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Protein

Heterogeneous nuclear ribonucleoproteins C1/C2

Gene

HNRNPC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm6A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671).5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • 3'-UTR-mediated mRNA stabilization Source: UniProtKB
  • ATP-dependent chromatin remodeling Source: UniProtKB
  • mRNA splicing, via spliceosome Source: UniProtKB
  • negative regulation of telomere maintenance via telomerase Source: BHF-UCL
  • osteoblast differentiation Source: UniProtKB
  • RNA metabolic process Source: Reactome
  • RNA splicing Source: ProtInc

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P07910

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoproteins C1/C2
Short name:
hnRNP C1/C2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HNRNPC
Synonyms:HNRPC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000092199.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5035 HNRNPC

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
164020 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P07910

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi197K → R: No effect on sumoylation. 1 Publication1
Mutagenesisi250K → R: Loss of sumoylation. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
3183

Open Targets

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OpenTargetsi
ENSG00000092199

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162391217

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2216742

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HNRNPC

Domain mapping of disease mutations (DMDM)

More...
DMDMi
108935845

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000818442 – 306Heterogeneous nuclear ribonucleoproteins C1/C2Add BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki8Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki50Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki89Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki94Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei109PhosphothreonineCombined sources1
Modified residuei113PhosphoserineCombined sources1
Modified residuei115PhosphoserineCombined sources1
Modified residuei121PhosphoserineBy similarity1
Modified residuei162PhosphoserineCombined sources1
Modified residuei166PhosphoserineCombined sources1
Modified residuei176N6-acetyllysine; alternateBy similarity1
Cross-linki176Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki223Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki229Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki232Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki232Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei233PhosphoserineCombined sources1
Modified residuei238PhosphoserineCombined sources1
Modified residuei239PhosphoserineCombined sources1
Modified residuei241PhosphoserineCombined sources1
Cross-linki243Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki244Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki250Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Cross-linki250Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei253PhosphoserineCombined sources1 Publication1
Modified residuei260PhosphoserineCombined sources1 Publication1
Modified residuei299PhosphoserineCombined sources1 Publication1
Modified residuei306PhosphoserineCombined sources1
Isoform C1 (identifier: P07910-2)
Modified residuei107PhosphoserineCombined sources1
Modified residuei108PhosphoserineCombined sources1
Isoform 4 (identifier: P07910-4)
Modified residuei107PhosphoserineCombined sources1
Modified residuei108PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on Ser-260 and Ser-299 in resting cells. Phosphorylated on Ser-253 and on 1 serine residue in the poly-Ser stretch at position 238 in response to hydrogen peroxide.1 Publication
Sumoylated. Sumoylation reduces affinity for mRNA.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P07910

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P07910

MaxQB - The MaxQuant DataBase

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MaxQBi
P07910

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P07910

PeptideAtlas

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PeptideAtlasi
P07910

PRoteomics IDEntifications database

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PRIDEi
P07910

ProteomicsDB human proteome resource

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ProteomicsDBi
52034
52035 [P07910-2]
52036 [P07910-3]
52037 [P07910-4]

Consortium for Top Down Proteomics

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TopDownProteomicsi
P07910-1 [P07910-1]
P07910-2 [P07910-2]

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P07910

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P07910

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P07910

SwissPalm database of S-palmitoylation events

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SwissPalmi
P07910

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000092199 Expressed in 199 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P07910 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P07910 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB005223
CAB075755
CAB075756
HPA051075

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Tetramer composed of 3 copies of isoform C1 and 1 copy of isoform C2. Assembly of 3 tetramers with bound pre-mRNA gives rise to a 19S complex that interacts with HNRNPA2B1 tetramers. Component of the 40S hnRNP particle. Identified in the spliceosome C complex. Interacts with IGF2BP1. Interacts with DHX9; this interaction is direct, enhanced probably by their concomitant binding to RNA and mediates the attachment to actin filaments (PubMed:11687588).6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109424, 200 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P07910

Database of interacting proteins

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DIPi
DIP-29854N

Protein interaction database and analysis system

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IntActi
P07910, 127 interactors

Molecular INTeraction database

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MINTi
P07910

STRING: functional protein association networks

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STRINGi
9606.ENSP00000319690

