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Protein

Superoxide dismutase [Mn], mitochondrial

Gene

Sod2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.1 Publication

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Mn2+By similarityNote: Binds 1 Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi50ManganeseBy similarity1
Metal bindingi98ManganeseBy similarity1
Metal bindingi183ManganeseBy similarity1
Metal bindingi187ManganeseBy similarity1

GO - Molecular functioni

  • DNA binding Source: RGD
  • enzyme binding Source: RGD
  • identical protein binding Source: RGD
  • manganese ion binding Source: RGD
  • metal ion binding Source: GO_Central
  • oxygen binding Source: RGD
  • superoxide dismutase activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandManganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-2151201 Transcriptional activation of mitochondrial biogenesis
R-RNO-3299685 Detoxification of Reactive Oxygen Species

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn], mitochondrial (EC:1.15.1.1)
Gene namesi
Name:Sod2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3732 Sod2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 24MitochondrionAdd BLAST24
ChainiPRO_000003287425 – 222Superoxide dismutase [Mn], mitochondrialAdd BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58Nitrated tyrosine1 Publication1
Modified residuei68N6-acetyllysine; alternateBy similarity1
Modified residuei68N6-succinyllysine; alternateBy similarity1
Modified residuei75N6-acetyllysine; alternateBy similarity1
Modified residuei75N6-succinyllysine; alternateBy similarity1
Modified residuei114N6-acetyllysineBy similarity1
Modified residuei122N6-acetyllysine; alternateBy similarity1
Modified residuei122N6-succinyllysine; alternateBy similarity1
Modified residuei130N6-acetyllysine; alternateBy similarity1
Modified residuei130N6-succinyllysine; alternateBy similarity1
Modified residuei202N6-acetyllysineBy similarity1

Post-translational modificationi

Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.2 Publications
Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting (By similarity).By similarity
Polyubiquitinated; leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability.By similarity

Keywords - PTMi

Acetylation, Nitration, Ubl conjugation

Proteomic databases

PaxDbiP07895
PRIDEiP07895

2D gel databases

World-2DPAGEi0004:P07895

PTM databases

iPTMnetiP07895
PhosphoSitePlusiP07895
SwissPalmiP07895

Expressioni

Gene expression databases

BgeeiENSRNOG00000019048 Expressed in 10 organ(s), highest expression level in heart
GenevisibleiP07895 RN

Interactioni

Subunit structurei

Homotetramer.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi246911, 1 interactor
IntActiP07895, 1 interactor
STRINGi10116.ENSRNOP00000025794

Structurei

3D structure databases

ProteinModelPortaliP07895
SMRiP07895
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0876 Eukaryota
COG0605 LUCA
GeneTreeiENSGT00390000011877
HOGENOMiHOG000013583
HOVERGENiHBG004451
InParanoidiP07895
KOiK04564
OMAiKWGSFDK
OrthoDBiEOG091G0MVL
PhylomeDBiP07895
TreeFamiTF105132

