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Entry version 218 (13 Feb 2019)
Sequence version 3 (21 Jun 2005)
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Protein

Cathepsin B

Gene

CTSB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:12220505). Cleaves matrix extracellular phosphoglycoprotein MEPE (PubMed:12220505). Has also been implicated in tumor invasion and metastasis (PubMed:3972105).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by leupeptin.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1081 Publication1
Active sitei2781 Publication1
Active sitei2981 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.22.1 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1442490 Collagen degradation
R-HSA-1679131 Trafficking and processing of endosomal TLR
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-2132295 MHC class II antigen presentation
R-HSA-6798695 Neutrophil degranulation

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C01.060

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cathepsin B (EC:3.4.22.12 Publications)
Alternative name(s):
APP secretase
Short name:
APPS
Cathepsin B1
Cleaved into the following 2 chains:
Cathepsin B light chain1 Publication
Cathepsin B heavy chain1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CTSB
Synonyms:CPSB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000164733.20

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2527 CTSB

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
116810 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P07858

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Keratolytic winter erythema (KWE)1 Publication
The gene represented in this entry is involved in disease pathogenesis. Tandem duplications in a non-coding genomic region containing an active enhancer element for CTSB result in CTSB abnormal expression with pathological consequences.1 Publication
Disease descriptionAn autosomal dominant genodermatosis characterized by recurrent episodes of palmoplantar erythema and epidermal peeling presenting seasonal variation. KWE manifests during childhood. Skin lesions may spread to the dorsum of hands and feet and to the interdigital spaces. Lower legs, knees and thighs may also be involved. A less common finding is a slowly migratory, annular erythema that is seen mostly on the extremities. Between flares, the skin can appear unremarkable. Itching can occur, and hyperhidrosis, associated with a pungent odor, is invariably present. Formation of vesicles is rare, whereas keratolysis that causes the formation of dry blisters is regularly seen. Cold weather, moisture, febrile diseases, and physical and mental stress can trigger exacerbations. In severely affected individuals, skin manifestations persist unremittingly. Penetrance of the disease is high, but expressivity is variable, even within the same family.
See also OMIM:148370

Organism-specific databases

DisGeNET

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DisGeNETi
1508

MalaCards human disease database

More...
MalaCardsi
CTSB
MIMi148370 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000164733

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
50943 Keratolytic winter erythema

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA27027

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4072

Drug and drug target database

More...
DrugBanki
DB02108 2-Aminoethanimidic Acid
DB03329 2-Pyridinethiol
DB02148 3-Amino-4-Oxybenzyl-2-Butanone
DB02685 3-Methylphenylalanine
DB03588 Diphenylacetic Acid
DB02855 N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline
DB04126 N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2343

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CTSB

Domain mapping of disease mutations (DMDM)

More...
DMDMi
68067549

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002614318 – 79Activation peptide1 PublicationAdd BLAST62
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002614480 – 333Cathepsin BAdd BLAST254
ChainiPRO_000002614580 – 126Cathepsin B light chain1 PublicationAdd BLAST47
ChainiPRO_0000026146129 – 333Cathepsin B heavy chain1 PublicationAdd BLAST205
PropeptideiPRO_0000026147334 – 3396

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi93 ↔ 1221 Publication
Disulfide bondi105 ↔ 1501 Publication
Disulfide bondi141 ↔ 2071 Publication
Disulfide bondi142 ↔ 1461 Publication
Disulfide bondi179 ↔ 2111 Publication
Disulfide bondi187 ↔ 1981 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi192N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei220N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P07858

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P07858

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P07858

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P07858

PeptideAtlas

More...
PeptideAtlasi
P07858

PRoteomics IDEntifications database

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PRIDEi
P07858

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52029

Consortium for Top Down Proteomics

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TopDownProteomicsi
P07858

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P07858

University College Dublin 2-DE Proteome Database

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UCD-2DPAGEi
P07858

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P07858

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P07858

SwissPalm database of S-palmitoylation events

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SwissPalmi
P07858

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P07858

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the stratum spinosum of the epidermis. Weak expression is detected in the stratum granulosum.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164733 Expressed in 232 organ(s), highest expression level in thyroid gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P07858 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P07858 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB000457
HPA018156

