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UniProtKB - P07988 (PSPB_HUMAN)

Entry version 211 (02 Dec 2020)
Sequence version 3 (01 May 1992)
Previous versions | rss
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Protein

Pulmonary surfactant-associated protein B

Gene

SFTPB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.

Miscellaneous

Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processGaseous exchange

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P07988

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5683826, Surfactant metabolism
R-HSA-5688031, Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)
R-HSA-5688849, Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)
R-HSA-5688890, Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)

SIGNOR Signaling Network Open Resource

More...SIGNORi		P07988

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pulmonary surfactant-associated protein B
Short name:
SP-B
Alternative name(s):
18 kDa pulmonary-surfactant protein
6 kDa protein
Pulmonary surfactant-associated proteolipid SPL(Phe)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SFTPB
Synonyms:SFTP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000168878.16

Human Gene Nomenclature Database

More...HGNCi		HGNC:10801, SFTPB

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		178640, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P07988

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted, Surface film

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Pulmonary surfactant metabolism dysfunction 1 (SMDP1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036856236R → C in SMDP1. 1 PublicationCorresponds to variant dbSNP:rs137853202EnsemblClinVar.1
Respiratory distress syndrome in premature infants (RDS)1 Publication
Disease susceptibility may be associated with variations affecting the gene represented in this entry. A variation Ile to Thr at position 131 influences the association between specific alleles of SFTPA1 and respiratory distress syndrome in premature infants.
Disease descriptionA lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'.
Related information in OMIM

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		6439

MalaCards human disease database

More...MalaCardsi		SFTPB
MIMi265120, phenotype
267450, phenotype

Open Targets

More...OpenTargetsi		ENSG00000168878

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		70587, Infant acute respiratory distress syndrome
217563, Neonatal acute respiratory distress due to SP-B deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35713

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P07988, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SFTPB

Domain mapping of disease mutations (DMDM)

More...DMDMi		131418

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000003164725 – 200Add BLAST176
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000031648201 – 279Pulmonary surfactant-associated protein BAdd BLAST79
PropeptideiPRO_0000031649280 – 381Add BLAST102

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi69 ↔ 143PROSITE-ProRule annotation
Disulfide bondi72 ↔ 137PROSITE-ProRule annotation
Disulfide bondi100 ↔ 112PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi129N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi208 ↔ 277PROSITE-ProRule annotation1 Publication
Disulfide bondi211 ↔ 271PROSITE-ProRule annotation1 Publication
Disulfide bondi235 ↔ 246PROSITE-ProRule annotation1 Publication
Disulfide bondi248InterchainPROSITE-ProRule annotation1 Publication
Disulfide bondi299 ↔ 366PROSITE-ProRule annotation
Disulfide bondi302 ↔ 360PROSITE-ProRule annotation
Glycosylationi311N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi325 ↔ 335PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P07988

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P07988

PeptideAtlas

More...PeptideAtlasi		P07988

PRoteomics IDEntifications database

More...PRIDEi		P07988

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52054

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P07988, 2 sites

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000168878, Expressed in visceral pleura and 217 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P07988, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P07988, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000168878, Tissue enriched (lung)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112337, 1 interactor

Protein interaction database and analysis system

More...IntActi		P07988, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000386346

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P07988, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1381
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P07988

The Protein Circular Dichroism Data Bank

More...PCDDBi		P07988

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P07988

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P07988

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 65Saposin A-typePROSITE-ProRule annotationAdd BLAST41
Domaini65 – 147Saposin B-type 1PROSITE-ProRule annotationAdd BLAST83
Domaini204 – 281Saposin B-type 2PROSITE-ProRule annotationAdd BLAST78
Domaini295 – 370Saposin B-type 3PROSITE-ProRule annotationAdd BLAST76

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1340, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161711

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P07988

Database of Orthologous Groups

More...OrthoDBi		865505at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P07988

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003119, SAP_A
IPR007856, SapB_1
IPR008138, SapB_2
IPR008373, Saposin
IPR011001, Saposin-like
IPR008139, SaposinB_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02199, SapA, 1 hit
PF05184, SapB_1, 1 hit
PF03489, SapB_2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01797, SAPOSIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00162, SAPA, 1 hit
SM00741, SapB, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47862, SSF47862, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51110, SAP_A, 1 hit
PS50015, SAP_B, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P07988-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAESHLLQWL LLLLPTLCGP GTAAWTTSSL ACAQGPEFWC QSLEQALQCR 
        60         70         80         90        100
ALGHCLQEVW GHVGADDLCQ ECEDIVHILN KMAKEAIFQD TMRKFLEQEC 
       110        120        130        140        150
NVLPLKLLMP QCNQVLDDYF PLVIDYFQNQ TDSNGICMHL GLCKSRQPEP 
       160        170        180        190        200
EQEPGMSDPL PKPLRDPLPD PLLDKLVLPV LPGALQARPG PHTQDLSEQQ 
       210        220        230        240        250
FPIPLPYCWL CRALIKRIQA MIPKGALAVA VAQVCRVVPL VAGGICQCLA 
       260        270        280        290        300
ERYSVILLDT LLGRMLPQLV CRLVLRCSMD DSAGPRSPTG EWLPRDSECH 
       310        320        330        340        350
LCMSVTTQAG NSSEQAIPQA MLQACVGSWL DREKCKQFVE QHTPQLLTLV 
       360        370        380 
PRGWDAHTTC QALGVCGTMS SPLQCIHSPD L
Length:381
Mass (Da):42,117
Last modified:May 1, 1992 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9FD7F66678A35153
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y7V6H0Y7V6_HUMAN
Pulmonary surfactant-associated pro...
SFTPB
374Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQT2U3KQT2_HUMAN
Pulmonary surfactant-associated pro...
SFTPB
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA88099 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti178L → V in AAA36628 (PubMed:3343343).Curated1
Sequence conflicti318P → L in AAA88099 (PubMed:3035561).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_006948131T → I2 PublicationsCorresponds to variant dbSNP:rs1130866EnsemblClinVar.1
Natural variantiVAR_013099176L → F1 PublicationCorresponds to variant dbSNP:rs3024801EnsemblClinVar.1
Natural variantiVAR_006950228A → I Requires 2 nucleotide substitutions. 1 Publication1
Natural variantiVAR_006949228A → R Requires 2 nucleotide substitutions. 2 Publications1
Natural variantiVAR_036856236R → C in SMDP1. 1 PublicationCorresponds to variant dbSNP:rs137853202EnsemblClinVar.1
Natural variantiVAR_013100272R → H1 PublicationCorresponds to variant dbSNP:rs3024809EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J02761 mRNA Translation: AAA60212.1
M24461 Genomic DNA Translation: AAB59541.1
AF400074 Genomic DNA Translation: AAK77913.1
BC032785 mRNA Translation: AAH32785.1
M16764 mRNA Translation: AAA88099.1 Different initiation.
M19097 mRNA Translation: AAA36628.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1983.2

