Zfp2

Functionⁱ

Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	100 – 122	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	128 – 150	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	156 – 178	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	184 – 206	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	212 – 234	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	240 – 262	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	268 – 290	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	296 – 318	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	324 – 346	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	352 – 374	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	380 – 402	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	408 – 430	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	436 – 458	C2H2-type 13PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
DNA-binding transcription factor activity Source: GO_Central
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of transcription, DNA-templated Source: GO_Central
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-212436 Generic Transcription Pathway

Reactomeⁱ

R-MMU-212436 Generic Transcription Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 2 Short name: Zfp-2 Alternative name(s): Protein mKR2
Gene namesⁱ	Name:Zfp2 Synonyms:Fnp-2, Mkr2, Zfp-2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:99167 Zfp2

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047282	1 – 459	Zinc finger protein 2Add BLAST		459

Proteomic databases

PaxDbⁱ	P08043
PRIDEⁱ	P08043

PTM databases

iPTMnetⁱ	P08043
PhosphoSitePlusⁱ	P08043

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000049321 Expressed in 251 organ(s), highest expression level in brain
CleanExⁱ	MM_ZFP2
Genevisibleⁱ	P08043 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000104756

STRINGⁱ

10090.ENSMUSP00000104756

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P08043
SMRⁱ	P08043
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	100 – 122	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	128 – 150	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	156 – 178	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	184 – 206	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	212 – 234	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	240 – 262	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	268 – 290	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	296 – 318	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	324 – 346	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	352 – 374	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	380 – 402	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	408 – 430	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	436 – 458	C2H2-type 13PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148943
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	P08043
OMAⁱ	KKIYECN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	P08043
TreeFamⁱ	TF350858

Family and domain databases

InterProⁱ	View protein in InterPro IPR017114 YY-1-like IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 13 hits
PIRSFⁱ	PIRSF037113 TF_Yin_yang, 1 hit
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 13 hits
SUPFAMⁱ	SSF57667 SSF57667, 7 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 13 hits PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P08043-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDREDLWHSA LGAVWDPTCW LKGQQERYLG QVTVAQKEIY NEKSVCGGNT 
        60         70         80         90        100
TENSSTEGSM LNTPQSIPVT PCNWNSYRKD SKQNSELMKT SRMFVQKKVY 
       110        120        130        140        150
GCDECGKTFR QSSSLLKHQR IHTGEKPYTC NVCDKHFIER SSLTVHQRTH 
       160        170        180        190        200
TGEKPYKCHE CGKAFSQSMN LTVHQRTHTG EKPYQCKECG KAFRKNSSLI 
       210        220        230        240        250
QHERIHTGEK PYKCHDCGKA FTQSMNLTVH QRTHTGEKPY ECNQCGKAFS 
       260        270        280        290        300
QSMHLIVHQR SHTGEKPYEC SECGKAFSKS STLTLHQRNH TGEKPYKCNK 
       310        320        330        340        350
CGKSFSQSTY LIEHQRLHSG VKPFECNQCG KAFSKNSSLT QHRRIHTGEK 
       360        370        380        390        400
PYECMICGKH FTGRSSLTVH QVIHTGEKPY ECTECGKAFS QSAYLIEHQR 
       410        420        430        440        450
IHTGEKPYEC DQCGKAFIKN SSLIVHQRIH TGEKPYQCNE CGKSFSRSTN 

LTRHQRTHT

Length:459

Mass (Da):52,534

Last modified:June 26, 2007 - v2

Checksum:ⁱ1211EBD2828F9284

GO

Isoform 2 (identifier: P08043-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
217-328: Missing.

« Hide

        10         20         30         40         50
MDREDLWHSA LGAVWDPTCW LKGQQERYLG QVTVAQKEIY NEKSVCGGNT 
        60         70         80         90        100
TENSSTEGSM LNTPQSIPVT PCNWNSYRKD SKQNSELMKT SRMFVQKKVY 
       110        120        130        140        150
GCDECGKTFR QSSSLLKHQR IHTGEKPYTC NVCDKHFIER SSLTVHQRTH 
       160        170        180        190        200
TGEKPYKCHE CGKAFSQSMN LTVHQRTHTG EKPYQCKECG KAFRKNSSLI 
       210        220        230        240        250
QHERIHTGEK PYKCHDCGKA FSKNSSLTQH RRIHTGEKPY ECMICGKHFT 
       260        270        280        290        300
GRSSLTVHQV IHTGEKPYEC TECGKAFSQS AYLIEHQRIH TGEKPYECDQ 
       310        320        330        340 
CGKAFIKNSS LIVHQRIHTG EKPYQCNECG KSFSRSTNLT RHQRTHT

Show »

Length:347

Mass (Da):39,817

Checksum:ⁱF0C8E9F6CECC548C

GO

Sequence cautionⁱ

The sequence BAE20918 differs from that shown. Reason: Frameshift at position 11.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	136	H → Q in BAE20918 (PubMed:16141072).Curated	1
Sequence conflictⁱ	399	Q → R in CAA68768 (PubMed:3409867).Curated	1
Sequence conflictⁱ	399	Q → R in AAA37640 (PubMed:3815523).Curated	1
Sequence conflictⁱ	436	Y → N in BAE20918 (PubMed:16141072).Curated	1
Sequence conflictⁱ	444	S → P in CAA68768 (PubMed:3409867).Curated	1
Sequence conflictⁱ	444	S → P in AAA37640 (PubMed:3815523).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_026332	217 – 328	Missing in isoform 2. 1 PublicationAdd BLAST		112

