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Protein

Zinc finger protein 2

Gene

Zfp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri100 – 122C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri128 – 150C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri156 – 178C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri184 – 206C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri212 – 234C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 2
Short name:
Zfp-2
Alternative name(s):
Protein mKR2
Gene namesi
Name:Zfp2
Synonyms:Fnp-2, Mkr2, Zfp-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:99167 Zfp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472821 – 459Zinc finger protein 2Add BLAST459

Proteomic databases

PaxDbiP08043
PRIDEiP08043

PTM databases

iPTMnetiP08043
PhosphoSitePlusiP08043

Expressioni

Gene expression databases

BgeeiENSMUSG00000049321 Expressed in 251 organ(s), highest expression level in brain
CleanExiMM_ZFP2
GenevisibleiP08043 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104756

Structurei

3D structure databases

ProteinModelPortaliP08043
SMRiP08043
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri100 – 122C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri128 – 150C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri156 – 178C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri184 – 206C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri212 – 234C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150844
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP08043
OMAiKKIYECN
OrthoDBiEOG091G02KC
PhylomeDBiP08043
TreeFamiTF350858

Family and domain databases

InterProiView protein in InterPro
IPR017114 YY-1-like
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 13 hits
PIRSFiPIRSF037113 TF_Yin_yang, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P08043-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDREDLWHSA LGAVWDPTCW LKGQQERYLG QVTVAQKEIY NEKSVCGGNT
60 70 80 90 100
TENSSTEGSM LNTPQSIPVT PCNWNSYRKD SKQNSELMKT SRMFVQKKVY
110 120 130 140 150
GCDECGKTFR QSSSLLKHQR IHTGEKPYTC NVCDKHFIER SSLTVHQRTH
160 170 180 190 200
TGEKPYKCHE CGKAFSQSMN LTVHQRTHTG EKPYQCKECG KAFRKNSSLI
210 220 230 240 250
QHERIHTGEK PYKCHDCGKA FTQSMNLTVH QRTHTGEKPY ECNQCGKAFS
260 270 280 290 300
QSMHLIVHQR SHTGEKPYEC SECGKAFSKS STLTLHQRNH TGEKPYKCNK
310 320 330 340 350
CGKSFSQSTY LIEHQRLHSG VKPFECNQCG KAFSKNSSLT QHRRIHTGEK
360 370 380 390 400
PYECMICGKH FTGRSSLTVH QVIHTGEKPY ECTECGKAFS QSAYLIEHQR
410 420 430 440 450
IHTGEKPYEC DQCGKAFIKN SSLIVHQRIH TGEKPYQCNE CGKSFSRSTN

LTRHQRTHT
Length:459
Mass (Da):52,534
Last modified:June 26, 2007 - v2
Checksum:i1211EBD2828F9284
GO
Isoform 2 (identifier: P08043-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     217-328: Missing.

Show »
Length:347
Mass (Da):39,817
Checksum:iF0C8E9F6CECC548C
GO

Sequence cautioni

The sequence BAE20918 differs from that shown. Reason: Frameshift at position 11.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136H → Q in BAE20918 (PubMed:16141072).Curated1
Sequence conflicti399Q → R in CAA68768 (PubMed:3409867).Curated1
Sequence conflicti399Q → R in AAA37640 (PubMed:3815523).Curated1
Sequence conflicti436Y → N in BAE20918 (PubMed:16141072).Curated1
Sequence conflicti444S → P in CAA68768 (PubMed:3409867).Curated1
Sequence conflicti444S → P in AAA37640 (PubMed:3815523).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026332217 – 328Missing in isoform 2. 1 PublicationAdd BLAST112

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00850 mRNA Translation: CAA68768.1
AF483520 mRNA Translation: AAL90794.1
AF483521 mRNA Translation: AAL90795.1
AK036776 mRNA Translation: BAC29572.1
AK131978 mRNA Translation: BAE20918.1 Frameshift.
AK141471 mRNA Translation: BAE24694.1
AL627215 Genomic DNA Translation: CAI35300.1
BC089506 mRNA Translation: AAH89506.1
M15709 Genomic DNA Translation: AAA37640.1
CCDSiCCDS36148.1 [P08043-1]
PIRiS00549
RefSeqiNP_001038162.1, NM_001044697.2 [P08043-1]
NP_001038163.1, NM_001044698.2 [P08043-1]
NP_001038165.1, NM_001044700.2 [P08043-1]
NP_001281252.1, NM_001294323.1 [P08043-1]
NP_848542.1, NM_178447.3 [P08043-1]
XP_017169995.1, XM_017314506.1 [P08043-1]
UniGeneiMm.259230

Genome annotation databases

EnsembliENSMUST00000109128; ENSMUSP00000104756; ENSMUSG00000049321 [P08043-1]
ENSMUST00000109129; ENSMUSP00000104757; ENSMUSG00000049321 [P08043-1]
ENSMUST00000116378; ENSMUSP00000112079; ENSMUSG00000049321 [P08043-1]
GeneIDi22678
KEGGimmu:22678
UCSCiuc007isy.2 mouse [P08043-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00850 mRNA Translation: CAA68768.1
AF483520 mRNA Translation: AAL90794.1
AF483521 mRNA Translation: AAL90795.1
AK036776 mRNA Translation: BAC29572.1
AK131978 mRNA Translation: BAE20918.1 Frameshift.
AK141471 mRNA Translation: BAE24694.1
AL627215 Genomic DNA Translation: CAI35300.1
BC089506 mRNA Translation: AAH89506.1
M15709 Genomic DNA Translation: AAA37640.1
CCDSiCCDS36148.1 [P08043-1]
PIRiS00549
RefSeqiNP_001038162.1, NM_001044697.2 [P08043-1]
NP_001038163.1, NM_001044698.2 [P08043-1]
NP_001038165.1, NM_001044700.2 [P08043-1]
NP_001281252.1, NM_001294323.1 [P08043-1]
NP_848542.1, NM_178447.3 [P08043-1]
XP_017169995.1, XM_017314506.1 [P08043-1]
UniGeneiMm.259230

3D structure databases

ProteinModelPortaliP08043
SMRiP08043
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104756

PTM databases

iPTMnetiP08043
PhosphoSitePlusiP08043

Proteomic databases

PaxDbiP08043
PRIDEiP08043

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109128; ENSMUSP00000104756; ENSMUSG00000049321 [P08043-1]
ENSMUST00000109129; ENSMUSP00000104757; ENSMUSG00000049321 [P08043-1]
ENSMUST00000116378; ENSMUSP00000112079; ENSMUSG00000049321 [P08043-1]
GeneIDi22678
KEGGimmu:22678
UCSCiuc007isy.2 mouse [P08043-1]

Organism-specific databases

CTDi80108
MGIiMGI:99167 Zfp2

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150844
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP08043
OMAiKKIYECN
OrthoDBiEOG091G02KC
PhylomeDBiP08043
TreeFamiTF350858

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Miscellaneous databases

PROiPR:P08043
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049321 Expressed in 251 organ(s), highest expression level in brain
CleanExiMM_ZFP2
GenevisibleiP08043 MM

Family and domain databases

InterProiView protein in InterPro
IPR017114 YY-1-like
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 13 hits
PIRSFiPIRSF037113 TF_Yin_yang, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZFP2_MOUSE
AccessioniPrimary (citable) accession number: P08043
Secondary accession number(s): Q3V280, Q8R012
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: June 26, 2007
Last modified: November 7, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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