UniProtKB - P07834 (CDC4_YEAST)

BLAST

>sp|P07834|CDC4_YEAST Cell division control protein 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=CDC4 PE=1 SV=2
MGSFPLAEFPLRDIPVPYSYRVSGGIASSGSVTALVTAAGTHRNSSTAKTVETEDGEEDI
DEYQRKRAAGSGESTPERSDFKRVKHDNHKTLHPVNLQNTGAASVDNDGLHNLTDISNDA
EKLLMSVDDGSAAPSTLSVNMGVASHNVAAPTTVNAATITGSDVSNNVNSATINNPMEEG
ALPLSPTASSPGTTTPLAKTTKTINNNNNIADLIESKDSIISPEYLSDEIFSAINNNLPH
AYFKNLLFRLVANMDRSELSDLGTLIKDNLKRDLITSLPFEISLKIFNYLQFEDIINSLG
VSQNWNKIIRKSTSLWKKLLISENFVSPKGFNSLNLKLSQKYPKLSQQDRLRLSFLENIF
ILKNWYNPKFVPQRTTLRGHMTSVITCLQFEDNYVITGADDKMIRVYDSINKKFLLQLSG
HDGGVWALKYAHGGILVSGSTDRTVRVWDIKKGCCTHVFKGHNSTVRCLDIVEYKNIKYI
VTGSRDNTLHVWKLPKESSVPDHGEEHDYPLVFHTPEENPYFVGVLRGHMASVRTVSGHG
NIVVSGSYDNTLIVWDVAQMKCLYILSGHTDRIYSTIYDHERKRCISASMDTTIRIWDLE
NIWNNGECSYATNSASPCAKILGAMYTLQGHTALVGLLRLSDKFLVSAAADGSIRGWDAN
DYSRKFSYHHTNLSAITTFYVSDNILVSGSENQFNIYNLRSGKLVHANILKDADQIWSVN
FKGKTLVAAVEKDGQSFLEILDFSKASKINYVSNPVNSSSSSLESISTSLGLTRTTIIP

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History
Entry version 196 (07 Nov 2018)
Sequence version 2 (01 Nov 1995)
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Protein

Cell division control protein 4

Gene

CDC4

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. Directs ubiquitination of the phosphorylated CDK inhibitor SIC1. Involved in the degradation of CDC6 together with CDC34/UBC3 and CDC53, and in restricting the degradation of FAR1 to the nucleus. Is essential for initiation of DNA replication and separation of the spindle pole bodies to form the poles of the mitotic spindle. It also plays a role in bud development, fusion of zygotic nuclei after conjugation and various aspects of sporulation. Required for HTA1-HTB1 locus transcription activation. Required for G1/S and G2/M transition.9 Publications

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functionⁱ

phosphoserine residue binding
Source: SGD
Inferred from direct assayⁱ
- 23314252
snoRNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ubiquitin binding
Source: SGD
Inferred from direct assayⁱ
- 21070969

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell division Source: UniProtKB-KW
G1/S transition of mitotic cell cycle
Source: SGD
Inferred from mutant phenotypeⁱ
- 10409741
G2/M transition of mitotic cell cycle
Source: SGD
Inferred from mutant phenotypeⁱ
- 10409741
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
meiotic cell cycle
Source: SGD
Inferred from mutant phenotypeⁱ
- 328339
protein ubiquitination
Source: SGD
Inferred from direct assayⁱ
- 23645675
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Source: SGD
Inferred from direct assayⁱ
- 9346238
- 9346239
sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
ubiquitin-dependent protein catabolic process
Source: SGD
Inferred from direct assayⁱ
- 9346238
- 9346239

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell cycle, Cell division, Mitosis, Sporulation, Ubl conjugation pathway

Biological process

Cell cycle, Cell division, Mitosis, Sporulation, Ubl conjugation pathway

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-30447-MONOMER
UniPathwayⁱ	UPA00143

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cell division control protein 4 Alternative name(s): E3 ubiquitin ligase complex SCF subunit CDC4 F-box protein CDC4
Gene namesⁱ	Name:CDC4 Ordered Locus Names:YFL009W
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome VI

Organism-specific databases

Saccharomyces Genome Database More...SGDⁱ	S000001885 CDC4

SGDⁱ

S000001885 CDC4

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	82	K → A: Prevents nuclear localization; when associated with A-83 and A-85.	1
Mutagenesisⁱ	83	R → A: Prevents nuclear localization; when associated with A-82 and A-85.	1
Mutagenesisⁱ	83	R → G: Prevents nuclear localization.	1
Mutagenesisⁱ	85	K → A: Prevents nuclear localization; when associated with A-82 and A-83. 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000050899	1 – 779	Cell division control protein 4Add BLAST		779

