URA3

Functionⁱ

Catalytic activityⁱ

Orotidine 5'-phosphate = UMP + CO₂.PROSITE-ProRule annotation

Pathwayⁱ: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:

Orotate phosphoribosyltransferase (URA5)
Orotidine 5'-phosphate decarboxylase (URA3)

This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	37	SubstrateBy similarity	1
Active siteⁱ	93	Proton donorPROSITE-ProRule annotation	1
Binding siteⁱ	217	SubstrateBy similarity	1
Binding siteⁱ	235	SubstrateBy similarity	1

GO - Molecular functionⁱ

orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

'de novo' pyrimidine nucleobase biosynthetic process Source: EnsemblFungi
'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Decarboxylase, Lyase
Biological process	Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayⁱ	UPA00070;UER00120

UniPathwayⁱ

UPA00070;UER00120

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23) Alternative name(s): OMP decarboxylase Short name: OMPDCase Short name: OMPdecase Uridine 5'-monophosphate synthase Short name: UMP synthase
Gene namesⁱ	Name:URA3 Ordered Locus Names:KLLA0E22902g
Organismⁱ	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifierⁱ	284590 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces › Kluyveromyces lactis
Proteomesⁱ	UP000000598 Componentⁱ: Chromosome E

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000134663	1 – 267	Orotidine 5'-phosphate decarboxylaseAdd BLAST		267

Proteomic databases

PRIDEⁱ	P07922

PRIDEⁱ

P07922

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	284590.XP_454981.1

STRINGⁱ

284590.XP_454981.1

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P07922
SMRⁱ	P07922
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	59 – 61	Substrate bindingBy similarity		3
Regionⁱ	91 – 100	Substrate bindingBy similarity		10

Sequence similaritiesⁱ

Belongs to the OMP decarboxylase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1377 Eukaryota COG0284 LUCA
HOGENOMⁱ	HOG000213905
InParanoidⁱ	P07922
KEGG Orthology (KO) More...KOⁱ	K01591
OMAⁱ	MGQQYRT
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C3SZ1

Family and domain databases

Gene3Dⁱ	3.20.20.70, 1 hit
InterProⁱ	View protein in InterPro IPR013785 Aldolase_TIM IPR014732 OMPdecase IPR018089 OMPdecase_AS IPR001754 OMPdeCOase_dom IPR011060 RibuloseP-bd_barrel
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00215 OMPdecase, 1 hit
SMARTⁱ	View protein in SMART SM00934 OMPdecase, 1 hit
SUPFAMⁱ	SSF51366 SSF51366, 1 hit
TIGRFAMsⁱ	TIGR01740 pyrF, 1 hit
PROSITEⁱ	View protein in PROSITE PS00156 OMPDECASE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P07922-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSTKSYTSRA ETHASPVASK LLRLMDEKKT NLCASLDVRS TDELLKLVET 
        60         70         80         90        100
LGPYICLLKT HVDILDDFSY EGTVVPLKAL AEKYKFLIFE DRKFADIGNT 
       110        120        130        140        150
VKLQYTSGVY RIAEWSDITN AHGVTGAGIV AGLKQGAQEV TKEPRGLLML 
       160        170        180        190        200
AELSSKGSLA HGEYTKGTVD IAKSDKDFVI GFIAQNDMGG REEGFDWLIM 
       210        220        230        240        250
TPGVGLDDKG DALGQQYRTV DEVVSGGSDI IIVGRGLFAK GRDPKVEGER 
       260 
YRNAGWEAYQ KRISAPH

Length:267

Mass (Da):29,241

Last modified:August 1, 1988 - v1

Checksum:ⁱC55224B57BC0D544

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y00454 Genomic DNA Translation: CAA68509.1 D00431 Genomic DNA Translation: BAA00333.1 CR382125 Genomic DNA Translation: CAH00068.1
PIRⁱ	A27836 DCVKOP
NCBI Reference Sequences More...RefSeqⁱ	XP_454981.1, XM_454981.1

Genome annotation databases

EnsemblFungiⁱ	CAH00068; CAH00068; KLLA0_E22771g
GeneIDⁱ	2894282
KEGGⁱ	kla:KLLA0E22771g

Protein	Similar proteins		Species	Score	Length	Source
P07922	Orotidine 5'-phosphate decarboxylase		SCHPO		264	UniRef50_P14965
Orotidine 5'-phosphate decarboxylase		PACTA		268
Orotidine 5'-phosphate decarboxylase		KODOH		261
Orotidine 5'-phosphate decarboxylase		PHYB8		267
Orotidine 5'-phosphate decarboxylase		PICAN		263
+115

Entry informationⁱ

Entry nameⁱ	PYRF_KLULA
Accessionⁱ	P07922Primary (citable) accession number: P07922
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
	Last sequence update:	August 1, 1988
	Last modified:	September 27, 2017
	This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB - P07922 (PYRF_KLULA)

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Orotidine 5'-phosphate decarboxylase

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Functionⁱ

Catalytic activityⁱ

Pathwayⁱ: UMP biosynthesis via de novo pathway

Sites

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

Subcellular locationⁱ

Cytosol

PTM / Processingⁱ

Molecule processing

Proteomic databases

Interactionⁱ

Protein-protein interaction databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Region

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProt is an ELIXIR core data resource

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P07922 (PYRF_KLULA)

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Orotidine 5'-phosphate decarboxylase

URA3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: UMP biosynthesis via de novo pathway

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

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Functionⁱ

Pathwayⁱ: UMP biosynthesis via de novo pathway

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