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UniProtKB - P08004 (CHS1_YEAST)

Entry version 189 (10 Feb 2021)
Sequence version 2 (21 Sep 2011)
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Protein

Chitin synthase 1

Gene

CHS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer (PubMed:2941152). Required for mitotic division septum formation during adverse conditions (PubMed:2523889).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Requires proteolytic activation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell wall biogenesis/degradation

Protein family/group databases

Carbohydrate-Active enZymes

More...CAZyi		GT2, Glycosyltransferase Family 2

Transport Classification Database

More...TCDBi		4.D.1.1.17, the putative vectorial glycosyl polymerization (vgp) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chitin synthase 1 (EC:2.4.1.16)
Alternative name(s):
Chitin-UDP acetyl-glucosaminyl transferase 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHS1
Ordered Locus Names:YNL192W
ORF Names:N1404
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIV

Organism-specific databases

Saccharomyces Genome Database

More...SGDi		S000005136, CHS1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:YNL192W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei795 – 815HelicalSequence analysisAdd BLAST21
Transmembranei833 – 853HelicalSequence analysisAdd BLAST21
Transmembranei866 – 886HelicalSequence analysisAdd BLAST21
Transmembranei914 – 934HelicalSequence analysisAdd BLAST21
Transmembranei942 – 962HelicalSequence analysisAdd BLAST21
Transmembranei1042 – 1062HelicalSequence analysisAdd BLAST21
Transmembranei1101 – 1121HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Cell lysis during cytokinesis.1 Publication

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3827

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001937271 – 1131Chitin synthase 1Add BLAST1131

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei34PhosphoserineCombined sources1
Modified residuei35PhosphoserineCombined sources1
Modified residuei270PhosphoserineCombined sources1
Modified residuei299PhosphoserineCombined sources1
Modified residuei318PhosphoserineCombined sources1
Modified residuei328PhosphothreonineCombined sources1
Modified residuei358PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P08004

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P08004

PRoteomics IDEntifications database

More...PRIDEi		P08004

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P08004

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		35641, 130 interactors

Database of interacting proteins

More...DIPi		DIP-4680N

Protein interaction database and analysis system

More...IntActi		P08004, 8 interactors

Molecular INTeraction database

More...MINTi		P08004

STRING: functional protein association networks

More...STRINGi		4932.YNL192W

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P08004

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P08004, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the chitin synthase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2571, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004760_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P08004

Identification of Orthologs from Complete Genome Data

More...OMAi		AKDEING

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004835, Chitin_synth
IPR004834, Chitin_synth_fun
IPR013616, Chitin_synth_N
IPR029044, Nucleotide-diphossugar_trans

