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Protein

DNA excision repair protein ERCC-1

Gene

ERCC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform 1: Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi134 – 156Sequence analysisAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • damaged DNA binding Source: UniProtKB
  • protein C-terminus binding Source: UniProtKB
  • protein domain specific binding Source: UniProtKB
  • single-stranded DNA binding Source: UniProtKB
  • single-stranded DNA endodeoxyribonuclease activity Source: GO_Central
  • TFIID-class transcription factor complex binding Source: Ensembl

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Endonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA repair

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-5685938 HDR through Single Strand Annealing (SSA)
R-HSA-5696395 Formation of Incision Complex in GG-NER
R-HSA-5696400 Dual Incision in GG-NER
R-HSA-6782135 Dual incision in TC-NER
R-HSA-6783310 Fanconi Anemia Pathway

SIGNOR Signaling Network Open Resource

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SIGNORi
P07992

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA excision repair protein ERCC-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ERCC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000012061.15

Human Gene Nomenclature Database

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HGNCi
HGNC:3433 ERCC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
126380 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P07992

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cerebro-oculo-facio-skeletal syndrome 4 (COFS4)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder of prenatal onset characterized by microcephaly, congenital cataracts, facial dysmorphism, neurogenic arthrogryposis, growth failure and severe psychomotor retardation. COFS is considered to be part of the nucleotide-excision repair disorders spectrum that include also xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome.
See also OMIM:610758
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032776231F → L in COFS4; does not alter interaction with XPF/ERCC4 or GTF2H1. 2 PublicationsCorresponds to variant dbSNP:rs121913028EnsemblClinVar.1

Keywords - Diseasei

Cataract

Organism-specific databases

DisGeNET

More...
DisGeNETi
2067

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
ERCC1

MalaCards human disease database

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MalaCardsi
ERCC1
MIMi610758 phenotype

Open Targets

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OpenTargetsi
ENSG00000012061

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
90322 Cockayne syndrome type 2
1466 COFS syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA155

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3883316

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
ERCC1

Domain mapping of disease mutations (DMDM)

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DMDMi
119538

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000870061 – 297DNA excision repair protein ERCC-1Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki21Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki37Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki243Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P07992

MaxQB - The MaxQuant DataBase

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MaxQBi
P07992

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P07992

PeptideAtlas

More...
PeptideAtlasi
P07992

PRoteomics IDEntifications database

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PRIDEi
P07992

ProteomicsDB human proteome resource

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ProteomicsDBi
52055
52056 [P07992-2]
52057 [P07992-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P07992

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P07992

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000012061 Expressed in 227 organ(s), highest expression level in apex of heart

CleanEx database of gene expression profiles

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CleanExi
HS_ERCC1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P07992 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P07992 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB004390
CAB072859
CAB072860
HPA029773
HPA050182

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer composed of ERCC1 isoform 1 and XPF/ERRC4.3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108379, 38 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-478 ERCC1-XPF endonuclease complex [P07992-1]

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P07992

Database of interacting proteins

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DIPi
DIP-24235N

Protein interaction database and analysis system

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IntActi
P07992, 19 interactors

Molecular INTeraction database

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MINTi
P07992

STRING: functional protein association networks

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STRINGi
9606.ENSP00000013807

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1297
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P07992

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P07992

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P07992

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni220 – 297HhH2, dimerization with ERCC4Add BLAST78

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi17 – 23Nuclear localization signalSequence analysis7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ERCC1/RAD10/SWI10 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2841 Eukaryota
COG5241 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000011275

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000037440

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG051497

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P07992

KEGG Orthology (KO)

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KOi
K10849

Identification of Orthologs from Complete Genome Data

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OMAi
LNPDYIC

Database of Orthologous Groups

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OrthoDBi
EOG091G0IRO

Database for complete collections of gene phylogenies

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PhylomeDBi
P07992

TreeFam database of animal gene trees

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TreeFami
TF101231

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR004579 ERCC1/RAD10/SWI10
IPR011335 Restrct_endonuc-II-like
IPR010994 RuvA_2-like

