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Entry version 168 (16 Oct 2019)
Sequence version 3 (07 Jul 2009)
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Protein

Spectrin alpha chain, erythrocytic 1

Gene

Spta1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.

Miscellaneous

This complex is anchored to the cytoplasmic face of the plasma membrane via another protein, ankyrin, which binds to beta-spectrin and mediates the binding of the whole complex to a transmembrane protein band 3. The interaction of erythrocyte spectrin with other proteins through specific binding domains lead to the formation of an extensive subplasmalemmal meshwork which is thought to be responsible for the maintenance of the biconcave shape of human erythrocytes, for the regulation of plasma membrane components and for the maintenance of the lipid asymmetry of the plasma membrane.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi2280 – 22911PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi2323 – 23342PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin capping, Actin-binding
Biological processCell shape
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-375165 NCAM signaling for neurite out-growth
R-MMU-445095 Interaction between L1 and Ankyrins
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6807878 COPI-mediated anterograde transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spectrin alpha chain, erythrocytic 1
Alternative name(s):
Erythroid alpha-spectrin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Spta1
Synonyms:Spna1, Spta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:98385 Spta1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000734531 – 2415Spectrin alpha chain, erythrocytic 1Add BLAST2415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei257PhosphoserineCombined sources1
Modified residuei990PhosphoserineBy similarity1
Modified residuei1972PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P08032

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P08032

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P08032

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P08032

PeptideAtlas

More...
PeptideAtlasi
P08032

PRoteomics IDEntifications database

More...
PRIDEi
P08032

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P08032

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P08032

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P08032

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000026532 Expressed in 106 organ(s), highest expression level in blood

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P08032 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Composed of non-homologous chains, alpha and beta, which aggregate to form dimers, tetramers, and higher polymers.

Interacts with FASLG (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
203458, 5 interactors

Protein interaction database and analysis system

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IntActi
P08032, 7 interactors

Molecular INTeraction database

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MINTi
P08032

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000027817

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P08032

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati52 – 152Spectrin 1Sequence analysisAdd BLAST101
Repeati157 – 259Spectrin 2Sequence analysisAdd BLAST103
Repeati263 – 365Spectrin 3Sequence analysisAdd BLAST103
Repeati370 – 471Spectrin 4Sequence analysisAdd BLAST102
Repeati475 – 576Spectrin 5Sequence analysisAdd BLAST102
Repeati580 – 681Spectrin 6Sequence analysisAdd BLAST102
Repeati686 – 787Spectrin 7Sequence analysisAdd BLAST102
Repeati792 – 894Spectrin 8Sequence analysisAdd BLAST103
Repeati898 – 967Spectrin 9Sequence analysisAdd BLAST70
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini975 – 1034SH3PROSITE-ProRule annotationAdd BLAST60
Repeati1085 – 1177Spectrin 10Sequence analysisAdd BLAST93
Repeati1183 – 1285Spectrin 11Sequence analysisAdd BLAST103
Repeati1287 – 1390Spectrin 12Sequence analysisAdd BLAST104
Repeati1394 – 1489Spectrin 13Sequence analysisAdd BLAST96
Repeati1499 – 1603Spectrin 14Sequence analysisAdd BLAST105
Repeati1606 – 1709Spectrin 15Sequence analysisAdd BLAST104
Repeati1712 – 1815Spectrin 16Sequence analysisAdd BLAST104
Repeati1818 – 1921Spectrin 17Sequence analysisAdd BLAST104
Repeati1924 – 2029Spectrin 18Sequence analysisAdd BLAST106
Repeati2040 – 2142Spectrin 19Sequence analysisAdd BLAST103
Repeati2154 – 2254Spectrin 20Sequence analysisAdd BLAST101
Domaini2267 – 2302EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini2310 – 2345EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini2347 – 2382EF-hand 3PROSITE-ProRule annotationAdd BLAST36

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the spectrin family.Curated

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0035 Eukaryota
COG5069 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161240

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000246965

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P08032

KEGG Orthology (KO)

