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Protein

Neuromodulin

Gene

Gap43

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity).By similarity

GO - Molecular functioni

  • calmodulin binding Source: GO_Central
  • lysophosphatidic acid binding Source: RGD
  • phosphatidylinositol phosphate binding Source: RGD
  • phosphatidylserine binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding, Developmental protein
Biological processDifferentiation, Growth regulation, Neurogenesis

Enzyme and pathway databases

ReactomeiR-RNO-373760 L1CAM interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromodulin
Alternative name(s):
Axonal membrane protein GAP-43
Growth-associated protein 43
Protein F1
Gene namesi
Name:Gap43
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi62071 Gap43

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001595991 – 226NeuromodulinAdd BLAST226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi3S-palmitoyl cysteineBy similarity1
Lipidationi4S-palmitoyl cysteineBy similarity1
Modified residuei41Phosphoserine; by PHK and PKC2 Publications1
Modified residuei86PhosphoserineCombined sources1
Modified residuei96PhosphoserineCombined sources1 Publication1
Modified residuei142PhosphoserineBy similarity1
Modified residuei144PhosphoserineBy similarity1
Modified residuei145PhosphoserineBy similarity1
Modified residuei172PhosphothreonineCombined sources2 Publications1
Modified residuei191PhosphoserineCombined sources1
Modified residuei192PhosphoserineCombined sources1

Post-translational modificationi

Palmitoylation by ARF6 is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2 (By similarity).By similarity
Phosphorylated at Ser-41 by PHK. Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity.3 Publications

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP07936
PRIDEiP07936

PTM databases

iPTMnetiP07936
PhosphoSitePlusiP07936
SwissPalmiP07936

Expressioni

Gene expression databases

BgeeiENSRNOG00000001528 Expressed in 9 organ(s), highest expression level in brain
GenevisibleiP07936 RN

Interactioni

Subunit structurei

Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds calmodulin with a greater affinity in the absence of Ca2+ than in its presence.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi248071, 4 interactors
STRINGi10116.ENSRNOP00000002091

Structurei

3D structure databases

SMRiP07936
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 60IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 4Important for membrane bindingBy similarity4

Sequence similaritiesi

Belongs to the neuromodulin family.Curated

Phylogenomic databases

eggNOGiENOG410IVZP Eukaryota
ENOG411256P LUCA
GeneTreeiENSGT00730000111265
HOGENOMiHOG000013014
HOVERGENiHBG006468
InParanoidiP07936
KOiK20041
OMAiIPLHALD
OrthoDBiEOG091G0Z3Z
PhylomeDBiP07936
TreeFamiTF333213

Family and domain databases

InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR001422 Neuromodulin
IPR017454 Neuromodulin_C
IPR018947 Neuromodulin_gap-junction_N
IPR033137 Neuromodulin_P_site
IPR018243 Neuromodulin_palmitoyl_site
PfamiView protein in Pfam
PF00612 IQ, 1 hit
PF06614 Neuromodulin, 1 hit
PF10580 Neuromodulin_N, 1 hit
PRINTSiPR00215 NEUROMODULIN
SMARTiView protein in SMART
SM00015 IQ, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS00412 NEUROMODULIN_1, 1 hit
PS00413 NEUROMODULIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

P07936-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLCCMRRTKQ VEKNDEDQKI EQDGVKPEDK AHKAATKIQA SFRGHITRKK
60 70 80 90 100
LKDEKKGDAP AAEAEAKEKD DAPVADGVEK KEGDGSATTD AAPATSPKAE
110 120 130 140 150
EPSKAGDAPS EEKKGEGDAA PSEEKAGSAE TESAAKATTD NSPSSKAEDG
160 170 180 190 200
PAKEEPKQAD VPAAVTDAAA TTPAAEDAAK AAQPPTETAE SSQAEEEKEA
210 220
VDEAKPKESA RQDEGKEDPE ADQEHA
Length:226
Mass (Da):23,603
Last modified:August 1, 1988 - v1
Checksum:i1314B2CDC61DB746
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16228 mRNA Translation: AAA41190.1
M16736 mRNA Translation: AAA41192.1
X06338 mRNA Translation: CAA29644.1
L21192, L21190, L21191 Genomic DNA Translation: AAA41189.1
BC127502 mRNA Translation: AAI27503.1
PIRiA26964
RefSeqiNP_058891.1, NM_017195.3
UniGeneiRn.10928

Genome annotation databases

EnsembliENSRNOT00000002091; ENSRNOP00000002091; ENSRNOG00000001528
GeneIDi29423
KEGGirno:29423
UCSCiRGD:62071 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16228 mRNA Translation: AAA41190.1
M16736 mRNA Translation: AAA41192.1
X06338 mRNA Translation: CAA29644.1
L21192, L21190, L21191 Genomic DNA Translation: AAA41189.1
BC127502 mRNA Translation: AAI27503.1
PIRiA26964
RefSeqiNP_058891.1, NM_017195.3
UniGeneiRn.10928

3D structure databases

SMRiP07936
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248071, 4 interactors
STRINGi10116.ENSRNOP00000002091

PTM databases

iPTMnetiP07936
PhosphoSitePlusiP07936
SwissPalmiP07936

Proteomic databases

PaxDbiP07936
PRIDEiP07936

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002091; ENSRNOP00000002091; ENSRNOG00000001528
GeneIDi29423
KEGGirno:29423
UCSCiRGD:62071 rat

Organism-specific databases

CTDi2596
RGDi62071 Gap43

Phylogenomic databases

eggNOGiENOG410IVZP Eukaryota
ENOG411256P LUCA
GeneTreeiENSGT00730000111265
HOGENOMiHOG000013014
HOVERGENiHBG006468
InParanoidiP07936
KOiK20041
OMAiIPLHALD
OrthoDBiEOG091G0Z3Z
PhylomeDBiP07936
TreeFamiTF333213

Enzyme and pathway databases

ReactomeiR-RNO-373760 L1CAM interactions

Miscellaneous databases

PROiPR:P07936

Gene expression databases

BgeeiENSRNOG00000001528 Expressed in 9 organ(s), highest expression level in brain
GenevisibleiP07936 RN

Family and domain databases

InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR001422 Neuromodulin
IPR017454 Neuromodulin_C
IPR018947 Neuromodulin_gap-junction_N
IPR033137 Neuromodulin_P_site
IPR018243 Neuromodulin_palmitoyl_site
PfamiView protein in Pfam
PF00612 IQ, 1 hit
PF06614 Neuromodulin, 1 hit
PF10580 Neuromodulin_N, 1 hit
PRINTSiPR00215 NEUROMODULIN
SMARTiView protein in SMART
SM00015 IQ, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS00412 NEUROMODULIN_1, 1 hit
PS00413 NEUROMODULIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNEUM_RAT
AccessioniPrimary (citable) accession number: P07936
Secondary accession number(s): A0JPM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 7, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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