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UniProtKB - P07864 (LDHC_HUMAN)
Protein
L-lactate dehydrogenase C chain
Gene
LDHC
Organism
Homo sapiens (Human)
Status
Functioni
Possible role in sperm motility.
Catalytic activityi
- EC:1.1.1.27
: pyruvate fermentation to lactate Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate. This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 99 | NADBy similarity | 1 | |
Binding sitei | 106 | SubstrateBy similarity | 1 | |
Binding sitei | 138 | NADBy similarity | 1 | |
Binding sitei | 138 | SubstrateBy similarity | 1 | |
Binding sitei | 169 | SubstrateBy similarity | 1 | |
Active sitei | 193 | Proton acceptorBy similarity | 1 | |
Binding sitei | 248 | SubstrateBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 29 – 57 | NADBy similarityAdd BLAST | 29 |
GO - Molecular functioni
- L-lactate dehydrogenase activity Source: GO_Central
GO - Biological processi
- ATP biosynthetic process Source: Ensembl
- flagellated sperm motility Source: Ensembl
- lactate biosynthetic process from pyruvate Source: Ensembl
- lactate metabolic process Source: ComplexPortal
- lactate oxidation Source: Ensembl
- pyruvate metabolic process Source: ComplexPortal
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Enzyme and pathway databases
BRENDAi | 1.1.1.27, 2681 |
PathwayCommonsi | P07864 |
Reactomei | R-HSA-70268, Pyruvate metabolism |
SignaLinki | P07864 |
UniPathwayi | UPA00554;UER00611 |
Names & Taxonomyi
Protein namesi | Recommended name: L-lactate dehydrogenase C chain (EC:1.1.1.27)Short name: LDH-C Alternative name(s): Cancer/testis antigen 32 Short name: CT32 LDH testis subunit LDH-X |
Gene namesi | Name:LDHC Synonyms:LDH3, LDHX |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6544, LDHC |
MIMi | 150150, gene |
neXtProti | NX_P07864 |
VEuPathDBi | HostDB:ENSG00000166796 |
Subcellular locationi
Cytoplasm and Cytosol
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Other locations
- motile cilium Source: Ensembl
- oxidoreductase complex Source: ComplexPortal
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 3948 |
OpenTargetsi | ENSG00000166796 |
PharmGKBi | PA30328 |
Miscellaneous databases
Pharosi | P07864, Tbio |
Chemistry databases
DrugBanki | DB00157, NADH |
Genetic variation databases
BioMutai | LDHC |
DMDMi | 76363520 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000168479 | 1 – 332 | L-lactate dehydrogenase C chainAdd BLAST | 332 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 301 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P07864 |
jPOSTi | P07864 |
MassIVEi | P07864 |
MaxQBi | P07864 |
PaxDbi | P07864 |
PeptideAtlasi | P07864 |
PRIDEi | P07864 |
ProteomicsDBi | 52030 |
PTM databases
iPTMneti | P07864 |
PhosphoSitePlusi | P07864 |
SwissPalmi | P07864 |
Expressioni
Gene expression databases
Bgeei | ENSG00000166796, Expressed in testis and 132 other tissues |
ExpressionAtlasi | P07864, baseline and differential |
Genevisiblei | P07864, HS |
Organism-specific databases
HPAi | ENSG00000166796, Tissue enriched (testis) |
Interactioni
Subunit structurei
Homotetramer.
Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2 (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 110140, 38 interactors |
ComplexPortali | CPX-6602, L-lactate dehydrogenase C complex |
IntActi | P07864, 7 interactors |
STRINGi | 9606.ENSP00000437783 |
Miscellaneous databases
RNActi | P07864, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1495, Eukaryota |
GeneTreei | ENSGT00940000161479 |
HOGENOMi | CLU_045401_0_2_1 |
InParanoidi | P07864 |
OMAi | AWSHVTI |
OrthoDBi | 1204514at2759 |
PhylomeDBi | P07864 |
TreeFami | TF314963 |
Family and domain databases
Gene3Di | 3.90.110.10, 1 hit |
HAMAPi | MF_00488, Lactate_dehydrog, 1 hit |
InterProi | View protein in InterPro IPR001557, L-lactate/malate_DH IPR011304, L-lactate_DH IPR018177, L-lactate_DH_AS IPR022383, Lactate/malate_DH_C IPR001236, Lactate/malate_DH_N IPR015955, Lactate_DH/Glyco_Ohase_4_C IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF02866, Ldh_1_C, 1 hit PF00056, Ldh_1_N, 1 hit |
PIRSFi | PIRSF000102, Lac_mal_DH, 1 hit |
PRINTSi | PR00086, LLDHDRGNASE |
SUPFAMi | SSF51735, SSF51735, 1 hit SSF56327, SSF56327, 1 hit |
TIGRFAMsi | TIGR01771, L-LDH-NAD, 1 hit |
PROSITEi | View protein in PROSITE PS00064, L_LDH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
P07864-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTVKEQLIE KLIEDDENSQ CKITIVGTGA VGMACAISIL LKDLADELAL
60 70 80 90 100
VDVALDKLKG EMMDLQHGSL FFSTSKITSG KDYSVSANSR IVIVTAGARQ
110 120 130 140 150
QEGETRLALV QRNVAIMKSI IPAIVHYSPD CKILVVSNPV DILTYIVWKI
160 170 180 190 200
SGLPVTRVIG SGCNLDSARF RYLIGEKLGV HPTSCHGWII GEHGDSSVPL
210 220 230 240 250
WSGVNVAGVA LKTLDPKLGT DSDKEHWKNI HKQVIQSAYE IIKLKGYTSW
260 270 280 290 300
AIGLSVMDLV GSILKNLRRV HPVSTMVKGL YGIKEELFLS IPCVLGRNGV
310 320 330
SDVVKINLNS EEEALFKKSA ETLWNIQKDL IF
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5H245 | F5H245_HUMAN | L-lactate dehydrogenase | LDHC | 318 | Annotation score: | ||
F5H5G7 | F5H5G7_HUMAN | L-lactate dehydrogenase | LDHC | 183 | Annotation score: | ||
F5H155 | F5H155_HUMAN | L-lactate dehydrogenase | LDHC | 225 | Annotation score: | ||
G3XAP5 | G3XAP5_HUMAN | L-lactate dehydrogenase | LDHC hCG_15532 | 241 | Annotation score: | ||
F5GZ11 | F5GZ11_HUMAN | L-lactate dehydrogenase C chain | LDHC | 167 | Annotation score: | ||
F5GWS6 | F5GWS6_HUMAN | L-lactate dehydrogenase C chain | LDHC | 45 | Annotation score: | ||
F5H326 | F5H326_HUMAN | L-lactate dehydrogenase C chain | LDHC | 51 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 77 | I → V in AAA59507 (PubMed:2440048).Curated | 1 | |
Sequence conflicti | 77 | I → V in AAA59508 (PubMed:2930531).Curated | 1 | |
Sequence conflicti | 82 | D → G in AAP37402 (PubMed:14985855).Curated | 1 | |
Sequence conflicti | 119 | S → I in AAA59507 (PubMed:2440048).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034068 | 285 | E → Q. Corresponds to variant dbSNP:rs2230150Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J02938 mRNA Translation: AAA59507.1 AH002865 Genomic DNA Translation: AAA59508.1 U13680 mRNA Translation: AAA21348.1 AY286300 mRNA Translation: AAP37402.1 CH471064 Genomic DNA Translation: EAW68392.1 CH471064 Genomic DNA Translation: EAW68394.1 BC019249 mRNA Translation: AAH19249.3 BC064388 mRNA Translation: AAH64388.1 BC090043 mRNA Translation: AAH90043.1 |
CCDSi | CCDS7840.1 |
PIRi | A30933, DEHULC |
RefSeqi | NP_002292.1, NM_002301.4 NP_059144.1, NM_017448.3 |
Genome annotation databases
Ensembli | ENST00000280704.8; ENSP00000280704.3; ENSG00000166796.12 ENST00000541669.6; ENSP00000437783.1; ENSG00000166796.12 |
GeneIDi | 3948 |
KEGGi | hsa:3948 |
MANE-Selecti | ENST00000541669.6; ENSP00000437783.1; NM_017448.5; NP_059144.1 |
