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Protein

Thrombospondin-1

Gene

THBS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity).By similarity2 Publications

GO - Molecular functioni

  • calcium ion binding Source: BHF-UCL
  • collagen V binding Source: BHF-UCL
  • extracellular matrix structural constituent Source: BHF-UCL
  • fibrinogen binding Source: BHF-UCL
  • fibroblast growth factor binding Source: BHF-UCL
  • fibronectin binding Source: BHF-UCL
  • heparin binding Source: BHF-UCL
  • identical protein binding Source: BHF-UCL
  • integrin binding Source: BHF-UCL
  • laminin binding Source: BHF-UCL
  • low-density lipoprotein particle binding Source: BHF-UCL
  • phosphatidylserine binding Source: UniProtKB
  • proteoglycan binding Source: BHF-UCL
  • transforming growth factor beta binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding
Biological processCell adhesion, Unfolded protein response
LigandCalcium

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-186797 Signaling by PDGF
R-HSA-216083 Integrin cell surface interactions
R-HSA-3000170 Syndecan interactions
R-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
SIGNORiP07996

Names & Taxonomyi

Protein namesi
Recommended name:
Thrombospondin-1
Alternative name(s):
Glycoprotein G1 Publication
Gene namesi
Name:THBS1
Synonyms:TSP, TSP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000137801.10
HGNCiHGNC:11785 THBS1
MIMi188060 gene
neXtProtiNX_P07996

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Extracellular matrix, Sarcoplasmic reticulum, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1067N → K: Loss of N-glycosylation site. 1 Publication1

Organism-specific databases

DisGeNETi7057
OpenTargetsiENSG00000137801
PharmGKBiPA36497

Polymorphism and mutation databases

BioMutaiTHBS1
DMDMi117949802

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000003584219 – 1170Thrombospondin-1Add BLAST1152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi171 ↔ 232Combined sources2 Publications
Glycosylationi248N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi270InterchainCurated
Disulfide bondi274InterchainCurated
Glycosylationi360N-linked (GlcNAc...) asparagineSequence analysis1
GlycosylationiCAR_000205385C-linked (Man) tryptophan1 Publication1
Disulfide bondi391 ↔ 423
GlycosylationiCAR_000206394O-linked (Fuc...) serine1 Publication1
Disulfide bondi395 ↔ 428
Disulfide bondi406 ↔ 413
GlycosylationiCAR_000207438C-linked (Man) tryptophan1 Publication1
GlycosylationiCAR_000208441C-linked (Man) tryptophan1 Publication1
Disulfide bondi447 ↔ 484Combined sources1 Publication
GlycosylationiCAR_000209450O-linked (Fuc...) threonine2 Publications1
Disulfide bondi451 ↔ 489Combined sources1 Publication
Disulfide bondi462 ↔ 474Combined sources1 Publication
GlycosylationiCAR_000210498C-linked (Man) tryptophan1 Publication1
Disulfide bondi504 ↔ 541Combined sources1 Publication
GlycosylationiCAR_000211507O-linked (Fuc...) threonine2 Publications1
Disulfide bondi508 ↔ 546Combined sources1 Publication
Disulfide bondi519 ↔ 531Combined sources1 Publication
Disulfide bondi551 ↔ 562By similarity
Disulfide bondi556 ↔ 572By similarity
Disulfide bondi575 ↔ 586By similarity
Disulfide bondi592 ↔ 608By similarity
Disulfide bondi599 ↔ 617By similarity
Disulfide bondi620 ↔ 644By similarity
Disulfide bondi650 ↔ 663By similarity
Disulfide bondi657 ↔ 676By similarity
Disulfide bondi678 ↔ 689By similarity
Disulfide bondi705 ↔ 713By similarity
Glycosylationi708N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi718 ↔ 738By similarity
Disulfide bondi754 ↔ 774By similarity
Disulfide bondi777 ↔ 797By similarity
Disulfide bondi813 ↔ 833By similarity
Disulfide bondi836 ↔ 856Combined sources1 Publication
Disulfide bondi874 ↔ 894Combined sources1 Publication
Disulfide bondi910 ↔ 930Combined sources1 Publication
Disulfide bondi946 ↔ 1167Combined sources1 Publication
Glycosylationi1067N-linked (GlcNAc...) asparagine4 Publications1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP07996
MaxQBiP07996
PaxDbiP07996
PeptideAtlasiP07996
PRIDEiP07996
ProteomicsDBi52058

