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UniProtKB - P08048 (ZFY_HUMAN)

Protein

Zinc finger Y-chromosomal protein

Gene

ZFY

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3'.1 Publication

Caution

Was originally thought to be the testis determining factor (TDF).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri421 – 443C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 538C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri544 – 566C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri572 – 595C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri601 – 623C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri629 – 652C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri658 – 680C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri686 – 709C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri715 – 737C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri743 – 766C2H2-type 12PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri772 – 795C2H2-type 13PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger Y-chromosomal protein
Gene namesi
Name:ZFY
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome Y

Organism-specific databases

EuPathDBiHostDB:ENSG00000067646.11
HGNCiHGNC:12870 ZFY
MIMi490000 gene
neXtProtiNX_P08048

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7544
OpenTargetsiENSG00000067646
PharmGKBiPA37459

Chemistry databases

DrugBankiDB02884 Beta-Cyclohexyl-Alanine
DB05483 PCL-016

Polymorphism and mutation databases

BioMutaiZFY
DMDMi51338719

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472611 – 801Zinc finger Y-chromosomal proteinAdd BLAST801

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei270PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP08048
PaxDbiP08048
PeptideAtlasiP08048
PRIDEiP08048
ProteomicsDBi52062
52063 [P08048-2]
52064 [P08048-3]

PTM databases

iPTMnetiP08048
PhosphoSitePlusiP08048

Expressioni

Gene expression databases

BgeeiENSG00000067646 Expressed in 160 organ(s), highest expression level in sperm
CleanExiHS_ZFY
ExpressionAtlasiP08048 baseline and differential
GenevisibleiP08048 HS

Organism-specific databases

HPAiHPA001748
HPA071863

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
L3MBTL2Q969R55EBI-12239601,EBI-739909

Protein-protein interaction databases

BioGridi113376, 5 interactors
IntActiP08048, 4 interactors
STRINGi9606.ENSP00000155093

Structurei

Secondary structure

1801
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP08048
SMRiP08048
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08048

Family & Domainsi

Domaini

The binding of ZFY to DNA is mediated by the interaction of the GGCC core base pairs with zinc fingers 12 and 13.1 Publication

Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri421 – 443C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 538C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri544 – 566C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri572 – 595C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri601 – 623C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri629 – 652C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri658 – 680C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri686 – 709C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri715 – 737C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri743 – 766C2H2-type 12PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri772 – 795C2H2-type 13PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063297
HOGENOMiHOG000231717
HOVERGENiHBG000337
InParanoidiP08048
OMAiGCENRNG
OrthoDBiEOG091G02CA
PhylomeDBiP08048
TreeFamiTF335557

Family and domain databases

InterProiView protein in InterPro
IPR006794 Transcrp_activ_Zfx/Zfy-dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 7 hits
PF04704 Zfx_Zfy_act, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P08048-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDEDEFELQP QEPNSFFDGI GADATHMDGD QIVVEIQEAV FVSNIVDSDI 
        60         70         80         90        100
TVHNFVPDDP DSVVIQDVVE DVVIEEDVQC SDILEEADVS ENVIIPEQVL 
       110        120        130        140        150
DSDVTEEVSL PHCTVPDDVL ASDITSTSMS MPEHVLTSES MHVCDIGHVE 
       160        170        180        190        200
HMVHDSVVEA EIITDPLTSD IVSEEVLVAD CAPEAVIDAS GISVDQQDND 
       210        220        230        240        250
KASCEDYLMI SLDDAGKIEH DGSTGVTIDA ESEMDPCKVD STCPEVIKVY 
       260        270        280        290        300
IFKADPGEDD LGGTVDIVES EPENDHGVEL LDQNSSIRVP REKMVYMTVN 
       310        320        330        340        350
DSQQEDEDLN VAEIADEVYM EVIVGEEDAA VAAAAAAVHE QQIDEDEMKT 
       360        370        380        390        400
FVPIAWAAAY GNNSDGIENR NGTASALLHI DESAGLGRLA KQKPKKKRRP 
       410        420        430        440        450
DSRQYQTAII IGPDGHPLTV YPCMICGKKF KSRGFLKRHM KNHPEHLAKK 
       460        470        480        490        500
KYHCTDCDYT TNKKISLHNH LESHKLTSKA EKAIECDECG KHFSHAGALF 
       510        520        530        540        550
THKMVHKEKG ANKMHKCKFC EYETAEQGLL NRHLLAVHSK NFPHICVECG 
       560        570        580        590        600
KGFRHPSELR KHMRIHTGEK PYQCQYCEYR SADSSNLKTH IKTKHSKEMP 
       610        620        630        640        650
FKCDICLLTF SDTKEVQQHT LVHQESKTHQ CLHCDHKSSN SSDLKRHVIS 
       660        670        680        690        700
VHTKDYPHKC EMCEKGFHRP SELKKHVAVH KGKKMHQCRH CDFKIADPFV 
       710        720        730        740        750
LSRHILSVHT KDLPFRCKRC RKGFRQQNEL KKHMKTHSGR KVYQCEYCEY 
       760        770        780        790        800
STTDASGFKR HVISIHTKDY PHRCEYCKKG FRRPSEKNQH IMRHHKEVGL 