Family and domain databases

Gene3Di1.10.287.990, 1 hit
2.40.500.20, 1 hit
InterProiView protein in InterPro
IPR001189 Mn/Fe_SOD
IPR019833 Mn/Fe_SOD_BS
IPR019832 Mn/Fe_SOD_C
IPR019831 Mn/Fe_SOD_N
IPR036324 Mn/Fe_SOD_N_sf
IPR036314 SOD_C_sf
PfamiView protein in Pfam
PF02777 Sod_Fe_C, 1 hit
PF00081 Sod_Fe_N, 1 hit
PIRSFiPIRSF000349 SODismutase, 1 hit
PRINTSiPR01703 MNSODISMTASE
SUPFAMiSSF46609 SSF46609, 1 hit
SSF54719 SSF54719, 1 hit
PROSITEiView protein in PROSITE
PS00088 SOD_MN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07895-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLCRAACSAG RRLGPAASTA GSRHKHSLPD LPYDYGALEP HINAQIMQLH
60 70 80 90 100
HSKHHATYVN NLNVTEEKYH EALAKGDVTT QVALQPALKF NGGGHINHSI
110 120 130 140 150
FWTNLSPKGG GEPKGELLEA IKRDFGSFEK FKEKLTAVSV GVQGSGWGWL
160 170 180 190 200
GFNKEQGRLQ IAACSNQDPL QGTTGLIPLL GIDVWEHAYY LQYKNVRPDY
210 220
LKAIWNVINW ENVSQRYIVC KK
Length:222
Mass (Da):24,674
Last modified:May 1, 1992 - v2
Checksum:i8CCC1E0E857B3138
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti167Q → H in CAA68549 (PubMed:3697077).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00497 mRNA Translation: CAA68549.1
X56600 Genomic DNA Translation: CAA39937.1
BC070913 mRNA Translation: AAH70913.1
PIRiS21661 DSRTN
RefSeqiNP_058747.1, NM_017051.2
UniGeneiRn.10488

Genome annotation databases

EnsembliENSRNOT00000025794; ENSRNOP00000025794; ENSRNOG00000019048
GeneIDi24787
KEGGirno:24787

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00497 mRNA Translation: CAA68549.1
X56600 Genomic DNA Translation: CAA39937.1
BC070913 mRNA Translation: AAH70913.1
PIRiS21661 DSRTN
RefSeqiNP_058747.1, NM_017051.2
UniGeneiRn.10488

3D structure databases

ProteinModelPortaliP07895
SMRiP07895
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi246911, 1 interactor
IntActiP07895, 1 interactor
STRINGi10116.ENSRNOP00000025794

PTM databases

iPTMnetiP07895
PhosphoSitePlusiP07895
SwissPalmiP07895

2D gel databases

World-2DPAGEi0004:P07895

Proteomic databases

PaxDbiP07895
PRIDEiP07895

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025794; ENSRNOP00000025794; ENSRNOG00000019048
GeneIDi24787
KEGGirno:24787

Organism-specific databases

CTDi6648
RGDi3732 Sod2

Phylogenomic databases

eggNOGiKOG0876 Eukaryota
COG0605 LUCA
GeneTreeiENSGT00390000011877
HOGENOMiHOG000013583
HOVERGENiHBG004451
InParanoidiP07895
KOiK04564
OMAiKWGSFDK
OrthoDBiEOG091G0MVL
PhylomeDBiP07895
TreeFamiTF105132

Enzyme and pathway databases

ReactomeiR-RNO-2151201 Transcriptional activation of mitochondrial biogenesis
R-RNO-3299685 Detoxification of Reactive Oxygen Species

Miscellaneous databases

PROiPR:P07895

Gene expression databases

BgeeiENSRNOG00000019048 Expressed in 10 organ(s), highest expression level in heart
GenevisibleiP07895 RN

Family and domain databases

Gene3Di1.10.287.990, 1 hit
2.40.500.20, 1 hit
InterProiView protein in InterPro
IPR001189 Mn/Fe_SOD
IPR019833 Mn/Fe_SOD_BS
IPR019832 Mn/Fe_SOD_C
IPR019831 Mn/Fe_SOD_N
IPR036324 Mn/Fe_SOD_N_sf
IPR036314 SOD_C_sf
PfamiView protein in Pfam
PF02777 Sod_Fe_C, 1 hit
PF00081 Sod_Fe_N, 1 hit
PIRSFiPIRSF000349 SODismutase, 1 hit
PRINTSiPR01703 MNSODISMTASE
SUPFAMiSSF46609 SSF46609, 1 hit
SSF54719 SSF54719, 1 hit
PROSITEiView protein in PROSITE
PS00088 SOD_MN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSODM_RAT
AccessioniPrimary (citable) accession number: P07895
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: May 1, 1992
Last modified: November 7, 2018
This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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