The PANTHER Classification System

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PANTHERi
PTHR12749 PTHR12749, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF03834 Rad10, 1 hit

ProDom; a protein domain database

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ProDomi
View protein in ProDom or Entries sharing at least one domain
PD013585 DNA_repair_Rad10, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47781 SSF47781, 1 hit
SSF52980 SSF52980, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00597 rad10, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P07992-1) [UniParc]FASTAAdd to basket
Also known as: 202

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPGKDKEGV PQPSGPPARK KFVIPLDEDE VPPGVAKPLF RSTQSLPTVD
60 70 80 90 100
TSAQAAPQTY AEYAISQPLE GAGATCPTGS EPLAGETPNQ ALKPGAKSNS
110 120 130 140 150
IIVSPRQRGN PVLKFVRNVP WEFGDVIPDY VLGQSTCALF LSLRYHNLHP
160 170 180 190 200
DYIHGRLQSL GKNFALRVLL VQVDVKDPQQ ALKELAKMCI LADCTLILAW
210 220 230 240 250
SPEEAGRYLE TYKAYEQKPA DLLMEKLEQD FVSRVTECLT TVKSVNKTDS
260 270 280 290
QTLLTTFGSL EQLIAASRED LALCPGLGPQ KARRLFDVLH EPFLKVP
Length:297
Mass (Da):32,562
Last modified:August 1, 1988 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6FCE3615732349E5
GO
Isoform 2 (identifier: P07992-2) [UniParc]FASTAAdd to basket
Also known as: 203

The sequence of this isoform differs from the canonical sequence as follows:
     235-258: Missing.

Note: Not functional in the nucleotide excision repair pathway. Does not interact with XPF/ERCC4.
Show »
Length:273
Mass (Da):29,993
Checksum:i04DA21E774A33524
GO
Isoform 3 (identifier: P07992-3) [UniParc]FASTAAdd to basket
Also known as: 201

The sequence of this isoform differs from the canonical sequence as follows:
     282-297: ARRLFDVLHEPFLKVP → VRALGKNPRSWGKERAPNKHNLRPQSFKVKKEPKTRHSGFRL

Note: Not functional in the nucleotide excision repair pathway. Does not interact with XPF/ERCC4.
Show »
Length:323
Mass (Da):35,563
Checksum:iD99BFAC9CE8E912E
GO
Isoform 4 (identifier: P07992-4) [UniParc]FASTAAdd to basket
Also known as: 204

The sequence of this isoform differs from the canonical sequence as follows:
     36-107: Missing.

Note: Not functional in the nucleotide excision repair pathway. Does not interact with XPF/ERCC4.
Show »
Length:225
Mass (Da):25,211
Checksum:iAF78F4C26AC7DA7E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ES46K7ES46_HUMAN
DNA excision repair protein ERCC-1
ERCC1
209Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ER89K7ER89_HUMAN
DNA excision repair protein ERCC-1
ERCC1
234Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ER60K7ER60_HUMAN
DNA excision repair protein ERCC-1
ERCC1
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EP14K7EP14_HUMAN
DNA excision repair protein ERCC-1
ERCC1
258Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJW9K7EJW9_HUMAN
DNA excision repair protein ERCC-1
ERCC1
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMT9K7EMT9_HUMAN
DNA excision repair protein ERCC-1
ERCC1
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EK97K7EK97_HUMAN
DNA excision repair protein ERCC-1
ERCC1
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJL2K7EJL2_HUMAN
DNA excision repair protein ERCC-1
ERCC1
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti53A → P in BAG37398 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032776231F → L in COFS4; does not alter interaction with XPF/ERCC4 or GTF2H1. 2 PublicationsCorresponds to variant dbSNP:rs121913028EnsemblClinVar.1
Natural variantiVAR_019167266A → T1 PublicationCorresponds to variant dbSNP:rs3212977Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05347436 – 107Missing in isoform 4. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_042727235 – 258Missing in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_043455282 – 297ARRLF…FLKVP → VRALGKNPRSWGKERAPNKH NLRPQSFKVKKEPKTRHSGF RL in isoform 3. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M13194 mRNA Translation: AAA52394.1
M26163 Genomic DNA Translation: AAA52395.1
M28650 mRNA Translation: AAA35810.1
AF001925 mRNA Translation: AAC16253.1
AB069681 mRNA Translation: BAB62810.1
BT019806 mRNA Translation: AAV38609.1
AF512555 Genomic DNA Translation: AAM34796.1
AK092039 mRNA Translation: BAG52472.1
AK314884 mRNA Translation: BAG37398.1
AC092309 Genomic DNA No translation available.
AC138128 Genomic DNA No translation available.
AC138534 Genomic DNA No translation available.
AC139353 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57349.1
BC008930 mRNA Translation: AAH08930.1
BC052813 mRNA Translation: AAH52813.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS12662.1 [P07992-1]
CCDS12663.1 [P07992-3]
CCDS54279.1 [P07992-2]

