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UniProtKB - P07864 (LDHC_HUMAN)

Entry version 203 (02 Jun 2021)
Sequence version 4 (23 Jan 2007)
Previous versions | rss
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Protein

L-lactate dehydrogenase C chain

Gene

LDHC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Possible role in sperm motility.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate. This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei99NADBy similarity1
Binding sitei106SubstrateBy similarity1
Binding sitei138NADBy similarity1
Binding sitei138SubstrateBy similarity1
Binding sitei169SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei193Proton acceptorBy similarity1
Binding sitei248SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi29 – 57NADBy similarityAdd BLAST29

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		1.1.1.27, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P07864

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-70268, Pyruvate metabolism

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00554;UER00611

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
L-lactate dehydrogenase C chain (EC:1.1.1.27)
Short name:
LDH-C
Alternative name(s):
Cancer/testis antigen 32
Short name:
CT32
LDH testis subunit
LDH-X
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LDHC
Synonyms:LDH3, LDHX
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6544, LDHC

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		150150, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P07864

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000166796.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3948

Open Targets

More...OpenTargetsi		ENSG00000166796

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30328

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P07864, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB00157, NADH

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LDHC

Domain mapping of disease mutations (DMDM)

More...DMDMi		76363520

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001684791 – 332L-lactate dehydrogenase C chainAdd BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei301PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P07864

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P07864

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P07864

MaxQB - The MaxQuant DataBase

More...MaxQBi		P07864

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P07864

PeptideAtlas

More...PeptideAtlasi		P07864

PRoteomics IDEntifications database

More...PRIDEi		P07864

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52030

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P07864

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P07864

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P07864

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000166796, Expressed in testis and 132 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P07864, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P07864, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000166796, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2 (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110140, 26 interactors

Protein interaction database and analysis system

More...IntActi		P07864, 7 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000437783

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P07864, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P07864

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1495, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161479

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_045401_0_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P07864

Identification of Orthologs from Complete Genome Data

More...OMAi		IAAKGCT

Database of Orthologous Groups

More...OrthoDBi		1204514at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P07864

TreeFam database of animal gene trees

More...TreeFami		TF314963

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.90.110.10, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00488, Lactate_dehydrog, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001557, L-lactate/malate_DH
IPR011304, L-lactate_DH
IPR018177, L-lactate_DH_AS
IPR022383, Lactate/malate_DH_C
IPR001236, Lactate/malate_DH_N
IPR015955, Lactate_DH/Glyco_Ohase_4_C
IPR036291, NAD(P)-bd_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02866, Ldh_1_C, 1 hit
PF00056, Ldh_1_N, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000102, Lac_mal_DH, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00086, LLDHDRGNASE

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51735, SSF51735, 1 hit
SSF56327, SSF56327, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01771, L-LDH-NAD, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00064, L_LDH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

P07864-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTVKEQLIE KLIEDDENSQ CKITIVGTGA VGMACAISIL LKDLADELAL 
        60         70         80         90        100
VDVALDKLKG EMMDLQHGSL FFSTSKITSG KDYSVSANSR IVIVTAGARQ 
       110        120        130        140        150
QEGETRLALV QRNVAIMKSI IPAIVHYSPD CKILVVSNPV DILTYIVWKI 
       160        170        180        190        200
SGLPVTRVIG SGCNLDSARF RYLIGEKLGV HPTSCHGWII GEHGDSSVPL 
       210        220        230        240        250
WSGVNVAGVA LKTLDPKLGT DSDKEHWKNI HKQVIQSAYE IIKLKGYTSW 
       260        270        280        290        300
AIGLSVMDLV GSILKNLRRV HPVSTMVKGL YGIKEELFLS IPCVLGRNGV 
       310        320        330 
SDVVKINLNS EEEALFKKSA ETLWNIQKDL IF
Length:332
Mass (Da):36,311
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDF7047FF5BCB101B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H245F5H245_HUMAN
L-lactate dehydrogenase
LDHC
318Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H5G7F5H5G7_HUMAN
L-lactate dehydrogenase
LDHC
183Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3XAP5G3XAP5_HUMAN
L-lactate dehydrogenase
LDHC hCG_15532
241Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H155F5H155_HUMAN
L-lactate dehydrogenase
LDHC
225Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GZ11F5GZ11_HUMAN
L-lactate dehydrogenase C chain
LDHC
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GWS6F5GWS6_HUMAN
L-lactate dehydrogenase C chain
LDHC
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H326F5H326_HUMAN
L-lactate dehydrogenase C chain
LDHC
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti77I → V in AAA59507 (PubMed:2440048).Curated1
Sequence conflicti77I → V in AAA59508 (PubMed:2930531).Curated1
Sequence conflicti82D → G in AAP37402 (PubMed:14985855).Curated1
Sequence conflicti119S → I in AAA59507 (PubMed:2440048).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034068285E → Q. Corresponds to variant dbSNP:rs2230150Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J02938 mRNA Translation: AAA59507.1
AH002865 Genomic DNA Translation: AAA59508.1
U13680 mRNA Translation: AAA21348.1
AY286300 mRNA Translation: AAP37402.1
CH471064 Genomic DNA Translation: EAW68392.1
CH471064 Genomic DNA Translation: EAW68394.1
BC019249 mRNA Translation: AAH19249.3
BC064388 mRNA Translation: AAH64388.1
BC090043 mRNA Translation: AAH90043.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7840.1