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	104	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P07834
PaxDbⁱ	P07834
PRIDEⁱ	P07834

PTM databases

iPTMnetⁱ	P07834

iPTMnetⁱ

P07834

Interactionⁱ

Subunit structureⁱ

Interacts with DCD53 and SKP1. Component of the SCF(CDC4) complex containing CDC53, SKP1, RBX1 and CDC4. CDC34. Interacts with CDC6 and CIC1. Interacts with SIC1; the interaction involves a SIC1 double phosphorylated motif (degron). Homodimerizes; the dimerization increases SIC1 ubiquitination in vitro.11 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CDC53	Q12018	8	EBI-4434,EBI-4321
CIC1	P38779	2	EBI-4434,EBI-24538
HRT1	Q08273	3	EBI-4434,EBI-31686
RCN1	P36054	4	EBI-4434,EBI-14898
SIC1	P38634	5	EBI-4434,EBI-17127
SKP1	P52286	12	EBI-4434,EBI-4090

GO - Molecular functionⁱ

phosphoserine residue binding
Source: SGD
Inferred from direct assayⁱ
- 23314252
ubiquitin binding
Source: SGD
Inferred from direct assayⁱ
- 21070969

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	31138, 607 interactors
ComplexPortalⁱ	CPX-3234 SCF-Cdc4 ubiquitin ligase complex
Database of interacting proteins More...DIPⁱ	DIP-1625N
IntActⁱ	P07834, 14 interactors
Molecular INTeraction database More...MINTⁱ	P07834
STRINGⁱ	4932.YFL009W

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	228 – 234	Combined sources	7
Helixⁱ	235 – 237	Combined sources	3
Helixⁱ	242 – 253	Combined sources	12
Helixⁱ	256 – 271	Combined sources	16
Helixⁱ	274 – 277	Combined sources	4
Helixⁱ	280 – 287	Combined sources	8
Helixⁱ	292 – 299	Combined sources	8
Helixⁱ	303 – 309	Combined sources	7
Helixⁱ	313 – 322	Combined sources	10
Turnⁱ	328 – 330	Combined sources	3
Helixⁱ	331 – 341	Combined sources	11
Helixⁱ	347 – 366	Combined sources	20
Beta strandⁱ	373 – 378	Combined sources	6
Beta strandⁱ	381 – 383	Combined sources	3
Beta strandⁱ	385 – 391	Combined sources	7
Beta strandⁱ	394 – 399	Combined sources	6
Beta strandⁱ	404 – 408	Combined sources	5
Turnⁱ	409 – 412	Combined sources	4
Beta strandⁱ	413 – 418	Combined sources	6
Beta strandⁱ	425 – 430	Combined sources	6
Turnⁱ	432 – 434	Combined sources	3
Beta strandⁱ	435 – 440	Combined sources	6
Beta strandⁱ	445 – 449	Combined sources	5
Turnⁱ	450 – 453	Combined sources	4
Beta strandⁱ	454 – 459	Combined sources	6
Beta strandⁱ	466 – 476	Combined sources	11
Beta strandⁱ	478 – 484	Combined sources	7
Beta strandⁱ	489 – 493	Combined sources	5
Beta strandⁱ	509 – 514	Combined sources	6
Helixⁱ	516 – 518	Combined sources	3
Beta strandⁱ	522 – 526	Combined sources	5
Beta strandⁱ	533 – 539	Combined sources	7
Beta strandⁱ	542 – 547	Combined sources	6
Beta strandⁱ	552 – 556	Combined sources	5
Turnⁱ	557 – 560	Combined sources	4
Beta strandⁱ	561 – 566	Combined sources	6
Beta strandⁱ	573 – 579	Combined sources	7
Turnⁱ	580 – 583	Combined sources	4
Beta strandⁱ	584 – 589	Combined sources	6
Beta strandⁱ	594 – 598	Combined sources	5
Turnⁱ	599 – 601	Combined sources	3
Beta strandⁱ	625 – 628	Combined sources	4
Beta strandⁱ	635 – 640	Combined sources	6
Beta strandⁱ	642 – 649	Combined sources	8
Beta strandⁱ	652 – 658	Combined sources	7
Turnⁱ	659 – 661	Combined sources	3
Beta strandⁱ	664 – 669	Combined sources	6
Beta strandⁱ	676 – 681	Combined sources	6
Beta strandⁱ	683 – 690	Combined sources	8
Beta strandⁱ	693 – 698	Combined sources	6
Turnⁱ	699 – 701	Combined sources	3
Beta strandⁱ	704 – 707	Combined sources	4
Turnⁱ	709 – 712	Combined sources	4
Beta strandⁱ	714 – 722	Combined sources	9
Beta strandⁱ	725 – 732	Combined sources	8
Beta strandⁱ	735 – 742	Combined sources	8

