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UniProtKB - P08043 (ZFP2_MOUSE)
Protein
Zinc finger protein ZFP2
Gene
Zfp2
Organism
Mus musculus (Mouse)
Status
Functioni
Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 100 – 122 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 128 – 150 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 156 – 178 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 184 – 206 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 212 – 234 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 240 – 262 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 268 – 290 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 296 – 318 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 324 – 346 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 352 – 374 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 380 – 402 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 408 – 430 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 436 – 458 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein ZFP2Short name: Zfp-2 Alternative name(s): Protein mKR2 |
Gene namesi | Name:Zfp2 Synonyms:Fnp-2, Mkr2, Zfp-2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:99167, Zfp2 |
VEuPathDBi | HostDB:ENSMUSG00000049321 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047282 | 1 – 459 | Zinc finger protein ZFP2Add BLAST | 459 |
Proteomic databases
PaxDbi | P08043 |
PRIDEi | P08043 |
ProteomicsDBi | 275355 [P08043-1] 275356 [P08043-2] |
PTM databases
iPTMneti | P08043 |
PhosphoSitePlusi | P08043 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000049321, Expressed in brain and 277 other tissues |
Genevisiblei | P08043, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 204647, 1 interactor |
STRINGi | 10090.ENSMUSP00000112079 |
Miscellaneous databases
RNActi | P08043, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 100 – 122 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 128 – 150 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 156 – 178 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 184 – 206 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 212 – 234 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 240 – 262 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 268 – 290 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 296 – 318 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 324 – 346 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 352 – 374 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 380 – 402 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 408 – 430 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 436 – 458 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162743 |
HOGENOMi | CLU_002678_44_0_1 |
InParanoidi | P08043 |
OMAi | TERRVCG |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P08043 |
TreeFami | TF350858 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 13 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 13 hits |
SUPFAMi | SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 13 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: P08043-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDREDLWHSA LGAVWDPTCW LKGQQERYLG QVTVAQKEIY NEKSVCGGNT
60 70 80 90 100
TENSSTEGSM LNTPQSIPVT PCNWNSYRKD SKQNSELMKT SRMFVQKKVY
110 120 130 140 150
GCDECGKTFR QSSSLLKHQR IHTGEKPYTC NVCDKHFIER SSLTVHQRTH
160 170 180 190 200
TGEKPYKCHE CGKAFSQSMN LTVHQRTHTG EKPYQCKECG KAFRKNSSLI
210 220 230 240 250
QHERIHTGEK PYKCHDCGKA FTQSMNLTVH QRTHTGEKPY ECNQCGKAFS
260 270 280 290 300
QSMHLIVHQR SHTGEKPYEC SECGKAFSKS STLTLHQRNH TGEKPYKCNK
310 320 330 340 350
CGKSFSQSTY LIEHQRLHSG VKPFECNQCG KAFSKNSSLT QHRRIHTGEK
360 370 380 390 400
PYECMICGKH FTGRSSLTVH QVIHTGEKPY ECTECGKAFS QSAYLIEHQR
410 420 430 440 450
IHTGEKPYEC DQCGKAFIKN SSLIVHQRIH TGEKPYQCNE CGKSFSRSTN
LTRHQRTHT
Sequence cautioni
The sequence BAE20918 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 136 | H → Q in BAE20918 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 399 | Q → R in CAA68768 (PubMed:3409867).Curated | 1 | |
