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UniProtKB - P08048 (ZFY_HUMAN)
Protein
Zinc finger Y-chromosomal protein
Gene
ZFY
Organism
Homo sapiens (Human)
Status
Functioni
Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3'.
1 PublicationCaution
Was originally thought to be the testis determining factor (TDF).Curated
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 421 – 443 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 452 – 474 | C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 484 – 506 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 515 – 538 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 544 – 566 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 572 – 595 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 601 – 623 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 629 – 652 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 658 – 680 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 686 – 709 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 715 – 737 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 743 – 766 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 772 – 795 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: ARUK-UCL
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: ARUK-UCL
- sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- fertilization Source: Ensembl
- homeostasis of number of cells Source: Ensembl
- multicellular organism growth Source: Ensembl
- oocyte development Source: Ensembl
- ovarian follicle development Source: Ensembl
- parental behavior Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: ARUK-UCL
- post-embryonic development Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
- spermatogenesis Source: Ensembl
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P08048 |
SignaLinki | P08048 |
SIGNORi | P08048 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger Y-chromosomal protein |
Gene namesi | Name:ZFY |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12870, ZFY |
MIMi | 490000, gene |
neXtProti | NX_P08048 |
VEuPathDBi | HostDB:ENSG00000067646 |
Subcellular locationi
Nucleus
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- chromatin Source: ARUK-UCL
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 7544 |
OpenTargetsi | ENSG00000067646 |
PharmGKBi | PA37459 |
Miscellaneous databases
Pharosi | P08048, Tdark |
Chemistry databases
DrugBanki | DB02884, 3-Cyclohexyl-L-alanine DB05483, PCL-016 |
Genetic variation databases
BioMutai | ZFY |
DMDMi | 51338719 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047261 | 1 – 801 | Zinc finger Y-chromosomal proteinAdd BLAST | 801 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 270 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | P08048 |
MassIVEi | P08048 |
MaxQBi | P08048 |
PaxDbi | P08048 |
PeptideAtlasi | P08048 |
PRIDEi | P08048 |
ProteomicsDBi | 52062 [P08048-1] 52063 [P08048-2] 52064 [P08048-3] |
PTM databases
iPTMneti | P08048 |
PhosphoSitePlusi | P08048 |
Expressioni
Gene expression databases
Bgeei | ENSG00000067646, Expressed in sperm and 176 other tissues |
ExpressionAtlasi | P08048, baseline and differential |
Genevisiblei | P08048, HS |
Organism-specific databases
HPAi | ENSG00000067646, Low tissue specificity |
Interactioni
Binary interactionsi
P08048
With | #Exp. | IntAct |
---|---|---|
DMRT3 [Q9NQL9] | 3 | EBI-12239601,EBI-9679045 |
KAT14 [Q9H8E8] | 3 | EBI-12239601,EBI-750907 |
L3MBTL2 [Q969R5] | 6 | EBI-12239601,EBI-739909 |
Protein-protein interaction databases
BioGRIDi | 113376, 12 interactors |
IntActi | P08048, 8 interactors |
Miscellaneous databases
RNActi | P08048, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P08048 |
SMRi | P08048 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P08048 |
Family & Domainsi
Domaini
The binding of ZFY to DNA is mediated by the interaction of the GGCC core base pairs with zinc fingers 12 and 13.1 Publication
