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UniProtKB - P07951 (TPM2_HUMAN)

Protein

Tropomyosin beta chain

Gene

TPM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization.By similarity

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin filament binding Source: UniProtKB
  • identical protein binding Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • structural constituent of muscle Source: ProtInc
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • actin filament organization Source: GO_Central
  • muscle contraction Source: Reactome
  • muscle filament sliding Source: Reactome
  • regulation of ATPase activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActin-binding, Muscle protein

Enzyme and pathway databases

ReactomeiR-HSA-390522 Striated Muscle Contraction
R-HSA-445355 Smooth Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomyosin beta chain
Alternative name(s):
Beta-tropomyosin
Tropomyosin-2
Gene namesi
Name:TPM2
Synonyms:TMSB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000198467.13
HGNCiHGNC:12011 TPM2
MIMi190990 gene
neXtProtiNX_P07951

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Nemaline myopathy 4 (NEM4)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-like or rod-shaped structures in muscle fibers on histologic examination. Nemaline myopathy type 4 presents from infancy to childhood with hypotonia and moderate-to-severe proximal weakness with minimal or no progression. Major motor milestones are delayed but independent ambulation is usually achieved, although a wheelchair may be needed in later life.
See also OMIM:609285
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0714863A → G in NEM4. 1 Publication1
Natural variantiVAR_0714877Missing in NEM4. 1 Publication1
Natural variantiVAR_07148814D → V in NEM4. 1 Publication1
Natural variantiVAR_07097841E → K in NEM4; also found in a patient with congenital myopathy with fiber-type disproportion and patients with undefined congenital myopathy. 2 PublicationsCorresponds to variant dbSNP:rs137853306EnsemblClinVar.1
Natural variantiVAR_013468117E → A in NEM4. 1 Publication1
Natural variantiVAR_071494143L → P in NEM4; also found in a patient with congenital myopathy with fiber-type disproportion. 1 Publication1
Natural variantiVAR_013469147Q → P in NEM4. 1 PublicationCorresponds to variant dbSNP:rs104894128EnsemblClinVar.1
Natural variantiVAR_071495148L → P in NEM4; also found in a patient with congenital myopathy with fiber-type disproportion. 1 Publication1
Arthrogryposis, distal, 1A (DA1A)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. Distal arthrogryposis type 1 is characterized largely by camptodactyly and clubfoot. Hypoplasia and/or absence of some interphalangeal creases is common. The shoulders and hips are less frequently affected.
See also OMIM:108120
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01608691R → G in DA1A. 1 PublicationCorresponds to variant dbSNP:rs104894127EnsemblClinVar.1
Natural variantiVAR_07149093Q → R in DA1A. 1 PublicationCorresponds to variant dbSNP:rs199476151EnsemblClinVar.1
Natural variantiVAR_071491117E → K in DA1A; also found in a patient with congenital myopathy with fiber-type disproportion. 1 PublicationCorresponds to variant dbSNP:rs104894129EnsemblClinVar.1
Natural variantiVAR_071498261Y → C in DA1A; also found in patients with undefined congenital myopathy. 1 Publication1
Cap myopathy 2 (CAPM2)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare congenital skeletal muscle disorder characterized by the presence of cap-like structures which are well demarcated and peripherally located under the sarcolemma and show abnormal accumulation of sarcomeric proteins. Clinical features are early onset of hypotonia and non-progressive or slowly progressive muscle weakness. Respiratory problems are common.
See also OMIM:609285
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07097949Missing in CAPM2. 1 Publication1
Natural variantiVAR_07098052G → GG in CAPM2. 1 Publication1
Natural variantiVAR_070982139Missing in CAPM2; also found in a patient with congenital myopathy with fiber-type disproportion. 3 Publications1
Natural variantiVAR_070983202N → K in CAPM2. 1 PublicationCorresponds to variant dbSNP:rs137853307EnsemblClinVar.1
Arthrogryposis, distal, 2B (DA2B)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. DA2B is characterized by contractures of the hands and feet, and a distinctive face characterized by prominent nasolabial folds, small mouth and downslanting palpebral fissures.
See also OMIM:601680
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070981133R → W in DA2B, NEM4 and DA1A; also found in a patient with congenital myopathy with fiber-type disproportion. 2 PublicationsCorresponds to variant dbSNP:rs137853305EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Nemaline myopathy

