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UniProtKB - P07951 (TPM2_HUMAN)

Protein

Tropomyosin beta chain

Gene

TPM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin filament binding Source: UniProtKB
  • identical protein binding Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • structural constituent of muscle Source: ProtInc
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • actin filament organization Source: GO_Central
  • muscle contraction Source: Reactome
  • muscle filament sliding Source: Reactome
  • regulation of ATPase activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Muscle protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-390522 Striated Muscle Contraction
R-HSA-445355 Smooth Muscle Contraction

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tropomyosin beta chain
Alternative name(s):
Beta-tropomyosin
Tropomyosin-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TPM2
Synonyms:TMSB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000198467.13

Human Gene Nomenclature Database

More...HGNCi		HGNC:12011 TPM2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		190990 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P07951

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Nemaline myopathy 4 (NEM4)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-like or rod-shaped structures in muscle fibers on histologic examination. Nemaline myopathy type 4 presents from infancy to childhood with hypotonia and moderate-to-severe proximal weakness with minimal or no progression. Major motor milestones are delayed but independent ambulation is usually achieved, although a wheelchair may be needed in later life.
See also OMIM:609285
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0714863A → G in NEM4. 1 Publication1
Natural variantiVAR_0714877Missing in NEM4. 1 Publication1
Natural variantiVAR_07148814D → V in NEM4. 1 Publication1
Natural variantiVAR_07097841E → K in NEM4; also found in a patient with congenital myopathy with fiber-type disproportion and patients with undefined congenital myopathy. 2 PublicationsCorresponds to variant dbSNP:rs137853306EnsemblClinVar.1
Natural variantiVAR_013468117E → A in NEM4. 1 Publication1
Natural variantiVAR_071494143L → P in NEM4; also found in a patient with congenital myopathy with fiber-type disproportion. 1 Publication1
Natural variantiVAR_013469147Q → P in NEM4. 1 PublicationCorresponds to variant dbSNP:rs104894128EnsemblClinVar.1
Natural variantiVAR_071495148L → P in NEM4; also found in a patient with congenital myopathy with fiber-type disproportion. 1 Publication1
Arthrogryposis, distal, 1A (DA1A)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. Distal arthrogryposis type 1 is characterized largely by camptodactyly and clubfoot. Hypoplasia and/or absence of some interphalangeal creases is common. The shoulders and hips are less frequently affected.
See also OMIM:108120
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01608691R → G in DA1A. 1 PublicationCorresponds to variant dbSNP:rs104894127EnsemblClinVar.1
Natural variantiVAR_07149093Q → R in DA1A. 1 PublicationCorresponds to variant dbSNP:rs199476151EnsemblClinVar.1
Natural variantiVAR_071491117E → K in DA1A; also found in a patient with congenital myopathy with fiber-type disproportion. 1 PublicationCorresponds to variant dbSNP:rs104894129EnsemblClinVar.1
Natural variantiVAR_070981133R → W in DA2B, NEM4 and DA1A; also found in a patient with congenital myopathy with fiber-type disproportion. 2 PublicationsCorresponds to variant dbSNP:rs137853305EnsemblClinVar.1
Natural variantiVAR_071498261Y → C in DA1A; also found in patients with undefined congenital myopathy. 1 Publication1
Cap myopathy 2 (CAPM2)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare congenital skeletal muscle disorder characterized by the presence of cap-like structures which are well demarcated and peripherally located under the sarcolemma and show abnormal accumulation of sarcomeric proteins. Clinical features are early onset of hypotonia and non-progressive or slowly progressive muscle weakness. Respiratory problems are common.
See also OMIM:609285
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07097949Missing in CAPM2. 1 Publication1
Natural variantiVAR_07098052G → GG in CAPM2. 1 Publication1
Natural variantiVAR_070982139Missing in CAPM2; also found in a patient with congenital myopathy with fiber-type disproportion. 3 Publications1
Natural variantiVAR_070983202N → K in CAPM2. 1 PublicationCorresponds to variant dbSNP:rs137853307EnsemblClinVar.1
Arthrogryposis, distal, 2B (DA2B)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. DA2B is characterized by contractures of the hands and feet, and a distinctive face characterized by prominent nasolabial folds, small mouth and downslanting palpebral fissures.
See also OMIM:601680
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070981133R → W in DA2B, NEM4 and DA1A; also found in a patient with congenital myopathy with fiber-type disproportion. 2 PublicationsCorresponds to variant dbSNP:rs137853305EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Nemaline myopathy