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Dimer of a heavy chain and a light chain cross-linked by a disulfide bond. Interacts with SRPX2. Directly interacts with SHKBP1 (PubMed:16733801).2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107888, 41 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-98 Cathepsin-B - cystatin-A complex

Database of interacting proteins

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DIPi
DIP-42785N

Protein interaction database and analysis system

More...
IntActi
P07858, 45 interactors

Molecular INTeraction database

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MINTi
P07858

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000342070

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P07858

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1339
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CSBX-ray2.00A/D80-126[»]
B/E129-333[»]
1GMYX-ray1.90A/B/C79-339[»]
1HUCX-ray2.10A/C80-126[»]
B/D129-333[»]
1PBHX-ray3.20A18-333[»]
2IPPX-ray2.15A80-126[»]
B129-333[»]
2PBHX-ray3.30A18-333[»]
3AI8X-ray2.11A/B78-333[»]
3CBJX-ray1.80A74-339[»]
3CBKX-ray2.67A74-339[»]
3K9MX-ray2.61A/B80-333[»]
3PBHX-ray2.50A18-333[»]
5MBLX-ray1.81A78-333[»]
5MBMX-ray2.76A/B78-333[»]
6AY2X-ray1.60A/B79-333[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P07858

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P07858

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P07858

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1543 Eukaryota
COG4870 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158680

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000241341

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG003480

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P07858

KEGG Orthology (KO)

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KOi
K01363

Identification of Orthologs from Complete Genome Data

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OMAi
HCGIESS

Database of Orthologous Groups

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OrthoDBi
865289at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P07858

TreeFam database of animal gene trees

More...
TreeFami
TF314576

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR000169 Pept_cys_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
IPR012599 Propeptide_C1A

The PANTHER Classification System

More...
PANTHERi
PTHR12411 PTHR12411, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00112 Peptidase_C1, 1 hit
PF08127 Propeptide_C1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00705 PAPAIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00645 Pept_C1, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 16 potential isoforms that are computationally mapped.Show allAlign All

P07858-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWQLWASLCC LLVLANARSR PSFHPLSDEL VNYVNKRNTT WQAGHNFYNV
60 70 80 90 100
DMSYLKRLCG TFLGGPKPPQ RVMFTEDLKL PASFDAREQW PQCPTIKEIR
110 120 130 140 150
DQGSCGSCWA FGAVEAISDR ICIHTNAHVS VEVSAEDLLT CCGSMCGDGC
160 170 180 190 200
NGGYPAEAWN FWTRKGLVSG GLYESHVGCR PYSIPPCEHH VNGSRPPCTG
210 220 230 240 250
EGDTPKCSKI CEPGYSPTYK QDKHYGYNSY SVSNSEKDIM AEIYKNGPVE
260 270 280 290 300
GAFSVYSDFL LYKSGVYQHV TGEMMGGHAI RILGWGVENG TPYWLVANSW
310 320 330
NTDWGDNGFF KILRGQDHCG IESEVVAGIP RTDQYWEKI
Length:339
Mass (Da):37,822
Last modified:June 21, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0FC818EA4C1F6D90
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PQM1E9PQM1_HUMAN
Cathepsin B
CTSB
175Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLY3E9PLY3_HUMAN
Cathepsin B
CTSB
165Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PSG5E9PSG5_HUMAN
Cathepsin B
CTSB
170Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKQ7E9PKQ7_HUMAN
Cathepsin B
CTSB
136Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PHZ5E9PHZ5_HUMAN
Cathepsin B
CTSB
148Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNL5E9PNL5_HUMAN
Cathepsin B
CTSB
143Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PCB3E9PCB3_HUMAN
Cathepsin B
CTSB
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJ67E9PJ67_HUMAN
Cathepsin B
CTSB
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PR54E9PR54_HUMAN
Cathepsin B
CTSB
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PS78E9PS78_HUMAN
Cathepsin B
CTSB
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti228N → D AA sequence (PubMed:3972105).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00672426L → V3 PublicationsCorresponds to variant dbSNP:rs12338Ensembl.1
Natural variantiVAR_05151153S → G1 PublicationCorresponds to variant dbSNP:rs1803250Ensembl.1
Natural variantiVAR_05151291P → L. Corresponds to variant dbSNP:rs11548596Ensembl.1
Natural variantiVAR_014696235S → N. Corresponds to variant dbSNP:rs17573Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M14221 mRNA Translation: AAA52129.1
L16510 mRNA Translation: AAC37547.1
AK092070 mRNA Translation: BAG52477.1
AK075393 mRNA Translation: BAG52127.1
CH471157 Genomic DNA Translation: EAW65630.1
BC010240 mRNA Translation: AAH10240.1
BC095408 mRNA Translation: AAH95408.1
M13230 mRNA Translation: AAA52125.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5986.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A26498 KHHUB