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KOi
K06114

Identification of Orthologs from Complete Genome Data

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OMAi
DYKDTQN

Database of Orthologous Groups

More...
OrthoDBi
543832at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P08032

TreeFam database of animal gene trees

More...
TreeFami
TF343803

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR014837 EF-hand_Ca_insen
IPR002048 EF_hand_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08726 EFhand_Ca_insen, 1 hit
PF00018 SH3_1, 1 hit
PF00435 Spectrin, 20 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00326 SH3, 1 hit
SM00150 SPEC, 20 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 1 hit
SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50222 EF_HAND_2, 3 hits
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P08032-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METPKETAVE SSGPKVLETA EEIQHRRAEV LNQYQRFKDR VAERGQKLEE
60 70 80 90 100
SYHYQVFRRD ADDLEKWIME KLEIAKDKTY EPTNIQGKYQ KHESFVSEVQ
110 120 130 140 150
AKSRVLPELE EIREARFAED HFAHEATKTH LKQLRLLWDL LLELTQEKSD
160 170 180 190 200
VLLRALKFYQ YSQECEDILE WVKEKEAIVT LVELGDDWER TEVLHKKFEE
210 220 230 240 250
FQEELTARKG KVDRVNQYAN ECAQEKHPKL PEIKAKQDEV NAAWDRLWSL
260 270 280 290 300
ALKRRESLSN AADLQRFKRD VNEAIQWMEE KEPQLTSEDY GKDLVSSEAL
310 320 330 340 350
FHNHKRLERN LAVMDDKVKE LCAKADKLMI SHSADAPQIQ QMKLDLVSNW
360 370 380 390 400
ERIRALATNR YAKLKASYGY HRFLSDYDEL SGWMKEKTAL INADELPTDV
410 420 430 440 450
ASGEALLARH QQHKHEIDSY DDRFQSADAT GQELLDGNHE ASEEIREKMT
460 470 480 490 500
ILANDWAALL ELWDKCQHQY RQCLDFHLFY RDSEQVDSWM SRQEAFLENE
510 520 530 540 550
DLGNSVGSVE ALLQKHDDFE EAFTAQEEKI ITLDETATKL IDNDHYDSEN
560 570 580 590 600
IAAIRDGLLA RRDALRERAA TRRKLLVDSQ LLQQLYQDSD DLKTWINKKK
610 620 630 640 650
KLADDDDYKD VQNLKSRVQK QQDFEEELAV NEIMLNNLEK TGQEMIEDGH
660 670 680 690 700
YASEAVAARL SEVANLWKEL LEATAQKGTQ LYEANQLLQF ENNAEDLKRW
710 720 730 740 750
LEEVEWQVTS EDYGKGLADV QNLLRKHGLL ESDVTARQNQ VDTLTDMAAH
760 770 780 790 800
FEEIGHPDSG DIRARQESLL SRFEALKEPL AIRKKKLIDL LKLQQICRDS
810 820 830 840 850
EDEEAWIQET EPSAASTHLG KDLVAAKNLL NRHEVILADI ASHEPRIQVI
860 870 880 890 900
TERGNKMVEE GHFAAEDIAS RVESLNKNME SLHARAIRRE NDLKANVQLQ
910 920 930 940 950
QYLADLHEAE AWIKEKEPIV DNKNYGADEE AAGALLKKHE AFLVDLNAFE
960 970 980 990 1000
NSIKALRDQA EVCQQQQAAP VDEAGREARV IALYDFEARS RREVSMKKND
1010 1020 1030 1040 1050
VLTLLSSINK DWWKVEADDH QGFVPAVYVR KLAPDELPGF PQHRQEEPVN
1060 1070 1080 1090 1100
IPQLQQQVET LYHSLLDRAE ERRRRLLQRY NEFLLAYEAG DMLEWIQEKK
1110 1120 1130 1140 1150
TENTGVELDD VWELQKKFDE FQRDLKSNEP RLKDINKVAD ELLFEELLTP
1160 1170 1180 1190 1200
EGAHIRQELN TRWNSLKRLA DEQYQLLSSA HAVEMFHREA DDVKEQIDKK
1210 1220 1230 1240 1250
CRALNAADPG SDLLSVQALQ RQHEVFERDI IPLGEKVTTL GETAERLCES
1260 1270 1280 1290 1300
HPDATEDLQK QRTELNEAWD TLQGLTSDRK ESLNEAHKFF LFLSKASDLE
1310 1320 1330 1340 1350
NWIKTIGGVI SSPELAEDLT GTEILLERHQ EHHDDIKRED PTFQALEDFG
