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Protein

Zinc finger protein 1

Gene

Zfp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri182 – 204C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri210 – 232C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri238 – 260C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri266 – 288C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri294 – 316C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri322 – 344C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri350 – 372C2H2-type 7; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri378 – 400C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 1
Short name:
Zfp-1
Alternative name(s):
Protein mKR1
Gene namesi
Name:Zfp1
Synonyms:Fnp-1, Zfp-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:99154 Zfp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472801 – 402Zinc finger protein 1Add BLAST402

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki73Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki113Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki143Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiP08042
PeptideAtlasiP08042
PRIDEiP08042

PTM databases

iPTMnetiP08042
PhosphoSitePlusiP08042

Expressioni

Developmental stagei

During murine embryogenesis, ZFP-1 was found to be expressed at a peak level in day 12 embryos.

Gene expression databases

CleanExiMM_ZFP1

Interactioni

Protein-protein interaction databases

BioGridi204630, 1 interactor
STRINGi10090.ENSMUSP00000076964

Structurei

3D structure databases

ProteinModelPortaliP08042
SMRiP08042
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 83KRABPROSITE-ProRule annotationAdd BLAST77

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri182 – 204C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri210 – 232C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri238 – 260C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri266 – 288C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri294 – 316C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri322 – 344C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri350 – 372C2H2-type 7; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri378 – 400C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP08042
KOiK09228

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 6 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P08042-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSQGSVSFT DVTVDFTQEE WEQLDPSQRI LYMDVMLENY SNLLSVEVWK
60 70 80 90 100
ADGQVERDPR DLQRQVGSLT TIKNQPPTEE RGSRFGKTLT LNTDFVSLRQ
110 120 130 140 150
VPYKYDLYEK TLKYNSDLLS SRNCVRKKGD GCGGFGEPLL YLKQEKPHAG
160 170 180 190 200
LEYSEYNGNG RALSHKDAIF KHRKIKSLVQ PFVCNYCDKT FSFKSLLVSH
210 220 230 240 250
KRIHTGEKPY ECDVCQKTFS HKANLIKHQR IHTGEKPFEC PECGKAFTHQ
260 270 280 290 300
SNLIVHQRAH MEKKPYGCSE CGKTFAQKFE LTTHQRIHTG ERPYECNECA
310 320 330 340 350
KTFFKKSNLI IHQKIHTGEK RYECSECGKS FIQNSQLIIH RRTHTGEKPY
360 370 380 390 400
ECTECGKTFS QRSTLRLHLR IRTGEKPYEC AECGKAFSRK SRLSVHQRVH

MA
Length:402
Mass (Da):46,511
Last modified:February 1, 2005 - v3
Checksum:i5FA205A7A37E3D09
GO
Isoform 2 (identifier: P08042-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MGSQGSVSFTDVTVDFT → MMGS

Show »
Length:389
Mass (Da):45,157
Checksum:i490C7DF13FE8E312
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3UI68Q3UI68_MOUSE
Zinc finger protein 1
Zfp1 mCG_3766
403Annotation score:
A0A1D5RLC5A0A1D5RLC5_MOUSE
Zinc finger protein 1
Zfp1
389Annotation score:
A0A1D5RLR2A0A1D5RLR2_MOUSE
Zinc finger protein 1
Zfp1 mCG_3766
64Annotation score:
A0A1D5RLU7A0A1D5RLU7_MOUSE
Zinc finger protein 1
Zfp1
370Annotation score:

Sequence cautioni

The sequence AAA37639 differs from that shown. Reason: Frameshift at positions 66, 373 and 391.Curated
The sequence CAA34510 differs from that shown. Reason: Frameshift at positions 373 and 391.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti372R → H in CAA34510 (PubMed:2574853).Curated1
Sequence conflicti372R → H in AAA37639 (PubMed:2574853).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0126831 – 17MGSQG…TVDFT → MMGS in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16493 mRNA Translation: CAA34510.1 Frameshift.
BC055796 mRNA Translation: AAH55796.1
BC062970 mRNA Translation: AAH62970.1
M15708 Genomic DNA Translation: AAA37639.1 Frameshift.
CCDSiCCDS85614.1 [P08042-2]
PIRiS15917
RefSeqiNP_001032754.1, NM_001037665.2
NP_035872.2, NM_011742.2
UniGeneiMm.4184

Genome annotation databases

GeneIDi22640
KEGGimmu:22640

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16493 mRNA Translation: CAA34510.1 Frameshift.
BC055796 mRNA Translation: AAH55796.1
BC062970 mRNA Translation: AAH62970.1
M15708 Genomic DNA Translation: AAA37639.1 Frameshift.
CCDSiCCDS85614.1 [P08042-2]
PIRiS15917
RefSeqiNP_001032754.1, NM_001037665.2
NP_035872.2, NM_011742.2
UniGeneiMm.4184

3D structure databases

ProteinModelPortaliP08042
SMRiP08042
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204630, 1 interactor
STRINGi10090.ENSMUSP00000076964

PTM databases

iPTMnetiP08042
PhosphoSitePlusiP08042

Proteomic databases

PaxDbiP08042
PeptideAtlasiP08042
PRIDEiP08042

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi22640
KEGGimmu:22640

Organism-specific databases

CTDi162239
MGIiMGI:99154 Zfp1

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP08042
KOiK09228

Miscellaneous databases

PROiPR:P08042
SOURCEiSearch...

Gene expression databases

CleanExiMM_ZFP1

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 6 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZFP1_MOUSE
AccessioniPrimary (citable) accession number: P08042
Secondary accession number(s): P16074, Q7TNS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: February 1, 2005
Last modified: October 10, 2018
This is version 166 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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