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Protein

Chitin synthase 1

Gene

CHS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Septum formation and repair, especially under certain adverse conditions.

Catalytic activityi

UDP-N-acetyl-alpha-D-glucosamine + (1,4-(N-acetyl-beta-D-glucosaminyl))(n) = UDP + (1,4-(N-acetyl-beta-D-glucosaminyl))(n+1).

Activity regulationi

Requires proteolytic activation.

GO - Molecular functioni

  • chitin synthase activity Source: SGD

GO - Biological processi

  • chitin biosynthetic process Source: InterPro
  • division septum site selection Source: GO_Central
  • fungal-type cell wall organization Source: GO_Central
  • septum digestion after cytokinesis Source: SGD

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell wall biogenesis/degradation

Enzyme and pathway databases

BioCyciYEAST:YNL192W-MONOMER

Protein family/group databases

CAZyiGT2 Glycosyltransferase Family 2

Names & Taxonomyi

Protein namesi
Recommended name:
Chitin synthase 1 (EC:2.4.1.16)
Alternative name(s):
Chitin-UDP acetyl-glucosaminyl transferase 1
Gene namesi
Name:CHS1
Ordered Locus Names:YNL192W
ORF Names:N1404
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

SGDiS000005136 CHS1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei795 – 815HelicalSequence analysisAdd BLAST21
Transmembranei833 – 853HelicalSequence analysisAdd BLAST21
Transmembranei866 – 886HelicalSequence analysisAdd BLAST21
Transmembranei914 – 934HelicalSequence analysisAdd BLAST21
Transmembranei942 – 962HelicalSequence analysisAdd BLAST21
Transmembranei1042 – 1062HelicalSequence analysisAdd BLAST21
Transmembranei1101 – 1121HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3827

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001937271 – 1131Chitin synthase 1Add BLAST1131

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34PhosphoserineCombined sources1
Modified residuei35PhosphoserineCombined sources1
Modified residuei270PhosphoserineCombined sources1
Modified residuei299PhosphoserineCombined sources1
Modified residuei318PhosphoserineCombined sources1
Modified residuei328PhosphothreonineCombined sources1
Modified residuei358PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP08004
PaxDbiP08004
PRIDEiP08004

PTM databases

iPTMnetiP08004

Interactioni

Protein-protein interaction databases

BioGridi35641, 128 interactors
DIPiDIP-4680N
IntActiP08004, 8 interactors
MINTiP08004
STRINGi4932.YNL192W

Chemistry databases

BindingDBiP08004

Structurei

3D structure databases

ProteinModelPortaliP08004
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chitin synthase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00920000150346
HOGENOMiHOG000162144
InParanoidiP08004
KOiK00698
OMAiCGEIRTD
OrthoDBiEOG092C0R1Z

Family and domain databases

InterProiView protein in InterPro
IPR004835 Chitin_synth
IPR004834 Chitin_synth_fun
IPR013616 Chitin_synth_N
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR22914 PTHR22914, 1 hit
PfamiView protein in Pfam
PF01644 Chitin_synth_1, 1 hit
PF08407 Chitin_synth_1N, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002998 Chitin_synth, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

Sequencei

Sequence statusi: Complete.