2D gel databases

OGPiP07996

PTM databases

GlyConnecti594
595
596
iPTMnetiP07996
PhosphoSitePlusiP07996
UniCarbKBiP07996

Miscellaneous databases

PMAP-CutDBiP07996

Expressioni

Gene expression databases

BgeeiENSG00000137801 Expressed in 218 organ(s), highest expression level in upper lobe of left lung
CleanExiHS_THBS1
ExpressionAtlasiP07996 baseline and differential
GenevisibleiP07996 HS

Organism-specific databases

HPAiCAB033678
HPA059756

Interactioni

Subunit structurei

Homotrimer; disulfide-linked. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS1 with CD36 (By similarity). Can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1, alpha-V/beta-3 and alpha-IIb/beta-3. Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect. Interacts with ATF6 (via lumenal domain) (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112915, 34 interactors
ComplexPortaliCPX-1785 Thrombospondin 1 complex
CORUMiP07996
DIPiDIP-1037N
IntActiP07996, 18 interactors
STRINGi9606.ENSP00000260356

Structurei

Secondary structure

11170
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP07996
SMRiP07996
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07996

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 270Laminin G-likeAdd BLAST206
Domaini316 – 373VWFCPROSITE-ProRule annotationAdd BLAST58
Domaini379 – 429TSP type-1 1PROSITE-ProRule annotationAdd BLAST51
Domaini435 – 490TSP type-1 2PROSITE-ProRule annotationAdd BLAST56
Domaini492 – 547TSP type-1 3PROSITE-ProRule annotationAdd BLAST56
Domaini547 – 587EGF-like 1PROSITE-ProRule annotationAdd BLAST41
Domaini646 – 690EGF-like 2PROSITE-ProRule annotationAdd BLAST45
Repeati691 – 726TSP type-3 1Add BLAST36
Repeati727 – 762TSP type-3 2Add BLAST36
Repeati763 – 785TSP type-3 3Add BLAST23
Repeati786 – 821TSP type-3 4Add BLAST36
Repeati822 – 844TSP type-3 5Add BLAST23
Repeati845 – 882TSP type-3 6Add BLAST38
Repeati883 – 918TSP type-3 7Add BLAST36
Repeati919 – 954TSP type-3 8Add BLAST36
Domaini958 – 1170TSP C-terminalPROSITE-ProRule annotationAdd BLAST213

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni47 – 95Heparin-bindingAdd BLAST49

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi926 – 928Cell attachment siteCurated3

Sequence similaritiesi

Belongs to the thrombospondin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IFQQ Eukaryota
ENOG410XQKE LUCA
GeneTreeiENSGT00930000150838
HOGENOMiHOG000007542
HOVERGENiHBG018006
InParanoidiP07996
KOiK16857
OMAiIDSCTEC
OrthoDBiEOG091G00TV
PhylomeDBiP07996
TreeFamiTF324917

