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UniProtKB - P08048 (ZFY_HUMAN)

Entry version 212 (25 May 2022)
Sequence version 3 (16 Aug 2004)
Previous versions | rss
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Protein

Zinc finger Y-chromosomal protein

Gene

ZFY

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3'.

1 Publication

Caution

Was originally thought to be the testis determining factor (TDF).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri421 – 443C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 538C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri544 – 566C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri572 – 595C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri601 – 623C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri629 – 652C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri658 – 680C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri686 – 709C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri715 – 737C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri743 – 766C2H2-type 12PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri772 – 795C2H2-type 13PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P08048

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P08048

SIGNOR Signaling Network Open Resource

More...SIGNORi		P08048

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger Y-chromosomal protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZFY
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome Y

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12870, ZFY

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		490000, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P08048

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000067646

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		7544

Open Targets

More...OpenTargetsi		ENSG00000067646

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37459

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P08048, Tdark

Chemistry databases

Drug and drug target database

More...DrugBanki		DB02884, 3-Cyclohexyl-L-alanine
DB05483, PCL-016

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZFY

Domain mapping of disease mutations (DMDM)

More...DMDMi		51338719

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000472611 – 801Zinc finger Y-chromosomal proteinAdd BLAST801

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei270PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P08048

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P08048

MaxQB - The MaxQuant DataBase

More...MaxQBi		P08048

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P08048

PeptideAtlas

More...PeptideAtlasi		P08048

PRoteomics IDEntifications database

More...PRIDEi		P08048

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52062 [P08048-1]
52063 [P08048-2]
52064 [P08048-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P08048

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P08048

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000067646, Expressed in sperm and 176 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P08048, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P08048, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000067646, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113376, 12 interactors

Protein interaction database and analysis system

More...IntActi		P08048, 8 interactors

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P08048, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1801
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P08048

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P08048

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P08048

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The binding of ZFY to DNA is mediated by the interaction of the GGCC core base pairs with zinc fingers 12 and 13.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri421 – 443C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 538C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri544 – 566C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri572 – 595C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri601 – 623C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri629 – 652C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri658 – 680C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri686 – 709C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri715 – 737C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri743 – 766C2H2-type 12PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri772 – 795C2H2-type 13PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158684

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P08048

Identification of Orthologs from Complete Genome Data

More...OMAi		HEHQLED

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P08048

TreeFam database of animal gene trees

More...TreeFami		TF335557

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006794, Transcrp_activ_Zfx/Zfy-dom
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096, zf-C2H2, 7 hits
PF04704, Zfx_Zfy_act, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355, ZnF_C2H2, 13 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 7 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 8 hits
PS50157, ZINC_FINGER_C2H2_2, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P08048-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDEDEFELQP QEPNSFFDGI GADATHMDGD QIVVEIQEAV FVSNIVDSDI 
        60         70         80         90        100
TVHNFVPDDP DSVVIQDVVE DVVIEEDVQC SDILEEADVS ENVIIPEQVL 
       110        120        130        140        150
DSDVTEEVSL PHCTVPDDVL ASDITSTSMS MPEHVLTSES MHVCDIGHVE 
       160        170        180        190        200
HMVHDSVVEA EIITDPLTSD IVSEEVLVAD CAPEAVIDAS GISVDQQDND 
       210        220        230        240        250
KASCEDYLMI SLDDAGKIEH DGSTGVTIDA ESEMDPCKVD STCPEVIKVY 
       260        270        280        290        300
IFKADPGEDD LGGTVDIVES EPENDHGVEL LDQNSSIRVP REKMVYMTVN 
       310        320        330        340        350
DSQQEDEDLN VAEIADEVYM EVIVGEEDAA VAAAAAAVHE QQIDEDEMKT 
       360        370        380        390        400
FVPIAWAAAY GNNSDGIENR NGTASALLHI DESAGLGRLA KQKPKKKRRP 
       410        420        430        440        450
DSRQYQTAII IGPDGHPLTV YPCMICGKKF KSRGFLKRHM KNHPEHLAKK 
       460        470        480        490        500
KYHCTDCDYT TNKKISLHNH LESHKLTSKA EKAIECDECG KHFSHAGALF 
       510        520        530        540        550
THKMVHKEKG ANKMHKCKFC EYETAEQGLL NRHLLAVHSK NFPHICVECG 
       560        570        580        590        600
KGFRHPSELR KHMRIHTGEK PYQCQYCEYR SADSSNLKTH IKTKHSKEMP 
       610        620        630        640        650
FKCDICLLTF SDTKEVQQHT LVHQESKTHQ CLHCDHKSSN SSDLKRHVIS 
       660        670        680        690        700
VHTKDYPHKC EMCEKGFHRP SELKKHVAVH KGKKMHQCRH CDFKIADPFV 
       710        720        730        740        750
LSRHILSVHT KDLPFRCKRC RKGFRQQNEL KKHMKTHSGR KVYQCEYCEY 
       760        770        780        790        800
STTDASGFKR HVISIHTKDY PHRCEYCKKG FRRPSEKNQH IMRHHKEVGL 