Organism-specific databases

DisGeNET

More...DisGeNETi		7169

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		TPM2

MalaCards human disease database

More...MalaCardsi		TPM2
MIMi108120 phenotype
601680 phenotype
609285 phenotype

Open Targets

More...OpenTargetsi		ENSG00000198467

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		171881 Cap myopathy
171439 Childhood-onset nemaline myopathy
2020 Congenital fiber-type disproportion myopathy
1146 Digitotalar dysmorphism
1147 Sheldon-Hall syndrome
171436 Typical nemaline myopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36691

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TPM2

Domain mapping of disease mutations (DMDM)

More...DMDMi		136090

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002056271 – 284Tropomyosin beta chainAdd BLAST284

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei53Phosphothreonine1 Publication1
Modified residuei61Phosphoserine; by PIK3CGBy similarity1
Modified residuei79Phosphothreonine1 Publication1
Modified residuei87PhosphoserineBy similarity1
Modified residuei108Phosphothreonine1 Publication1
Modified residuei158Phosphoserine1 Publication1
Modified residuei206Phosphoserine1 Publication1
Modified residuei215PhosphoserineBy similarity1
Modified residuei252Phosphothreonine1 Publication1
Modified residuei261PhosphotyrosineBy similarity1
Modified residuei271PhosphoserineBy similarity1
Modified residuei282Phosphothreonine1 Publication1
Modified residuei283Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on Ser-61 by PIK3CG. Phosphorylation on Ser-61 is required for ADRB2 internalization (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P07951

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P07951

MaxQB - The MaxQuant DataBase

More...MaxQBi		P07951

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P07951

PeptideAtlas

More...PeptideAtlasi		P07951

PRoteomics IDEntifications database

More...PRIDEi		P07951

ProteomicsDB human proteome resource

More...ProteomicsDBi		52049
52050 [P07951-2]
52051 [P07951-3]

2D gel databases

DOSAC-COBS 2D-PAGE database

More...DOSAC-COBS-2DPAGEi		P07951

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00220709

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		P07951

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P07951

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P07951

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present in primary breast cancer tissue, absent from normal breast tissue.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000198467 Expressed in 231 organ(s), highest expression level in myometrium

CleanEx database of gene expression profiles

More...CleanExi		HS_TPM2

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P07951 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P07951 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA009066
HPA047089
HPA053624

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain.By similarity

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		113022, 133 interactors

Protein interaction database and analysis system

More...IntActi		P07951, 44 interactors

Molecular INTeraction database

More...MINTi		P07951

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000354219

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P07951

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P07951

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1 – 284By similarityAdd BLAST284

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tropomyosin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1003 Eukaryota
ENOG410XR5K LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153531

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG107404

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P07951

KEGG Orthology (KO)

More...KOi		K10374

Identification of Orthologs from Complete Genome Data

More...OMAi		TEPTHEC

Database of Orthologous Groups

More...OrthoDBi		1013139at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P07951

TreeFam database of animal gene trees

More...TreeFami		TF351519

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000533 Tropomyosin

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00261 Tropomyosin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00194 TROPOMYOSIN

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00326 TROPOMYOSIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P07951-1) [UniParc]FASTAAdd to basket
Also known as: Skeletal muscle