Sequence conflicti | 399 | Q → R in AAA37640 (PubMed:3815523).Curated | 1 | |
Sequence conflicti | 436 | Y → N in BAE20918 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 444 | S → P in CAA68768 (PubMed:3409867).Curated | 1 | |
Sequence conflicti | 444 | S → P in AAA37640 (PubMed:3815523).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_026332 | 217 – 328 | Missing in isoform 2. 1 PublicationAdd BLAST | 112 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y00850 mRNA Translation: CAA68768.1 AF483520 mRNA Translation: AAL90794.1 AF483521 mRNA Translation: AAL90795.1 AK036776 mRNA Translation: BAC29572.1 AK131978 mRNA Translation: BAE20918.1 Frameshift. AK141471 mRNA Translation: BAE24694.1 AL627215 Genomic DNA No translation available. BC089506 mRNA Translation: AAH89506.1 M15709 Genomic DNA Translation: AAA37640.1 |
CCDSi | CCDS36148.1 [P08043-1] |
PIRi | S00549 |
RefSeqi | NP_001038162.1, NM_001044697.2 [P08043-1] NP_001038163.1, NM_001044698.2 [P08043-1] NP_001038165.1, NM_001044700.2 [P08043-1] NP_001281252.1, NM_001294323.1 [P08043-1] NP_848542.1, NM_178447.3 [P08043-1] XP_017169995.1, XM_017314506.1 [P08043-1] |
Genome annotation databases
Ensembli | ENSMUST00000109128; ENSMUSP00000104756; ENSMUSG00000049321 [P08043-1] ENSMUST00000109129; ENSMUSP00000104757; ENSMUSG00000049321 [P08043-1] ENSMUST00000116378; ENSMUSP00000112079; ENSMUSG00000049321 [P08043-1] |
GeneIDi | 22678 |
KEGGi | mmu:22678 |
UCSCi | uc007isy.2, mouse [P08043-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y00850 mRNA Translation: CAA68768.1 AF483520 mRNA Translation: AAL90794.1 AF483521 mRNA Translation: AAL90795.1 AK036776 mRNA Translation: BAC29572.1 AK131978 mRNA Translation: BAE20918.1 Frameshift. AK141471 mRNA Translation: BAE24694.1 AL627215 Genomic DNA No translation available. BC089506 mRNA Translation: AAH89506.1 M15709 Genomic DNA Translation: AAA37640.1 |
CCDSi | CCDS36148.1 [P08043-1] |
PIRi | S00549 |
RefSeqi | NP_001038162.1, NM_001044697.2 [P08043-1] NP_001038163.1, NM_001044698.2 [P08043-1] NP_001038165.1, NM_001044700.2 [P08043-1] NP_001281252.1, NM_001294323.1 [P08043-1] NP_848542.1, NM_178447.3 [P08043-1] XP_017169995.1, XM_017314506.1 [P08043-1] |
3D structure databases
AlphaFoldDBi | P08043 |
SMRi | P08043 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 204647, 1 interactor |
STRINGi | 10090.ENSMUSP00000112079 |
PTM databases
iPTMneti | P08043 |
PhosphoSitePlusi | P08043 |
Proteomic databases
PaxDbi | P08043 |
PRIDEi | P08043 |
ProteomicsDBi | 275355 [P08043-1] 275356 [P08043-2] |
Protocols and materials databases
Antibodypediai | 29457, 46 antibodies from 17 providers |
DNASUi | 22678 |
Genome annotation databases
Ensembli | ENSMUST00000109128; ENSMUSP00000104756; ENSMUSG00000049321 [P08043-1] ENSMUST00000109129; ENSMUSP00000104757; ENSMUSG00000049321 [P08043-1] ENSMUST00000116378; ENSMUSP00000112079; ENSMUSG00000049321 [P08043-1] |
GeneIDi | 22678 |
KEGGi | mmu:22678 |
UCSCi | uc007isy.2, mouse [P08043-1] |
Organism-specific databases
CTDi | 80108 |
MGIi | MGI:99167, Zfp2 |
VEuPathDBi | HostDB:ENSMUSG00000049321 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162743 |
HOGENOMi | CLU_002678_44_0_1 |
InParanoidi | P08043 |
OMAi | TERRVCG |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P08043 |
TreeFami | TF350858 |
Miscellaneous databases
BioGRID-ORCSi | 22678, 2 hits in 71 CRISPR screens |
PROi | PR:P08043 |
RNActi | P08043, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000049321, Expressed in brain and 277 other tissues |
Genevisiblei | P08043, MM |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 13 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 13 hits |
SUPFAMi | SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 13 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZFP2_MOUSE | |
Accessioni | P08043Primary (citable) accession number: P08043 Secondary accession number(s): Q3V280, Q8R012 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | June 26, 2007 | |
Last modified: | May 25, 2022 | |
This is version 175 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families