1360 1370 1380 1390 1400
TELIDSGHRN RREIDNTLQN INSKRDNLEK SWENRKKMLD QCLELQLFRG
1410 1420 1430 1440 1450
KCDQVESWMV ARENSLRSDD RDHLNSLQAL MKKRDDLDKA ITAQEGKISD
1460 1470 1480 1490 1500
LENVATRLID NDHYAKEEIA ARLQRVLDRW KALKEQLLTE LGKLGDYADL
1510 1520 1530 1540 1550
KQFYRDLEDL EEWINEMLPI ACDESYKDPT NIQRKYLKHQ AFENEVNGRA
1560 1570 1580 1590 1600
EQVDGVINLG NSLIERRVCD GDEENMQEQL DKLKENWDYL LERTTDKGQK
1610 1620 1630 1640 1650
LNEASRQQRF NTSIRDFEFW LSEAEGLLAM KDQARDLTSA GNLLKKHQLL
1660 1670 1680 1690 1700
EAEMLAREDP LKDLNDLAQE LISSGTFNID QIEEKMNGVN ERFENVQSLA
1710 1720 1730 1740 1750
AAHHEKLKET YALFQFFQDL DDEEAWIEEK LLRVSSQDYG RDLQSVQNLL
1760 1770 1780 1790 1800
KKHKRLEGEL VAHEPAVQNV LDTAESLRDK AAVGKEEIQE RLAQFVQHWE
1810 1820 1830 1840 1850
KLKELAKTRG VNLEESLEYL QFMENAEEEE AWLGEKCALV SRGDSGDTLA
1860 1870 1880 1890 1900
ATQSLLKKHE ALENDFAVHK NRVQDVCAQG EDILNKEETQ NKDKISTKIQ
1910 1920 1930 1940 1950
VLNEKTASLA KALAAWKSQL DDVHAFQQFN WKADVVESWI GEKEASLKTK
1960 1970 1980 1990 2000
SNGADLTAFL TLLAKHDTLD ASLQSFQQER LSEIAELKDQ LVAGEHSQAK
2010 2020 2030 2040 2050
AIEEQHAALL RHWEQLLEAS RVHRQKLLEK QLPLQKAEEL FMEFAHKASA
2060 2070 2080 2090 2100
FNNWCENAEE DLSEPVHCVS LNEIRQLQKE HEAFLASLAG AQEDFNYLLE
2110 2120 2130 2140 2150
LDKQIKALNV PSSPYTWLTV DVLGRIWNHL PDIIKEREQE LQKEEARQIK
2160 2170 2180 2190 2200
NFEMCQEFEQ NASAFLQWIQ ETRAYFLDGS LLKETGTLES QLEANKRKQK
2210 2220 2230 2240 2250
EIQAMKRHLT KIEDLGDSME EALILDIKYS TIGLAQQWDQ LHQLGMRMQH
2260 2270 2280 2290 2300
NLEQQIQAKD TIGVSEETLK EFSTTYKHFD ENLTGRLTHK EFRSCLRGLN
2310 2320 2330 2340 2350
YYLPMVEEGE PEPKFEKFLN AVDPGRKGYV SLEDYTSFLI DKESENIKTS
2360 2370 2380 2390 2400
DDIESAFQAL AEGKAYITKE DMKQALTPEQ VSFCTIHMQQ YMDPRGRSQP
2410
AGYDYVGFTN SFFGN
Length:2,415
Mass (Da):279,865
Last modified:July 7, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i510B61CDEC4FAD13
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti337P → L in AAB47540 (Ref. 1) Curated1
Sequence conflicti501D → Y in AAI50748 (PubMed:15489334).Curated1
Sequence conflicti716G → V in AAB47540 (Ref. 1) Curated1
Sequence conflicti741V → M in AAB47540 (Ref. 1) Curated1
Sequence conflicti741V → M in AAI50748 (PubMed:15489334).Curated1
Sequence conflicti1044 – 1045RQ → QR in AAB47540 (Ref. 1) Curated2
Sequence conflicti1044 – 1045RQ → QR in AAI50748 (PubMed:15489334).Curated2
Sequence conflicti1225V → C in AAB47540 (Ref. 1) Curated1
Sequence conflicti1238T → N in AAB47540 (Ref. 1) Curated1
Sequence conflicti1425N → D in AAB47540 (Ref. 1) Curated1
Sequence conflicti1582K → M in AAB47540 (Ref. 1) Curated1
Sequence conflicti2062L → M in AAB47540 (Ref. 1) Curated1
Sequence conflicti2062L → M in AAI50748 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U87455 mRNA Translation: AAB47540.1
AF093576 mRNA Translation: AAC61874.1
AC113483 mRNA No translation available.
AC156549 mRNA No translation available.
BC150747 mRNA Translation: AAI50748.1
M10276 mRNA Translation: AAA40123.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS35795.1