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 421 – 443 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 452 – 474 | C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 484 – 506 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 515 – 538 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 544 – 566 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 572 – 595 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 601 – 623 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 629 – 652 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 658 – 680 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 686 – 709 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 715 – 737 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 743 – 766 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 772 – 795 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
GeneTreei | ENSGT00940000158684 |
InParanoidi | P08048 |
OMAi | HEHQLED |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P08048 |
TreeFami | TF335557 |
Family and domain databases
InterProi | View protein in InterPro IPR006794, Transcrp_activ_Zfx/Zfy-dom IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 7 hits PF04704, Zfx_Zfy_act, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 13 hits |
SUPFAMi | SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 8 hits PS50157, ZINC_FINGER_C2H2_2, 12 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: P08048-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDEDEFELQP QEPNSFFDGI GADATHMDGD QIVVEIQEAV FVSNIVDSDI
60 70 80 90 100
TVHNFVPDDP DSVVIQDVVE DVVIEEDVQC SDILEEADVS ENVIIPEQVL
110 120 130 140 150
DSDVTEEVSL PHCTVPDDVL ASDITSTSMS MPEHVLTSES MHVCDIGHVE
160 170 180 190 200
HMVHDSVVEA EIITDPLTSD IVSEEVLVAD CAPEAVIDAS GISVDQQDND
210 220 230 240 250
KASCEDYLMI SLDDAGKIEH DGSTGVTIDA ESEMDPCKVD STCPEVIKVY
260 270 280 290 300
IFKADPGEDD LGGTVDIVES EPENDHGVEL LDQNSSIRVP REKMVYMTVN
310 320 330 340 350
DSQQEDEDLN VAEIADEVYM EVIVGEEDAA VAAAAAAVHE QQIDEDEMKT
360 370 380 390 400
FVPIAWAAAY GNNSDGIENR NGTASALLHI DESAGLGRLA KQKPKKKRRP
410 420 430 440 450
DSRQYQTAII IGPDGHPLTV YPCMICGKKF KSRGFLKRHM KNHPEHLAKK
460 470 480 490 500
KYHCTDCDYT TNKKISLHNH LESHKLTSKA EKAIECDECG KHFSHAGALF
510 520 530 540 550
THKMVHKEKG ANKMHKCKFC EYETAEQGLL NRHLLAVHSK NFPHICVECG
560 570 580 590 600
KGFRHPSELR KHMRIHTGEK PYQCQYCEYR SADSSNLKTH IKTKHSKEMP
610 620 630 640 650
FKCDICLLTF SDTKEVQQHT LVHQESKTHQ CLHCDHKSSN SSDLKRHVIS
660 670 680 690 700
VHTKDYPHKC EMCEKGFHRP SELKKHVAVH KGKKMHQCRH CDFKIADPFV
710 720 730 740 750
LSRHILSVHT KDLPFRCKRC RKGFRQQNEL KKHMKTHSGR KVYQCEYCEY
760 770 780 790 800
STTDASGFKR HVISIHTKDY PHRCEYCKKG FRRPSEKNQH IMRHHKEVGL
P
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9JQM1 | C9JQM1_HUMAN | Zinc finger Y-chromosomal protein | ZFY | 91 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 333 | A → R in AAA72344 (PubMed:2511751).Curated | 1 | |
Sequence conflicti | 398 – 407 | RRPDSRQYQT → ALILLSFPFL (PubMed:2498838).Curated | 10 | |
Sequence conflicti | 554 | R → S (PubMed:2041734).Curated | 1 | |
Sequence conflicti | 555 | H → Y in AAA61310 (PubMed:2308929).Curated | 1 | |
Sequence conflicti | 630 | Missing (PubMed:2041734).Curated | 1 | |
Sequence conflicti | 767 | T → R (PubMed:2041734).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042824 | 1 – 26 | Missing in isoform 3. 1 PublicationAdd BLAST | 26 | |
Alternative sequenceiVSP_042774 | 21 | G → V in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_042775 | 22 – 212 | Missing in isoform 2. 1 PublicationAdd BLAST | 191 | |
Alternative sequenceiVSP_042825 | 310 | N → S in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_042826 | 311 – 361 | Missing in isoform 3. 1 PublicationAdd BLAST | 51 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L10393 mRNA Translation: AAA72344.1 M30607 mRNA Translation: AAA61310.1 AF114156 Genomic DNA Translation: AAF21973.1 AK301061 mRNA Translation: BAG62669.1 AC006157 Genomic DNA Translation: AAD15612.1 BC114526 mRNA Translation: AAI14527.1 BC114960 mRNA Translation: AAI14961.1 X15470 Genomic DNA Translation: CAA33498.1 |
CCDSi | CCDS14774.1 [P08048-1] CCDS48200.1 [P08048-2] CCDS48201.1 [P08048-3] |
PIRi | A33630 |
RefSeqi | NP_001138747.1, NM_001145275.1 [P08048-3] NP_001138748.1, NM_001145276.1 [P08048-2] NP_003402.2, NM_003411.3 [P08048-1] XP_005262627.1, XM_005262570.2 XP_016885564.1, XM_017030075.1 [P08048-1] XP_016885566.1, XM_017030077.1 |
Genome annotation databases