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDAIKKKMQM LKLDKENAID RAEQAEADKK QAEDRCKQLE EEQQALQKKL 
        60         70         80         90        100
KGTEDEVEKY SESVKEAQEK LEQAEKKATD AEADVASLNR RIQLVEEELD 
       110        120        130        140        150
RAQERLATAL QKLEEAEKAA DESERGMKVI ENRAMKDEEK MELQEMQLKE 
       160        170        180        190        200
AKHIAEDSDR KYEEVARKLV ILEGELERSE ERAEVAESKC GDLEEELKIV 
       210        220        230        240        250
TNNLKSLEAQ ADKYSTKEDK YEEEIKLLEE KLKEAETRAE FAERSVAKLE 
       260        270        280 
KTIDDLEDEV YAQKMKYKAI SEELDNALND ITSL
Length:284
Mass (Da):32,851
Last modified:August 1, 1988 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i18E330568E14E0BE
GO
Isoform 2 (identifier: P07951-2) [UniParc]FASTAAdd to basket
Also known as: non-muscle, Fibroblast TM36, Epithelial TMe1

The sequence of this isoform differs from the canonical sequence as follows:
     189-213: KCGDLEEELKIVTNNLKSLEAQADK → RARQLEEELRTMDQALKSLMASEEE
     258-284: DEVYAQKMKYKAISEELDNALNDITSL → ETLASAKEENVEIHQTLDQTLLELNNL

Show »
Length:284
Mass (Da):32,990
Checksum:i584D60A8A4D6E9CA
GO
Isoform 3 (identifier: P07951-3) [UniParc]FASTAAdd to basket
Also known as: non-muscle

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: MDAIKKKMQM...LEQAEKKATD → MAGISSIDAV...ADAERQARER
     189-213: KCGDLEEELKIVTNNLKSLEAQADK → RARQLEEELRTMDQALKSLMASEEE
     258-284: DEVYAQKMKYKAISEELDNALNDITSL → ETLASAKEENVEIHQTLDQTLLELNNL

Show »
Length:248
Mass (Da):28,684
Checksum:iD89A89A37CF9D026
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A7XZE4A7XZE4_HUMAN
Beta tropomyosin isoform
TPM2 TPM2b
284Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5TCU3Q5TCU3_HUMAN
Tropomyosin beta chain
TPM2
284Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5TCU8Q5TCU8_HUMAN
Tropomyosin beta chain
TPM2
322Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQK2U3KQK2_HUMAN
Tropomyosin beta chain
TPM2
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y6A3A0A2R8Y6A3_HUMAN
Tropomyosin beta chain
TPM2
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti89N → S in BAD96978 (Ref. 4) Curated1