Protein sequence database of the Protein Information Resource

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PIRi
A05283

NCBI Reference Sequences

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RefSeqi
NP_035595.2, NM_011465.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000027817; ENSMUSP00000027817; ENSMUSG00000026532

Database of genes from NCBI RefSeq genomes

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GeneIDi
20739

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:20739

UCSC genome browser

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UCSCi
uc007dsw.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U87455 mRNA Translation: AAB47540.1
AF093576 mRNA Translation: AAC61874.1
AC113483 mRNA No translation available.
AC156549 mRNA No translation available.
BC150747 mRNA Translation: AAI50748.1
M10276 mRNA Translation: AAA40123.1
CCDSiCCDS35795.1
PIRiA05283
RefSeqiNP_035595.2, NM_011465.4

3D structure databases

SMRiP08032
ModBaseiSearch...

Protein-protein interaction databases

BioGridi203458, 5 interactors
IntActiP08032, 7 interactors
MINTiP08032
STRINGi10090.ENSMUSP00000027817

PTM databases

iPTMnetiP08032
PhosphoSitePlusiP08032
SwissPalmiP08032

Proteomic databases

EPDiP08032
jPOSTiP08032
MaxQBiP08032
PaxDbiP08032
PeptideAtlasiP08032
PRIDEiP08032

Genome annotation databases

EnsembliENSMUST00000027817; ENSMUSP00000027817; ENSMUSG00000026532
GeneIDi20739
KEGGimmu:20739
UCSCiuc007dsw.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6708
MGIiMGI:98385 Spta1

Phylogenomic databases

eggNOGiKOG0035 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00940000161240
HOGENOMiHOG000246965
InParanoidiP08032
KOiK06114
OMAiDYKDTQN
OrthoDBi543832at2759
PhylomeDBiP08032
TreeFamiTF343803

Enzyme and pathway databases

ReactomeiR-MMU-375165 NCAM signaling for neurite out-growth
R-MMU-445095 Interaction between L1 and Ankyrins
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6807878 COPI-mediated anterograde transport

Miscellaneous databases

Protein Ontology

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PROi
PR:P08032

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000026532 Expressed in 106 organ(s), highest expression level in blood
GenevisibleiP08032 MM

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR014837 EF-hand_Ca_insen
IPR002048 EF_hand_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
PfamiView protein in Pfam
PF08726 EFhand_Ca_insen, 1 hit
PF00018 SH3_1, 1 hit
PF00435 Spectrin, 20 hits
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SM00150 SPEC, 20 hits
SUPFAMiSSF47473 SSF47473, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 3 hits
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPTA1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08032
Secondary accession number(s): B2RWX6, P97502
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: July 7, 2009
Last modified: October 16, 2019
This is version 168 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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