CHS1

Functionⁱ

Septum formation and repair, especially under certain adverse conditions.

Catalytic activityⁱ

UDP-N-acetyl-alpha-D-glucosamine + (1,4-(N-acetyl-beta-D-glucosaminyl))(n) = UDP + (1,4-(N-acetyl-beta-D-glucosaminyl))(n+1).

Activity regulationⁱ

Requires proteolytic activation.

GO - Molecular functionⁱ

chitin synthase activity
Source: SGD
Inferred from direct assayⁱ
- 7952171

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chitin biosynthetic process Source: InterPro
division septum site selection
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
fungal-type cell wall organization
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
septum digestion after cytokinesis
Source: SGD
Inferred from mutant phenotypeⁱ
- 2523889

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Glycosyltransferase, Transferase
Biological process	Cell wall biogenesis/degradation

Enzyme and pathway databases

BioCycⁱ	YEAST:YNL192W-MONOMER

BioCycⁱ

YEAST:YNL192W-MONOMER

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GT2 Glycosyltransferase Family 2

CAZyⁱ

GT2 Glycosyltransferase Family 2

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Chitin synthase 1 (EC:2.4.1.16) Alternative name(s): Chitin-UDP acetyl-glucosaminyl transferase 1
Gene namesⁱ	Name:CHS1 Ordered Locus Names:YNL192W ORF Names:N1404
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome XIV

Organism-specific databases

Saccharomyces Genome Database More...SGDⁱ	S000005136 CHS1

SGDⁱ

S000005136 CHS1

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	795 – 815	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	833 – 853	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	866 – 886	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	914 – 934	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	942 – 962	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	1042 – 1062	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	1101 – 1121	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL3827

ChEMBLⁱ

CHEMBL3827

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000193727	1 – 1131	Chitin synthase 1Add BLAST		1131

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	34	PhosphoserineCombined sources	1
Modified residueⁱ	35	PhosphoserineCombined sources	1
Modified residueⁱ	270	PhosphoserineCombined sources	1
Modified residueⁱ	299	PhosphoserineCombined sources	1
Modified residueⁱ	318	PhosphoserineCombined sources	1
Modified residueⁱ	328	PhosphothreonineCombined sources	1
Modified residueⁱ	358	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P08004
PaxDbⁱ	P08004
PRIDEⁱ	P08004

PTM databases

iPTMnetⁱ	P08004

iPTMnetⁱ

P08004

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	35641, 128 interactors
Database of interacting proteins More...DIPⁱ	DIP-4680N
IntActⁱ	P08004, 8 interactors
Molecular INTeraction database More...MINTⁱ	P08004
STRINGⁱ	4932.YNL192W

Chemistry databases

BindingDBⁱ

P08004

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P08004
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the chitin synthase family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000150346
HOGENOMⁱ	HOG000162144
InParanoidⁱ	P08004
KEGG Orthology (KO) More...KOⁱ	K00698
OMAⁱ	CGEIRTD
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C0R1Z

Family and domain databases

InterProⁱ	View protein in InterPro IPR004835 Chitin_synth IPR004834 Chitin_synth_fun IPR013616 Chitin_synth_N IPR029044 Nucleotide-diphossugar_trans
PANTHERⁱ	PTHR22914 PTHR22914, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01644 Chitin_synth_1, 1 hit PF08407 Chitin_synth_1N, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD002998 Chitin_synth, 1 hit
SUPFAMⁱ	SSF53448 SSF53448, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P08004-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSDQNNRSRN EYHSNRKNEP SYELQNAHSG LFHSSNEELT NRNQRYTNQN 
        60         70         80         90        100
ASMGSFTPVQ SLQFPEQSQQ TNMLYNGDDG NNNTINDNER DIYGGFVNHH 
       110        120        130        140        150
RQRPPPATAE YNDVFNTNSQ QLPSEHQYNN VPSYPLPSIN VIQTTPELIH 
       160        170        180        190        200
NGSQTMATPI ERPFFNENDY YYNNRNSRTS PSIASSSDGY ADQEARPILE 
       210        220        230        240        250
QPNNNMNSGN IPQYHDQPFG YNNGYHGLQA KDYYDDPEGG YIDQRGDDYQ 
       260        270        280        290        300
INSYLGRNGE MVDPYDYENS LRHMTPMERR EYLHDDSRPV NDGKEELDSV 
       310        320        330        340        350
KSGYSHRDLG EYDKDDFSRD DEYDDLNTID KLQFQANGVP ASSSVSSIGS 
       360        370        380        390        400
KESDIIVSND NLTANRALKR SGTEIRKFKL WNGNFVFDSP ISKTLLDQYA 
       410        420        430        440        450
TTTENANTLP NEFKFMRYQA VTCEPNQLAE KNFTVRQLKY LTPRETELML 
       460        470        480        490        500
VVTMYNEDHI LLGRTLKGIM DNVKYMVKKK NSSTWGPDAW KKIVVCIISD 
       510        520        530        540        550
GRSKINERSL ALLSSLGCYQ DGFAKDEINE KKVAMHVYEH TTMINITNIS 
       560        570        580        590        600
ESEVSLECNQ GTVPIQLLFC LKEQNQKKIN SHRWAFEGFA ELLRPNIVTL 
       610        620        630        640        650
LDAGTMPGKD SIYQLWREFR NPNVGGACGE IRTDLGKRFV KLLNPLVASQ 
       660        670        680        690        700
NFEYKMSNIL DKTTESNFGF ITVLPGAFSA YRFEAVRGQP LQKYFYGEIM 
       710        720        730        740        750
ENEGFHFFSS NMYLAEDRIL CFEVVTKKNC NWILKYCRSS YASTDVPERV 
       760        770        780        790        800
PEFILQRRRW LNGSFFASVY SFCHFYRVWS SGHNIGRKLL LTVEFFYLFF 
       810        820        830        840        850
NTLISWFSLS SFFLVFRILT VSIALAYHSA FNVLSVIFLW LYGICTLSTF 
       860        870        880        890        900
ILSLGNKPKS TEKFYVLTCV IFAVMMIYMI FCSIFMSVKS FQNILKNDTI 
       910        920        930        940        950
SFEGLITTEA FRDIVISLGS TYCLYLISSI IYLQPWHMLT SFIQYILLSP 
       960        970        980        990       1000
SYINVLNIYA FCNVHDLSWG TKGAMANPLG KINTTEDGTF KMEVLVSSSE 
      1010       1020       1030       1040       1050
IQANYDKYLK VLNDFDPKSE SRPTEPSYDE KKTGYYANVR SLVIIFWVIT 
      1060       1070       1080       1090       1100
NFIIVAVVLE TGGIADYIAM KSISTDDTLE TAKKAEIPLM TSKASIYFNV 
      1110       1120       1130 
ILWLVALSAL IRFIGCSIYM IVRFFKKVTF R