Family and domain databases

Gene3Di2.20.100.10, 3 hits
4.10.1080.10, 2 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR001791 Laminin_G
IPR037349 Thrombospondin
IPR028499 Thrombospondin-1
IPR003367 Thrombospondin_3-like_rpt
IPR017897 Thrombospondin_3_rpt
IPR008859 Thrombospondin_C
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR028974 TSP_type-3_rpt
IPR001007 VWF_dom
PANTHERiPTHR10199 PTHR10199, 2 hits
PTHR10199:SF78 PTHR10199:SF78, 2 hits
PfamiView protein in Pfam
PF00090 TSP_1, 3 hits
PF02412 TSP_3, 7 hits
PF05735 TSP_C, 1 hit
PF00093 VWC, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00179 EGF_CA, 2 hits
SM00209 TSP1, 3 hits
SM00210 TSPN, 1 hit
SM00214 VWC, 1 hit
SUPFAMiSSF103647 SSF103647, 3 hits
SSF49899 SSF49899, 2 hits
SSF82895 SSF82895, 3 hits
PROSITEiView protein in PROSITE
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS50092 TSP1, 3 hits
PS51234 TSP3, 8 hits
PS51236 TSP_CTER, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P07996-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLAWGLGVL FLMHVCGTNR IPESGGDNSV FDIFELTGAA RKGSGRRLVK
60 70 80 90 100
GPDPSSPAFR IEDANLIPPV PDDKFQDLVD AVRAEKGFLL LASLRQMKKT
110 120 130 140 150
RGTLLALERK DHSGQVFSVV SNGKAGTLDL SLTVQGKQHV VSVEEALLAT
160 170 180 190 200
GQWKSITLFV QEDRAQLYID CEKMENAELD VPIQSVFTRD LASIARLRIA
210 220 230 240 250
KGGVNDNFQG VLQNVRFVFG TTPEDILRNK GCSSSTSVLL TLDNNVVNGS
260 270 280 290 300
SPAIRTNYIG HKTKDLQAIC GISCDELSSM VLELRGLRTI VTTLQDSIRK
310 320 330 340 350
VTEENKELAN ELRRPPLCYH NGVQYRNNEE WTVDSCTECH CQNSVTICKK
360 370 380 390 400
VSCPIMPCSN ATVPDGECCP RCWPSDSADD GWSPWSEWTS CSTSCGNGIQ
410 420 430 440 450
QRGRSCDSLN NRCEGSSVQT RTCHIQECDK RFKQDGGWSH WSPWSSCSVT
460 470 480 490 500
CGDGVITRIR LCNSPSPQMN GKPCEGEARE TKACKKDACP INGGWGPWSP
510 520 530 540 550
WDICSVTCGG GVQKRSRLCN NPTPQFGGKD CVGDVTENQI CNKQDCPIDG
560 570 580 590 600
CLSNPCFAGV KCTSYPDGSW KCGACPPGYS GNGIQCTDVD ECKEVPDACF
610 620 630 640 650
NHNGEHRCEN TDPGYNCLPC PPRFTGSQPF GQGVEHATAN KQVCKPRNPC
660 670 680 690 700
TDGTHDCNKN AKCNYLGHYS DPMYRCECKP GYAGNGIICG EDTDLDGWPN
710 720 730 740 750
ENLVCVANAT YHCKKDNCPN LPNSGQEDYD KDGIGDACDD DDDNDKIPDD
760 770 780 790 800
RDNCPFHYNP AQYDYDRDDV GDRCDNCPYN HNPDQADTDN NGEGDACAAD
810 820 830 840 850
IDGDGILNER DNCQYVYNVD QRDTDMDGVG DQCDNCPLEH NPDQLDSDSD
860 870 880 890 900
RIGDTCDNNQ DIDEDGHQNN LDNCPYVPNA NQADHDKDGK GDACDHDDDN
910 920 930 940 950
DGIPDDKDNC RLVPNPDQKD SDGDGRGDAC KDDFDHDSVP DIDDICPENV
960 970 980 990 1000
DISETDFRRF QMIPLDPKGT SQNDPNWVVR HQGKELVQTV NCDPGLAVGY
1010 1020 1030 1040 1050
DEFNAVDFSG TFFINTERDD DYAGFVFGYQ SSSRFYVVMW KQVTQSYWDT
1060 1070 1080 1090 1100
NPTRAQGYSG LSVKVVNSTT GPGEHLRNAL WHTGNTPGQV RTLWHDPRHI
1110 1120 1130 1140 1150
GWKDFTAYRW RLSHRPKTGF IRVVMYEGKK IMADSGPIYD KTYAGGRLGL
1160 1170
FVFSQEMVFF SDLKYECRDP
Length:1,170
Mass (Da):129,383
Last modified:October 31, 2006 - v2
Checksum:i74749B2418E0943B
GO
Isoform 2 (identifier: P07996-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     17-101: Missing.