NCBI Reference Sequences

More...
RefSeqi
NP_001899.1, NM_001908.4
NP_680090.1, NM_147780.3
NP_680091.1, NM_147781.3
NP_680092.1, NM_147782.3
NP_680093.1, NM_147783.3
XP_006716307.1, XM_006716244.2
XP_006716308.1, XM_006716245.2
XP_011542114.1, XM_011543812.2
XP_016868586.1, XM_017013097.1
XP_016868587.1, XM_017013098.1
XP_016868588.1, XM_017013099.1
XP_016868589.1, XM_017013100.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.520898

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000345125; ENSP00000342070; ENSG00000164733
ENST00000353047; ENSP00000345672; ENSG00000164733
ENST00000453527; ENSP00000409917; ENSG00000164733
ENST00000530640; ENSP00000435105; ENSG00000164733
ENST00000531089; ENSP00000433215; ENSG00000164733
ENST00000533455; ENSP00000432244; ENSG00000164733
ENST00000534510; ENSP00000434217; ENSG00000164733

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1508

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1508

UCSC genome browser

More...
UCSCi
uc003wun.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14221 mRNA Translation: AAA52129.1
L16510 mRNA Translation: AAC37547.1
AK092070 mRNA Translation: BAG52477.1
AK075393 mRNA Translation: BAG52127.1
CH471157 Genomic DNA Translation: EAW65630.1
BC010240 mRNA Translation: AAH10240.1
BC095408 mRNA Translation: AAH95408.1
M13230 mRNA Translation: AAA52125.1
CCDSiCCDS5986.1
PIRiA26498 KHHUB
RefSeqiNP_001899.1, NM_001908.4
NP_680090.1, NM_147780.3
NP_680091.1, NM_147781.3
NP_680092.1, NM_147782.3
NP_680093.1, NM_147783.3
XP_006716307.1, XM_006716244.2
XP_006716308.1, XM_006716245.2
XP_011542114.1, XM_011543812.2
XP_016868586.1, XM_017013097.1
XP_016868587.1, XM_017013098.1
XP_016868588.1, XM_017013099.1
XP_016868589.1, XM_017013100.1
UniGeneiHs.520898

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CSBX-ray2.00A/D80-126[»]
B/E129-333[»]
1GMYX-ray1.90A/B/C79-339[»]
1HUCX-ray2.10A/C80-126[»]
B/D129-333[»]
1PBHX-ray3.20A18-333[»]
2IPPX-ray2.15A80-126[»]
B129-333[»]
2PBHX-ray3.30A18-333[»]
3AI8X-ray2.11A/B78-333[»]
3CBJX-ray1.80A74-339[»]
3CBKX-ray2.67A74-339[»]
3K9MX-ray2.61A/B80-333[»]
3PBHX-ray2.50A18-333[»]
5MBLX-ray1.81A78-333[»]
5MBMX-ray2.76A/B78-333[»]
6AY2X-ray1.60A/B79-333[»]
ProteinModelPortaliP07858
SMRiP07858
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107888, 41 interactors
ComplexPortaliCPX-98 Cathepsin-B - cystatin-A complex
DIPiDIP-42785N
IntActiP07858, 45 interactors
MINTiP07858
STRINGi9606.ENSP00000342070

