UniProtKB - P07850 (SUOX_CHICK)
Protein
Sulfite oxidase
Gene
SUOX
Organism
Gallus gallus (Chicken)
Status
Functioni
Catalytic activityi
- EC:1.8.3.1
Cofactori
Protein has several cofactor binding sites:- heme b1 PublicationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.1 Publication
- Mo-molybdopterin1 PublicationNote: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.1 Publication
: sulfur metabolism Pathwayi
This protein is involved in the pathway sulfur metabolism, which is part of Energy metabolism.View all proteins of this organism that are known to be involved in the pathway sulfur metabolism and in Energy metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 40 | Iron (heme axial ligand) | 1 | |
Metal bindingi | 65 | Iron (heme axial ligand) | 1 | |
Binding sitei | 69 | Heme b1 Publication | 1 | |
Metal bindingi | 185 | Molybdenum | 1 | |
Binding sitei | 244 | Molybdopterin | 1 | |
Binding sitei | 283 | Molybdopterin | 1 | |
Binding sitei | 288 | Molybdopterin | 1 |
GO - Molecular functioni
- heme binding Source: GO_Central
- molybdenum ion binding Source: InterPro
- molybdopterin cofactor binding Source: GO_Central
- sulfite oxidase activity Source: GO_Central
GO - Biological processi
- sulfur compound metabolic process Source: GO_Central
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Heme, Iron, Metal-binding, Molybdenum |
Enzyme and pathway databases
BRENDAi | 1.8.2.1, 1306 1.8.3.1, 1306 |
UniPathwayi | UPA00096 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:SUOX |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Mitochondrion
Mitochondrion
- mitochondrial intermembrane space Source: UniProtKB-SubCell
- mitochondrion Source: GO_Central
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000166076 | 1 – 459 | Sulfite oxidaseAdd BLAST | 459 |
Proteomic databases
PRIDEi | P07850 |
Interactioni
Subunit structurei
Homodimer.
1 PublicationStructurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P07850 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P07850 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 83 | Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd BLAST | 80 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 86 – 95 | Hinge | 10 | |
Regioni | 96 – 323 | Moco domainAdd BLAST | 228 | |
Regioni | 136 – 140 | Molybdopterin-binding | 5 | |
Regioni | 299 – 301 | Molybdopterin-binding | 3 | |
Regioni | 324 – 459 | HomodimerizationAdd BLAST | 136 |
Phylogenomic databases
InParanoidi | P07850 |
PhylomeDBi | P07850 |
Family and domain databases
Gene3Di | 3.10.120.10, 1 hit 3.90.420.10, 1 hit |
InterProi | View protein in InterPro IPR001199, Cyt_B5-like_heme/steroid-bd IPR036400, Cyt_B5-like_heme/steroid_sf IPR018506, Cyt_B5_heme-BS IPR014756, Ig_E-set IPR005066, MoCF_OxRdtse_dimer IPR008335, Mopterin_OxRdtase_euk IPR000572, OxRdtase_Mopterin-bd_dom IPR036374, OxRdtase_Mopterin-bd_sf IPR022407, OxRdtase_Mopterin_BS |
Pfami | View protein in Pfam PF00173, Cyt-b5, 1 hit PF03404, Mo-co_dimer, 1 hit PF00174, Oxidored_molyb, 1 hit |
PRINTSi | PR00363, CYTOCHROMEB5 PR00407, EUMOPTERIN |
SMARTi | View protein in SMART SM01117, Cyt-b5, 1 hit |
SUPFAMi | SSF55856, SSF55856, 1 hit SSF56524, SSF56524, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS00191, CYTOCHROME_B5_1, 1 hit PS50255, CYTOCHROME_B5_2, 1 hit PS00559, MOLYBDOPTERIN_EUK, 1 hit |
i Sequence
Sequence statusi: Complete.