Protein sequence database of the Protein Information Resource

More...PIRi		A31361, LNHUB

NCBI Reference Sequences

More...RefSeqi		NP_000533.3, NM_000542.3
NP_942140.2, NM_198843.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000393822; ENSP00000377409; ENSG00000168878
ENST00000409383; ENSP00000386346; ENSG00000168878
ENST00000519937; ENSP00000428719; ENSG00000168878

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6439

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6439

UCSC genome browser

More...UCSCi		uc061lja.1, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02761 mRNA Translation: AAA60212.1
M24461 Genomic DNA Translation: AAB59541.1
AF400074 Genomic DNA Translation: AAK77913.1
BC032785 mRNA Translation: AAH32785.1
M16764 mRNA Translation: AAA88099.1 Different initiation.
M19097 mRNA Translation: AAA36628.1
CCDSiCCDS1983.2
PIRiA31361, LNHUB
RefSeqiNP_000533.3, NM_000542.3
NP_942140.2, NM_198843.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DFWinfrared-A201-225[»]
1KMRNMR-A211-225[»]
1RG3NMR-A263-278[»]
1RG4NMR-A263-278[»]
1SSZinfrared-A208-278[»]
2DWFNMR-A208-278[»]
2JOUNMR-A208-278[»]
2M0HNMR-A259-280[»]
2M1TNMR-A259-278[»]
BMRBiP07988
PCDDBiP07988
SMRiP07988
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112337, 1 interactor
IntActiP07988, 1 interactor
STRINGi9606.ENSP00000386346

PTM databases

GlyGeniP07988, 2 sites

Polymorphism and mutation databases

BioMutaiSFTPB
DMDMi131418

Proteomic databases

MassIVEiP07988
PaxDbiP07988
PeptideAtlasiP07988
PRIDEiP07988
ProteomicsDBi52054

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31946, 348 antibodies

The DNASU plasmid repository

More...DNASUi		6439

Genome annotation databases

EnsembliENST00000393822; ENSP00000377409; ENSG00000168878
ENST00000409383; ENSP00000386346; ENSG00000168878
ENST00000519937; ENSP00000428719; ENSG00000168878
GeneIDi6439
KEGGihsa:6439
UCSCiuc061lja.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6439
DisGeNETi6439
EuPathDBiHostDB:ENSG00000168878.16

GeneCards: human genes, protein and diseases

More...GeneCardsi		SFTPB
HGNCiHGNC:10801, SFTPB
HPAiENSG00000168878, Tissue enriched (lung)
MalaCardsiSFTPB
MIMi178640, gene
265120, phenotype
267450, phenotype
neXtProtiNX_P07988
OpenTargetsiENSG00000168878
Orphaneti70587, Infant acute respiratory distress syndrome
217563, Neonatal acute respiratory distress due to SP-B deficiency
PharmGKBiPA35713

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1340, Eukaryota
GeneTreeiENSGT00940000161711
InParanoidiP07988
OrthoDBi865505at2759
PhylomeDBiP07988

Enzyme and pathway databases

PathwayCommonsiP07988
ReactomeiR-HSA-5683826, Surfactant metabolism
R-HSA-5688031, Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)
R-HSA-5688849, Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)
R-HSA-5688890, Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)
SIGNORiP07988

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6439, 6 hits in 841 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SFTPB, human
EvolutionaryTraceiP07988

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Pulmonary_surfactant-associated_protein_B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6439
PharosiP07988, Tbio

Protein Ontology

More...PROi		PR:P07988
RNActiP07988, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000168878, Expressed in visceral pleura and 217 other tissues
ExpressionAtlasiP07988, baseline and differential
GenevisibleiP07988, HS

Family and domain databases

InterProiView protein in InterPro
IPR003119, SAP_A
IPR007856, SapB_1
IPR008138, SapB_2
IPR008373, Saposin
IPR011001, Saposin-like
IPR008139, SaposinB_dom
PfamiView protein in Pfam
PF02199, SapA, 1 hit
PF05184, SapB_1, 1 hit
PF03489, SapB_2, 2 hits
PRINTSiPR01797, SAPOSIN
SMARTiView protein in SMART
SM00162, SAPA, 1 hit
SM00741, SapB, 3 hits
SUPFAMiSSF47862, SSF47862, 3 hits
PROSITEiView protein in PROSITE
PS51110, SAP_A, 1 hit
PS50015, SAP_B, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPSPB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07988
Secondary accession number(s): Q96R04
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: May 1, 1992
Last modified: December 2, 2020
This is version 211 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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