Show more details

3D structure databases

ProteinModelPortalⁱ	P07834
SMRⁱ	P07834
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P07834

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	272 – 319	F-boxPROSITE-ProRule annotationAdd BLAST	48
Repeatⁱ	380 – 408	WD 1Add BLAST	29
Repeatⁱ	420 – 449	WD 2Add BLAST	30
Repeatⁱ	461 – 493	WD 3Add BLAST	33
Repeatⁱ	528 – 556	WD 4Add BLAST	29
Repeatⁱ	568 – 598	WD 5Add BLAST	31
Repeatⁱ	630 – 658	WD 6Add BLAST	29
Repeatⁱ	669 – 698	WD 7Add BLAST	30

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	82 – 85	Nuclear localization signal		4

Keywords - Domainⁱ

Repeat, WD repeat

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000142520
HOGENOMⁱ	HOG000111495
InParanoidⁱ	P07834
KEGG Orthology (KO) More...KOⁱ	K03361
OMAⁱ	CLQHDDE
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C172M

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR031740 Cdc4_D IPR036047 F-box-like_dom_sf IPR001810 F-box_dom IPR020472 G-protein_beta_WD-40_rep IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16856 CDC4_D, 1 hit PF12937 F-box-like, 1 hit PF00400 WD40, 5 hits
PRINTSⁱ	PR00320 GPROTEINBRPT
SMARTⁱ	View protein in SMART SM00256 FBOX, 1 hit SM00320 WD40, 7 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit SSF81383 SSF81383, 1 hit
PROSITEⁱ	View protein in PROSITE PS50181 FBOX, 1 hit PS00678 WD_REPEATS_1, 4 hits PS50082 WD_REPEATS_2, 5 hits PS50294 WD_REPEATS_REGION, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P07834-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGSFPLAEFP LRDIPVPYSY RVSGGIASSG SVTALVTAAG THRNSSTAKT 
        60         70         80         90        100
VETEDGEEDI DEYQRKRAAG SGESTPERSD FKRVKHDNHK TLHPVNLQNT 
       110        120        130        140        150
GAASVDNDGL HNLTDISNDA EKLLMSVDDG SAAPSTLSVN MGVASHNVAA 
       160        170        180        190        200
PTTVNAATIT GSDVSNNVNS ATINNPMEEG ALPLSPTASS PGTTTPLAKT 
       210        220        230        240        250
TKTINNNNNI ADLIESKDSI ISPEYLSDEI FSAINNNLPH AYFKNLLFRL 
       260        270        280        290        300
VANMDRSELS DLGTLIKDNL KRDLITSLPF EISLKIFNYL QFEDIINSLG 
       310        320        330        340        350
VSQNWNKIIR KSTSLWKKLL ISENFVSPKG FNSLNLKLSQ KYPKLSQQDR 
       360        370        380        390        400
LRLSFLENIF ILKNWYNPKF VPQRTTLRGH MTSVITCLQF EDNYVITGAD 
       410        420        430        440        450
DKMIRVYDSI NKKFLLQLSG HDGGVWALKY AHGGILVSGS TDRTVRVWDI 
       460        470        480        490        500
KKGCCTHVFK GHNSTVRCLD IVEYKNIKYI VTGSRDNTLH VWKLPKESSV 
       510        520        530        540        550
PDHGEEHDYP LVFHTPEENP YFVGVLRGHM ASVRTVSGHG NIVVSGSYDN 
       560        570        580        590        600
TLIVWDVAQM KCLYILSGHT DRIYSTIYDH ERKRCISASM DTTIRIWDLE 
       610        620        630        640        650
NIWNNGECSY ATNSASPCAK ILGAMYTLQG HTALVGLLRL SDKFLVSAAA 
       660        670        680        690        700
DGSIRGWDAN DYSRKFSYHH TNLSAITTFY VSDNILVSGS ENQFNIYNLR 
       710        720        730        740        750
SGKLVHANIL KDADQIWSVN FKGKTLVAAV EKDGQSFLEI LDFSKASKIN 
       760        770 
YVSNPVNSSS SSLESISTSL GLTRTTIIP