P
Length:801
Mass (Da):90,505
Last modified:August 16, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i956B9B3DA16648FA
GO
Isoform 2 (identifier: P08048-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     21-21: G → V
     22-212: Missing.

Show »
Length:610
Mass (Da):69,907
Checksum:iFA9C3797807D5C3C
GO
Isoform 3 (identifier: P08048-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: Missing.
     310-310: N → S
     311-361: Missing.

Show »
Length:724
Mass (Da):82,165
Checksum:i95DDCD4D9E11A43C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JQM1C9JQM1_HUMAN
Zinc finger Y-chromosomal protein
ZFY
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti333A → R in AAA72344 (PubMed:2511751).Curated1
Sequence conflicti398 – 407RRPDSRQYQT → ALILLSFPFL (PubMed:2498838).Curated10
Sequence conflicti554R → S (PubMed:2041734).Curated1
Sequence conflicti555H → Y in AAA61310 (PubMed:2308929).Curated1
Sequence conflicti630Missing (PubMed:2041734).Curated1
Sequence conflicti767T → R (PubMed:2041734).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0428241 – 26Missing in isoform 3. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_04277421G → V in isoform 2. 1 Publication1
Alternative sequenceiVSP_04277522 – 212Missing in isoform 2. 1 PublicationAdd BLAST191
Alternative sequenceiVSP_042825310N → S in isoform 3. 1 Publication1
Alternative sequenceiVSP_042826311 – 361Missing in isoform 3. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L10393 mRNA Translation: AAA72344.1
M30607 mRNA Translation: AAA61310.1
AF114156 Genomic DNA Translation: AAF21973.1
AK301061 mRNA Translation: BAG62669.1
AC006157 Genomic DNA Translation: AAD15612.1
BC114526 mRNA Translation: AAI14527.1
BC114960 mRNA Translation: AAI14961.1
X15470 Genomic DNA Translation: CAA33498.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14774.1 [P08048-1]
CCDS48200.1 [P08048-2]
CCDS48201.1 [P08048-3]

Protein sequence database of the Protein Information Resource

More...PIRi		A33630

NCBI Reference Sequences

More...RefSeqi		NP_001138747.1, NM_001145275.1 [P08048-3]
NP_001138748.1, NM_001145276.1 [P08048-2]
NP_003402.2, NM_003411.3 [P08048-1]
XP_005262627.1, XM_005262570.2
XP_016885564.1, XM_017030075.1 [P08048-1]
XP_016885566.1, XM_017030077.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000155093.8; ENSP00000155093.3; ENSG00000067646.12
ENST00000383052.5; ENSP00000372525.1; ENSG00000067646.12
ENST00000449237.4; ENSP00000393908.1; ENSG00000067646.12 [P08048-3]
ENST00000625061.3; ENSP00000485605.1; ENSG00000067646.12 [P08048-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7544

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7544

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000155093.8; ENSP00000155093.3; NM_003411.4; NP_003402.2