P
Length:801
Mass (Da):90,505
Last modified:August 16, 2004 - v3
Checksum:i956B9B3DA16648FA
GO
Isoform 2 (identifier: P08048-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     21-21: G → V
     22-212: Missing.

Note: No experimental confirmation available.
Show »
Length:610
Mass (Da):69,907
Checksum:iFA9C3797807D5C3C
GO
Isoform 3 (identifier: P08048-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: Missing.
     310-310: N → S
     311-361: Missing.

Note: No experimental confirmation available.
Show »
Length:724
Mass (Da):82,165
Checksum:i95DDCD4D9E11A43C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JQM1C9JQM1_HUMAN
Zinc finger Y-chromosomal protein
ZFY
91Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti333A → R in AAA72344 (PubMed:2511751).Curated1
Sequence conflicti398 – 407RRPDSRQYQT → ALILLSFPFL (PubMed:2498838).Curated10
Sequence conflicti554R → S (PubMed:2041734).Curated1
Sequence conflicti555H → Y in AAA61310 (PubMed:2308929).Curated1
Sequence conflicti630Missing (PubMed:2041734).Curated1
Sequence conflicti767T → R (PubMed:2041734).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0428241 – 26Missing in isoform 3. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_04277421G → V in isoform 2. 1 Publication1
Alternative sequenceiVSP_04277522 – 212Missing in isoform 2. 1 PublicationAdd BLAST191
Alternative sequenceiVSP_042825310N → S in isoform 3. 1 Publication1
Alternative sequenceiVSP_042826311 – 361Missing in isoform 3. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10393 mRNA Translation: AAA72344.1
M30607 mRNA Translation: AAA61310.1
AF114156 Genomic DNA Translation: AAF21973.1
AK301061 mRNA Translation: BAG62669.1
AC006157 Genomic DNA Translation: AAD15612.1
BC114526 mRNA Translation: AAI14527.1
BC114960 mRNA Translation: AAI14961.1
X15470 Genomic DNA Translation: CAA33498.1
CCDSiCCDS14774.1 [P08048-1]
CCDS48200.1 [P08048-2]
CCDS48201.1 [P08048-3]
PIRiA33630
RefSeqiNP_001138747.1, NM_001145275.1 [P08048-3]
NP_001138748.1, NM_001145276.1 [P08048-2]
NP_003402.2, NM_003411.3 [P08048-1]
XP_005262627.1, XM_005262570.2 [P08048-1]
XP_016885564.1, XM_017030075.1 [P08048-1]
XP_016885566.1, XM_017030077.1 [P08048-3]
UniGeneiHs.522845