Length:1,131

Mass (Da):129,871

Last modified:September 21, 2011 - v2

Checksum:ⁱC1856F3C0C857E07

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	815	V → F in AAA34491 (PubMed:2941152).Curated		1
Sequence conflictⁱ	815	V → F in CAA96086 (PubMed:9169873).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M14045 Genomic DNA Translation: AAA34491.1 Z71468 Genomic DNA Translation: CAA96086.1 BK006947 Genomic DNA Translation: DAA10361.2
PIRⁱ	A23944
NCBI Reference Sequences More...RefSeqⁱ	NP_014207.2, NM_001183030.2

Genome annotation databases

EnsemblFungiⁱ	YNL192W; YNL192W; YNL192W
GeneIDⁱ	855529
KEGGⁱ	sce:YNL192W

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P08004	Chs1p		YEASC		1131	UniRef100_P08004
Chitin synthase		YEAS7		1131

Protein	Similar proteins		Species	Score	Length	Source
P08004	Chs1p		YEASC		1131	UniRef90_P08004
Chitin synthase		YEAS7		1131
Chitin synthase 1		YEAS1		1131
YNL192Wp-like protein		YEAS6		1131
K7_Chs1p		YEASK		1131
+2

Protein	Similar proteins		Species	Score	Length	Source
P08004	Chs1p		YEASC		1131	UniRef50_P08004
Chitin synthase		YEAS7		1131
Chs1p		YEAS2		1131
Chs1p		YEAS8		1131
Chitin synthase 1		YEAS1		1131
+24

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M14045 Genomic DNA Translation: AAA34491.1 Z71468 Genomic DNA Translation: CAA96086.1 BK006947 Genomic DNA Translation: DAA10361.2
PIRⁱ	A23944
RefSeqⁱ	NP_014207.2, NM_001183030.2

3D structure databases

ProteinModelPortalⁱ	P08004
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	35641, 128 interactors
DIPⁱ	DIP-4680N
IntActⁱ	P08004, 8 interactors
MINTⁱ	P08004
STRINGⁱ	4932.YNL192W

Chemistry databases

BindingDBⁱ	P08004
ChEMBLⁱ	CHEMBL3827

Protein family/group databases

CAZyⁱ	GT2 Glycosyltransferase Family 2

CAZyⁱ

GT2 Glycosyltransferase Family 2

PTM databases

iPTMnetⁱ	P08004

iPTMnetⁱ

P08004

Proteomic databases

MaxQBⁱ	P08004
PaxDbⁱ	P08004
PRIDEⁱ	P08004

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YNL192W; YNL192W; YNL192W
GeneIDⁱ	855529
KEGGⁱ	sce:YNL192W

Organism-specific databases

SGDⁱ	S000005136 CHS1

Phylogenomic databases

GeneTreeⁱ	ENSGT00920000150346
HOGENOMⁱ	HOG000162144
InParanoidⁱ	P08004
KOⁱ	K00698
OMAⁱ	CGEIRTD
OrthoDBⁱ	EOG092C0R1Z

Enzyme and pathway databases

BioCycⁱ	YEAST:YNL192W-MONOMER

BioCycⁱ

YEAST:YNL192W-MONOMER

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P08004

PROⁱ

PR:P08004

Family and domain databases

InterProⁱ	View protein in InterPro IPR004835 Chitin_synth IPR004834 Chitin_synth_fun IPR013616 Chitin_synth_N IPR029044 Nucleotide-diphossugar_trans
PANTHERⁱ	PTHR22914 PTHR22914, 1 hit
Pfamⁱ	View protein in Pfam PF01644 Chitin_synth_1, 1 hit PF08407 Chitin_synth_1N, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD002998 Chitin_synth, 1 hit
SUPFAMⁱ	SSF53448 SSF53448, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CHS1_YEAST
Accessionⁱ	P08004Primary (citable) accession number: P08004 Secondary accession number(s): D6W0Z5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
	Last sequence update:	September 21, 2011
	Last modified:	November 7, 2018
	This is version 174 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Yeast chromosome XIV
Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

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UniParc

Help

UniRef

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Annotation systems

Supporting data

UniProtKB - P08004 (CHS1_YEAST)

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Chitin synthase 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