YES1

Functionⁱ

Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.5 Publications

Catalytic activityⁱ

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	305	ATPPROSITE-ProRule annotation		1
Active siteⁱ	396	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	283 – 291	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cellular protein modification process
Source: ProtInc
Traceable author statementⁱ
- 2436037
cellular response to platelet-derived growth factor stimulus Source: Ensembl
cellular response to retinoic acid Source: Ensembl
cellular response to transforming growth factor beta stimulus Source: Ensembl
ephrin receptor signaling pathway Source: Reactome
Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
leukocyte migration Source: Reactome
peptidyl-tyrosine autophosphorylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
positive regulation of transcription by RNA polymerase II Source: Ensembl
regulation of glucose transmembrane transport Source: Ensembl
regulation of vascular permeability
Source: BHF-UCL
Traceable author statementⁱ
- 19267251
T cell costimulation Source: Reactome
transmembrane receptor protein tyrosine kinase signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Transferase, Tyrosine-protein kinase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.10.2 2681
Reactomeⁱ	R-HSA-1227986 Signaling by ERBB2 R-HSA-1433557 Signaling by SCF-KIT R-HSA-1433559 Regulation of KIT signaling R-HSA-2029481 FCGR activation R-HSA-210990 PECAM1 interactions R-HSA-2682334 EPH-Ephrin signaling R-HSA-389356 CD28 co-stimulation R-HSA-389513 CTLA4 inhibitory signaling R-HSA-3928662 EPHB-mediated forward signaling R-HSA-3928663 EPHA-mediated growth cone collapse R-HSA-3928665 EPH-ephrin mediated repulsion of cells R-HSA-8940973 RUNX2 regulates osteoblast differentiation R-HSA-912631 Regulation of signaling by CBL
SignaLinkⁱ	P07947
SIGNORⁱ	P07947

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tyrosine-protein kinase Yes (EC:2.7.10.2) Alternative name(s): Proto-oncogene c-Yes p61-Yes
Gene namesⁱ	Name:YES1 Synonyms:YES
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 18

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000176105.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12841 YES1
MIMⁱ	164880 gene
neXtProtⁱ	NX_P07947

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	426	Y → F: About 50% loss of CSK-mediated inhibition. 1 Publication		1

Keywords - Diseaseⁱ

Proto-oncogene

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7525
Open Targets More...OpenTargetsⁱ	ENSG00000176105
PharmGKBⁱ	PA37432

Chemistry databases

ChEMBLⁱ	CHEMBL2073
Drug and drug target database More...DrugBankⁱ	DB01254 Dasatinib
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2284

Polymorphism and mutation databases

BioMutaⁱ	YES1
DMDMⁱ	125870

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed
ChainⁱPRO_0000088181	2 – 543	Tyrosine-protein kinase YesAdd BLAST		542

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Lipidationⁱ	2	N-myristoyl glycineBy similarity	1
Lipidationⁱ	3	S-palmitoyl cysteine; in membrane formBy similarity	1
Modified residueⁱ	21	PhosphothreonineCombined sources	1
Modified residueⁱ	32	PhosphotyrosineBy similarity	1
Modified residueⁱ	40	PhosphoserineCombined sources	1
Modified residueⁱ	336	PhosphotyrosineCombined sources	1
Modified residueⁱ	345	PhosphotyrosineCombined sources	1
Modified residueⁱ	426	Phosphotyrosine; by autocatalysis1 Publication	1
Modified residueⁱ	446	PhosphotyrosineCurated	1
Modified residueⁱ	537	Phosphotyrosine; by CSKCombined sources	1

Post-translational modificationⁱ

Phosphorylation by CSK on the C-terminal tail maintains the enzyme in an inactive state. Autophosphorylation at Tyr-426 maintains enzyme activity by blocking CSK-mediated inhibition.3 Publications

Palmitoylation at Cys-3 promotes membrane localization.By similarity

Keywords - PTMⁱ

Lipoprotein, Myristate, Palmitate, Phosphoprotein

Proteomic databases

EPDⁱ	P07947
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P07947
PaxDbⁱ	P07947
PeptideAtlas More...PeptideAtlasⁱ	P07947
PRIDEⁱ	P07947
ProteomicsDBⁱ	52044

PTM databases

iPTMnetⁱ	P07947
PhosphoSitePlusⁱ	P07947
SwissPalmⁱ	P07947

Expressionⁱ

Tissue specificityⁱ

Expressed in the epithelial cells of renal proximal tubules and stomach as well as hematopoietic cells in the bone marrow and spleen in the fetal tissues. In adult, expressed in epithelial cells of the renal proximal tubules and present in keratinocytes in the basal epidermal layer of epidermis.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000176105 Expressed in 233 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_YES1
ExpressionAtlasⁱ	P07947 baseline and differential
Genevisibleⁱ	P07947 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB004370 HPA026480