UCSCi | uc001mom.5, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Lactate dehydrogenase entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J02938 mRNA Translation: AAA59507.1 AH002865 Genomic DNA Translation: AAA59508.1 U13680 mRNA Translation: AAA21348.1 AY286300 mRNA Translation: AAP37402.1 CH471064 Genomic DNA Translation: EAW68392.1 CH471064 Genomic DNA Translation: EAW68394.1 BC019249 mRNA Translation: AAH19249.3 BC064388 mRNA Translation: AAH64388.1 BC090043 mRNA Translation: AAH90043.1 |
CCDSi | CCDS7840.1 |
PIRi | A30933, DEHULC |
RefSeqi | NP_002292.1, NM_002301.4 NP_059144.1, NM_017448.3 |
3D structure databases
AlphaFoldDBi | P07864 |
SMRi | P07864 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 110140, 38 interactors |
ComplexPortali | CPX-6602, L-lactate dehydrogenase C complex |
IntActi | P07864, 7 interactors |
STRINGi | 9606.ENSP00000437783 |
Chemistry databases
DrugBanki | DB00157, NADH |
PTM databases
iPTMneti | P07864 |
PhosphoSitePlusi | P07864 |
SwissPalmi | P07864 |
Genetic variation databases
BioMutai | LDHC |
DMDMi | 76363520 |
Proteomic databases
EPDi | P07864 |
jPOSTi | P07864 |
MassIVEi | P07864 |
MaxQBi | P07864 |
PaxDbi | P07864 |
PeptideAtlasi | P07864 |
PRIDEi | P07864 |
ProteomicsDBi | 52030 |
Protocols and materials databases
Antibodypediai | 25085, 249 antibodies from 33 providers |
DNASUi | 3948 |
Genome annotation databases
Ensembli | ENST00000280704.8; ENSP00000280704.3; ENSG00000166796.12 ENST00000541669.6; ENSP00000437783.1; ENSG00000166796.12 |
GeneIDi | 3948 |
KEGGi | hsa:3948 |
MANE-Selecti | ENST00000541669.6; ENSP00000437783.1; NM_017448.5; NP_059144.1 |
UCSCi | uc001mom.5, human |
Organism-specific databases
CTDi | 3948 |
DisGeNETi | 3948 |
GeneCardsi | LDHC |
HGNCi | HGNC:6544, LDHC |
HPAi | ENSG00000166796, Tissue enriched (testis) |
MIMi | 150150, gene |
neXtProti | NX_P07864 |
OpenTargetsi | ENSG00000166796 |
PharmGKBi | PA30328 |
VEuPathDBi | HostDB:ENSG00000166796 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1495, Eukaryota |
GeneTreei | ENSGT00940000161479 |
HOGENOMi | CLU_045401_0_2_1 |
InParanoidi | P07864 |
OMAi | AWSHVTI |
OrthoDBi | 1204514at2759 |
PhylomeDBi | P07864 |
TreeFami | TF314963 |
Enzyme and pathway databases
UniPathwayi | UPA00554;UER00611 |
BRENDAi | 1.1.1.27, 2681 |
PathwayCommonsi | P07864 |
Reactomei | R-HSA-70268, Pyruvate metabolism |
SignaLinki | P07864 |
Miscellaneous databases
BioGRID-ORCSi | 3948, 8 hits in 1071 CRISPR screens |
ChiTaRSi | LDHC, human |
GenomeRNAii | 3948 |
Pharosi | P07864, Tbio |
PROi | PR:P07864 |
RNActi | P07864, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166796, Expressed in testis and 132 other tissues |
ExpressionAtlasi | P07864, baseline and differential |
Genevisiblei | P07864, HS |
Family and domain databases
Gene3Di | 3.90.110.10, 1 hit |
HAMAPi | MF_00488, Lactate_dehydrog, 1 hit |
InterProi | View protein in InterPro IPR001557, L-lactate/malate_DH IPR011304, L-lactate_DH IPR018177, L-lactate_DH_AS IPR022383, Lactate/malate_DH_C IPR001236, Lactate/malate_DH_N IPR015955, Lactate_DH/Glyco_Ohase_4_C IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF02866, Ldh_1_C, 1 hit PF00056, Ldh_1_N, 1 hit |
PIRSFi | PIRSF000102, Lac_mal_DH, 1 hit |
PRINTSi | PR00086, LLDHDRGNASE |
SUPFAMi | SSF51735, SSF51735, 1 hit SSF56327, SSF56327, 1 hit |
TIGRFAMsi | TIGR01771, L-LDH-NAD, 1 hit |
PROSITEi | View protein in PROSITE PS00064, L_LDH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LDHC_HUMAN | |
Accessioni | P07864Primary (citable) accession number: P07864 Secondary accession number(s): D3DQY4, Q6GSG8, Q7Z7J4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 206 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families