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Protein

Pulmonary surfactant-associated protein B

Gene

SFTPB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.

Miscellaneous

Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processGaseous exchange

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5683826 Surfactant metabolism
R-HSA-5688031 Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)
R-HSA-5688354 Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS)
R-HSA-5688849 Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)
R-HSA-5688890 Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P07988

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pulmonary surfactant-associated protein B
Short name:
SP-B
Alternative name(s):
18 kDa pulmonary-surfactant protein
6 kDa protein
Pulmonary surfactant-associated proteolipid SPL(Phe)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SFTPB
Synonyms:SFTP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000168878.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10801 SFTPB

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
178640 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P07988

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted, Surface film

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Pulmonary surfactant metabolism dysfunction 1 (SMDP1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.
See also OMIM:265120
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036856236R → C in SMDP1. 1 PublicationCorresponds to variant dbSNP:rs137853202Ensembl.1
Respiratory distress syndrome in premature infants (RDS)1 Publication
Disease susceptibility may be associated with variations affecting the gene represented in this entry. A variation Ile to Thr at position 131 influences the association between specific alleles of SFTPA1 and respiratory distress syndrome in premature infants.
Disease descriptionA lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'.
See also OMIM:267450

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
6439

MalaCards human disease database

More...
MalaCardsi
SFTPB
MIMi265120 phenotype
267450 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000168878

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
70587 Infant acute respiratory distress syndrome
217563 Neonatal acute respiratory distress due to SP-B deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35713

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SFTPB

Domain mapping of disease mutations (DMDM)

More...
DMDMi
131418

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000003164725 – 200Add BLAST176
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000031648201 – 279Pulmonary surfactant-associated protein BAdd BLAST79
PropeptideiPRO_0000031649280 – 381Add BLAST102

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi69 ↔ 143PROSITE-ProRule annotation
Disulfide bondi72 ↔ 137PROSITE-ProRule annotation
Disulfide bondi100 ↔ 112PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi129N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi208 ↔ 277PROSITE-ProRule annotation1 Publication
Disulfide bondi211 ↔ 271PROSITE-ProRule annotation1 Publication
Disulfide bondi235 ↔ 246PROSITE-ProRule annotation1 Publication
Disulfide bondi248InterchainPROSITE-ProRule annotation1 Publication
Disulfide bondi299 ↔ 366PROSITE-ProRule annotation
Disulfide bondi302 ↔ 360PROSITE-ProRule annotation
Glycosylationi311N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi325 ↔ 335PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P07988

PeptideAtlas

More...
PeptideAtlasi
P07988

PRoteomics IDEntifications database

More...
PRIDEi
P07988

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52054

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P07988

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000168878 Expressed in 211 organ(s), highest expression level in visceral pleura

CleanEx database of gene expression profiles

More...
CleanExi
HS_SFTPB

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P07988 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P07988 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002440
HPA034820
HPA062148

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked.1 Publication

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P07988, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000377409

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1381
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DFWinfrared-A201-225[»]
1KMRNMR-A211-225[»]
1RG3NMR-A263-278[»]
1RG4NMR-A263-278[»]
1SSZinfrared-A208-278[»]
2DWFNMR-A208-278[»]
2JOUNMR-A208-278[»]
2M0HNMR-A259-280[»]
2M1TNMR-A259-278[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P07988

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P07988

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P07988

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 65Saposin A-typePROSITE-ProRule annotationAdd BLAST41
Domaini65 – 147Saposin B-type 1PROSITE-ProRule annotationAdd BLAST83
Domaini204 – 281Saposin B-type 2PROSITE-ProRule annotationAdd BLAST78
Domaini295 – 370Saposin B-type 3PROSITE-ProRule annotationAdd BLAST76

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1340 Eukaryota
ENOG410XSI5 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161711

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000115745

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006905

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P07988

Database of Orthologous Groups

More...
OrthoDBi
865505at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P07988

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003119 SAP_A
IPR007856 SapB_1
IPR008138 SapB_2
IPR008373 Saposin
IPR011001 Saposin-like
IPR008139 SaposinB_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02199 SapA, 1 hit
PF05184 SapB_1, 1 hit
PF03489 SapB_2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01797 SAPOSIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00162 SAPA, 1 hit
SM00741 SapB, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47862 SSF47862, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51110 SAP_A, 1 hit
PS50015 SAP_B, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P07988-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAESHLLQWL LLLLPTLCGP GTAAWTTSSL ACAQGPEFWC QSLEQALQCR
60 70 80 90 100
ALGHCLQEVW GHVGADDLCQ ECEDIVHILN KMAKEAIFQD TMRKFLEQEC
110 120 130 140 150
NVLPLKLLMP QCNQVLDDYF PLVIDYFQNQ TDSNGICMHL GLCKSRQPEP
160 170 180 190 200
EQEPGMSDPL PKPLRDPLPD PLLDKLVLPV LPGALQARPG PHTQDLSEQQ
210 220 230 240 250
FPIPLPYCWL CRALIKRIQA MIPKGALAVA VAQVCRVVPL VAGGICQCLA
260 270 280 290 300
ERYSVILLDT LLGRMLPQLV CRLVLRCSMD DSAGPRSPTG EWLPRDSECH
310 320 330 340 350
LCMSVTTQAG NSSEQAIPQA MLQACVGSWL DREKCKQFVE QHTPQLLTLV
360 370 380
PRGWDAHTTC QALGVCGTMS SPLQCIHSPD L
Length:381
Mass (Da):42,117
Last modified:May 1, 1992 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9FD7F66678A35153
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6W5L6D6W5L6_HUMAN
Pulmonary surfactant-associated pro...
SFTPB hCG_34600
393Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y7V6H0Y7V6_HUMAN
Pulmonary surfactant-associated pro...
SFTPB
374Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQT2U3KQT2_HUMAN
Pulmonary surfactant-associated pro...
SFTPB
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA88099 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti178L → V in AAA36628 (PubMed:3343343).Curated1
Sequence conflicti318P → L in AAA88099 (PubMed:3035561).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_006948131T → I2 PublicationsCorresponds to variant dbSNP:rs1130866Ensembl.1
Natural variantiVAR_013099176L → F1 PublicationCorresponds to variant dbSNP:rs3024801Ensembl.1
Natural variantiVAR_006950228A → I Requires 2 nucleotide substitutions. 1 Publication1
Natural variantiVAR_006949228A → R Requires 2 nucleotide substitutions. 2 Publications1
Natural variantiVAR_036856236R → C in SMDP1. 1 PublicationCorresponds to variant dbSNP:rs137853202Ensembl.1
Natural variantiVAR_013100272R → H1 PublicationCorresponds to variant dbSNP:rs3024809Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J02761 mRNA Translation: AAA60212.1
M24461 Genomic DNA Translation: AAB59541.1
AF400074 Genomic DNA Translation: AAK77913.1
BC032785 mRNA Translation: AAH32785.1
M16764 mRNA Translation: AAA88099.1 Different initiation.
M19097 mRNA Translation: AAA36628.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A31361 LNHUB