Chemistry databases

BindingDBiP07858
ChEMBLiCHEMBL4072
DrugBankiDB02108 2-Aminoethanimidic Acid
DB03329 2-Pyridinethiol
DB02148 3-Amino-4-Oxybenzyl-2-Butanone
DB02685 3-Methylphenylalanine
DB03588 Diphenylacetic Acid
DB02855 N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline
DB04126 N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane
GuidetoPHARMACOLOGYi2343

Protein family/group databases

MEROPSiC01.060

PTM databases

iPTMnetiP07858
PhosphoSitePlusiP07858
SwissPalmiP07858

Polymorphism and mutation databases

BioMutaiCTSB
DMDMi68067549

2D gel databases

SWISS-2DPAGEiP07858
UCD-2DPAGEiP07858

Proteomic databases

EPDiP07858
jPOSTiP07858
MaxQBiP07858
PaxDbiP07858
PeptideAtlasiP07858
PRIDEiP07858
ProteomicsDBi52029
TopDownProteomicsiP07858

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1508
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345125; ENSP00000342070; ENSG00000164733
ENST00000353047; ENSP00000345672; ENSG00000164733
ENST00000453527; ENSP00000409917; ENSG00000164733
ENST00000530640; ENSP00000435105; ENSG00000164733
ENST00000531089; ENSP00000433215; ENSG00000164733
ENST00000533455; ENSP00000432244; ENSG00000164733
ENST00000534510; ENSP00000434217; ENSG00000164733
GeneIDi1508
KEGGihsa:1508
UCSCiuc003wun.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1508
DisGeNETi1508
EuPathDBiHostDB:ENSG00000164733.20

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CTSB

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0007320
HGNCiHGNC:2527 CTSB
HPAiCAB000457
HPA018156
MalaCardsiCTSB
MIMi116810 gene
148370 phenotype
neXtProtiNX_P07858
OpenTargetsiENSG00000164733
Orphaneti50943 Keratolytic winter erythema
PharmGKBiPA27027

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1543 Eukaryota
COG4870 LUCA
GeneTreeiENSGT00940000158680
HOGENOMiHOG000241341
HOVERGENiHBG003480
InParanoidiP07858
KOiK01363
OMAiHCGIESS
OrthoDBi865289at2759
PhylomeDBiP07858
TreeFamiTF314576

Enzyme and pathway databases

BRENDAi3.4.22.1 2681
ReactomeiR-HSA-1442490 Collagen degradation
R-HSA-1679131 Trafficking and processing of endosomal TLR
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-2132295 MHC class II antigen presentation
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CTSB human
EvolutionaryTraceiP07858

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Cathepsin_B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1508
PMAP-CutDBiP07858

Protein Ontology

More...
PROi
PR:P07858

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164733 Expressed in 232 organ(s), highest expression level in thyroid gland
ExpressionAtlasiP07858 baseline and differential
GenevisibleiP07858 HS

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR000169 Pept_cys_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
IPR012599 Propeptide_C1A
PANTHERiPTHR12411 PTHR12411, 1 hit
PfamiView protein in Pfam
PF00112 Peptidase_C1, 1 hit
PF08127 Propeptide_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00645 Pept_C1, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCATB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07858
Secondary accession number(s): B3KQR5
, B3KRR5, Q503A6, Q96D87
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: June 21, 2005
Last modified: February 13, 2019
This is version 218 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Peptidase families
    Classification of peptidase families and list of entries
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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