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Protein

Peroxisomal acyl-coenzyme A oxidase 1

Gene

Acox1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 1 shows optimum activity with a chain length of 10 carbons while isoform 2 exhibits optimum activity with 14 carbons.1 Publication

Catalytic activityi

Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.3 Publications

Cofactori

FAD2 Publications

Pathwayi: peroxisomal fatty acid beta-oxidation

This protein is involved in the pathway peroxisomal fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway peroxisomal fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei139FAD2 Publications1
Binding sitei178FAD; via amide nitrogen2 Publications1
Active sitei421Proton acceptor2 Publications1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid metabolism, Lipid metabolism
LigandFAD, Flavoprotein

Enzyme and pathway databases

BRENDAi1.3.3.6 5301
SABIO-RKiP07872
UniPathwayi
UPA00661

Chemistry databases

SwissLipidsiSLP:000000408

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal acyl-coenzyme A oxidase 1By similarity (EC:1.3.3.61 Publication)
Short name:
AOXBy similarity
Alternative name(s):
Palmitoyl-CoA oxidaseBy similarity
Cleaved into the following 3 chains:
Peroxisomal acyl-CoA oxidase 1, A chain1 Publication
Peroxisomal acyl-CoA oxidase 1, B chain1 Publication
Peroxisomal acyl-CoA oxidase 1, C chain1 Publication
Gene namesi
Name:Acox1Imported
Synonyms:Acox1 Publication
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619757 Acox1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4632

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000005521 – 661Peroxisomal acyl-CoA oxidase 1, A chainAdd BLAST661
ChainiPRO_00000005531 – 438Peroxisomal acyl-CoA oxidase 1, B chainAdd BLAST438
ChainiPRO_0000000554439 – 661Peroxisomal acyl-CoA oxidase 1, C chainAdd BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26PhosphoserineBy similarity1
Modified residuei65N6-acetyllysineBy similarity1
Modified residuei89N6-succinyllysineBy similarity1
Modified residuei90N6-succinyllysineBy similarity1
Modified residuei159N6-succinyllysineBy similarity1
Modified residuei216N6-acetyllysineBy similarity1
Modified residuei241N6-succinyllysineBy similarity1
Modified residuei255N6-acetyllysineBy similarity1
Modified residuei267N6-acetyllysineBy similarity1
Modified residuei272N6-acetyllysineBy similarity1
Modified residuei349N6-succinyllysineBy similarity1
Modified residuei437N6-acetyllysine; alternateBy similarity1
Modified residuei437N6-succinyllysine; alternateBy similarity1
Modified residuei446N6-acetyllysine; alternateBy similarity1
Modified residuei446N6-succinyllysine; alternateBy similarity1
Modified residuei500N6-acetyllysineBy similarity1
Modified residuei512N6-acetyllysine; alternateBy similarity1
Modified residuei512N6-succinyllysine; alternateBy similarity1
Modified residuei542N6-succinyllysineBy similarity1
Modified residuei637N6-acetyllysine; alternateBy similarity1
Modified residuei637N6-succinyllysine; alternateBy similarity1
Modified residuei643N6-succinyllysineBy similarity1
Modified residuei649PhosphoserineBy similarity1
Modified residuei652N6-acetyllysineBy similarity1
Modified residuei655N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP07872
PRIDEiP07872

PTM databases

CarbonylDBiP07872
iPTMnetiP07872
PhosphoSitePlusiP07872

Miscellaneous databases

PMAP-CutDBiP07872

Interactioni

Subunit structurei

Homodimer. The enzyme contains three components A, B and C, the latter two being produced from the first by a proteolytic cleavage. Interacts with LONP2 (By similarity).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

IntActiP07872, 1 interactor
STRINGi10116.ENSRNOP00000051538

Chemistry databases

BindingDBiP07872

Structurei

Secondary structure

1661
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP07872
SMRiP07872
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07872

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi659 – 661Microbody targeting signal3

Sequence similaritiesi

Belongs to the acyl-CoA oxidase family.Curated

Phylogenomic databases

eggNOGiKOG0136 Eukaryota
COG1960 LUCA
HOGENOMiHOG000181256
HOVERGENiHBG050451
InParanoidiP07872
KOiK00232
PhylomeDBiP07872

Family and domain databases

CDDicd01150 AXO, 1 hit
Gene3Di1.10.540.10, 1 hit
InterProiView protein in InterPro
IPR034171 ACO
IPR029320 Acyl-CoA_ox_N
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR012258 Acyl-CoA_oxidase
IPR002655 Acyl-CoA_oxidase_C
IPR036250 AcylCo_DH-like_C
IPR037069 AcylCoA_DH/ox_N_sf
IPR009100 AcylCoA_DH/oxidase_NM_dom
PfamiView protein in Pfam
PF01756 ACOX, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PF14749 Acyl-CoA_ox_N, 1 hit
PIRSFiPIRSF000168 Acyl-CoA_oxidase, 1 hit
SUPFAMiSSF47203 SSF47203, 2 hits
SSF56645 SSF56645, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P07872-1) [UniParc]FASTAAdd to basket
Also known as: ACO-I