P07850-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
APSYPRYTRE EVGRHRSPEE RVWVTHGTDV FDVTDFVELH PGGPDKILLA
60 70 80 90 100
AGGALEPFWA LYAVHGEPHV LELLQQYKVG ELSPDEAPAA PDAQDPFAGD
110 120 130 140 150
PPRHPGLRVN SQKPFNAEPP AELLAERFLT PNELFFTRNH LPVPAVEPSS
160 170 180 190 200
YRLRVDGPGG RTLSLSLAEL RSRFPKHEVT ATLQCAGNRR SEMSRVRPVK
210 220 230 240 250
GLPWDIGAIS TARWGGASLR DVLLHAGFPE ELQGGEHVCF EGLDADPGGA
260 270 280 290 300
PYGASIPYGR ALSPAADVLL AYEMNGTELP RDHRFPVRVV VPGVVGARSV
310 320 330 340 350
KWLRRVAVSP DESPSRWQQN DYKGFSPCVD WDTVDYRTAP AIQELPVQSA
360 370 380 390 400
VTQPRPGAAV PPGELTVKGY AWSGGGREVV RVDVSLDGGR TWKVARLMGD
410 420 430 440 450
KAPPGRAWAW ALWELTVPVE AGTELEIVCK AVDSSYNVQP DSVAPIWNLR
GVLSTAWHR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 152 | R → RR AA sequence (PubMed:2687265).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X52559 mRNA Translation: CAA36793.1 |
PIRi | A34180 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X52559 mRNA Translation: CAA36793.1 |
PIRi | A34180 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1SOX | X-ray | 1.90 | A/B | 1-459 | [»] | |
2A99 | X-ray | 2.20 | A | 95-459 | [»] | |
2A9A | X-ray | 2.00 | A/B | 95-459 | [»] | |
2A9B | X-ray | 2.50 | A | 95-459 | [»] | |
2A9C | X-ray | 2.50 | A/B | 95-459 | [»] | |
2A9D | X-ray | 1.70 | A/B | 95-459 | [»] | |
3HBG | X-ray | 1.90 | A | 1-459 | [»] | |
3HBP | X-ray | 2.40 | A | 1-459 | [»] | |
3HBQ | X-ray | 2.80 | A | 1-459 | [»] | |
3R18 | X-ray | 2.40 | A | 1-459 | [»] | |
3R19 | X-ray | 2.10 | A | 1-459 | [»] | |
SMRi | P07850 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Proteomic databases
PRIDEi | P07850 |
Phylogenomic databases
InParanoidi | P07850 |
PhylomeDBi | P07850 |
Enzyme and pathway databases
UniPathwayi | UPA00096 |
BRENDAi | 1.8.2.1, 1306 1.8.3.1, 1306 |
Miscellaneous databases
EvolutionaryTracei | P07850 |
Family and domain databases
Gene3Di | 3.10.120.10, 1 hit 3.90.420.10, 1 hit |
InterProi | View protein in InterPro IPR001199, Cyt_B5-like_heme/steroid-bd IPR036400, Cyt_B5-like_heme/steroid_sf IPR018506, Cyt_B5_heme-BS IPR014756, Ig_E-set IPR005066, MoCF_OxRdtse_dimer IPR008335, Mopterin_OxRdtase_euk IPR000572, OxRdtase_Mopterin-bd_dom IPR036374, OxRdtase_Mopterin-bd_sf IPR022407, OxRdtase_Mopterin_BS |
Pfami | View protein in Pfam PF00173, Cyt-b5, 1 hit PF03404, Mo-co_dimer, 1 hit PF00174, Oxidored_molyb, 1 hit |
PRINTSi | PR00363, CYTOCHROMEB5 PR00407, EUMOPTERIN |
SMARTi | View protein in SMART SM01117, Cyt-b5, 1 hit |
SUPFAMi | SSF55856, SSF55856, 1 hit SSF56524, SSF56524, 1 hit SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS00191, CYTOCHROME_B5_1, 1 hit PS50255, CYTOCHROME_B5_2, 1 hit PS00559, MOLYBDOPTERIN_EUK, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SUOX_CHICK | |
Accessioni | P07850Primary (citable) accession number: P07850 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | February 22, 2003 | |
Last modified: | October 7, 2020 | |
This is version 143 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references