Organism-specific databases

DisGeNETi7169
GeneReviewsiTPM2
MalaCardsiTPM2
MIMi108120 phenotype
601680 phenotype
609285 phenotype
OpenTargetsiENSG00000198467
Orphaneti171881 Cap myopathy
171439 Childhood-onset nemaline myopathy
2020 Congenital fiber-type disproportion myopathy
1146 Digitotalar dysmorphism
1147 Sheldon-Hall syndrome
171436 Typical nemaline myopathy
PharmGKBiPA36691

Polymorphism and mutation databases

BioMutaiTPM2
DMDMi136090

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002056271 – 284Tropomyosin beta chainAdd BLAST284

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei53Phosphothreonine1 Publication1
Modified residuei61Phosphoserine; by PIK3CGBy similarity1
Modified residuei79Phosphothreonine1 Publication1
Modified residuei87PhosphoserineBy similarity1
Modified residuei108Phosphothreonine1 Publication1
Modified residuei158Phosphoserine1 Publication1
Modified residuei206Phosphoserine1 Publication1
Modified residuei215PhosphoserineBy similarity1
Modified residuei252Phosphothreonine1 Publication1
Modified residuei261PhosphotyrosineBy similarity1
Modified residuei271PhosphoserineBy similarity1
Modified residuei282Phosphothreonine1 Publication1
Modified residuei283Phosphoserine1 Publication1

Post-translational modificationi

Phosphorylated on Ser-61 by PIK3CG. Phosphorylation on Ser-61 is required for ADRB2 internalization (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP07951
MaxQBiP07951
PaxDbiP07951
PeptideAtlasiP07951
PRIDEiP07951
ProteomicsDBi52049
52050 [P07951-2]
52051 [P07951-3]

2D gel databases

DOSAC-COBS-2DPAGEiP07951
REPRODUCTION-2DPAGEiIPI00220709
UCD-2DPAGEiP07951

PTM databases

iPTMnetiP07951
PhosphoSitePlusiP07951

Expressioni

Tissue specificityi

Present in primary breast cancer tissue, absent from normal breast tissue.1 Publication

Gene expression databases

BgeeiENSG00000198467 Expressed in 231 organ(s), highest expression level in myometrium
CleanExiHS_TPM2
ExpressionAtlasiP07951 baseline and differential
GenevisibleiP07951 HS

Organism-specific databases

HPAiHPA009066
HPA047089
HPA053624

Interactioni

Subunit structurei

Homodimer. Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain.By similarity

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi113022, 132 interactors
IntActiP07951, 44 interactors
MINTiP07951
STRINGi9606.ENSP00000354219

Structurei

3D structure databases

ProteinModelPortaliP07951
SMRiP07951
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 284By similarityAdd BLAST284

Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Sequence similaritiesi

Belongs to the tropomyosin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1003 Eukaryota
ENOG410XR5K LUCA
GeneTreeiENSGT00550000074494
HOVERGENiHBG107404
InParanoidiP07951
KOiK10374
OMAiTEPTHEC
PhylomeDBiP07951
TreeFamiTF351519

Family and domain databases

InterProiView protein in InterPro
IPR000533 Tropomyosin
PfamiView protein in Pfam
PF00261 Tropomyosin, 1 hit
PRINTSiPR00194 TROPOMYOSIN
PROSITEiView protein in PROSITE
PS00326 TROPOMYOSIN, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P07951-1) [UniParc]FASTAAdd to basket
Also known as: Skeletal muscle