HPAⁱ

CAB004370
HPA026480

Interactionⁱ

Subunit structureⁱ

Interacts with YAP1 and CSF1R (By similarity). Interacts with CTNND1; this interaction allows YES1-mediated activation of FYN and FER and subsequent phosphorylation of CTNND1 (By similarity). Interacts with FASLG.By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ALOX5	P09917	2	EBI-515331,EBI-79934
AR	P10275	5	EBI-515331,EBI-608057
C1orf94	Q6P1W5	3	EBI-515331,EBI-946029
CDCP1	Q9H5V8	2	EBI-515331,EBI-1019736
EGFR	P00533	3	EBI-515331,EBI-297353
FAS	P25445-1	2	EBI-515331,EBI-15749113
FUNDC1	Q8IVP5	3	EBI-515331,EBI-3059266
FXR2	P51116	5	EBI-515331,EBI-740459
GAB1	Q13480	7	EBI-515331,EBI-517684
KIT	P10721	7	EBI-515331,EBI-1379503
MED28	Q9H204	2	EBI-515331,EBI-514199
MET	P08581	3	EBI-515331,EBI-1039152
NIF3L1	Q9GZT8	3	EBI-515331,EBI-740897
OLIG1	Q8TAK6	3	EBI-515331,EBI-3867416
PTK2	I6L996	5	EBI-515331,EBI-10181089
SOCS3	O14543	5	EBI-515331,EBI-714146
SSBP3	Q9BWW4	5	EBI-515331,EBI-2902395
THAP1	Q9NVV9	5	EBI-515331,EBI-741515
TRAF2	Q12933	3	EBI-515331,EBI-355744
TRAF6	Q9Y4K3	5	EBI-515331,EBI-359276
ZBTB8A	Q96BR9	5	EBI-515331,EBI-742740

GO - Molecular functionⁱ

enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 20605918
epidermal growth factor receptor binding Source: Ensembl
ion channel binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 12538589
phosphotyrosine residue binding
Source: CAFA
Inferred from physical interactionⁱ
- 20624904
signaling receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	113357, 127 interactors
CORUMⁱ	P07947
Database of interacting proteins More...DIPⁱ	DIP-33849N
ELMⁱ	P07947
IntActⁱ	P07947, 89 interactors
Molecular INTeraction database More...MINTⁱ	P07947
STRINGⁱ	9606.ENSP00000324740

Chemistry databases

BindingDBⁱ

P07947

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	93 – 100	Combined sources	8
Beta strandⁱ	117 – 121	Combined sources	5
Beta strandⁱ	126 – 133	Combined sources	8
Turnⁱ	134 – 136	Combined sources	3
Beta strandⁱ	139 – 143	Combined sources	5
Helixⁱ	144 – 146	Combined sources	3
Beta strandⁱ	147 – 149	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P07947
SMRⁱ	P07947
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P07947

EvolutionaryTraceⁱ

P07947

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	91 – 152	SH3PROSITE-ProRule annotationAdd BLAST	62
Domainⁱ	158 – 255	SH2PROSITE-ProRule annotationAdd BLAST	98
Domainⁱ	277 – 530	Protein kinasePROSITE-ProRule annotationAdd BLAST	254

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

SH2 domain, SH3 domain

Phylogenomic databases

eggNOGⁱ	KOG0197 Eukaryota COG0515 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118938
HOGENOMⁱ	HOG000233858
HOVERGENⁱ	HBG008761
InParanoidⁱ	P07947
KEGG Orthology (KO) More...KOⁱ	K05705
PhylomeDBⁱ	P07947
TreeFamⁱ	TF351634