UCSC genome browser

More...UCSCi		uc004fqj.4, human [P08048-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10393 mRNA Translation: AAA72344.1
M30607 mRNA Translation: AAA61310.1
AF114156 Genomic DNA Translation: AAF21973.1
AK301061 mRNA Translation: BAG62669.1
AC006157 Genomic DNA Translation: AAD15612.1
BC114526 mRNA Translation: AAI14527.1
BC114960 mRNA Translation: AAI14961.1
X15470 Genomic DNA Translation: CAA33498.1
CCDSiCCDS14774.1 [P08048-1]
CCDS48200.1 [P08048-2]
CCDS48201.1 [P08048-3]
PIRiA33630
RefSeqiNP_001138747.1, NM_001145275.1 [P08048-3]
NP_001138748.1, NM_001145276.1 [P08048-2]
NP_003402.2, NM_003411.3 [P08048-1]
XP_005262627.1, XM_005262570.2
XP_016885564.1, XM_017030075.1 [P08048-1]
XP_016885566.1, XM_017030077.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KLRNMR-A570-598[»]
1KLSNMR-A570-598[»]
1XRZNMR-A570-598[»]
5ZNFNMR-A570-598[»]
7ZNFNMR-A570-598[»]
AlphaFoldDBiP08048
SMRiP08048
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113376, 12 interactors
IntActiP08048, 8 interactors

Chemistry databases

DrugBankiDB02884, 3-Cyclohexyl-L-alanine
DB05483, PCL-016

PTM databases

iPTMnetiP08048
PhosphoSitePlusiP08048

Genetic variation databases

BioMutaiZFY
DMDMi51338719

Proteomic databases

jPOSTiP08048
MassIVEiP08048
MaxQBiP08048
PaxDbiP08048
PeptideAtlasiP08048
PRIDEiP08048
ProteomicsDBi52062 [P08048-1]
52063 [P08048-2]
52064 [P08048-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		21843, 102 antibodies from 15 providers

The DNASU plasmid repository

More...DNASUi		7544

Genome annotation databases

EnsembliENST00000155093.8; ENSP00000155093.3; ENSG00000067646.12
ENST00000383052.5; ENSP00000372525.1; ENSG00000067646.12
ENST00000449237.4; ENSP00000393908.1; ENSG00000067646.12 [P08048-3]
ENST00000625061.3; ENSP00000485605.1; ENSG00000067646.12 [P08048-2]
GeneIDi7544
KEGGihsa:7544
MANE-SelectiENST00000155093.8; ENSP00000155093.3; NM_003411.4; NP_003402.2
UCSCiuc004fqj.4, human [P08048-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7544
DisGeNETi7544

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZFY
HGNCiHGNC:12870, ZFY
HPAiENSG00000067646, Low tissue specificity
MIMi490000, gene
neXtProtiNX_P08048
OpenTargetsiENSG00000067646
PharmGKBiPA37459
VEuPathDBiHostDB:ENSG00000067646

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00940000158684
InParanoidiP08048
OMAiHEHQLED
OrthoDBi1318335at2759
PhylomeDBiP08048
TreeFamiTF335557

Enzyme and pathway databases

PathwayCommonsiP08048
SignaLinkiP08048
SIGNORiP08048

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7544, 9 hits in 722 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZFY, human
EvolutionaryTraceiP08048

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ZFY

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7544
PharosiP08048, Tdark

Protein Ontology

More...PROi		PR:P08048
RNActiP08048, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000067646, Expressed in sperm and 176 other tissues
ExpressionAtlasiP08048, baseline and differential
GenevisibleiP08048, HS

Family and domain databases

InterProiView protein in InterPro
IPR006794, Transcrp_activ_Zfx/Zfy-dom
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 7 hits
PF04704, Zfx_Zfy_act, 1 hit
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 13 hits
SUPFAMiSSF57667, SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 8 hits
PS50157, ZINC_FINGER_C2H2_2, 12 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZFY_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08048
Secondary accession number(s): B4DVF7
, Q14021, Q15558, Q1RME9, Q24JR0, Q96TF3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 16, 2004
Last modified: May 25, 2022
This is version 212 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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