Genome annotation databases

EnsembliENST00000155093; ENSP00000155093; ENSG00000067646 [P08048-1]
ENST00000383052; ENSP00000372525; ENSG00000067646 [P08048-1]
ENST00000449237; ENSP00000393908; ENSG00000067646 [P08048-3]
ENST00000625061; ENSP00000485605; ENSG00000067646 [P08048-2]
GeneIDi7544
KEGGihsa:7544
UCSCiuc004fqj.4 human [P08048-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10393 mRNA Translation: AAA72344.1
M30607 mRNA Translation: AAA61310.1
AF114156 Genomic DNA Translation: AAF21973.1
AK301061 mRNA Translation: BAG62669.1
AC006157 Genomic DNA Translation: AAD15612.1
BC114526 mRNA Translation: AAI14527.1
BC114960 mRNA Translation: AAI14961.1
X15470 Genomic DNA Translation: CAA33498.1
CCDSiCCDS14774.1 [P08048-1]
CCDS48200.1 [P08048-2]
CCDS48201.1 [P08048-3]
PIRiA33630
RefSeqiNP_001138747.1, NM_001145275.1 [P08048-3]
NP_001138748.1, NM_001145276.1 [P08048-2]
NP_003402.2, NM_003411.3 [P08048-1]
XP_005262627.1, XM_005262570.2 [P08048-1]
XP_016885564.1, XM_017030075.1 [P08048-1]
XP_016885566.1, XM_017030077.1 [P08048-3]
UniGeneiHs.522845

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KLRNMR-A570-598[»]
1KLSNMR-A570-598[»]
1XRZNMR-A570-598[»]
5ZNFNMR-A570-598[»]
7ZNFNMR-A570-598[»]
ProteinModelPortaliP08048
SMRiP08048
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113376, 5 interactors
IntActiP08048, 4 interactors
STRINGi9606.ENSP00000155093

Chemistry databases

DrugBankiDB02884 Beta-Cyclohexyl-Alanine
DB05483 PCL-016

PTM databases

iPTMnetiP08048
PhosphoSitePlusiP08048

Polymorphism and mutation databases

BioMutaiZFY
DMDMi51338719

Proteomic databases

MaxQBiP08048
PaxDbiP08048
PeptideAtlasiP08048
PRIDEiP08048
ProteomicsDBi52062
52063 [P08048-2]
52064 [P08048-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000155093; ENSP00000155093; ENSG00000067646 [P08048-1]
ENST00000383052; ENSP00000372525; ENSG00000067646 [P08048-1]
ENST00000449237; ENSP00000393908; ENSG00000067646 [P08048-3]
ENST00000625061; ENSP00000485605; ENSG00000067646 [P08048-2]
GeneIDi7544
KEGGihsa:7544
UCSCiuc004fqj.4 human [P08048-1]

Organism-specific databases

CTDi7544
DisGeNETi7544
EuPathDBiHostDB:ENSG00000067646.11
GeneCardsiZFY
HGNCiHGNC:12870 ZFY
HPAiHPA001748
HPA071863
MIMi490000 gene
neXtProtiNX_P08048
OpenTargetsiENSG00000067646
PharmGKBiPA37459
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063297
HOGENOMiHOG000231717
HOVERGENiHBG000337
InParanoidiP08048
OMAiGCENRNG
OrthoDBiEOG091G02CA
PhylomeDBiP08048
TreeFamiTF335557

Miscellaneous databases

ChiTaRSiZFY human
EvolutionaryTraceiP08048
GeneWikiiZFY
GenomeRNAii7544
PROiPR:P08048
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000067646 Expressed in 160 organ(s), highest expression level in sperm
CleanExiHS_ZFY
ExpressionAtlasiP08048 baseline and differential
GenevisibleiP08048 HS

Family and domain databases

InterProiView protein in InterPro
IPR006794 Transcrp_activ_Zfx/Zfy-dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 7 hits
PF04704 Zfx_Zfy_act, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZFY_HUMAN
AccessioniPrimary (citable) accession number: P08048
Secondary accession number(s): B4DVF7
, Q14021, Q15558, Q1RME9, Q24JR0, Q96TF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 16, 2004
Last modified: November 7, 2018
This is version 191 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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