Protein sequence database of the Protein Information Resource

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PIRi
A32875 A24781

NCBI Reference Sequences

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RefSeqi
NP_001159521.1, NM_001166049.1 [P07992-2]
NP_001974.1, NM_001983.3 [P07992-1]
NP_973730.1, NM_202001.2 [P07992-3]
XP_005258691.1, XM_005258634.1 [P07992-3]
XP_005258692.1, XM_005258635.2 [P07992-3]
XP_005258693.1, XM_005258636.4 [P07992-3]
XP_011524912.1, XM_011526610.2 [P07992-3]
XP_016881948.1, XM_017026459.1 [P07992-3]
XP_016881949.1, XM_017026460.1 [P07992-1]
XP_016881950.1, XM_017026461.1 [P07992-1]
XP_016881951.1, XM_017026462.1 [P07992-1]
XP_016881952.1, XM_017026463.1 [P07992-1]
XP_016881953.1, XM_017026464.1 [P07992-1]
XP_016881954.1, XM_017026465.1 [P07992-2]
XP_016881955.1, XM_017026466.1 [P07992-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.435981

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000013807; ENSP00000013807; ENSG00000012061 [P07992-3]
ENST00000300853; ENSP00000300853; ENSG00000012061 [P07992-1]
ENST00000340192; ENSP00000345203; ENSG00000012061 [P07992-2]
ENST00000423698; ENSP00000394875; ENSG00000012061 [P07992-4]
ENST00000589165; ENSP00000468035; ENSG00000012061 [P07992-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
2067

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2067

UCSC genome browser

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UCSCi
uc002pbs.3 human [P07992-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13194 mRNA Translation: AAA52394.1
M26163 Genomic DNA Translation: AAA52395.1
M28650 mRNA Translation: AAA35810.1
AF001925 mRNA Translation: AAC16253.1
AB069681 mRNA Translation: BAB62810.1
BT019806 mRNA Translation: AAV38609.1
AF512555 Genomic DNA Translation: AAM34796.1
AK092039 mRNA Translation: BAG52472.1
AK314884 mRNA Translation: BAG37398.1
AC092309 Genomic DNA No translation available.
AC138128 Genomic DNA No translation available.
AC138534 Genomic DNA No translation available.
AC139353 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57349.1
BC008930 mRNA Translation: AAH08930.1
BC052813 mRNA Translation: AAH52813.1
CCDSiCCDS12662.1 [P07992-1]
CCDS12663.1 [P07992-3]
CCDS54279.1 [P07992-2]
PIRiA32875 A24781
RefSeqiNP_001159521.1, NM_001166049.1 [P07992-2]
NP_001974.1, NM_001983.3 [P07992-1]
NP_973730.1, NM_202001.2 [P07992-3]
XP_005258691.1, XM_005258634.1 [P07992-3]
XP_005258692.1, XM_005258635.2 [P07992-3]
XP_005258693.1, XM_005258636.4 [P07992-3]
XP_011524912.1, XM_011526610.2 [P07992-3]
XP_016881948.1, XM_017026459.1 [P07992-3]
XP_016881949.1, XM_017026460.1 [P07992-1]
XP_016881950.1, XM_017026461.1 [P07992-1]
XP_016881951.1, XM_017026462.1 [P07992-1]
XP_016881952.1, XM_017026463.1 [P07992-1]
XP_016881953.1, XM_017026464.1 [P07992-1]
XP_016881954.1, XM_017026465.1 [P07992-2]
XP_016881955.1, XM_017026466.1 [P07992-2]
UniGeneiHs.435981