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1306
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TXPNMR-A/B/C/D194-220[»]
1WF2NMR-A8-92[»]
2MXYNMR-A2-106[»]
2MZ1NMR-A2-106[»]
3LN4X-ray1.30C102-117[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P07910

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P07910

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P07910

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 87RRMPROSITE-ProRule annotationAdd BLAST72

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili190 – 238Sequence analysisAdd BLAST49

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi155 – 161Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi181 – 303Asp/Glu-rich (acidic)Add BLAST123

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RRM HNRPC family. RALY subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0118 Eukaryota
COG0724 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153402

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG002302

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P07910

KEGG Orthology (KO)

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KOi
K12884

Identification of Orthologs from Complete Genome Data

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OMAi
HRSKTSK

Database of Orthologous Groups

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OrthoDBi
1211602at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P07910

TreeFam database of animal gene trees

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TreeFami
TF330974

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR017347 hnRNP_C
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00076 RRM_1, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF037992 hnRNP-C_Raly, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00360 RRM, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54928 SSF54928, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50102 RRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 16 potential isoforms that are computationally mapped.Show allAlign All

Isoform C2 (identifier: P07910-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASNVTNKTD PRSMNSRVFI GNLNTLVVKK SDVEAIFSKY GKIVGCSVHK
60 70 80 90 100
GFAFVQYVNE RNARAAVAGE DGRMIAGQVL DINLAAEPKV NRGKAGVKRS
110 120 130 140 150
AAEMYGSVTE HPSPSPLLSS SFDLDYDFQR DYYDRMYSYP ARVPPPPPIA
160 170 180 190 200
RAVVPSKRQR VSGNTSRRGK SGFNSKSGQR GSSKSGKLKG DDLQAIKKEL
210 220 230 240 250
TQIKQKVDSL LENLEKIEKE QSKQAVEMKN DKSEEEQSSS SVKKDETNVK
260 270 280 290 300
MESEGGADDS AEEGDLLDDD DNEDRGDDQL ELIKDDEKEA EEGEDDRDSA

NGEDDS
Length:306
Mass (Da):33,670
Last modified:June 13, 2006 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i17BBC78690C69C5C
GO
Isoform C1 (identifier: P07910-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     108-120: Missing.

Show »
Length:293
Mass (Da):32,338
Checksum:iB90DDFD06A77FEE8
GO
Isoform 3 (identifier: P07910-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-119: KYGKIVGCSV...EHPSPSPLLS → N

Show »
Length:226
Mass (Da):25,230
Checksum:iBE6EC8C7A9FD7114
GO
Isoform 4 (identifier: P07910-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     108-120: Missing.
     153-195: Missing.

Show »
Length:250
Mass (Da):27,822
Checksum:i543388C3EC431836
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V2Q1G3V2Q1_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPC
305Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V576G3V576_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPC
231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V575G3V575_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPC
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V555G3V555_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPC
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DY08B4DY08_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPC
288Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B2R5W2B2R5W2_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPC
290Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V4C1G3V4C1_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPC
292Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V4W0G3V4W0_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPC
262Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2D6G3V2D6_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPC
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5V7G3V5V7_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPC
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD92764 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti110E → G in AAH08423 (PubMed:15489334).Curated1
Sequence conflicti217I → M (PubMed:2557628).Curated1
Sequence conflicti217I → M (PubMed:3110598).Curated1
Sequence conflicti224Q → R in AAH08364 (PubMed:15489334).Curated1
Sequence conflicti244K → R in AAH08364 (PubMed:15489334).Curated1
Sequence conflicti254E → G in AAH07052 (PubMed:15489334).Curated1
Sequence conflicti303 – 306EDDS → G (PubMed:2557628).Curated4
Sequence conflicti303 – 306EDDS → G (PubMed:3110598).Curated4

