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Protein

Cytochrome b-c1 complex subunit 6, mitochondrial

Gene

UQCRH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.

GO - Molecular functioni

  • ubiquinol-cytochrome-c reductase activity Source: ProtInc

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-HSA-611105 Respiratory electron transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 6, mitochondrial
Alternative name(s):
Complex III subunit 6
Complex III subunit VIII
Cytochrome c1 non-heme 11 kDa protein
Mitochondrial hinge protein
Ubiquinol-cytochrome c reductase complex 11 kDa protein
Gene namesi
Name:UQCRH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000173660.11
HGNCiHGNC:12590 UQCRH
MIMi613844 gene
neXtProtiNX_P07919

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7388
OpenTargetsiENSG00000173660
PharmGKBiPA37220

Chemistry databases

DrugBankiDB08453 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE
DB07778 FAMOXADONE
DB07401 METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE
DB08330 METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE
DB08690 UBIQUINONE-2

Polymorphism and mutation databases

BioMutaiUQCRH
DMDMi20455515

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 13MitochondrionBy similarityAdd BLAST13
ChainiPRO_000003599014 – 91Cytochrome b-c1 complex subunit 6, mitochondrialAdd BLAST78

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 81By similarity
Modified residuei42N6-acetyllysineBy similarity1
Disulfide bondi53 ↔ 67By similarity
Modified residuei85N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

EPDiP07919
MaxQBiP07919
PaxDbiP07919
PeptideAtlasiP07919
PRIDEiP07919
ProteomicsDBi52042
TopDownProteomicsiP07919

PTM databases

iPTMnetiP07919
PhosphoSitePlusiP07919

Expressioni

Gene expression databases

BgeeiENSG00000173660 Expressed in 92 organ(s), highest expression level in heart left ventricle
CleanExiHS_UQCRH
ExpressionAtlasiP07919 baseline and differential
GenevisibleiP07919 HS

Organism-specific databases

HPAiHPA042574

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Binary interactionsi

Protein-protein interaction databases

BioGridi113234, 46 interactors
ComplexPortaliCPX-560 Mitochondrial respiratory chain complex III
IntActiP07919, 19 interactors
MINTiP07919
STRINGi9606.ENSP00000309565

Structurei

Secondary structure

191
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP07919
SMRiP07919
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 25Poly-Glu9

Sequence similaritiesi

Belongs to the UQCRH/QCR6 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4763 Eukaryota
ENOG411247S LUCA
GeneTreeiENSGT00390000003860
HOGENOMiHOG000243673
HOVERGENiHBG001487
InParanoidiP07919
KOiK00416
OMAiFLHCVDH
OrthoDBiEOG091G13DH
PhylomeDBiP07919
TreeFamiTF105036

Family and domain databases

Gene3Di1.10.287.20, 1 hit
InterProiView protein in InterPro
IPR003422 Cyt_b-c1_6
IPR023184 Ubol_cytC_Rdtase_hinge_dom
IPR036811 Ubol_cytC_Rdtase_hinge_dom_sf
PANTHERiPTHR15336 PTHR15336, 1 hit
PfamiView protein in Pfam
PF02320 UCR_hinge, 1 hit
PIRSFiPIRSF000019 Bc1_11K, 1 hit
SUPFAMiSSF81531 SSF81531, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P07919-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLEDEQKML TESGDPEEEE EEEEELVDPL TTVREQCEQL EKCVKARERL
60 70 80 90
ELCDERVSSR SHTEEDCTEE LFDFLHARDH CVAHKLFNNL K
Length:91
Mass (Da):10,739
Last modified:May 2, 2002 - v2
Checksum:i499B5D069E738F4C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X2B9A0A087X2B9_HUMAN
Cytochrome b-c1 complex subunit 6, ...
UQCRH
58Annotation score:
A0A087WTF2A0A087WTF2_HUMAN
Cytochrome b-c1 complex subunit 6, ...
UQCRH
102Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57V → D in AAA36317 (PubMed:2826252).Curated1
Sequence conflicti57V → D in CAA68733 (PubMed:2826252).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03457951E → Q. Corresponds to variant dbSNP:rs34813470Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36647 mRNA Translation: AAA36317.1
Y00764 mRNA Translation: CAA68733.1
BT007070 mRNA Translation: AAP35733.1
AK311967 mRNA Translation: BAG34906.1
AL122001 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06922.1
CH471059 Genomic DNA Translation: EAX06924.1
BC001426 mRNA Translation: AAH01426.1
BC001934 mRNA Translation: AAH01934.1
BC015177 mRNA Translation: AAH15177.1
BC107703 mRNA Translation: AAI07704.1
S61826 Genomic DNA Translation: AAD13930.1
CCDSiCCDS30704.1
PIRiS00219
RefSeqiNP_005995.2, NM_006004.3
UniGeneiHs.481571