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDAIKKKMQM LKLDKENAID RAEQAEADKK QAEDRCKQLE EEQQALQKKL 
        60         70         80         90        100
KGTEDEVEKY SESVKEAQEK LEQAEKKATD AEADVASLNR RIQLVEEELD 
       110        120        130        140        150
RAQERLATAL QKLEEAEKAA DESERGMKVI ENRAMKDEEK MELQEMQLKE 
       160        170        180        190        200
AKHIAEDSDR KYEEVARKLV ILEGELERSE ERAEVAESKC GDLEEELKIV 
       210        220        230        240        250
TNNLKSLEAQ ADKYSTKEDK YEEEIKLLEE KLKEAETRAE FAERSVAKLE 
       260        270        280 
KTIDDLEDEV YAQKMKYKAI SEELDNALND ITSL
Length:284
Mass (Da):32,851
Last modified:August 1, 1988 - v1
Checksum:i18E330568E14E0BE
GO
Isoform 2 (identifier: P07951-2) [UniParc]FASTAAdd to basket
Also known as: non-muscle, Fibroblast TM36, Epithelial TMe1

The sequence of this isoform differs from the canonical sequence as follows:
     189-213: KCGDLEEELKIVTNNLKSLEAQADK → RARQLEEELRTMDQALKSLMASEEE
     258-284: DEVYAQKMKYKAISEELDNALNDITSL → ETLASAKEENVEIHQTLDQTLLELNNL

Show »
Length:284
Mass (Da):32,990
Checksum:i584D60A8A4D6E9CA
GO
Isoform 3 (identifier: P07951-3) [UniParc]FASTAAdd to basket
Also known as: non-muscle

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: MDAIKKKMQM...LEQAEKKATD → MAGISSIDAV...ADAERQARER
     189-213: KCGDLEEELKIVTNNLKSLEAQADK → RARQLEEELRTMDQALKSLMASEEE
     258-284: DEVYAQKMKYKAISEELDNALNDITSL → ETLASAKEENVEIHQTLDQTLLELNNL

Show »
Length:248
Mass (Da):28,684
Checksum:iD89A89A37CF9D026
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A7XZE4A7XZE4_HUMAN
Beta tropomyosin isoform
TPM2 TPM2b
284Annotation score:
Q5TCU3Q5TCU3_HUMAN
Tropomyosin beta chain
TPM2
284Annotation score:
Q5TCU8Q5TCU8_HUMAN
Tropomyosin beta chain
TPM2
322Annotation score:
U3KQK2U3KQK2_HUMAN
Tropomyosin beta chain
TPM2
111Annotation score:
A0A2R8Y6A3A0A2R8Y6A3_HUMAN
Tropomyosin beta chain
TPM2
133Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89N → S in BAD96978 (Ref. 4) Curated1

