808665
PDZ domain binding
Source: CAFA
Inferred from physical interactionⁱ
- 14699011
- 15492000
protein domain specific binding
Source: RGD
Inferred from direct assayⁱ
- 17008717
protein tyrosine kinase binding Source: Ensembl
scaffold protein binding Source: Ensembl
SH3 domain binding
Source: RGD
Inferred from direct assayⁱ
- 14699011
signaling receptor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	246562, 301 interactors
CORUMⁱ	P08050
Database of interacting proteins More...DIPⁱ	DIP-34793N
IntActⁱ	P08050, 18 interactors
Molecular INTeraction database More...MINTⁱ	P08050
STRINGⁱ	10116.ENSRNOP00000001054

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	256 – 259	Combined sources	4
Beta strandⁱ	263 – 265	Combined sources	3
Beta strandⁱ	283 – 285	Combined sources	3
Beta strandⁱ	297 – 300	Combined sources	4
Helixⁱ	317 – 325	Combined sources	9
Helixⁱ	342 – 348	Combined sources	7
Turnⁱ	349 – 352	Combined sources	4
Beta strandⁱ	360 – 362	Combined sources	3
Turnⁱ	366 – 370	Combined sources	5
Beta strandⁱ	379 – 381	Combined sources	3

Show more details

3D structure databases

Database of protein disorder More...DisProtⁱ	DP00278
ProteinModelPortalⁱ	P08050
SMRⁱ	P08050
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P08050

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	244 – 382	Interaction with NOV2 PublicationsAdd BLAST		139
Regionⁱ	264 – 382	Interaction with UBQLN4By similarityAdd BLAST		119

Sequence similaritiesⁱ

Belongs to the connexin family. Alpha-type (group II) subfamily.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IF97 Eukaryota ENOG4110JTW LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143998
HOGENOMⁱ	HOG000231127
HOVERGENⁱ	HBG009576
InParanoidⁱ	P08050
KEGG Orthology (KO) More...KOⁱ	K07372
OMAⁱ	GANVDMH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FKH
PhylomeDBⁱ	P08050
TreeFamⁱ	TF329606

Family and domain databases

Gene3Dⁱ	1.20.1440.80, 1 hit 1.20.5.1130, 1 hit
InterProⁱ	View protein in InterPro IPR035091 Alpha_helix_dom_sf IPR000500 Connexin IPR002261 Connexin43 IPR013124 Connexin43_C IPR034634 Connexin_C IPR019570 Connexin_CCC IPR017990 Connexin_CS IPR013092 Connexin_N IPR038359 Connexin_N_sf
PANTHERⁱ	PTHR11984 PTHR11984, 1 hit PTHR11984:SF33 PTHR11984:SF33, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00029 Connexin, 1 hit PF03508 Connexin43, 1 hit
PRINTSⁱ	PR00206 CONNEXIN PR01132 CONNEXINA1
SMARTⁱ	View protein in SMART SM00037 CNX, 1 hit SM01089 Connexin_CCC, 1 hit
SUPFAMⁱ	SSF118220 SSF118220, 1 hit
PROSITEⁱ	View protein in PROSITE PS00407 CONNEXINS_1, 1 hit PS00408 CONNEXINS_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P08050-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGDWSALGKL LDKVQAYSTA GGKVWLSVLF IFRILLLGTA VESAWGDEQS 
        60         70         80         90        100
AFRCNTQQPG CENVCYDKSF PISHVRFWVL QIIFVSVPTL LYLAHVFYVM 
       110        120        130        140        150
RKEEKLNKKE EELKVAQTDG VNVEMHLKQI EIKKFKYGIE EHGKVKMRGG 
       160        170        180        190        200
LLRTYIISIL FKSVFEVAFL LIQWYIYGFS LSAVYTCKRD PCPHQVDCFL 
       210        220        230        240        250
SRPTEKTIFI IFMLVVSLVS LALNIIELFY VFFKGVKDRV KGRSDPYHAT 
       260        270        280        290        300
TGPLSPSKDC GSPKYAYFNG CSSPTAPLSP MSPPGYKLVT GDRNNSSCRN 
       310        320        330        340        350
YNKQASEQNW ANYSAEQNRM GQAGSTISNS HAQPFDFPDD NQNAKKVAAG 
       360        370        380 
HELQPLAIVD QRPSSRASSR ASSRPRPDDL EI

Length:382

Mass (Da):43,031

Last modified:January 23, 2007 - v2

Checksum:ⁱ0196416EA6A69490

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	2	G → A AA sequence (PubMed:2987225).Curated	1
Sequence conflictⁱ	16	A → T no nucleotide entry (PubMed:1852114).Curated	1
Sequence conflictⁱ	28	V → I AA sequence (PubMed:2987225).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X06656 mRNA Translation: CAA29855.1 AY324140 mRNA Translation: AAP88589.1 BC081842 mRNA Translation: AAH81842.1
PIRⁱ	A24047 S00532
NCBI Reference Sequences More...RefSeqⁱ	NP_036699.1, NM_012567.2
UniGeneⁱ	Rn.10346