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNPDLRKERA SATFNPELIT HILDGSPENT RRRREIENLI LNDPDFQHED
60 70 80 90 100
YNFLTRSQRY EVAVKKSATM VKKMREYGIS DPEEIMWFKK LYLANFVEPV
110 120 130 140 150
GLNYSMFIPT LLNQGTTAQQ EKWMRPSQEL QIIGTYAQTE MGHGTHLRGL
160 170 180 190 200
ETTATYDPKT QEFILNSPTV TSIKWWPGGL GKTSNHAIVL AQLITQGECY
210 220 230 240 250
GLHAFVVPIR EIGTHKPLPG ITVGDIGPKF GYEEMDNGYL KMDNYRIPRE
260 270 280 290 300
NMLMKYAQVK PDGTYVKPLS NKLTYGTMVF VRSFLVGNAA QSLSKACTIA
310 320 330 340 350
IRYSAVRRQS EIKQSEPEPQ ILDFQTQQYK LFPLLATAYA FHFVGRYMKE
360 370 380 390 400
TYLRINESIG QGDLSELPEL HALTAGLKAF TTWTANAGIE ECRMACGGHG
410 420 430 440 450
YSHSSGIPNI YVTFTPACTF EGENTVMMLQ TARFLMKIYD QVRSGKLVGG
460 470 480 490 500
MVSYLNDLPS QRIQPQQVAV WPTMVDINSL EGLTEAYKLR AARLVEIAAK
510 520 530 540 550
NLQTHVSHRK SKEVAWNLTS VDLVRASEAH CHYVVVKVFS DKLPKIQDKA
560 570 580 590 600
VQAVLRNLCL LYSLYGISQK GGDFLEGSII TGAQLSQVNA RILELLTLIR
610 620 630 640 650
PNAVALVDAF DFKDMTLGSV LGRYDGNVYE NLFEWAKKSP LNKTEVHESY
660
HKHLKPLQSK L
Length:661
Mass (Da):74,679
Last modified:August 1, 1988 - v1
Checksum:i24B1F10DF066C29E
GO
Isoform 2 (identifier: P07872-2) [UniParc]FASTAAdd to basket
Also known as: ACO-II

The sequence of this isoform differs from the canonical sequence as follows:
     90-133: KLYLANFVEP...MRPSQELQII → NSVHRGHPEP...FMPAWNLEIT

Show »
Length:661
Mass (Da):74,691
Checksum:i23EBDE0CDEE70559
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LQC1F1LQC1_RAT
Acyl-coenzyme A oxidase
Acox1
660Annotation score:
F1M609F1M609_RAT
Acyl-coenzyme A oxidase
Acox1
588Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00014790 – 133KLYLA…ELQII → NSVHRGHPEPLDLHLGMFLP TLLHQATAEQQERFFMPAWN LEIT in isoform 2. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02752 mRNA Translation: AAA40666.1
BC085743 mRNA Translation: AAH85743.1
J02753 Genomic DNA Translation: AAA40667.1
PIRiA29328 OXRTA1
B29328 OXRTA2
RefSeqiNP_059036.1, NM_017340.2 [P07872-1]
UniGeneiRn.31796

Genome annotation databases

GeneIDi50681
KEGGirno:50681

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02752 mRNA Translation: AAA40666.1
BC085743 mRNA Translation: AAH85743.1
J02753 Genomic DNA Translation: AAA40667.1
PIRiA29328 OXRTA1
B29328 OXRTA2
RefSeqiNP_059036.1, NM_017340.2 [P07872-1]
UniGeneiRn.31796

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IS2X-ray2.20A/B1-661[»]
2DDHX-ray2.07A1-661[»]
ProteinModelPortaliP07872
SMRiP07872
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP07872, 1 interactor
STRINGi10116.ENSRNOP00000051538

Chemistry databases

BindingDBiP07872
ChEMBLiCHEMBL4632
SwissLipidsiSLP:000000408

PTM databases

CarbonylDBiP07872
iPTMnetiP07872
PhosphoSitePlusiP07872

Proteomic databases

PaxDbiP07872
PRIDEiP07872

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi50681
KEGGirno:50681

Organism-specific databases

CTDi51
RGDi619757 Acox1

Phylogenomic databases

eggNOGiKOG0136 Eukaryota
COG1960 LUCA
HOGENOMiHOG000181256
HOVERGENiHBG050451
InParanoidiP07872
KOiK00232
PhylomeDBiP07872

Enzyme and pathway databases

UniPathwayi
UPA00661

BRENDAi1.3.3.6 5301
SABIO-RKiP07872

Miscellaneous databases

EvolutionaryTraceiP07872
PMAP-CutDBiP07872
PROiPR:P07872

Family and domain databases

CDDicd01150 AXO, 1 hit
Gene3Di1.10.540.10, 1 hit
InterProiView protein in InterPro
IPR034171 ACO
IPR029320 Acyl-CoA_ox_N
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR012258 Acyl-CoA_oxidase
IPR002655 Acyl-CoA_oxidase_C
IPR036250 AcylCo_DH-like_C
IPR037069 AcylCoA_DH/ox_N_sf
IPR009100 AcylCoA_DH/oxidase_NM_dom
PfamiView protein in Pfam
PF01756 ACOX, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PF14749 Acyl-CoA_ox_N, 1 hit
PIRSFiPIRSF000168 Acyl-CoA_oxidase, 1 hit
SUPFAMiSSF47203 SSF47203, 2 hits
SSF56645 SSF56645, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACOX1_RAT
AccessioniPrimary (citable) accession number: P07872
Secondary accession number(s): P11354
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: May 23, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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