UniProtKB - P08009 (GSTM7_RAT)
Protein
Glutathione S-transferase Mu 7
Gene
Gstm7
Organism
Rattus norvegicus (Rat)
Status
Functioni
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity
Miscellaneous
Yb subclass selectively binds steroid hormones.
Caution
Gstm7 is the putative ortholog of human GSTM2.Curated
Catalytic activityi
- EC:2.5.1.18By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 116 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- glutathione transferase activity Source: GO_Central
GO - Biological processi
- glutathione metabolic process Source: GO_Central
Keywordsi
Molecular function | Transferase |
Enzyme and pathway databases
Reactomei | R-RNO-156590, Glutathione conjugation |
Names & Taxonomyi
Protein namesi | Recommended name: Glutathione S-transferase Mu 7 (EC:2.5.1.18By similarity)Alternative name(s): Chain 4 GST Yb3 GST class-mu 3 Glutathione S-transferase Yb-31 Publication |
Gene namesi | |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621287, Gstm7 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000185833 | 1 – 218 | Glutathione S-transferase Mu 7Add BLAST | 218 |
Proteomic databases
jPOSTi | P08009 |
PaxDbi | P08009 |
PRIDEi | P08009 |
2D gel databases
World-2DPAGEi | 0004:P08009 |
PTM databases
iPTMneti | P08009 |
PhosphoSitePlusi | P08009 |
SwissPalmi | P08009 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000018937, Expressed in liver and 21 other tissues |
ExpressionAtlasi | P08009, baseline and differential |
Genevisiblei | P08009, RN |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000025689 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 88 | GST N-terminalAdd BLAST | 87 | |
Domaini | 90 – 208 | GST C-terminalAdd BLAST | 119 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 7 – 8 | Glutathione bindingBy similarity | 2 | |
Regioni | 46 – 50 | Glutathione bindingBy similarity | 5 | |
Regioni | 59 – 60 | Glutathione bindingBy similarity | 2 | |
Regioni | 72 – 73 | Glutathione bindingBy similarity | 2 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1695, Eukaryota |
GeneTreei | ENSGT00940000155416 |
HOGENOMi | CLU_039475_2_0_1 |
InParanoidi | P08009 |
OrthoDBi | 1162336at2759 |
PhylomeDBi | P08009 |
TreeFami | TF353040 |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR010987, Glutathione-S-Trfase_C-like IPR036282, Glutathione-S-Trfase_C_sf IPR004045, Glutathione_S-Trfase_N IPR004046, GST_C IPR003081, GST_mu IPR036249, Thioredoxin-like_sf |
Pfami | View protein in Pfam PF14497, GST_C_3, 1 hit PF02798, GST_N, 1 hit |
PRINTSi | PR01267, GSTRNSFRASEM |
SUPFAMi | SSF47616, SSF47616, 1 hit SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS50405, GST_CTER, 1 hit PS50404, GST_NTER, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P08009-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPMTLGYWDI RGLAHAIRLL LEYTDSSYEE KRYTMGDAPD FDRSQWLNEK
60 70 80 90 100
FKLGLDFPNL PYLIDGSHKI TQSNAILRYL GRKHNLCGET EEERIRVDIL
110 120 130 140 150
ENQLMDNRMV LARLCYNPDF EKLKPGYLEQ LPGMMRLYSE FLGKRPWFAG
160 170 180 190 200
DKITFVDFIA YDVLERNQVF EATCLDAFPN LKDFIARFEG LKKISDYMKS
210
SRFLPRPLFT KMAIWGSK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2K4U2 | A0A0G2K4U2_RAT | Glutathione transferase | Gstm7 Gstm2 | 218 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J02744 mRNA Translation: AAA41292.1 L35330 Genomic DNA Translation: AAB00123.1 BC059130 mRNA Translation: AAH59130.1 |
PIRi | A29036 |
RefSeqi | NP_112416.1, NM_031154.1 |
Genome annotation databases
Ensembli | ENSRNOT00000025689; ENSRNOP00000025689; ENSRNOG00000018937 |
GeneIDi | 81869 |
KEGGi | rno:81869 |
UCSCi | RGD:621287, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J02744 mRNA Translation: AAA41292.1 L35330 Genomic DNA Translation: AAB00123.1 BC059130 mRNA Translation: AAH59130.1 |
PIRi | A29036 |
RefSeqi | NP_112416.1, NM_031154.1 |
3D structure databases
SMRi | P08009 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000025689 |
PTM databases
iPTMneti | P08009 |
PhosphoSitePlusi | P08009 |
SwissPalmi | P08009 |
2D gel databases
World-2DPAGEi | 0004:P08009 |
Proteomic databases
jPOSTi | P08009 |
PaxDbi | P08009 |
PRIDEi | P08009 |
Genome annotation databases
Ensembli | ENSRNOT00000025689; ENSRNOP00000025689; ENSRNOG00000018937 |
GeneIDi | 81869 |
KEGGi | rno:81869 |
UCSCi | RGD:621287, rat |
Organism-specific databases
CTDi | 68312 |
RGDi | 621287, Gstm7 |
Phylogenomic databases
eggNOGi | KOG1695, Eukaryota |
GeneTreei | ENSGT00940000155416 |
HOGENOMi | CLU_039475_2_0_1 |
InParanoidi | P08009 |
OrthoDBi | 1162336at2759 |
PhylomeDBi | P08009 |
TreeFami | TF353040 |
Enzyme and pathway databases
Reactomei | R-RNO-156590, Glutathione conjugation |
Miscellaneous databases
PROi | PR:P08009 |
Gene expression databases
Bgeei | ENSRNOG00000018937, Expressed in liver and 21 other tissues |
ExpressionAtlasi | P08009, baseline and differential |
Genevisiblei | P08009, RN |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR010987, Glutathione-S-Trfase_C-like IPR036282, Glutathione-S-Trfase_C_sf IPR004045, Glutathione_S-Trfase_N IPR004046, GST_C IPR003081, GST_mu IPR036249, Thioredoxin-like_sf |
Pfami | View protein in Pfam PF14497, GST_C_3, 1 hit PF02798, GST_N, 1 hit |
PRINTSi | PR01267, GSTRNSFRASEM |
SUPFAMi | SSF47616, SSF47616, 1 hit SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS50405, GST_CTER, 1 hit PS50404, GST_NTER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GSTM7_RAT | |
Accessioni | P08009Primary (citable) accession number: P08009 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 157 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families