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01922539 – 119KYGKI…SPLLS → N in isoform 3. 1 PublicationAdd BLAST81
Alternative sequenceiVSP_005831108 – 120Missing in isoform C1 and isoform 4. 3 PublicationsAdd BLAST13
Alternative sequenceiVSP_019226153 – 195Missing in isoform 4. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M29063 mRNA Translation: AAA36576.1
M16342 mRNA Translation: AAA52680.1
BX161480 mRNA Translation: CAD61934.1
BX247961 mRNA Translation: CAD62300.1
BX247992 mRNA Translation: CAD62326.1
AB209527 mRNA Translation: BAD92764.1 Different initiation.
AK223517 mRNA Translation: BAD97237.1
CH471078 Genomic DNA Translation: EAW66392.1
CH471078 Genomic DNA Translation: EAW66393.1
CH471078 Genomic DNA Translation: EAW66394.1
CH471078 Genomic DNA Translation: EAW66395.1
CH471078 Genomic DNA Translation: EAW66396.1
CH471078 Genomic DNA Translation: EAW66399.1
CH471078 Genomic DNA Translation: EAW66400.1
BC003394 mRNA Translation: AAH03394.1
BC007052 mRNA Translation: AAH07052.1
BC008364 mRNA Translation: AAH08364.1
BC008423 mRNA Translation: AAH08423.1
BC066932 mRNA Translation: AAH66932.1
BC089438 mRNA Translation: AAH89438.1
BC108658 mRNA Translation: AAI08659.1
BC103758 mRNA Translation: AAI03759.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS41915.1 [P07910-1]
CCDS45079.1 [P07910-2]

Protein sequence database of the Protein Information Resource

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PIRi
A26885
C34504

NCBI Reference Sequences

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RefSeqi
NP_001070910.1, NM_001077442.1 [P07910-1]
NP_001070911.1, NM_001077443.1 [P07910-2]
NP_004491.2, NM_004500.3 [P07910-2]
NP_112604.2, NM_031314.2 [P07910-1]
XP_006720188.1, XM_006720125.2 [P07910-2]
XP_011535010.1, XM_011536708.1 [P07910-1]
XP_011535011.1, XM_011536709.2 [P07910-1]
XP_011535012.1, XM_011536710.2 [P07910-1]
XP_011535013.1, XM_011536711.2 [P07910-1]
XP_011535014.1, XM_011536712.1 [P07910-2]
XP_016876741.1, XM_017021252.1 [P07910-2]
XP_016876742.1, XM_017021253.1 [P07910-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.508848
Hs.675546

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000420743; ENSP00000404848; ENSG00000092199 [P07910-1]
ENST00000430246; ENSP00000442816; ENSG00000092199 [P07910-2]
ENST00000553300; ENSP00000450544; ENSG00000092199 [P07910-2]
ENST00000554455; ENSP00000451291; ENSG00000092199 [P07910-1]
ENST00000554969; ENSP00000450725; ENSG00000092199 [P07910-2]
ENST00000555883; ENSP00000450629; ENSG00000092199 [P07910-4]
ENST00000556628; ENSP00000451652; ENSG00000092199 [P07910-3]
ENST00000556897; ENSP00000451176; ENSG00000092199 [P07910-2]
ENST00000557201; ENSP00000452276; ENSG00000092199 [P07910-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
3183

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3183

UCSC genome browser

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UCSCi
uc001vzw.5 human [P07910-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29063 mRNA Translation: AAA36576.1
M16342 mRNA Translation: AAA52680.1
BX161480 mRNA Translation: CAD61934.1
BX247961 mRNA Translation: CAD62300.1
BX247992 mRNA Translation: CAD62326.1
AB209527 mRNA Translation: BAD92764.1 Different initiation.
AK223517 mRNA Translation: BAD97237.1
CH471078 Genomic DNA Translation: EAW66392.1
CH471078 Genomic DNA Translation: EAW66393.1
CH471078 Genomic DNA Translation: EAW66394.1
CH471078 Genomic DNA Translation: EAW66395.1
CH471078 Genomic DNA Translation: EAW66396.1
CH471078 Genomic DNA Translation: EAW66399.1
CH471078 Genomic DNA Translation: EAW66400.1
BC003394 mRNA Translation: AAH03394.1
BC007052 mRNA Translation: AAH07052.1
BC008364 mRNA Translation: AAH08364.1
BC008423 mRNA Translation: AAH08423.1
BC066932 mRNA Translation: AAH66932.1
BC089438 mRNA Translation: AAH89438.1
BC108658 mRNA Translation: AAI08659.1
BC103758 mRNA Translation: AAI03759.1
CCDSiCCDS41915.1 [P07910-1]
CCDS45079.1 [P07910-2]
PIRiA26885
C34504
RefSeqiNP_001070910.1, NM_001077442.1 [P07910-1]
NP_001070911.1, NM_001077443.1 [P07910-2]
NP_004491.2, NM_004500.3 [P07910-2]
NP_112604.2, NM_031314.2 [P07910-1]
XP_006720188.1, XM_006720125.2 [P07910-2]
XP_011535010.1, XM_011536708.1 [P07910-1]
XP_011535011.1, XM_011536709.2 [P07910-1]
XP_011535012.1, XM_011536710.2 [P07910-1]
XP_011535013.1, XM_011536711.2 [P07910-1]
XP_011535014.1, XM_011536712.1 [P07910-2]
XP_016876741.1, XM_017021252.1 [P07910-2]
XP_016876742.1, XM_017021253.1 [P07910-2]
UniGeneiHs.508848
Hs.675546