Ensembli | ENST00000155093.8; ENSP00000155093.3; ENSG00000067646.12 ENST00000383052.5; ENSP00000372525.1; ENSG00000067646.12 ENST00000449237.4; ENSP00000393908.1; ENSG00000067646.12 [P08048-3] ENST00000625061.3; ENSP00000485605.1; ENSG00000067646.12 [P08048-2] |
GeneIDi | 7544 |
KEGGi | hsa:7544 |
MANE-Selecti | ENST00000155093.8; ENSP00000155093.3; NM_003411.4; NP_003402.2 |
UCSCi | uc004fqj.4, human [P08048-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L10393 mRNA Translation: AAA72344.1 M30607 mRNA Translation: AAA61310.1 AF114156 Genomic DNA Translation: AAF21973.1 AK301061 mRNA Translation: BAG62669.1 AC006157 Genomic DNA Translation: AAD15612.1 BC114526 mRNA Translation: AAI14527.1 BC114960 mRNA Translation: AAI14961.1 X15470 Genomic DNA Translation: CAA33498.1 |
CCDSi | CCDS14774.1 [P08048-1] CCDS48200.1 [P08048-2] CCDS48201.1 [P08048-3] |
PIRi | A33630 |
RefSeqi | NP_001138747.1, NM_001145275.1 [P08048-3] NP_001138748.1, NM_001145276.1 [P08048-2] NP_003402.2, NM_003411.3 [P08048-1] XP_005262627.1, XM_005262570.2 XP_016885564.1, XM_017030075.1 [P08048-1] XP_016885566.1, XM_017030077.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1KLR | NMR | - | A | 570-598 | [»] | |
1KLS | NMR | - | A | 570-598 | [»] | |
1XRZ | NMR | - | A | 570-598 | [»] | |
5ZNF | NMR | - | A | 570-598 | [»] | |
7ZNF | NMR | - | A | 570-598 | [»] | |
AlphaFoldDBi | P08048 | |||||
SMRi | P08048 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113376, 12 interactors |
IntActi | P08048, 8 interactors |
Chemistry databases
DrugBanki | DB02884, 3-Cyclohexyl-L-alanine DB05483, PCL-016 |
PTM databases
iPTMneti | P08048 |
PhosphoSitePlusi | P08048 |
Genetic variation databases
BioMutai | ZFY |
DMDMi | 51338719 |
Proteomic databases
jPOSTi | P08048 |
MassIVEi | P08048 |
MaxQBi | P08048 |
PaxDbi | P08048 |
PeptideAtlasi | P08048 |
PRIDEi | P08048 |
ProteomicsDBi | 52062 [P08048-1] 52063 [P08048-2] 52064 [P08048-3] |
Protocols and materials databases
Antibodypediai | 21843, 102 antibodies from 15 providers |
DNASUi | 7544 |
Genome annotation databases
Ensembli | ENST00000155093.8; ENSP00000155093.3; ENSG00000067646.12 ENST00000383052.5; ENSP00000372525.1; ENSG00000067646.12 ENST00000449237.4; ENSP00000393908.1; ENSG00000067646.12 [P08048-3] ENST00000625061.3; ENSP00000485605.1; ENSG00000067646.12 [P08048-2] |
GeneIDi | 7544 |
KEGGi | hsa:7544 |
MANE-Selecti | ENST00000155093.8; ENSP00000155093.3; NM_003411.4; NP_003402.2 |
UCSCi | uc004fqj.4, human [P08048-1] |
Organism-specific databases
CTDi | 7544 |
DisGeNETi | 7544 |
GeneCardsi | ZFY |
HGNCi | HGNC:12870, ZFY |
HPAi | ENSG00000067646, Low tissue specificity |
MIMi | 490000, gene |
neXtProti | NX_P08048 |
OpenTargetsi | ENSG00000067646 |
PharmGKBi | PA37459 |
VEuPathDBi | HostDB:ENSG00000067646 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000158684 |
InParanoidi | P08048 |
OMAi | HEHQLED |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P08048 |
TreeFami | TF335557 |
Enzyme and pathway databases
PathwayCommonsi | P08048 |
SignaLinki | P08048 |
SIGNORi | P08048 |
Miscellaneous databases
BioGRID-ORCSi | 7544, 9 hits in 722 CRISPR screens |
ChiTaRSi | ZFY, human |
EvolutionaryTracei | P08048 |
GeneWikii | ZFY |
GenomeRNAii | 7544 |
Pharosi | P08048, Tdark |
PROi | PR:P08048 |
RNActi | P08048, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000067646, Expressed in sperm and 176 other tissues |
ExpressionAtlasi | P08048, baseline and differential |
Genevisiblei | P08048, HS |
Family and domain databases
InterProi | View protein in InterPro IPR006794, Transcrp_activ_Zfx/Zfy-dom IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 7 hits PF04704, Zfx_Zfy_act, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 13 hits |
SUPFAMi | SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 8 hits PS50157, ZINC_FINGER_C2H2_2, 12 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZFY_HUMAN | |
Accessioni | P08048Primary (citable) accession number: P08048 Secondary accession number(s): B4DVF7 Q96TF3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | August 16, 2004 | |
Last modified: | May 25, 2022 | |
This is version 212 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome Y
Human chromosome Y: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families