Genome annotation databases

EnsembliENST00000311672; ENSP00000309565; ENSG00000173660
GeneIDi7388
KEGGihsa:7388
UCSCiuc001cpp.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36647 mRNA Translation: AAA36317.1
Y00764 mRNA Translation: CAA68733.1
BT007070 mRNA Translation: AAP35733.1
AK311967 mRNA Translation: BAG34906.1
AL122001 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06922.1
CH471059 Genomic DNA Translation: EAX06924.1
BC001426 mRNA Translation: AAH01426.1
BC001934 mRNA Translation: AAH01934.1
BC015177 mRNA Translation: AAH15177.1
BC107703 mRNA Translation: AAI07704.1
S61826 Genomic DNA Translation: AAD13930.1
CCDSiCCDS30704.1
PIRiS00219
RefSeqiNP_005995.2, NM_006004.3
UniGeneiHs.481571

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XTEelectron microscopy3.40E/R17-91[»]
5XTHelectron microscopy3.90AE/AR18-91[»]
5XTIelectron microscopy17.40AE/AR18-91[»]
ProteinModelPortaliP07919
SMRiP07919
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113234, 46 interactors
ComplexPortaliCPX-560 Mitochondrial respiratory chain complex III
IntActiP07919, 19 interactors
MINTiP07919
STRINGi9606.ENSP00000309565

Chemistry databases

DrugBankiDB08453 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE
DB07778 FAMOXADONE
DB07401 METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE
DB08330 METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE
DB08690 UBIQUINONE-2

PTM databases

iPTMnetiP07919
PhosphoSitePlusiP07919

Polymorphism and mutation databases

BioMutaiUQCRH
DMDMi20455515

Proteomic databases

EPDiP07919
MaxQBiP07919
PaxDbiP07919
PeptideAtlasiP07919
PRIDEiP07919
ProteomicsDBi52042
TopDownProteomicsiP07919

Protocols and materials databases

DNASUi7388
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311672; ENSP00000309565; ENSG00000173660
GeneIDi7388
KEGGihsa:7388
UCSCiuc001cpp.4 human

Organism-specific databases

CTDi7388
DisGeNETi7388
EuPathDBiHostDB:ENSG00000173660.11
GeneCardsiUQCRH
H-InvDBiHIX0023863
HGNCiHGNC:12590 UQCRH
HPAiHPA042574
MIMi613844 gene
neXtProtiNX_P07919
OpenTargetsiENSG00000173660
PharmGKBiPA37220
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4763 Eukaryota
ENOG411247S LUCA
GeneTreeiENSGT00390000003860
HOGENOMiHOG000243673
HOVERGENiHBG001487
InParanoidiP07919
KOiK00416
OMAiFLHCVDH
OrthoDBiEOG091G13DH
PhylomeDBiP07919
TreeFamiTF105036

Enzyme and pathway databases

ReactomeiR-HSA-611105 Respiratory electron transport

Miscellaneous databases

ChiTaRSiUQCRH human
GeneWikiiUQCRH
GenomeRNAii7388
PROiPR:P07919
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173660 Expressed in 92 organ(s), highest expression level in heart left ventricle
CleanExiHS_UQCRH
ExpressionAtlasiP07919 baseline and differential
GenevisibleiP07919 HS

Family and domain databases

Gene3Di1.10.287.20, 1 hit
InterProiView protein in InterPro
IPR003422 Cyt_b-c1_6
IPR023184 Ubol_cytC_Rdtase_hinge_dom
IPR036811 Ubol_cytC_Rdtase_hinge_dom_sf
PANTHERiPTHR15336 PTHR15336, 1 hit
PfamiView protein in Pfam
PF02320 UCR_hinge, 1 hit
PIRSFiPIRSF000019 Bc1_11K, 1 hit
SUPFAMiSSF81531 SSF81531, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQCR6_HUMAN
AccessioniPrimary (citable) accession number: P07919
Secondary accession number(s): B2R4V9
, D3DQ18, Q5TDF6, Q6LDB8, Q9BQ91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: May 2, 2002
Last modified: November 7, 2018
This is version 184 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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