Mass spectrometryi

Isoform 1 : Molecular mass is 32850.73 Da from positions 1 - 284. Determined by MALDI. 1 Publication
Isoform 2 : Molecular mass is 32989.81 Da from positions 1 - 284. Determined by MALDI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0714852D → V Probable disease-associated mutation found in patients with undefined congenital myopathy. 1 PublicationCorresponds to variant dbSNP:rs199476145EnsemblClinVar.1
Natural variantiVAR_0714863A → G in NEM4. 1 Publication1
Natural variantiVAR_0714877Missing in NEM4. 1 Publication1
Natural variantiVAR_07148814D → V in NEM4. 1 Publication1
Natural variantiVAR_07097841E → K in NEM4; also found in a patient with congenital myopathy with fiber-type disproportion and patients with undefined congenital myopathy. 2 PublicationsCorresponds to variant dbSNP:rs137853306EnsemblClinVar.1
Natural variantiVAR_07097949Missing in CAPM2. 1 Publication1
Natural variantiVAR_07098052G → GG in CAPM2. 1 Publication1
Natural variantiVAR_01608691R → G in DA1A. 1 PublicationCorresponds to variant dbSNP:rs104894127EnsemblClinVar.1
Natural variantiVAR_07148993Q → H Probable disease-associated mutation found in patients with undefined congenital myopathy. 1 PublicationCorresponds to variant dbSNP:rs727504180EnsemblClinVar.1
Natural variantiVAR_07149093Q → R in DA1A. 1 PublicationCorresponds to variant dbSNP:rs199476151EnsemblClinVar.1
Natural variantiVAR_013468117E → A in NEM4. 1 Publication1
Natural variantiVAR_071491117E → K in DA1A; also found in a patient with congenital myopathy with fiber-type disproportion. 1 PublicationCorresponds to variant dbSNP:rs104894129EnsemblClinVar.1
Natural variantiVAR_071492128K → E Probable disease-associated mutation found in a patient with congenital myopathy with fiber-type disproportion and patients with undefined congenital myopathy. 1 Publication1
Natural variantiVAR_071493133R → P Probable disease-associated mutation found in a patient with congenital myopathy with fiber-type disproportion and patients with undefined congenital myopathy. 1 PublicationCorresponds to variant dbSNP:rs199476152EnsemblClinVar.1
Natural variantiVAR_070981133R → W in DA2B, NEM4 and DA1A; also found in a patient with congenital myopathy with fiber-type disproportion. 2 PublicationsCorresponds to variant dbSNP:rs137853305EnsemblClinVar.1
Natural variantiVAR_070982139Missing in CAPM2; also found in a patient with congenital myopathy with fiber-type disproportion. 3 Publications1
Natural variantiVAR_071494143L → P in NEM4; also found in a patient with congenital myopathy with fiber-type disproportion. 1 Publication1
Natural variantiVAR_013469147Q → P in NEM4. 1 PublicationCorresponds to variant dbSNP:rs104894128EnsemblClinVar.1
Natural variantiVAR_071495148L → P in NEM4; also found in a patient with congenital myopathy with fiber-type disproportion. 1 Publication1
Natural variantiVAR_071496155A → T Probable disease-associated mutation found in patients with undefined congenital myopathy. 1 Publication1
Natural variantiVAR_070983202N → K in CAPM2. 1 PublicationCorresponds to variant dbSNP:rs137853307EnsemblClinVar.1
Natural variantiVAR_071497218Missing Probable disease-associated mutation in patients with undefined congenital myopathy. 1 Publication1
Natural variantiVAR_071498261Y → C in DA1A; also found in patients with undefined congenital myopathy. 1 Publication1
Natural variantiVAR_052402273E → K. Corresponds to variant dbSNP:rs3180843Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0065941 – 80MDAIK…KKATD → MAGISSIDAVKKKIQSLQQV ADEAEERAEHLQREADAERQ ARER in isoform 3. CuratedAdd BLAST80
Alternative sequenceiVSP_006595189 – 213KCGDL…AQADK → RARQLEEELRTMDQALKSLM ASEEE in isoform 2 and isoform 3. 4 PublicationsAdd BLAST25
Alternative sequenceiVSP_006596258 – 284DEVYA…DITSL → ETLASAKEENVEIHQTLDQT LLELNNL in isoform 2 and isoform 3. 4 PublicationsAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12126 mRNA Translation: AAA61229.1
M12125 mRNA Translation: AAA36773.1
X06825 mRNA Translation: CAA29971.1
M75165 mRNA Translation: AAB59509.1
M74817 mRNA Translation: AAA61230.1
AK223258 mRNA Translation: BAD96978.1
AL133410 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58354.1
BC011776 mRNA Translation: AAH11776.1
AF209746 Genomic DNA Translation: AAF17621.1
J05247 Genomic DNA Translation: AAA51842.1
CCDSiCCDS6586.1 [P07951-2]
CCDS6587.1 [P07951-1]
PIRiA23562
S00922
RefSeqiNP_003280.2, NM_003289.3 [P07951-1]
NP_998839.1, NM_213674.1 [P07951-2]
XP_016870580.1, XM_017015091.1 [P07951-1]
UniGeneiHs.300772

