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Protein

Gap junction beta-1 protein

Gene

Gjb1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Molecular functioni

  • gap junction channel activity Source: RGD
  • protein homodimerization activity Source: Ensembl

GO - Biological processi

  • cell communication Source: RGD
  • epididymis development Source: RGD
  • protein complex oligomerization Source: RGD
  • purine ribonucleotide transport Source: RGD

Enzyme and pathway databases

ReactomeiR-RNO-190704 Oligomerization of connexins into connexons
R-RNO-190861 Gap junction assembly

Protein family/group databases

TCDBi1.A.24.1.2 the gap junction-forming connexin (connexin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction beta-1 protein
Alternative name(s):
Connexin-32
Short name:
Cx32
GAP junction 28 kDa liver protein
Gene namesi
Name:Gjb1
Synonyms:Cxn-32
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi61926 Gjb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
Transmembranei23 – 45HelicalSequence analysisAdd BLAST23
Topological domaini46 – 75ExtracellularSequence analysisAdd BLAST30
Transmembranei76 – 95HelicalSequence analysisAdd BLAST20
Topological domaini96 – 130CytoplasmicSequence analysisAdd BLAST35
Transmembranei131 – 153HelicalSequence analysisAdd BLAST23
Topological domaini154 – 191ExtracellularSequence analysisAdd BLAST38
Transmembranei192 – 214HelicalSequence analysisAdd BLAST23
Topological domaini215 – 283CytoplasmicSequence analysisAdd BLAST69

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000578521 – 283Gap junction beta-1 proteinAdd BLAST283

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei233PhosphoserineCombined sources1
Modified residuei258PhosphoserineCombined sources1
Modified residuei266PhosphoserineCombined sources1
Modified residuei277PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP08033
PRIDEiP08033

PTM databases

iPTMnetiP08033
PhosphoSitePlusiP08033

Expressioni

Gene expression databases

BgeeiENSRNOG00000003746
ExpressionAtlasiP08033 baseline and differential
GenevisibleiP08033 RN

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins. Interacts with CNST (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi248217, 1 interactor
STRINGi10116.ENSRNOP00000004979

Structurei

3D structure databases

ProteinModelPortaliP08033
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFM8 Eukaryota
ENOG410Y7VN LUCA
GeneTreeiENSGT00910000144026
HOGENOMiHOG000231127
HOVERGENiHBG009576
InParanoidiP08033
KOiK07620
OMAiYLVVRAC
OrthoDBiEOG091G0FKH
PhylomeDBiP08033
TreeFamiTF329606

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002267 Connexin32
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
PR01138 CONNEXINB1
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

P08033-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNWTGLYTLL SGVNRHSTAI GRVWLSVIFI FRIMVLVVAA ESVWGDEKSS
60 70 80 90 100
FICNTLQPGC NSVCYDHFFP ISHVRLWSLQ LILVSTPALL VAMHVAHQQH
110 120 130 140 150
IEKKMLRLEG HGDPLHLEEV KRHKVHISGT LWWTYVISVV FRLLFEAVFM
160 170 180 190 200
YVFYLLYPGY AMVRLVKCEA FPCPNTVDCF VSRPTEKTVF TVFMLAASGI
210 220 230 240 250
CIILNVAEVV YLIIRACARR AQRRSNPPSR KGSGFGHRLS PEYKQNEINK
260 270 280
LLSEQDGSLK DILRRSPGTG AGLAEKSDRC SAC
Length:283
Mass (Da):32,004
Last modified:August 1, 1988 - v1
Checksum:iC79FC46AA13BC5D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04070 mRNA Translation: CAA27705.1
X04303 mRNA Translation: CAA27846.1
M23565 Genomic DNA Translation: AAA81569.1
BC078868 mRNA Translation: AAH78868.1
AH003192 Genomic DNA Translation: AAA75195.1
PIRiA92745 GJRT
I52552
RefSeqiNP_058947.1, NM_017251.2
XP_008771477.1, XM_008773255.2
XP_017457434.1, XM_017601945.1
UniGeneiRn.10444

Genome annotation databases

EnsembliENSRNOT00000076816; ENSRNOP00000068248; ENSRNOG00000003746
GeneIDi29584
KEGGirno:29584

Similar proteinsi

Entry informationi

Entry nameiCXB1_RAT
AccessioniPrimary (citable) accession number: P08033
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: May 23, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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