Note: No experimental confirmation available.
Show »
Length:1,085
Mass (Da):120,148
Checksum:i3670FD07DED233DD
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MZG1A8MZG1_HUMAN
Thrombospondin-1
THBS1
94Annotation score:

Sequence cautioni

The sequence BAD93149 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4A → S in BAG65509 (PubMed:14702039).Curated1
Sequence conflicti84A → T in CAA28370 (PubMed:2430973).Curated1
Sequence conflicti84A → T in AAA61178 (PubMed:2544587).Curated1
Sequence conflicti431R → I in BAG65509 (PubMed:14702039).Curated1
Sequence conflicti451C → R in BAG65509 (PubMed:14702039).Curated1
Sequence conflicti546C → Y in BAF84328 (PubMed:14702039).Curated1
Sequence conflicti812N → D in BAG65509 (PubMed:14702039).Curated1
Sequence conflicti1008F → S in BAF84328 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05265724S → A. Corresponds to variant dbSNP:rs41515347Ensembl.1
Natural variantiVAR_028938523T → A2 PublicationsCorresponds to variant dbSNP:rs2292305EnsemblClinVar.1
Natural variantiVAR_028939700N → S1 PublicationCorresponds to variant dbSNP:rs2228262Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05575717 – 101Missing in isoform 2. 1 PublicationAdd BLAST85

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04665 mRNA Translation: CAA28370.1
X14787 mRNA Translation: CAA32889.1
AK291639 mRNA Translation: BAF84328.1
AK304754 mRNA Translation: BAG65509.1
AB209912 mRNA Translation: BAD93149.1 Different initiation.
AC037198 Genomic DNA No translation available.
BC136469 mRNA Translation: AAI36470.1
BC136470 mRNA Translation: AAI36471.1
M25631 mRNA Translation: AAA36741.1
M14326 mRNA Translation: AAA61237.1 Sequence problems.
J04835 Genomic DNA Translation: AAA61178.1
M99425 mRNA Translation: AAB59366.1
CCDSiCCDS32194.1 [P07996-1]
PIRiA26155 TSHUP1
RefSeqiNP_003237.2, NM_003246.3 [P07996-1]
UniGeneiHs.164226
Hs.732539

Genome annotation databases

EnsembliENST00000260356; ENSP00000260356; ENSG00000137801 [P07996-1]
GeneIDi7057
KEGGihsa:7057
UCSCiuc001zkh.4 human [P07996-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04665 mRNA Translation: CAA28370.1
X14787 mRNA Translation: CAA32889.1
AK291639 mRNA Translation: BAF84328.1
AK304754 mRNA Translation: BAG65509.1
AB209912 mRNA Translation: BAD93149.1 Different initiation.
AC037198 Genomic DNA No translation available.
BC136469 mRNA Translation: AAI36470.1
BC136470 mRNA Translation: AAI36471.1
M25631 mRNA Translation: AAA36741.1
M14326 mRNA Translation: AAA61237.1 Sequence problems.
J04835 Genomic DNA Translation: AAA61178.1
M99425 mRNA Translation: AAB59366.1
CCDSiCCDS32194.1 [P07996-1]
PIRiA26155 TSHUP1
RefSeqiNP_003237.2, NM_003246.3 [P07996-1]
UniGeneiHs.164226
Hs.732539