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd12007 SH3_Yes, 1 hit
Gene3Dⁱ	3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR000980 SH2 IPR036860 SH2_dom_sf IPR036028 SH3-like_dom_sf IPR001452 SH3_domain IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom IPR035751 Yes_SH3
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07714 Pkinase_Tyr, 1 hit PF00017 SH2, 1 hit PF00018 SH3_1, 1 hit
PRINTSⁱ	PR00401 SH2DOMAIN PR00452 SH3DOMAIN PR00109 TYRKINASE
SMARTⁱ	View protein in SMART SM00252 SH2, 1 hit SM00326 SH3, 1 hit SM00219 TyrKc, 1 hit
SUPFAMⁱ	SSF50044 SSF50044, 1 hit SSF55550 SSF55550, 1 hit SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit PS50001 SH2, 1 hit PS50002 SH3, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P07947-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGCIKSKENK SPAIKYRPEN TPEPVSTSVS HYGAEPTTVS PCPSSSAKGT 
        60         70         80         90        100
AVNFSSLSMT PFGGSSGVTP FGGASSSFSV VPSSYPAGLT GGVTIFVALY 
       110        120        130        140        150
DYEARTTEDL SFKKGERFQI INNTEGDWWE ARSIATGKNG YIPSNYVAPA 
       160        170        180        190        200
DSIQAEEWYF GKMGRKDAER LLLNPGNQRG IFLVRESETT KGAYSLSIRD 
       210        220        230        240        250
WDEIRGDNVK HYKIRKLDNG GYYITTRAQF DTLQKLVKHY TEHADGLCHK 
       260        270        280        290        300
LTTVCPTVKP QTQGLAKDAW EIPRESLRLE VKLGQGCFGE VWMGTWNGTT 
       310        320        330        340        350
KVAIKTLKPG TMMPEAFLQE AQIMKKLRHD KLVPLYAVVS EEPIYIVTEF 
       360        370        380        390        400
MSKGSLLDFL KEGDGKYLKL PQLVDMAAQI ADGMAYIERM NYIHRDLRAA 
       410        420        430        440        450
NILVGENLVC KIADFGLARL IEDNEYTARQ GAKFPIKWTA PEAALYGRFT 
       460        470        480        490        500
IKSDVWSFGI LQTELVTKGR VPYPGMVNRE VLEQVERGYR MPCPQGCPES 
       510        520        530        540 
LHELMNLCWK KDPDERPTFE YIQSFLEDYF TATEPQYQPG ENL

Length:543

Mass (Da):60,801

Last modified:January 23, 2007 - v3

Checksum:ⁱA2B376084686BBCD

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	J3QRU1	J3QRU1_HUMAN		Tyrosine-protein kinase Tyrosine-protein kinase, EC 2.7.10.2	YES1	548	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_041879	198	I → V1 PublicationCorresponds to variant dbSNP:rs34580680Ensembl.		1
Natural variantⁱVAR_041880	282	K → R1 PublicationCorresponds to variant dbSNP:rs35126906Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M15990 mRNA Translation: AAA35735.1 AP001178 Genomic DNA No translation available. CH471113 Genomic DNA Translation: EAX01709.1 CH471113 Genomic DNA Translation: EAX01710.1 BC048960 mRNA Translation: AAH48960.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11824.1
PIRⁱ	A26714 TVHUYS
NCBI Reference Sequences More...RefSeqⁱ	NP_005424.1, NM_005433.3 XP_016881449.1, XM_017025960.1
UniGeneⁱ	Hs.194148

Genome annotation databases

Ensemblⁱ	ENST00000314574; ENSP00000324740; ENSG00000176105 ENST00000584307; ENSP00000462468; ENSG00000176105
GeneIDⁱ	7525
KEGGⁱ	hsa:7525
UCSC genome browser More...UCSCⁱ	uc002kky.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P07947	Tyrosine-protein kinase		PANTR		594	UniRef100_P07947
Tyrosine-protein kinase		PANTR		543

Protein	Similar proteins		Species	Score	Length	Source
P07947	Tyrosine-protein kinase Yes		RAT		541	UniRef90_P07947
Tyrosine-protein kinase Yes	)	MOUSE		541
Tyrosine-protein kinase Yes		CHICK		541
Tyrosine-protein kinase Yes		CANLF		539
Tyrosine-protein kinase Yes		XENLA		537
+195

Protein	Similar proteins		Species	Score	Length	Source
P07947	Proto-oncogene tyrosine-protein kinase Src	)	HUMAN		536	UniRef50_P12931
Neuronal proto-oncogene tyrosine-protein kinase Src	)	MOUSE		541
Proto-oncogene tyrosine-protein kinase Src		RAT		536
Proto-oncogene tyrosine-protein kinase Src	)	CHICK		533
Tyrosine-protein kinase transforming protein Src	)	RSVSE		526
+841

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M15990 mRNA Translation: AAA35735.1 AP001178 Genomic DNA No translation available. CH471113 Genomic DNA Translation: EAX01709.1 CH471113 Genomic DNA Translation: EAX01710.1 BC048960 mRNA Translation: AAH48960.1
CCDSⁱ	CCDS11824.1
PIRⁱ	A26714 TVHUYS
RefSeqⁱ	NP_005424.1, NM_005433.3 XP_016881449.1, XM_017025960.1
UniGeneⁱ	Hs.194148