NCBI Reference Sequences

More...
RefSeqi
NP_000533.3, NM_000542.3
NP_942140.2, NM_198843.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.512690

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000393822; ENSP00000377409; ENSG00000168878
ENST00000519937; ENSP00000428719; ENSG00000168878

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6439

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6439

UCSC genome browser

More...
UCSCi
uc061lja.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02761 mRNA Translation: AAA60212.1
M24461 Genomic DNA Translation: AAB59541.1
AF400074 Genomic DNA Translation: AAK77913.1
BC032785 mRNA Translation: AAH32785.1
M16764 mRNA Translation: AAA88099.1 Different initiation.
M19097 mRNA Translation: AAA36628.1
PIRiA31361 LNHUB
RefSeqiNP_000533.3, NM_000542.3
NP_942140.2, NM_198843.2
UniGeneiHs.512690

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DFWinfrared-A201-225[»]
1KMRNMR-A211-225[»]
1RG3NMR-A263-278[»]
1RG4NMR-A263-278[»]
1SSZinfrared-A208-278[»]
2DWFNMR-A208-278[»]
2JOUNMR-A208-278[»]
2M0HNMR-A259-280[»]
2M1TNMR-A259-278[»]
ProteinModelPortaliP07988
SMRiP07988
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP07988, 1 interactor
STRINGi9606.ENSP00000377409

Polymorphism and mutation databases

BioMutaiSFTPB
DMDMi131418

Proteomic databases

PaxDbiP07988
PeptideAtlasiP07988
PRIDEiP07988
ProteomicsDBi52054

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
6439
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393822; ENSP00000377409; ENSG00000168878
ENST00000519937; ENSP00000428719; ENSG00000168878
GeneIDi6439
KEGGihsa:6439
UCSCiuc061lja.1 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6439
DisGeNETi6439
EuPathDBiHostDB:ENSG00000168878.16

GeneCards: human genes, protein and diseases

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GeneCardsi
SFTPB
HGNCiHGNC:10801 SFTPB
HPAiCAB002440
HPA034820
HPA062148
MalaCardsiSFTPB
MIMi178640 gene
265120 phenotype
267450 phenotype
neXtProtiNX_P07988
OpenTargetsiENSG00000168878
Orphaneti70587 Infant acute respiratory distress syndrome
217563 Neonatal acute respiratory distress due to SP-B deficiency
PharmGKBiPA35713

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1340 Eukaryota
ENOG410XSI5 LUCA
GeneTreeiENSGT00940000161711
HOGENOMiHOG000115745
HOVERGENiHBG006905
InParanoidiP07988
OrthoDBi865505at2759
PhylomeDBiP07988

Enzyme and pathway databases

ReactomeiR-HSA-5683826 Surfactant metabolism
R-HSA-5688031 Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)
R-HSA-5688354 Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS)
R-HSA-5688849 Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)
R-HSA-5688890 Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)
SIGNORiP07988

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SFTPB human
EvolutionaryTraceiP07988

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Pulmonary_surfactant-associated_protein_B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6439
PMAP-CutDBiP07988

Protein Ontology

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PROi
PR:P07988

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000168878 Expressed in 211 organ(s), highest expression level in visceral pleura
CleanExiHS_SFTPB
ExpressionAtlasiP07988 baseline and differential
GenevisibleiP07988 HS

Family and domain databases

InterProiView protein in InterPro
IPR003119 SAP_A
IPR007856 SapB_1
IPR008138 SapB_2
IPR008373 Saposin
IPR011001 Saposin-like
IPR008139 SaposinB_dom
PfamiView protein in Pfam
PF02199 SapA, 1 hit
PF05184 SapB_1, 1 hit
PF03489 SapB_2, 2 hits
PRINTSiPR01797 SAPOSIN
SMARTiView protein in SMART
SM00162 SAPA, 1 hit
SM00741 SapB, 3 hits
SUPFAMiSSF47862 SSF47862, 3 hits
PROSITEiView protein in PROSITE
PS51110 SAP_A, 1 hit
PS50015 SAP_B, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPSPB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07988
Secondary accession number(s): Q96R04
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: May 1, 1992
Last modified: January 16, 2019
This is version 198 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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