Length:779

Mass (Da):86,090

Last modified:November 1, 1995 - v2

Checksum:ⁱ0348F2F8FA78F3BC

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	460	K → E in CAA29113 (PubMed:3309335).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X05625 Genomic DNA Translation: CAA29113.1 D50617 Genomic DNA Translation: BAA09229.1 Z46255 Genomic DNA Translation: CAA86341.1 BK006940 Genomic DNA Translation: DAA12431.1
PIRⁱ	S56245
NCBI Reference Sequences More...RefSeqⁱ	NP_116585.1, NM_001179957.1

Genome annotation databases

EnsemblFungiⁱ	BAA09229; BAA09229; BAA09229 YFL009W; YFL009W; YFL009W
GeneIDⁱ	850539
KEGGⁱ	sce:YFL009W

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P07834	Cdc4p		YEASB		779	UniRef90_P07834
Ubiquitin ligase subunit		YEAS1		779
Cdc4p		YEASA		779
Cdc4p		YEAS8		779
CDC4p F-box protein required for both the G1/S and G2/M phase transitions		Saccharomyces sp. 'boulardii'		779
+6

Protein	Similar proteins		Species	Score	Length	Source
P07834	Cdc4p		YEASC		779	UniRef50_P07834
K7_Cdc4p		YEASK		779
YFL009Wp-like protein (Fragment)		YEAS6		412
Cdc4p		YEASB		779
Cdc4p		SACCK		779
+15

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X05625 Genomic DNA Translation: CAA29113.1 D50617 Genomic DNA Translation: BAA09229.1 Z46255 Genomic DNA Translation: CAA86341.1 BK006940 Genomic DNA Translation: DAA12431.1
PIRⁱ	S56245
RefSeqⁱ	NP_116585.1, NM_001179957.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1NEX	X-ray	2.70	B/D	263-744	[»]
	2P63	X-ray	2.67	A/B/C/D	222-273	[»]
	3MKS	X-ray	2.60	B/D	263-744	[»]
	3V7D	X-ray	2.31	B/D	263-744	[»]
ProteinModelPortalⁱ	P07834
SMRⁱ	P07834
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	31138, 607 interactors
ComplexPortalⁱ	CPX-3234 SCF-Cdc4 ubiquitin ligase complex
DIPⁱ	DIP-1625N
IntActⁱ	P07834, 14 interactors
MINTⁱ	P07834
STRINGⁱ	4932.YFL009W

PTM databases

iPTMnetⁱ	P07834

iPTMnetⁱ

P07834

Proteomic databases

MaxQBⁱ	P07834
PaxDbⁱ	P07834
PRIDEⁱ	P07834

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	BAA09229; BAA09229; BAA09229 YFL009W; YFL009W; YFL009W
GeneIDⁱ	850539
KEGGⁱ	sce:YFL009W

Organism-specific databases

SGDⁱ	S000001885 CDC4

Phylogenomic databases

GeneTreeⁱ	ENSGT00900000142520
HOGENOMⁱ	HOG000111495
InParanoidⁱ	P07834
KOⁱ	K03361
OMAⁱ	CLQHDDE
OrthoDBⁱ	EOG092C172M

Enzyme and pathway databases

UniPathwayⁱ	UPA00143
BioCycⁱ	YEAST:G3O-30447-MONOMER

Miscellaneous databases

EvolutionaryTraceⁱ	P07834
Protein Ontology More...PROⁱ	PR:P07834

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR031740 Cdc4_D IPR036047 F-box-like_dom_sf IPR001810 F-box_dom IPR020472 G-protein_beta_WD-40_rep IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfamⁱ	View protein in Pfam PF16856 CDC4_D, 1 hit PF12937 F-box-like, 1 hit PF00400 WD40, 5 hits
PRINTSⁱ	PR00320 GPROTEINBRPT
SMARTⁱ	View protein in SMART SM00256 FBOX, 1 hit SM00320 WD40, 7 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit SSF81383 SSF81383, 1 hit
PROSITEⁱ	View protein in PROSITE PS50181 FBOX, 1 hit PS00678 WD_REPEATS_1, 4 hits PS50082 WD_REPEATS_2, 5 hits PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CDC4_YEAST
Accessionⁱ	P07834Primary (citable) accession number: P07834 Secondary accession number(s): D6VTM1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
	Last sequence update:	November 1, 1995
	Last modified:	November 7, 2018
	This is version 196 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
Yeast chromosome VI
Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P07834 (CDC4_YEAST)

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Cell division control protein 4

CDC4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