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z00NMR-A220-297[»]
2A1IX-ray1.90A96-227[»]
2A1JX-ray2.70B220-296[»]
2JNWNMR-A96-214[»]
2JPDNMR-A96-219[»]
2MUTNMR-A220-297[»]
ProteinModelPortaliP07992
SMRiP07992
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108379, 38 interactors
ComplexPortaliCPX-478 ERCC1-XPF endonuclease complex [P07992-1]
CORUMiP07992
DIPiDIP-24235N
IntActiP07992, 19 interactors
MINTiP07992
STRINGi9606.ENSP00000013807

Chemistry databases

ChEMBLiCHEMBL3883316

PTM databases

iPTMnetiP07992
PhosphoSitePlusiP07992

Polymorphism and mutation databases

BioMutaiERCC1
DMDMi119538

Proteomic databases

EPDiP07992
MaxQBiP07992
PaxDbiP07992
PeptideAtlasiP07992
PRIDEiP07992
ProteomicsDBi52055
52056 [P07992-2]
52057 [P07992-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2067
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000013807; ENSP00000013807; ENSG00000012061 [P07992-3]
ENST00000300853; ENSP00000300853; ENSG00000012061 [P07992-1]
ENST00000340192; ENSP00000345203; ENSG00000012061 [P07992-2]
ENST00000423698; ENSP00000394875; ENSG00000012061 [P07992-4]
ENST00000589165; ENSP00000468035; ENSG00000012061 [P07992-1]
GeneIDi2067
KEGGihsa:2067
UCSCiuc002pbs.3 human [P07992-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2067
DisGeNETi2067
EuPathDBiHostDB:ENSG00000012061.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ERCC1
GeneReviewsiERCC1
HGNCiHGNC:3433 ERCC1
HPAiCAB004390
CAB072859
CAB072860
HPA029773
HPA050182
MalaCardsiERCC1
MIMi126380 gene
610758 phenotype
neXtProtiNX_P07992
OpenTargetsiENSG00000012061
Orphaneti90322 Cockayne syndrome type 2
1466 COFS syndrome
PharmGKBiPA155

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2841 Eukaryota
COG5241 LUCA
GeneTreeiENSGT00390000011275
HOGENOMiHOG000037440
HOVERGENiHBG051497
InParanoidiP07992
KOiK10849
OMAiLNPDYIC
OrthoDBiEOG091G0IRO
PhylomeDBiP07992
TreeFamiTF101231

Enzyme and pathway databases

ReactomeiR-HSA-5685938 HDR through Single Strand Annealing (SSA)
R-HSA-5696395 Formation of Incision Complex in GG-NER
R-HSA-5696400 Dual Incision in GG-NER
R-HSA-6782135 Dual incision in TC-NER
R-HSA-6783310 Fanconi Anemia Pathway
SIGNORiP07992

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ERCC1 human
EvolutionaryTraceiP07992

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ERCC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2067

Protein Ontology

More...
PROi
PR:P07992

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000012061 Expressed in 227 organ(s), highest expression level in apex of heart
CleanExiHS_ERCC1
ExpressionAtlasiP07992 baseline and differential
GenevisibleiP07992 HS

Family and domain databases

InterProiView protein in InterPro
IPR004579 ERCC1/RAD10/SWI10
IPR011335 Restrct_endonuc-II-like
IPR010994 RuvA_2-like
PANTHERiPTHR12749 PTHR12749, 1 hit
PfamiView protein in Pfam
PF03834 Rad10, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD013585 DNA_repair_Rad10, 1 hit
SUPFAMiSSF47781 SSF47781, 1 hit
SSF52980 SSF52980, 1 hit
TIGRFAMsiTIGR00597 rad10, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiERCC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07992
Secondary accession number(s): B2RC01
, B3KRR0, Q7Z7F5, Q96S40
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 7, 2018
This is version 185 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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