Protein sequence database of the Protein Information Resource

More...PIRi		A30933, DEHULC

NCBI Reference Sequences

More...RefSeqi		NP_002292.1, NM_002301.4
NP_059144.1, NM_017448.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000280704; ENSP00000280704; ENSG00000166796
ENST00000541669; ENSP00000437783; ENSG00000166796

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3948

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3948

UCSC genome browser

More...UCSCi		uc001mom.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Lactate dehydrogenase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02938 mRNA Translation: AAA59507.1
AH002865 Genomic DNA Translation: AAA59508.1
U13680 mRNA Translation: AAA21348.1
AY286300 mRNA Translation: AAP37402.1
CH471064 Genomic DNA Translation: EAW68392.1
CH471064 Genomic DNA Translation: EAW68394.1
BC019249 mRNA Translation: AAH19249.3
BC064388 mRNA Translation: AAH64388.1
BC090043 mRNA Translation: AAH90043.1
CCDSiCCDS7840.1
PIRiA30933, DEHULC
RefSeqiNP_002292.1, NM_002301.4
NP_059144.1, NM_017448.3

3D structure databases

SMRiP07864
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi110140, 26 interactors
IntActiP07864, 7 interactors
STRINGi9606.ENSP00000437783

Chemistry databases

DrugBankiDB00157, NADH

PTM databases

iPTMnetiP07864
PhosphoSitePlusiP07864
SwissPalmiP07864

Genetic variation databases

BioMutaiLDHC
DMDMi76363520

Proteomic databases

EPDiP07864
jPOSTiP07864
MassIVEiP07864
MaxQBiP07864
PaxDbiP07864
PeptideAtlasiP07864
PRIDEiP07864
ProteomicsDBi52030

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		25085, 241 antibodies

The DNASU plasmid repository

More...DNASUi		3948

Genome annotation databases

EnsembliENST00000280704; ENSP00000280704; ENSG00000166796
ENST00000541669; ENSP00000437783; ENSG00000166796
GeneIDi3948
KEGGihsa:3948
UCSCiuc001mom.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3948
DisGeNETi3948

GeneCards: human genes, protein and diseases

More...GeneCardsi		LDHC
HGNCiHGNC:6544, LDHC
HPAiENSG00000166796, Tissue enriched (testis)
MIMi150150, gene
neXtProtiNX_P07864
OpenTargetsiENSG00000166796
PharmGKBiPA30328
VEuPathDBiHostDB:ENSG00000166796.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1495, Eukaryota
GeneTreeiENSGT00940000161479
HOGENOMiCLU_045401_0_2_1
InParanoidiP07864
OMAiIAAKGCT
OrthoDBi1204514at2759
PhylomeDBiP07864
TreeFamiTF314963

Enzyme and pathway databases

UniPathwayiUPA00554;UER00611
BRENDAi1.1.1.27, 2681
PathwayCommonsiP07864
ReactomeiR-HSA-70268, Pyruvate metabolism

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3948, 6 hits in 988 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LDHC, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3948
PharosiP07864, Tbio

Protein Ontology

More...PROi		PR:P07864
RNActiP07864, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000166796, Expressed in testis and 132 other tissues
ExpressionAtlasiP07864, baseline and differential
GenevisibleiP07864, HS

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488, Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557, L-lactate/malate_DH
IPR011304, L-lactate_DH
IPR018177, L-lactate_DH_AS
IPR022383, Lactate/malate_DH_C
IPR001236, Lactate/malate_DH_N
IPR015955, Lactate_DH/Glyco_Ohase_4_C
IPR036291, NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866, Ldh_1_C, 1 hit
PF00056, Ldh_1_N, 1 hit
PIRSFiPIRSF000102, Lac_mal_DH, 1 hit
PRINTSiPR00086, LLDHDRGNASE
SUPFAMiSSF51735, SSF51735, 1 hit
SSF56327, SSF56327, 1 hit
TIGRFAMsiTIGR01771, L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064, L_LDH, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLDHC_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07864
Secondary accession number(s): D3DQY4, Q6GSG8, Q7Z7J4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: June 2, 2021
This is version 203 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families
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