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Isoform 1 : Molecular mass is 32850.73 Da from positions 1 - 284. Determined by MALDI. 1 Publication
Isoform 2 : Molecular mass is 32989.81 Da from positions 1 - 284. Determined by MALDI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0714852D → V Probable disease-associated mutation found in patients with undefined congenital myopathy. 1 PublicationCorresponds to variant dbSNP:rs199476145EnsemblClinVar.1
Natural variantiVAR_0714863A → G in NEM4. 1 Publication1
Natural variantiVAR_0714877Missing in NEM4. 1 Publication1
Natural variantiVAR_07148814D → V in NEM4. 1 Publication1
Natural variantiVAR_07097841E → K in NEM4; also found in a patient with congenital myopathy with fiber-type disproportion and patients with undefined congenital myopathy. 2 PublicationsCorresponds to variant dbSNP:rs137853306EnsemblClinVar.1
Natural variantiVAR_07097949Missing in CAPM2. 1 Publication1
Natural variantiVAR_07098052G → GG in CAPM2. 1 Publication1
Natural variantiVAR_01608691R → G in DA1A. 1 PublicationCorresponds to variant dbSNP:rs104894127EnsemblClinVar.1
Natural variantiVAR_07148993Q → H Probable disease-associated mutation found in patients with undefined congenital myopathy. 1 PublicationCorresponds to variant dbSNP:rs727504180EnsemblClinVar.1
Natural variantiVAR_07149093Q → R in DA1A. 1 PublicationCorresponds to variant dbSNP:rs199476151EnsemblClinVar.1
Natural variantiVAR_013468117E → A in NEM4. 1 Publication1
Natural variantiVAR_071491117E → K in DA1A; also found in a patient with congenital myopathy with fiber-type disproportion. 1 PublicationCorresponds to variant dbSNP:rs104894129EnsemblClinVar.1
Natural variantiVAR_071492128K → E Probable disease-associated mutation found in a patient with congenital myopathy with fiber-type disproportion and patients with undefined congenital myopathy. 1 Publication1
Natural variantiVAR_071493133R → P Probable disease-associated mutation found in a patient with congenital myopathy with fiber-type disproportion and patients with undefined congenital myopathy. 1 PublicationCorresponds to variant dbSNP:rs199476152EnsemblClinVar.1
Natural variantiVAR_070981133R → W in DA2B, NEM4 and DA1A; also found in a patient with congenital myopathy with fiber-type disproportion. 2 PublicationsCorresponds to variant dbSNP:rs137853305EnsemblClinVar.1
Natural variantiVAR_070982139Missing in CAPM2; also found in a patient with congenital myopathy with fiber-type disproportion. 3 Publications1
Natural variantiVAR_071494143L → P in NEM4; also found in a patient with congenital myopathy with fiber-type disproportion. 1 Publication1
Natural variantiVAR_013469147Q → P in NEM4. 1 PublicationCorresponds to variant dbSNP:rs104894128EnsemblClinVar.1
Natural variantiVAR_071495148L → P in NEM4; also found in a patient with congenital myopathy with fiber-type disproportion. 1 Publication1
Natural variantiVAR_071496155A → T Probable disease-associated mutation found in patients with undefined congenital myopathy. 1 Publication1
Natural variantiVAR_070983202N → K in CAPM2. 1 PublicationCorresponds to variant dbSNP:rs137853307EnsemblClinVar.1
Natural variantiVAR_071497218Missing Probable disease-associated mutation in patients with undefined congenital myopathy. 1 Publication1
Natural variantiVAR_071498261Y → C in DA1A; also found in patients with undefined congenital myopathy. 1 Publication1
Natural variantiVAR_052402273E → K. Corresponds to variant dbSNP:rs3180843Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0065941 – 80MDAIK…KKATD → MAGISSIDAVKKKIQSLQQV ADEAEERAEHLQREADAERQ ARER in isoform 3. CuratedAdd BLAST80
Alternative sequenceiVSP_006595189 – 213KCGDL…AQADK → RARQLEEELRTMDQALKSLM ASEEE in isoform 2 and isoform 3. 4 PublicationsAdd BLAST25
Alternative sequenceiVSP_006596258 – 284DEVYA…DITSL → ETLASAKEENVEIHQTLDQT LLELNNL in isoform 2 and isoform 3. 4 PublicationsAdd BLAST27

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M12126 mRNA Translation: AAA61229.1
M12125 mRNA Translation: AAA36773.1
X06825 mRNA Translation: CAA29971.1
M75165 mRNA Translation: AAB59509.1
M74817 mRNA Translation: AAA61230.1
AK223258 mRNA Translation: BAD96978.1
AL133410 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58354.1
BC011776 mRNA Translation: AAH11776.1
AF209746 Genomic DNA Translation: AAF17621.1
J05247 Genomic DNA Translation: AAA51842.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6586.1 [P07951-2]
CCDS6587.1 [P07951-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A23562
S00922

NCBI Reference Sequences

More...RefSeqi		NP_003280.2, NM_003289.3 [P07951-1]
NP_998839.1, NM_213674.1 [P07951-2]
XP_016870580.1, XM_017015091.1 [P07951-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.300772

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000360958; ENSP00000354219; ENSG00000198467 [P07951-1]
ENST00000378292; ENSP00000367542; ENSG00000198467 [P07951-2]
ENST00000378300; ENSP00000367550; ENSG00000198467 [P07951-2]
ENST00000645482; ENSP00000496494; ENSG00000198467 [P07951-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7169