The PANTHER Classification System

More...PANTHERi		PTHR22914, PTHR22914, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01644, Chitin_synth_1, 1 hit
PF08407, Chitin_synth_1N, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53448, SSF53448, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P08004-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDQNNRSRN EYHSNRKNEP SYELQNAHSG LFHSSNEELT NRNQRYTNQN 
        60         70         80         90        100
ASMGSFTPVQ SLQFPEQSQQ TNMLYNGDDG NNNTINDNER DIYGGFVNHH 
       110        120        130        140        150
RQRPPPATAE YNDVFNTNSQ QLPSEHQYNN VPSYPLPSIN VIQTTPELIH 
       160        170        180        190        200
NGSQTMATPI ERPFFNENDY YYNNRNSRTS PSIASSSDGY ADQEARPILE 
       210        220        230        240        250
QPNNNMNSGN IPQYHDQPFG YNNGYHGLQA KDYYDDPEGG YIDQRGDDYQ 
       260        270        280        290        300
INSYLGRNGE MVDPYDYENS LRHMTPMERR EYLHDDSRPV NDGKEELDSV 
       310        320        330        340        350
KSGYSHRDLG EYDKDDFSRD DEYDDLNTID KLQFQANGVP ASSSVSSIGS 
       360        370        380        390        400
KESDIIVSND NLTANRALKR SGTEIRKFKL WNGNFVFDSP ISKTLLDQYA 
       410        420        430        440        450
TTTENANTLP NEFKFMRYQA VTCEPNQLAE KNFTVRQLKY LTPRETELML 
       460        470        480        490        500
VVTMYNEDHI LLGRTLKGIM DNVKYMVKKK NSSTWGPDAW KKIVVCIISD 
       510        520        530        540        550
GRSKINERSL ALLSSLGCYQ DGFAKDEINE KKVAMHVYEH TTMINITNIS 
       560        570        580        590        600
ESEVSLECNQ GTVPIQLLFC LKEQNQKKIN SHRWAFEGFA ELLRPNIVTL 
       610        620        630        640        650
LDAGTMPGKD SIYQLWREFR NPNVGGACGE IRTDLGKRFV KLLNPLVASQ 
       660        670        680        690        700
NFEYKMSNIL DKTTESNFGF ITVLPGAFSA YRFEAVRGQP LQKYFYGEIM 
       710        720        730        740        750
ENEGFHFFSS NMYLAEDRIL CFEVVTKKNC NWILKYCRSS YASTDVPERV 
       760        770        780        790        800
PEFILQRRRW LNGSFFASVY SFCHFYRVWS SGHNIGRKLL LTVEFFYLFF 
       810        820        830        840        850
NTLISWFSLS SFFLVFRILT VSIALAYHSA FNVLSVIFLW LYGICTLSTF 
       860        870        880        890        900
ILSLGNKPKS TEKFYVLTCV IFAVMMIYMI FCSIFMSVKS FQNILKNDTI 
       910        920        930        940        950
SFEGLITTEA FRDIVISLGS TYCLYLISSI IYLQPWHMLT SFIQYILLSP 
       960        970        980        990       1000
SYINVLNIYA FCNVHDLSWG TKGAMANPLG KINTTEDGTF KMEVLVSSSE 
      1010       1020       1030       1040       1050
IQANYDKYLK VLNDFDPKSE SRPTEPSYDE KKTGYYANVR SLVIIFWVIT 
      1060       1070       1080       1090       1100
NFIIVAVVLE TGGIADYIAM KSISTDDTLE TAKKAEIPLM TSKASIYFNV 
      1110       1120       1130 
ILWLVALSAL IRFIGCSIYM IVRFFKKVTF R
Length:1,131
Mass (Da):129,871
Last modified:September 21, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC1856F3C0C857E07
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti815V → F in AAA34491 (PubMed:2941152).Curated1
Sequence conflicti815V → F in CAA96086 (PubMed:9169873).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M14045 Genomic DNA Translation: AAA34491.1
Z71468 Genomic DNA Translation: CAA96086.1
BK006947 Genomic DNA Translation: DAA10361.2

Protein sequence database of the Protein Information Resource

More...PIRi		A23944

NCBI Reference Sequences

More...RefSeqi		NP_014207.2, NM_001183030.2

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YNL192W_mRNA; YNL192W; YNL192W

Database of genes from NCBI RefSeq genomes

More...GeneIDi		855529

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YNL192W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14045 Genomic DNA Translation: AAA34491.1
Z71468 Genomic DNA Translation: CAA96086.1
BK006947 Genomic DNA Translation: DAA10361.2
PIRiA23944
RefSeqiNP_014207.2, NM_001183030.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi35641, 130 interactors
DIPiDIP-4680N
IntActiP08004, 8 interactors
MINTiP08004
STRINGi4932.YNL192W

Chemistry databases

BindingDBiP08004
ChEMBLiCHEMBL3827

Protein family/group databases

CAZyiGT2, Glycosyltransferase Family 2
TCDBi4.D.1.1.17, the putative vectorial glycosyl polymerization (vgp) family

PTM databases

iPTMnetiP08004

Proteomic databases

MaxQBiP08004
PaxDbiP08004
PRIDEiP08004

Genome annotation databases

EnsemblFungiiYNL192W_mRNA; YNL192W; YNL192W
GeneIDi855529
KEGGisce:YNL192W

Organism-specific databases

SGDiS000005136, CHS1
VEuPathDBiFungiDB:YNL192W

Phylogenomic databases

eggNOGiKOG2571, Eukaryota
HOGENOMiCLU_004760_3_1_1
InParanoidiP08004
OMAiAKDEING

Miscellaneous databases

Protein Ontology

More...PROi		PR:P08004
RNActiP08004, protein

Family and domain databases

InterProiView protein in InterPro
IPR004835, Chitin_synth
IPR004834, Chitin_synth_fun
IPR013616, Chitin_synth_N
IPR029044, Nucleotide-diphossugar_trans
PANTHERiPTHR22914, PTHR22914, 1 hit
PfamiView protein in Pfam
PF01644, Chitin_synth_1, 1 hit
PF08407, Chitin_synth_1N, 1 hit
SUPFAMiSSF53448, SSF53448, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHS1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08004
Secondary accession number(s): D6W0Z5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: September 21, 2011
Last modified: February 10, 2021
This is version 189 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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