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LSLX-ray1.90A434-546[»]
1UX6X-ray1.90A834-1170[»]
1Z78X-ray1.80A19-233[»]
1ZA4X-ray1.90A19-257[»]
2ERFX-ray1.45A25-233[»]
2ES3X-ray1.85A/B25-233[»]
2OUHX-ray2.40A/B19-257[»]
2OUJX-ray1.90A19-257[»]
3R6BX-ray2.40A434-547[»]
5FOEX-ray1.98A/B378-429[»]
ProteinModelPortaliP07996
SMRiP07996
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112915, 34 interactors
ComplexPortaliCPX-1785 Thrombospondin 1 complex
CORUMiP07996
DIPiDIP-1037N
IntActiP07996, 18 interactors
STRINGi9606.ENSP00000260356

PTM databases

GlyConnecti594
595
596
iPTMnetiP07996
PhosphoSitePlusiP07996
UniCarbKBiP07996

Polymorphism and mutation databases

BioMutaiTHBS1
DMDMi117949802

2D gel databases

OGPiP07996

Proteomic databases

EPDiP07996
MaxQBiP07996
PaxDbiP07996
PeptideAtlasiP07996
PRIDEiP07996
ProteomicsDBi52058

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260356; ENSP00000260356; ENSG00000137801 [P07996-1]
GeneIDi7057
KEGGihsa:7057
UCSCiuc001zkh.4 human [P07996-1]

Organism-specific databases

CTDi7057
DisGeNETi7057
EuPathDBiHostDB:ENSG00000137801.10
GeneCardsiTHBS1
H-InvDBiHIX0038125
HGNCiHGNC:11785 THBS1
HPAiCAB033678
HPA059756
MIMi188060 gene
neXtProtiNX_P07996
OpenTargetsiENSG00000137801
PharmGKBiPA36497
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFQQ Eukaryota
ENOG410XQKE LUCA
GeneTreeiENSGT00930000150838
HOGENOMiHOG000007542
HOVERGENiHBG018006
InParanoidiP07996
KOiK16857
OMAiIDSCTEC
OrthoDBiEOG091G00TV
PhylomeDBiP07996
TreeFamiTF324917

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-186797 Signaling by PDGF
R-HSA-216083 Integrin cell surface interactions
R-HSA-3000170 Syndecan interactions
R-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
SIGNORiP07996

Miscellaneous databases

ChiTaRSiTHBS1 human
EvolutionaryTraceiP07996
GeneWikiiThrombospondin_1
GenomeRNAii7057
PMAP-CutDBiP07996
PROiPR:P07996
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137801 Expressed in 218 organ(s), highest expression level in upper lobe of left lung
CleanExiHS_THBS1
ExpressionAtlasiP07996 baseline and differential
GenevisibleiP07996 HS

Family and domain databases

Gene3Di2.20.100.10, 3 hits
4.10.1080.10, 2 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR001791 Laminin_G
IPR037349 Thrombospondin
IPR028499 Thrombospondin-1
IPR003367 Thrombospondin_3-like_rpt
IPR017897 Thrombospondin_3_rpt
IPR008859 Thrombospondin_C
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR028974 TSP_type-3_rpt
IPR001007 VWF_dom
PANTHERiPTHR10199 PTHR10199, 2 hits
PTHR10199:SF78 PTHR10199:SF78, 2 hits
PfamiView protein in Pfam
PF00090 TSP_1, 3 hits
PF02412 TSP_3, 7 hits
PF05735 TSP_C, 1 hit
PF00093 VWC, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00179 EGF_CA, 2 hits
SM00209 TSP1, 3 hits
SM00210 TSPN, 1 hit
SM00214 VWC, 1 hit
SUPFAMiSSF103647 SSF103647, 3 hits
SSF49899 SSF49899, 2 hits
SSF82895 SSF82895, 3 hits
PROSITEiView protein in PROSITE
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS50092 TSP1, 3 hits
PS51234 TSP3, 8 hits
PS51236 TSP_CTER, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTSP1_HUMAN
AccessioniPrimary (citable) accession number: P07996
Secondary accession number(s): A8K6H4
, B4E3J7, B9EGH6, Q15667, Q59E99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: October 31, 2006
Last modified: November 7, 2018
This is version 227 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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