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7169

UCSC genome browser

More...UCSCi		uc003zxs.4 human [P07951-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12126 mRNA Translation: AAA61229.1
M12125 mRNA Translation: AAA36773.1
X06825 mRNA Translation: CAA29971.1
M75165 mRNA Translation: AAB59509.1
M74817 mRNA Translation: AAA61230.1
AK223258 mRNA Translation: BAD96978.1
AL133410 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58354.1
BC011776 mRNA Translation: AAH11776.1
AF209746 Genomic DNA Translation: AAF17621.1
J05247 Genomic DNA Translation: AAA51842.1
CCDSiCCDS6586.1 [P07951-2]
CCDS6587.1 [P07951-1]
PIRiA23562
S00922
RefSeqiNP_003280.2, NM_003289.3 [P07951-1]
NP_998839.1, NM_213674.1 [P07951-2]
XP_016870580.1, XM_017015091.1 [P07951-1]
UniGeneiHs.300772

3D structure databases

ProteinModelPortaliP07951
SMRiP07951
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113022, 133 interactors
IntActiP07951, 44 interactors
MINTiP07951
STRINGi9606.ENSP00000354219

PTM databases

iPTMnetiP07951
PhosphoSitePlusiP07951

Polymorphism and mutation databases

BioMutaiTPM2
DMDMi136090

2D gel databases

DOSAC-COBS-2DPAGEiP07951
REPRODUCTION-2DPAGEiIPI00220709
UCD-2DPAGEiP07951

Proteomic databases

EPDiP07951
jPOSTiP07951
MaxQBiP07951
PaxDbiP07951
PeptideAtlasiP07951
PRIDEiP07951
ProteomicsDBi52049
52050 [P07951-2]
52051 [P07951-3]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		7169
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360958; ENSP00000354219; ENSG00000198467 [P07951-1]
ENST00000378292; ENSP00000367542; ENSG00000198467 [P07951-2]
ENST00000378300; ENSP00000367550; ENSG00000198467 [P07951-2]
ENST00000645482; ENSP00000496494; ENSG00000198467 [P07951-1]
GeneIDi7169
KEGGihsa:7169
UCSCiuc003zxs.4 human [P07951-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7169
DisGeNETi7169
EuPathDBiHostDB:ENSG00000198467.13

GeneCards: human genes, protein and diseases

More...GeneCardsi		TPM2
GeneReviewsiTPM2
HGNCiHGNC:12011 TPM2
HPAiHPA009066
HPA047089
HPA053624
MalaCardsiTPM2
MIMi108120 phenotype
190990 gene
601680 phenotype
609285 phenotype
neXtProtiNX_P07951
OpenTargetsiENSG00000198467
Orphaneti171881 Cap myopathy
171439 Childhood-onset nemaline myopathy
2020 Congenital fiber-type disproportion myopathy
1146 Digitotalar dysmorphism
1147 Sheldon-Hall syndrome
171436 Typical nemaline myopathy
PharmGKBiPA36691

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1003 Eukaryota
ENOG410XR5K LUCA
GeneTreeiENSGT00940000153531
HOVERGENiHBG107404
InParanoidiP07951
KOiK10374
OMAiTEPTHEC
OrthoDBi1013139at2759
PhylomeDBiP07951
TreeFamiTF351519

Enzyme and pathway databases

ReactomeiR-HSA-390522 Striated Muscle Contraction
R-HSA-445355 Smooth Muscle Contraction

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TPM2 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TPM2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7169

Protein Ontology

More...PROi		PR:P07951

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000198467 Expressed in 231 organ(s), highest expression level in myometrium
CleanExiHS_TPM2
ExpressionAtlasiP07951 baseline and differential
GenevisibleiP07951 HS

Family and domain databases

InterProiView protein in InterPro
IPR000533 Tropomyosin
PfamiView protein in Pfam
PF00261 Tropomyosin, 1 hit
PRINTSiPR00194 TROPOMYOSIN
PROSITEiView protein in PROSITE
PS00326 TROPOMYOSIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPM2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07951
Secondary accession number(s): A6NM85
, P06468, Q13894, Q53FM4, Q5TCU4, Q5TCU7, Q9UH67
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: January 16, 2019
This is version 194 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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