P08004-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDQNNRSRN EYHSNRKNEP SYELQNAHSG LFHSSNEELT NRNQRYTNQN
60 70 80 90 100
ASMGSFTPVQ SLQFPEQSQQ TNMLYNGDDG NNNTINDNER DIYGGFVNHH
110 120 130 140 150
RQRPPPATAE YNDVFNTNSQ QLPSEHQYNN VPSYPLPSIN VIQTTPELIH
160 170 180 190 200
NGSQTMATPI ERPFFNENDY YYNNRNSRTS PSIASSSDGY ADQEARPILE
210 220 230 240 250
QPNNNMNSGN IPQYHDQPFG YNNGYHGLQA KDYYDDPEGG YIDQRGDDYQ
260 270 280 290 300
INSYLGRNGE MVDPYDYENS LRHMTPMERR EYLHDDSRPV NDGKEELDSV
310 320 330 340 350
KSGYSHRDLG EYDKDDFSRD DEYDDLNTID KLQFQANGVP ASSSVSSIGS
360 370 380 390 400
KESDIIVSND NLTANRALKR SGTEIRKFKL WNGNFVFDSP ISKTLLDQYA
410 420 430 440 450
TTTENANTLP NEFKFMRYQA VTCEPNQLAE KNFTVRQLKY LTPRETELML
460 470 480 490 500
VVTMYNEDHI LLGRTLKGIM DNVKYMVKKK NSSTWGPDAW KKIVVCIISD
510 520 530 540 550
GRSKINERSL ALLSSLGCYQ DGFAKDEINE KKVAMHVYEH TTMINITNIS
560 570 580 590 600
ESEVSLECNQ GTVPIQLLFC LKEQNQKKIN SHRWAFEGFA ELLRPNIVTL
610 620 630 640 650
LDAGTMPGKD SIYQLWREFR NPNVGGACGE IRTDLGKRFV KLLNPLVASQ
660 670 680 690 700
NFEYKMSNIL DKTTESNFGF ITVLPGAFSA YRFEAVRGQP LQKYFYGEIM
710 720 730 740 750
ENEGFHFFSS NMYLAEDRIL CFEVVTKKNC NWILKYCRSS YASTDVPERV
760 770 780 790 800
PEFILQRRRW LNGSFFASVY SFCHFYRVWS SGHNIGRKLL LTVEFFYLFF
810 820 830 840 850
NTLISWFSLS SFFLVFRILT VSIALAYHSA FNVLSVIFLW LYGICTLSTF
860 870 880 890 900
ILSLGNKPKS TEKFYVLTCV IFAVMMIYMI FCSIFMSVKS FQNILKNDTI
910 920 930 940 950
SFEGLITTEA FRDIVISLGS TYCLYLISSI IYLQPWHMLT SFIQYILLSP
960 970 980 990 1000
SYINVLNIYA FCNVHDLSWG TKGAMANPLG KINTTEDGTF KMEVLVSSSE
1010 1020 1030 1040 1050
IQANYDKYLK VLNDFDPKSE SRPTEPSYDE KKTGYYANVR SLVIIFWVIT
1060 1070 1080 1090 1100
NFIIVAVVLE TGGIADYIAM KSISTDDTLE TAKKAEIPLM TSKASIYFNV
1110 1120 1130
ILWLVALSAL IRFIGCSIYM IVRFFKKVTF R
Length:1,131
Mass (Da):129,871
Last modified:September 21, 2011 - v2
Checksum:iC1856F3C0C857E07
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti815V → F in AAA34491 (PubMed:2941152).Curated1
Sequence conflicti815V → F in CAA96086 (PubMed:9169873).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14045 Genomic DNA Translation: AAA34491.1
Z71468 Genomic DNA Translation: CAA96086.1
BK006947 Genomic DNA Translation: DAA10361.2
PIRiA23944
RefSeqiNP_014207.2, NM_001183030.2

Genome annotation databases

EnsemblFungiiYNL192W; YNL192W; YNL192W
GeneIDi855529
KEGGisce:YNL192W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14045 Genomic DNA Translation: AAA34491.1
Z71468 Genomic DNA Translation: CAA96086.1
BK006947 Genomic DNA Translation: DAA10361.2
PIRiA23944
RefSeqiNP_014207.2, NM_001183030.2

3D structure databases

ProteinModelPortaliP08004
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35641, 128 interactors
DIPiDIP-4680N
IntActiP08004, 8 interactors
MINTiP08004
STRINGi4932.YNL192W

Chemistry databases

BindingDBiP08004
ChEMBLiCHEMBL3827

Protein family/group databases

CAZyiGT2 Glycosyltransferase Family 2

PTM databases

iPTMnetiP08004

Proteomic databases

MaxQBiP08004
PaxDbiP08004
PRIDEiP08004

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL192W; YNL192W; YNL192W
GeneIDi855529
KEGGisce:YNL192W

Organism-specific databases

SGDiS000005136 CHS1

Phylogenomic databases

GeneTreeiENSGT00920000150346
HOGENOMiHOG000162144
InParanoidiP08004
KOiK00698
OMAiCGEIRTD
OrthoDBiEOG092C0R1Z

Enzyme and pathway databases

BioCyciYEAST:YNL192W-MONOMER

Miscellaneous databases

PROiPR:P08004

Family and domain databases

InterProiView protein in InterPro
IPR004835 Chitin_synth
IPR004834 Chitin_synth_fun
IPR013616 Chitin_synth_N
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR22914 PTHR22914, 1 hit
PfamiView protein in Pfam
PF01644 Chitin_synth_1, 1 hit
PF08407 Chitin_synth_1N, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002998 Chitin_synth, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCHS1_YEAST
AccessioniPrimary (citable) accession number: P08004
Secondary accession number(s): D6W0Z5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: September 21, 2011
Last modified: November 7, 2018
This is version 174 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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