Genome annotation databases

Ensemblⁱ	ENSRNOT00000001054; ENSRNOP00000001054; ENSRNOG00000000805
GeneIDⁱ	24392
KEGGⁱ	rno:24392
UCSC genome browser More...UCSCⁱ	RGD:2690 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P08050	Gap junction alpha-1 protein		BOVIN		383	UniRef90_P08050
Gap junction alpha-1 protein		CHLAE		382
Gap junction alpha-1 protein		RABIT		382
Gap junction alpha-1 protein		PIG		382
Gap junction alpha-1 protein		MACFA		382
+191

Protein	Similar proteins		Species	Score	Length	Source
P08050	Gap junction alpha-1 protein		MOUSE		382	UniRef50_P23242
Gap junction alpha-1 protein		XENLA		379
Gap junction alpha-1 protein		BOVIN		383
Gap junction alpha-1 protein		CANLF		382
Gap junction alpha-1 protein	)	HUMAN		382
+354

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X06656 mRNA Translation: CAA29855.1 AY324140 mRNA Translation: AAP88589.1 BC081842 mRNA Translation: AAH81842.1
PIRⁱ	A24047 S00532
RefSeqⁱ	NP_036699.1, NM_012567.2
UniGeneⁱ	Rn.10346

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1R5S	NMR	-	A	255-382	[»]
	2N8T	NMR	-	B	276-289	[»]
	3CYY	X-ray	2.40	C/D	374-382	[»]
DisProtⁱ	DP00278
ProteinModelPortalⁱ	P08050
SMRⁱ	P08050
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	246562, 301 interactors
CORUMⁱ	P08050
DIPⁱ	DIP-34793N
IntActⁱ	P08050, 18 interactors
MINTⁱ	P08050
STRINGⁱ	10116.ENSRNOP00000001054

Protein family/group databases

TCDBⁱ	1.A.24.1.1 the gap junction-forming connexin (connexin) family

TCDBⁱ

1.A.24.1.1 the gap junction-forming connexin (connexin) family

PTM databases

iPTMnetⁱ	P08050
PhosphoSitePlusⁱ	P08050

Proteomic databases

PaxDbⁱ	P08050
PRIDEⁱ	P08050

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000001054; ENSRNOP00000001054; ENSRNOG00000000805
GeneIDⁱ	24392
KEGGⁱ	rno:24392
UCSCⁱ	RGD:2690 rat

Organism-specific databases

CTDⁱ	2697
RGDⁱ	2690 Gja1

Phylogenomic databases

eggNOGⁱ	ENOG410IF97 Eukaryota ENOG4110JTW LUCA
GeneTreeⁱ	ENSGT00910000143998
HOGENOMⁱ	HOG000231127
HOVERGENⁱ	HBG009576
InParanoidⁱ	P08050
KOⁱ	K07372
OMAⁱ	GANVDMH
OrthoDBⁱ	EOG091G0FKH
PhylomeDBⁱ	P08050
TreeFamⁱ	TF329606

Enzyme and pathway databases

Reactomeⁱ	R-RNO-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane R-RNO-190861 Gap junction assembly R-RNO-190873 Gap junction degradation R-RNO-191647 c-src mediated regulation of Cx43 function and closure of gap junctions R-RNO-196025 Formation of annular gap junctions R-RNO-215126 Transport of connexins along the secretory pathway

Reactomeⁱ

R-RNO-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
R-RNO-190861 Gap junction assembly
R-RNO-190873 Gap junction degradation
R-RNO-191647 c-src mediated regulation of Cx43 function and closure of gap junctions
R-RNO-196025 Formation of annular gap junctions
R-RNO-215126 Transport of connexins along the secretory pathway

Miscellaneous databases

EvolutionaryTraceⁱ	P08050
Protein Ontology More...PROⁱ	PR:P08050

Gene expression databases

Bgeeⁱ	ENSRNOG00000000805 Expressed in 10 organ(s), highest expression level in heart
Genevisibleⁱ	P08050 RN

Family and domain databases

Gene3Dⁱ	1.20.1440.80, 1 hit 1.20.5.1130, 1 hit
InterProⁱ	View protein in InterPro IPR035091 Alpha_helix_dom_sf IPR000500 Connexin IPR002261 Connexin43 IPR013124 Connexin43_C IPR034634 Connexin_C IPR019570 Connexin_CCC IPR017990 Connexin_CS IPR013092 Connexin_N IPR038359 Connexin_N_sf
PANTHERⁱ	PTHR11984 PTHR11984, 1 hit PTHR11984:SF33 PTHR11984:SF33, 1 hit
Pfamⁱ	View protein in Pfam PF00029 Connexin, 1 hit PF03508 Connexin43, 1 hit
PRINTSⁱ	PR00206 CONNEXIN PR01132 CONNEXINA1
SMARTⁱ	View protein in SMART SM00037 CNX, 1 hit SM01089 Connexin_CCC, 1 hit
SUPFAMⁱ	SSF118220 SSF118220, 1 hit
PROSITEⁱ	View protein in PROSITE PS00407 CONNEXINS_1, 1 hit PS00408 CONNEXINS_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CXA1_RAT
Accessionⁱ	P08050Primary (citable) accession number: P08050 Secondary accession number(s): Q53ZE1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 190 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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Supporting data

UniProtKB - P08050 (CXA1_RAT)

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Gap junction alpha-1 protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Endoplasmic reticulum

Other locations

Cytoskeleton

Cytosol

Endoplasmic reticulum

Endosome

Golgi apparatus

Lysosome

Mitochondrion

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