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y00850 mRNA Translation: CAA68768.1 AF483520 mRNA Translation: AAL90794.1 AF483521 mRNA Translation: AAL90795.1 AK036776 mRNA Translation: BAC29572.1 AK131978 mRNA Translation: BAE20918.1 Frameshift. AK141471 mRNA Translation: BAE24694.1 AL627215 Genomic DNA Translation: CAI35300.1 BC089506 mRNA Translation: AAH89506.1 M15709 Genomic DNA Translation: AAA37640.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS36148.1 [P08043-1]
PIRⁱ	S00549
NCBI Reference Sequences More...RefSeqⁱ	NP_001038162.1, NM_001044697.2 [P08043-1] NP_001038163.1, NM_001044698.2 [P08043-1] NP_001038165.1, NM_001044700.2 [P08043-1] NP_001281252.1, NM_001294323.1 [P08043-1] NP_848542.1, NM_178447.3 [P08043-1] XP_017169995.1, XM_017314506.1 [P08043-1]
UniGeneⁱ	Mm.259230

Genome annotation databases

Ensemblⁱ	ENSMUST00000109128; ENSMUSP00000104756; ENSMUSG00000049321 [P08043-1] ENSMUST00000109129; ENSMUSP00000104757; ENSMUSG00000049321 [P08043-1] ENSMUST00000116378; ENSMUSP00000112079; ENSMUSG00000049321 [P08043-1]
GeneIDⁱ	22678
KEGGⁱ	mmu:22678
UCSC genome browser More...UCSCⁱ	uc007isy.2 mouse [P08043-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P08043	RCG63490		RAT		461	UniRef90_P08043
UPI0007EC716E		MOUSE		494
UPI000A31A647		MUSCR		459

Protein	Similar proteins		Species	Score	Length	Source
P08043	RCG63490		RAT		461	UniRef50_P08043
zinc finger protein 3 homolog isoform X1		ERIEU		501
Zinc finger protein 16		CRIGR		539
Uncharacterized protein		PELSI		497
zinc finger protein 420-like		ALLSI		505
+14
P08043-2	Uncharacterized protein		MONDO		347	UniRef50_P08043-2
zinc finger protein 501-like		NEOSC		348
Zinc finger protein 3		PANTR		398
Zinc finger protein 397		HETGA		432
Zinc finger protein 397		MYOBR		421
+3

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y00850 mRNA Translation: CAA68768.1 AF483520 mRNA Translation: AAL90794.1 AF483521 mRNA Translation: AAL90795.1 AK036776 mRNA Translation: BAC29572.1 AK131978 mRNA Translation: BAE20918.1 Frameshift. AK141471 mRNA Translation: BAE24694.1 AL627215 Genomic DNA Translation: CAI35300.1 BC089506 mRNA Translation: AAH89506.1 M15709 Genomic DNA Translation: AAA37640.1
CCDSⁱ	CCDS36148.1 [P08043-1]
PIRⁱ	S00549
RefSeqⁱ	NP_001038162.1, NM_001044697.2 [P08043-1] NP_001038163.1, NM_001044698.2 [P08043-1] NP_001038165.1, NM_001044700.2 [P08043-1] NP_001281252.1, NM_001294323.1 [P08043-1] NP_848542.1, NM_178447.3 [P08043-1] XP_017169995.1, XM_017314506.1 [P08043-1]
UniGeneⁱ	Mm.259230

3D structure databases

ProteinModelPortalⁱ	P08043
SMRⁱ	P08043
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000104756

STRINGⁱ

10090.ENSMUSP00000104756

PTM databases

iPTMnetⁱ	P08043
PhosphoSitePlusⁱ	P08043

Proteomic databases

PaxDbⁱ	P08043
PRIDEⁱ	P08043

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000109128; ENSMUSP00000104756; ENSMUSG00000049321 [P08043-1] ENSMUST00000109129; ENSMUSP00000104757; ENSMUSG00000049321 [P08043-1] ENSMUST00000116378; ENSMUSP00000112079; ENSMUSG00000049321 [P08043-1]
GeneIDⁱ	22678
KEGGⁱ	mmu:22678
UCSCⁱ	uc007isy.2 mouse [P08043-1]

Organism-specific databases

CTDⁱ	80108
MGIⁱ	MGI:99167 Zfp2

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00920000148943
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	P08043
OMAⁱ	KKIYECN
OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	P08043
TreeFamⁱ	TF350858

Enzyme and pathway databases

Reactomeⁱ	R-MMU-212436 Generic Transcription Pathway

Reactomeⁱ

R-MMU-212436 Generic Transcription Pathway

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P08043
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000049321 Expressed in 251 organ(s), highest expression level in brain
CleanExⁱ	MM_ZFP2
Genevisibleⁱ	P08043 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR017114 YY-1-like IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 13 hits
PIRSFⁱ	PIRSF037113 TF_Yin_yang, 1 hit
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 13 hits
SUPFAMⁱ	SSF57667 SSF57667, 7 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 13 hits PS50157 ZINC_FINGER_C2H2_2, 13 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZFP2_MOUSE
Accessionⁱ	P08043Primary (citable) accession number: P08043 Secondary accession number(s): Q3V280, Q8R012
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
	Last sequence update:	June 26, 2007
	Last modified:	October 10, 2018
	This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P08043 (ZFP2_MOUSE)

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Zinc finger protein 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