NP - Nucleoprotein - Influenza C virus (strain C/California/1978)

Functionⁱ

Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway. Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.UniRule annotation

GO - Molecular functionⁱ

RNA binding Source: UniProtKB-KW
structural molecule activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

viral entry into host cell Source: UniProtKB-KW
viral penetration into host nucleus Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ribonucleoprotein, RNA-binding, Viral nucleoprotein
Biological process	Host-virus interaction, Viral penetration into host nucleus, Virus entry into host cell

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: NucleoproteinUniRule annotation Alternative name(s): Nucleocapsid proteinUniRule annotation Short name: Protein NUniRule annotation
Gene namesⁱ	Name:NPUniRule annotation
Organismⁱ	Influenza C virus (strain C/California/1978)
Taxonomic identifierⁱ	203224 [NCBI]
Taxonomic lineageⁱ	Viruses › ssRNA viruses › ssRNA negative-strand viruses › Orthomyxoviridae › Gammainfluenzavirus › Influenza C virus
Virus hostⁱ	Homo sapiens (Human) [TaxID: 9606] Sus scrofa (Pig) [TaxID: 9823]

Subcellular locationⁱ

GO - Cellular componentⁱ

helical viral capsid Source: UniProtKB-KW
host cell nucleus Source: UniProtKB-SubCell
viral nucleocapsid Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Capsid protein, Helical capsid protein, Host nucleus, Virion

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000079145	1 – 565	NucleoproteinAdd BLAST		565

Post-translational modificationⁱ

Late in virus-infected cells, may be cleaved from a 56-kDa protein to a 53-kDa protein by a cellular caspase. This cleavage might be a marker for the onset of apoptosis in infected cells or have a specific function in virus host interaction.UniRule annotation

Interactionⁱ

Subunit structureⁱ

Homomultimerizes to form the nucleocapsid. May bind host exportin-1/XPO1. Binds to viral genomic RNA. Protein-RNA contacts are mediated by a combination of electrostatic interactions between positively charged residues and the phosphate backbone and planar interactions between aromatic side chains and bases.UniRule annotation

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P08028
SMRⁱ	P08028
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the influenza viruses nucleoprotein family.UniRule annotation

Family and domain databases

HAMAPⁱ	MF_04070 INFV_NCAP, 1 hit
InterProⁱ	View protein in InterPro IPR002141 Flu_NP
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00506 Flu_NP, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P08028-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSDRRQNRKT PDEQRKANAL IINENIEAYI AICKEVGLNG DEMLILENGI 
        60         70         80         90        100
AIEKAIRICC DGKYQEKREK KAREAQRADS NFNADSIGIR LVKRAGSGTN 
       110        120        130        140        150
ITYHAVVELT SRSRIVQILK SHWGNELNRA KIAGKRLGFS ALFASNLEAI 
       160        170        180        190        200
IYQRGRNAAR RNGSAELFTL TQGAGIETRY KWIMEKHIGI GVLIADAKGL 
       210        220        230        240        250
INGKREGKRG VDANVKLRAG TTGSPLERAM QGIEKKAFPG PLRALARRVV 
       260        270        280        290        300
KANYNDAREA LNVIAEASLL LKPQITNKMT MPWCMWLAAR LTLKDEFTNF 
       310        320        330        340        350
CAYAGRRAFE VFNIAMEKIG ICSFQGTIMN DDEIESIEDK AQVLMMACFG 
       360        370        380        390        400
LAYEDFSLVS AMVSHPLKLR NRMKIGNFRV GEKVSTVLSP LLRFTRWAAF 
       410        420        430        440        450
AQRFALQANT SREGTQISNS AVFAVERKIT TDVQRVEELL NKVQAHEDEP 
       460        470        480        490        500
LQTLYKKVRE QISIIGRNKS EIKEFLGSSM YDLNDQEKQN PINFRSGAHP 
       510        520        530        540        550
FFFEFDPDYN PIRVKRPKKP IAKRNSNISR LEEEGMDENS EIGQAKKMKP 
       560 
LDQLASTSSN IPGEN

Length:565

Mass (Da):63,598

Last modified:August 1, 1988 - v1

Checksum:ⁱ22C10CCB1A85AA84

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M17700 Genomic RNA Translation: AAA43798.1

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

M17700 Genomic RNA Translation: AAA43798.1

Protein	Similar proteins		Species	Score	Length	Source
P08028	Nucleoprotein		INCAA		565	UniRef90_Q6I7C0
Nucleoprotein		INCJH		556
NP (Fragment)		Influenza C virus (C/Miyagi/1/94)		199
Nucleocapsid protein (Fragment)		Influenza C virus (C/Sendai/TU5/2008)		199
NP (Fragment)		Influenza C virus (C/Miyagi/6/93)		199
+206

Protein	Similar proteins		Species	Score	Length	Source
P08028	Nucleoprotein		INCAA		565	UniRef50_Q6I7C0
Nucleoprotein		INCJH		556
NP (Fragment)		Influenza C virus (C/Miyagi/1/94)		199
Nucleocapsid protein (Fragment)		Influenza C virus (C/Sendai/TU5/2008)		199
NP (Fragment)		Influenza C virus (C/Miyagi/6/93)		199
+206

Entry informationⁱ

Entry nameⁱ	NCAP_INCCA
Accessionⁱ	P08028Primary (citable) accession number: P08028
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
	Last sequence update:	August 1, 1988
	Last modified:	June 20, 2018
	This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Viral Protein Annotation Program

UniProtKB - P08028 (NCAP_INCCA)

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Nucleoprotein

NP

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Molecule processing

Post-translational modificationⁱ

Interactionⁱ

Subunit structureⁱ

Structureⁱ

3D structure databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Family and domain databases

Sequenceⁱ

Sequence databases

Similar proteinsⁱ

Entry informationⁱ

UniProt is an ELIXIR core data resource

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UniParc

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Annotation systems

Supporting data

UniProtKB - P08028 (NCAP_INCCA)

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Nucleoprotein

NP

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Sequence databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Entry informationⁱ