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2HDA	X-ray	1.90	A	91-152	[»]
ProteinModelPortalⁱ	P07947
SMRⁱ	P07947
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113357, 127 interactors
CORUMⁱ	P07947
DIPⁱ	DIP-33849N
ELMⁱ	P07947
IntActⁱ	P07947, 89 interactors
MINTⁱ	P07947
STRINGⁱ	9606.ENSP00000324740

Chemistry databases

BindingDBⁱ	P07947
ChEMBLⁱ	CHEMBL2073
DrugBankⁱ	DB01254 Dasatinib
GuidetoPHARMACOLOGYⁱ	2284

PTM databases

iPTMnetⁱ	P07947
PhosphoSitePlusⁱ	P07947
SwissPalmⁱ	P07947

Polymorphism and mutation databases

BioMutaⁱ	YES1
DMDMⁱ	125870

Proteomic databases

EPDⁱ	P07947
MaxQBⁱ	P07947
PaxDbⁱ	P07947
PeptideAtlasⁱ	P07947
PRIDEⁱ	P07947
ProteomicsDBⁱ	52044

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7525
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000314574; ENSP00000324740; ENSG00000176105 ENST00000584307; ENSP00000462468; ENSG00000176105
GeneIDⁱ	7525
KEGGⁱ	hsa:7525
UCSCⁱ	uc002kky.4 human

Organism-specific databases

CTDⁱ	7525
DisGeNETⁱ	7525
EuPathDBⁱ	HostDB:ENSG00000176105.13
GeneCardsⁱ	YES1
HGNCⁱ	HGNC:12841 YES1
HPAⁱ	CAB004370 HPA026480
MIMⁱ	164880 gene
neXtProtⁱ	NX_P07947
OpenTargetsⁱ	ENSG00000176105
PharmGKBⁱ	PA37432
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0197 Eukaryota COG0515 LUCA
GeneTreeⁱ	ENSGT00760000118938
HOGENOMⁱ	HOG000233858
HOVERGENⁱ	HBG008761
InParanoidⁱ	P07947
KOⁱ	K05705
PhylomeDBⁱ	P07947
TreeFamⁱ	TF351634

Enzyme and pathway databases

BRENDAⁱ	2.7.10.2 2681
Reactomeⁱ	R-HSA-1227986 Signaling by ERBB2 R-HSA-1433557 Signaling by SCF-KIT R-HSA-1433559 Regulation of KIT signaling R-HSA-2029481 FCGR activation R-HSA-210990 PECAM1 interactions R-HSA-2682334 EPH-Ephrin signaling R-HSA-389356 CD28 co-stimulation R-HSA-389513 CTLA4 inhibitory signaling R-HSA-3928662 EPHB-mediated forward signaling R-HSA-3928663 EPHA-mediated growth cone collapse R-HSA-3928665 EPH-ephrin mediated repulsion of cells R-HSA-8940973 RUNX2 regulates osteoblast differentiation R-HSA-912631 Regulation of signaling by CBL
SignaLinkⁱ	P07947
SIGNORⁱ	P07947

Miscellaneous databases

ChiTaRSⁱ	YES1 human
EvolutionaryTraceⁱ	P07947
GeneWikiⁱ	YES1
GenomeRNAiⁱ	7525
Protein Ontology More...PROⁱ	PR:P07947
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000176105 Expressed in 233 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_YES1
ExpressionAtlasⁱ	P07947 baseline and differential
Genevisibleⁱ	P07947 HS

Family and domain databases

CDDⁱ	cd12007 SH3_Yes, 1 hit
Gene3Dⁱ	3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR000980 SH2 IPR036860 SH2_dom_sf IPR036028 SH3-like_dom_sf IPR001452 SH3_domain IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom IPR035751 Yes_SH3
Pfamⁱ	View protein in Pfam PF07714 Pkinase_Tyr, 1 hit PF00017 SH2, 1 hit PF00018 SH3_1, 1 hit
PRINTSⁱ	PR00401 SH2DOMAIN PR00452 SH3DOMAIN PR00109 TYRKINASE
SMARTⁱ	View protein in SMART SM00252 SH2, 1 hit SM00326 SH3, 1 hit SM00219 TyrKc, 1 hit
SUPFAMⁱ	SSF50044 SSF50044, 1 hit SSF55550 SSF55550, 1 hit SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit PS50001 SH2, 1 hit PS50002 SH3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	YES_HUMAN
Accessionⁱ	P07947Primary (citable) accession number: P07947 Secondary accession number(s): A6NLB3, D3DUH1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 218 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

UniProtKB

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UniProtKB - P07947 (YES_HUMAN)

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Tyrosine-protein kinase Yes

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytosol

Plasma membrane

Cytoskeleton

Cytosol

Extracellular region or secreted

Golgi apparatus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