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TXPNMR-A/B/C/D194-220[»]
1WF2NMR-A8-92[»]
2MXYNMR-A2-106[»]
2MZ1NMR-A2-106[»]
3LN4X-ray1.30C102-117[»]
ProteinModelPortaliP07910
SMRiP07910
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109424, 200 interactors
CORUMiP07910
DIPiDIP-29854N
IntActiP07910, 127 interactors
MINTiP07910
STRINGi9606.ENSP00000319690

Chemistry databases

ChEMBLiCHEMBL2216742

PTM databases

iPTMnetiP07910
PhosphoSitePlusiP07910
SwissPalmiP07910

Polymorphism and mutation databases

BioMutaiHNRNPC
DMDMi108935845

2D gel databases

SWISS-2DPAGEiP07910

Proteomic databases

EPDiP07910
jPOSTiP07910
MaxQBiP07910
PaxDbiP07910
PeptideAtlasiP07910
PRIDEiP07910
ProteomicsDBi52034
52035 [P07910-2]
52036 [P07910-3]
52037 [P07910-4]
TopDownProteomicsiP07910-1 [P07910-1]
P07910-2 [P07910-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3183
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000420743; ENSP00000404848; ENSG00000092199 [P07910-1]
ENST00000430246; ENSP00000442816; ENSG00000092199 [P07910-2]
ENST00000553300; ENSP00000450544; ENSG00000092199 [P07910-2]
ENST00000554455; ENSP00000451291; ENSG00000092199 [P07910-1]
ENST00000554969; ENSP00000450725; ENSG00000092199 [P07910-2]
ENST00000555883; ENSP00000450629; ENSG00000092199 [P07910-4]
ENST00000556628; ENSP00000451652; ENSG00000092199 [P07910-3]
ENST00000556897; ENSP00000451176; ENSG00000092199 [P07910-2]
ENST00000557201; ENSP00000452276; ENSG00000092199 [P07910-1]
GeneIDi3183
KEGGihsa:3183
UCSCiuc001vzw.5 human [P07910-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3183
DisGeNETi3183
EuPathDBiHostDB:ENSG00000092199.17

GeneCards: human genes, protein and diseases

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GeneCardsi
HNRNPC
HGNCiHGNC:5035 HNRNPC
HPAiCAB005223
CAB075755
CAB075756
HPA051075
MIMi164020 gene
neXtProtiNX_P07910
OpenTargetsiENSG00000092199
PharmGKBiPA162391217

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00940000153402
HOVERGENiHBG002302
InParanoidiP07910
KOiK12884
OMAiHRSKTSK
OrthoDBi1211602at2759
PhylomeDBiP07910
TreeFamiTF330974

Enzyme and pathway databases

ReactomeiR-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
SIGNORiP07910

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HNRNPC human
EvolutionaryTraceiP07910

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
HNRNPC

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3183

Protein Ontology

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PROi
PR:P07910

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000092199 Expressed in 199 organ(s), highest expression level in testis
ExpressionAtlasiP07910 baseline and differential
GenevisibleiP07910 HS

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR017347 hnRNP_C
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
PIRSFiPIRSF037992 hnRNP-C_Raly, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHNRPC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07910
Secondary accession number(s): D3DS19
, D3DS22, P22628, Q53EX2, Q59FD3, Q5FWE8, Q86SF8, Q86U45, Q96HK7, Q96HM4, Q96IY5, Q9BTS3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: June 13, 2006
Last modified: January 16, 2019
This is version 231 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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