Genome annotation databases

EnsembliENST00000360958; ENSP00000354219; ENSG00000198467 [P07951-1]
ENST00000378292; ENSP00000367542; ENSG00000198467 [P07951-2]
ENST00000378300; ENSP00000367550; ENSG00000198467 [P07951-2]
ENST00000645482; ENSP00000496494; ENSG00000198467 [P07951-1]
GeneIDi7169
KEGGihsa:7169
UCSCiuc003zxs.4 human [P07951-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12126 mRNA Translation: AAA61229.1
M12125 mRNA Translation: AAA36773.1
X06825 mRNA Translation: CAA29971.1
M75165 mRNA Translation: AAB59509.1
M74817 mRNA Translation: AAA61230.1
AK223258 mRNA Translation: BAD96978.1
AL133410 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58354.1
BC011776 mRNA Translation: AAH11776.1
AF209746 Genomic DNA Translation: AAF17621.1
J05247 Genomic DNA Translation: AAA51842.1
CCDSiCCDS6586.1 [P07951-2]
CCDS6587.1 [P07951-1]
PIRiA23562
S00922
RefSeqiNP_003280.2, NM_003289.3 [P07951-1]
NP_998839.1, NM_213674.1 [P07951-2]
XP_016870580.1, XM_017015091.1 [P07951-1]
UniGeneiHs.300772

3D structure databases

ProteinModelPortaliP07951
SMRiP07951
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113022, 132 interactors
IntActiP07951, 44 interactors
MINTiP07951
STRINGi9606.ENSP00000354219

PTM databases

iPTMnetiP07951
PhosphoSitePlusiP07951

Polymorphism and mutation databases

BioMutaiTPM2
DMDMi136090

2D gel databases

DOSAC-COBS-2DPAGEiP07951
REPRODUCTION-2DPAGEiIPI00220709
UCD-2DPAGEiP07951

Proteomic databases

EPDiP07951
MaxQBiP07951
PaxDbiP07951
PeptideAtlasiP07951
PRIDEiP07951
ProteomicsDBi52049
52050 [P07951-2]
52051 [P07951-3]

Protocols and materials databases

DNASUi7169
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360958; ENSP00000354219; ENSG00000198467 [P07951-1]
ENST00000378292; ENSP00000367542; ENSG00000198467 [P07951-2]
ENST00000378300; ENSP00000367550; ENSG00000198467 [P07951-2]
ENST00000645482; ENSP00000496494; ENSG00000198467 [P07951-1]
GeneIDi7169
KEGGihsa:7169
UCSCiuc003zxs.4 human [P07951-1]

Organism-specific databases

CTDi7169
DisGeNETi7169
EuPathDBiHostDB:ENSG00000198467.13
GeneCardsiTPM2
GeneReviewsiTPM2
HGNCiHGNC:12011 TPM2
HPAiHPA009066
HPA047089
HPA053624
MalaCardsiTPM2
MIMi108120 phenotype
190990 gene
601680 phenotype
609285 phenotype
neXtProtiNX_P07951
OpenTargetsiENSG00000198467
Orphaneti171881 Cap myopathy
171439 Childhood-onset nemaline myopathy
2020 Congenital fiber-type disproportion myopathy
1146 Digitotalar dysmorphism
1147 Sheldon-Hall syndrome
171436 Typical nemaline myopathy
PharmGKBiPA36691
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1003 Eukaryota
ENOG410XR5K LUCA
GeneTreeiENSGT00550000074494
HOVERGENiHBG107404
InParanoidiP07951
KOiK10374
OMAiTEPTHEC
PhylomeDBiP07951
TreeFamiTF351519

Enzyme and pathway databases

ReactomeiR-HSA-390522 Striated Muscle Contraction
R-HSA-445355 Smooth Muscle Contraction

Miscellaneous databases

ChiTaRSiTPM2 human
GeneWikiiTPM2
GenomeRNAii7169
PROiPR:P07951
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198467 Expressed in 231 organ(s), highest expression level in myometrium
CleanExiHS_TPM2
ExpressionAtlasiP07951 baseline and differential
GenevisibleiP07951 HS

Family and domain databases

InterProiView protein in InterPro
IPR000533 Tropomyosin
PfamiView protein in Pfam
PF00261 Tropomyosin, 1 hit
PRINTSiPR00194 TROPOMYOSIN
PROSITEiView protein in PROSITE
PS00326 TROPOMYOSIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTPM2_HUMAN
AccessioniPrimary (citable) accession number: P07951
Secondary accession number(s): A6NM85
, P06468, Q13894, Q53FM4, Q5TCU4, Q5TCU7, Q9UH67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 7, 2018
This is version 192 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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