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Protein

Heterogeneous nuclear ribonucleoprotein A1

Gene

Hrb98DE

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This protein is a component of ribonucleosomes.

GO - Molecular functioni

  • mRNA 5'-UTR binding Source: FlyBase
  • mRNA binding Source: FlyBase
  • RNA binding Source: GO_Central
  • sequence-specific DNA binding Source: FlyBase

GO - Biological processi

  • compound eye morphogenesis Source: FlyBase
  • female germ-line stem cell population maintenance Source: FlyBase
  • negative regulation of RNA splicing Source: FlyBase
  • oogenesis Source: FlyBase
  • positive regulation of translation Source: FlyBase
  • regulation of alternative mRNA splicing, via spliceosome Source: FlyBase

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding

Enzyme and pathway databases

ReactomeiR-DME-6803529 FGFR2 alternative splicing
R-DME-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein A1
Short name:
hnRNP A1
Alternative name(s):
PEN repeat clone P9
hnRNP core protein A1-A
Gene namesi
Name:Hrb98DE
Synonyms:Pen9
ORF Names:CG9983
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0001215 Hrb98DE

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000818341 – 365Heterogeneous nuclear ribonucleoprotein A1Add BLAST365

Proteomic databases

PaxDbiP07909
PRIDEiP07909

Expressioni

Developmental stagei

Expressed both maternally and zygotically. Highest zygotic expression found in adult females and pupae.1 Publication

Gene expression databases

BgeeiFBgn0001215 Expressed in 38 organ(s), highest expression level in embryo
ExpressionAtlasiP07909 baseline and differential
GenevisibleiP07909 DM

Interactioni

Protein-protein interaction databases

BioGridi68261, 28 interactors
DIPiDIP-19217N
IntActiP07909, 8 interactors
STRINGi7227.FBpp0084669

Structurei

3D structure databases

ProteinModelPortaliP07909
SMRiP07909
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 107RRM 1PROSITE-ProRule annotationAdd BLAST77
Domaini122 – 199RRM 2PROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi206 – 365Gly-richAdd BLAST160

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00900000140828
InParanoidiP07909
KOiK12741
OMAiGAHITVK
OrthoDBiEOG091G1CPI
PhylomeDBiP07909

Family and domain databases

Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform B (identifier: P07909-1) [UniParc]FASTAAdd to basket
Also known as: C

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVNSNQNQNG NSNGHDDDFP QDSITEPEHM RKLFIGGLDY RTTDENLKAH
60 70 80 90 100
FEKWGNIVDV VVMKDPRTKR SRGFGFITYS HSSMIDEAQK SRPHKIDGRV
110 120 130 140 150
VEPKRAVPRQ DIDSPNAGAT VKKLFVGALK DDHDEQSIRD YFQHFGNIVD
160 170 180 190 200
INIVIDKETG KKRGFAFVEF DDYDPVDKVV LQKQHQLNGK MVDVKKALPK
210 220 230 240 250
QNDQQGGGGG RGGPGGRAGG NRGNMGGGNY GNQNGGGNWN NGGNNWGNNR
260 270 280 290 300
GGNDNWGNNS FGGGGGGGGG YGGGNNSWGN NNPWDNGNGG GNFGGGGNNW
310 320 330 340 350
NNGGNDFGGY QQNYGGGPQR GGGNFNNNRM QPYQGGGGFK AGGGNQGNYG
360
GNNQGFNNGG NNRRY
Length:365
Mass (Da):39,038
Last modified:August 1, 1988 - v1
Checksum:iBCC707CA2A2EC580
GO
Isoform A (identifier: P07909-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MVNSNQNQNGNSNGHD → MGGHDNWNNGQNEEQ

Show »
Length:364
Mass (Da):39,038
Checksum:i7653D03DBB79E364
GO
Isoform E (identifier: P07909-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MVNSNQNQNGNSNGHDDDFPQ → MGGHDNWNNGQNEEQD

Show »
Length:360
Mass (Da):38,550
Checksum:i0997302969DE0623
GO
Isoform D (identifier: P07909-4) [UniParc]FASTAAdd to basket
Also known as: F

The sequence of this isoform differs from the canonical sequence as follows:
     18-21: Missing.

Show »
Length:361
Mass (Da):38,550
Checksum:i08C016CDF6D9918C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A4V3J5A4V3J5_DROME
Heterogeneous nuclear ribonucleopro...
Hrb98DE anon-E7Delta6, B1, Dmel\CG9983, E7Delta6, HDP(P9)
365Annotation score:
A4V3J6A4V3J6_DROME
Heterogeneous nuclear ribonucleopro...
Hrb98DE anon-E7Delta6, B1, Dmel\CG9983, E7Delta6, HDP(P9)
361Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0058281 – 21MVNSN…DDFPQ → MGGHDNWNNGQNEEQD in isoform E. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_0058271 – 16MVNSN…SNGHD → MGGHDNWNNGQNEEQ in isoform A. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_00582918 – 21Missing in isoform D. 2 Publications4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15766 mRNA Translation: AAA70426.1
M25545
, M28871, M28872, M33955, M31560 Genomic DNA Translation: AAA28621.1
M25545
, M28870, M28872, M33955, M31560 Genomic DNA Translation: AAA28622.1
M25545
, M28870, M28872, M33955, M31560 Genomic DNA Translation: AAA28623.1
M25545
, M28871, M28872, M33955, M31560 Genomic DNA Translation: AAA28624.1
AE014297 Genomic DNA Translation: AAF56800.2
AE014297 Genomic DNA Translation: AAF56801.1
AE014297 Genomic DNA Translation: AAN14141.1
AE014297 Genomic DNA Translation: AAN14143.1
AY061448 mRNA Translation: AAL28996.1
PIRiA26459
RefSeqiNP_524543.1, NM_079819.3 [P07909-1]
NP_733249.1, NM_170370.2 [P07909-2]
NP_733250.1, NM_170371.2 [P07909-3]
NP_733251.1, NM_170372.2 [P07909-1]
NP_733252.1, NM_170373.2 [P07909-4]
NP_733253.1, NM_170374.2 [P07909-4]
UniGeneiDm.7147

Genome annotation databases

EnsemblMetazoaiFBtr0085298; FBpp0084667; FBgn0001215 [P07909-2]
FBtr0085299; FBpp0084668; FBgn0001215 [P07909-3]
FBtr0085300; FBpp0084669; FBgn0001215 [P07909-1]
FBtr0085301; FBpp0084670; FBgn0001215 [P07909-1]
FBtr0085302; FBpp0084671; FBgn0001215 [P07909-4]
FBtr0085303; FBpp0084672; FBgn0001215 [P07909-4]
GeneIDi43385
KEGGidme:Dmel_CG9983

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15766 mRNA Translation: AAA70426.1
M25545
, M28871, M28872, M33955, M31560 Genomic DNA Translation: AAA28621.1
M25545
, M28870, M28872, M33955, M31560 Genomic DNA Translation: AAA28622.1
M25545
, M28870, M28872, M33955, M31560 Genomic DNA Translation: AAA28623.1
M25545
, M28871, M28872, M33955, M31560 Genomic DNA Translation: AAA28624.1
AE014297 Genomic DNA Translation: AAF56800.2
AE014297 Genomic DNA Translation: AAF56801.1
AE014297 Genomic DNA Translation: AAN14141.1
AE014297 Genomic DNA Translation: AAN14143.1
AY061448 mRNA Translation: AAL28996.1
PIRiA26459
RefSeqiNP_524543.1, NM_079819.3 [P07909-1]
NP_733249.1, NM_170370.2 [P07909-2]
NP_733250.1, NM_170371.2 [P07909-3]
NP_733251.1, NM_170372.2 [P07909-1]
NP_733252.1, NM_170373.2 [P07909-4]
NP_733253.1, NM_170374.2 [P07909-4]
UniGeneiDm.7147

3D structure databases

ProteinModelPortaliP07909
SMRiP07909
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi68261, 28 interactors
DIPiDIP-19217N
IntActiP07909, 8 interactors
STRINGi7227.FBpp0084669

Proteomic databases

PaxDbiP07909
PRIDEiP07909

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0085298; FBpp0084667; FBgn0001215 [P07909-2]
FBtr0085299; FBpp0084668; FBgn0001215 [P07909-3]
FBtr0085300; FBpp0084669; FBgn0001215 [P07909-1]
FBtr0085301; FBpp0084670; FBgn0001215 [P07909-1]
FBtr0085302; FBpp0084671; FBgn0001215 [P07909-4]
FBtr0085303; FBpp0084672; FBgn0001215 [P07909-4]
GeneIDi43385
KEGGidme:Dmel_CG9983

Organism-specific databases

CTDi43385
FlyBaseiFBgn0001215 Hrb98DE

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00900000140828
InParanoidiP07909
KOiK12741
OMAiGAHITVK
OrthoDBiEOG091G1CPI
PhylomeDBiP07909

Enzyme and pathway databases

ReactomeiR-DME-6803529 FGFR2 alternative splicing
R-DME-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

ChiTaRSiHrb98DE fly
GenomeRNAii43385
PROiPR:P07909

Gene expression databases

BgeeiFBgn0001215 Expressed in 38 organ(s), highest expression level in embryo
ExpressionAtlasiP07909 baseline and differential
GenevisibleiP07909 DM

Family and domain databases

Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiROA1_DROME
AccessioniPrimary (citable) accession number: P07909
Secondary accession number(s): Q24359
, Q24360, Q99361, Q9VAU7, Q9VAU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 7, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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Main funding by: National Institutes of Health

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