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Protein

Major actin

Gene

act1

more
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • myosin binding Source: dictyBase
  • structural constituent of cytoskeleton Source: dictyBase

GO - Biological processi

  • cell morphogenesis Source: dictyBase
  • chemotaxis Source: dictyBase
  • endocytosis Source: dictyBase
  • hyperosmotic response Source: dictyBase
  • mitotic cytokinesis Source: dictyBase
  • phagocytosis Source: dictyBase
  • phototaxis Source: dictyBase
  • response to cAMP Source: dictyBase
  • vesicle-mediated transport Source: dictyBase

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DDI-2029482 Regulation of actin dynamics for phagocytic cup formation
R-DDI-5626467 RHO GTPases activate IQGAPs
R-DDI-5663213 RHO GTPases Activate WASPs and WAVEs

Names & Taxonomyi

Protein namesi
Recommended name:
Major actin
Alternative name(s):
Actin A1
Actin A12
Actin A8
Actin III
Actin M6
Actin-1
Actin-11
Actin-12
Actin-13
Actin-14
Actin-15
Actin-16
Actin-19
Actin-2
Actin-2-sub 1
Actin-20
Actin-21
Actin-3a
Actin-4
Actin-5
Actin-6
Actin-7
Actin-8
Actin-9
Actin-IEL1
Gene namesi
Name:act1
Synonyms:act1a
ORF Names:DDB_G0289553
AND
Name:act2
Synonyms:act2-1
ORF Names:DDB_G0274133
AND
Name:act4
ORF Names:DDB_G0289005
AND
Name:act5
ORF Names:DDB_G0289663
AND
Name:act6
ORF Names:DDB_G0274135
AND
Name:act7
ORF Names:DDB_G0280545
AND
Name:act8
Synonyms:actA8
ORF Names:DDB_G0269234
AND
Name:act9
ORF Names:DDB_G0274601
AND
Name:act11
ORF Names:DDB_G0288879
AND
Name:act12
ORF Names:DDB_G0274129
AND
Name:act13
ORF Names:DDB_G0274599
AND
Name:act14
Synonyms:actB1
ORF Names:DDB_G0274137
AND
Name:act15
Synonyms:actA1
ORF Names:DDB_G0272520
AND
Name:act16
Synonyms:actM6
ORF Names:DDB_G0272248
AND
Name:act19
ORF Names:DDB_G0274727
AND
Name:act20
ORF Names:DDB_G0274285
AND
Name:act21
ORF Names:DDB_G0274561
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 1, Chromosome 2, Chromosome 3, Chromosome 5, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0289553 act1
DDB_G0288879 act11
DDB_G0274129 act12
DDB_G0274599 act13
DDB_G0274137 act14
DDB_G0272520 act15
DDB_G0272248 act16
DDB_G0274727 act19
DDB_G0274133 act2
DDB_G0274285 act20
DDB_G0274561 act21
DDB_G0289005 act4
DDB_G0289663 act5
DDB_G0274135 act6
DDB_G0280545 act7
DDB_G0269234 act8
DDB_G0274601 act9

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000889262 – 376Major actinAdd BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei54Phosphotyrosine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP07830
PRIDEiP07830

2D gel databases

SWISS-2DPAGEiP07830

PTM databases

iPTMnetiP07830

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-40989N
IntActiP07830, 3 interactors
MINTiP07830
STRINGi44689.DDB0220456

Structurei

Secondary structure

1376
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP07830
SMRiP07830
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07830

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0676 Eukaryota
COG5277 LUCA
InParanoidiP07830
KOiK10355
OMAiKCDESIC
PhylomeDBiP07830

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
PANTHERiPTHR11937 PTHR11937, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS00406 ACTINS_1, 1 hit
PS00432 ACTINS_2, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07830-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDGEDVQALV IDNGSGMCKA GFAGDDAPRA VFPSIVGRPR HTGVMVGMGQ
60 70 80 90 100
KDSYVGDEAQ SKRGILTLKY PIEHGIVTNW DDMEKIWHHT FYNELRVAPE
110 120 130 140 150
EHPVLLTEAP LNPKANREKM TQIMFETFNT PAMYVAIQAV LSLYASGRTT
160 170 180 190 200
GIVMDSGDGV SHTVPIYEGY ALPHAILRLD LAGRDLTDYM MKILTERGYS
210 220 230 240 250
FTTTAEREIV RDIKEKLAYV ALDFEAEMQT AASSSALEKS YELPDGQVIT
260 270 280 290 300
IGNERFRCPE ALFQPSFLGM ESAGIHETTY NSIMKCDVDI RKDLYGNVVL
310 320 330 340 350
SGGTTMFPGI ADRMNKELTA LAPSTMKIKI IAPPERKYSV WIGGSILASL
360 370
STFQQMWISK EEYDESGPSI VHRKCF
Length:376
Mass (Da):41,733
Last modified:January 23, 2007 - v2
Checksum:i3610737F3B525123
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31V → L in CAA23479 (PubMed:293714).Curated1
Sequence conflicti32F → S in CAA27032 (PubMed:3003365).Curated1
Sequence conflicti41H → Y in CAA23479 (PubMed:293714).Curated1
Sequence conflicti57D → E in CAA27032 (PubMed:3003365).Curated1
Sequence conflicti109A → G in CAA27032 (PubMed:3003365).Curated1
Sequence conflicti140V → A in CAA27032 (PubMed:3003365).Curated1
Sequence conflicti145A → E in AAA74186 (Ref. 5) Curated1
Sequence conflicti226A → Q AA sequence (PubMed:6892652).Curated1
Sequence conflicti228M → I in AAA74186 (Ref. 5) Curated1
Sequence conflicti229Q → A AA sequence (PubMed:6892652).Curated1
Sequence conflicti313R → G in AAA51619 (PubMed:6276562).Curated1
Sequence conflicti313R → G in AAA33148 (PubMed:6276562).Curated1
Sequence conflicti313R → G in AAA33157 (PubMed:6276562).Curated1
Sequence conflicti357W → L in AAA33152 (PubMed:6276562).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03281 Genomic DNA Translation: CAA27031.1
X03282 Genomic DNA Translation: CAA27032.1
M14146 Genomic DNA Translation: AAA33145.1
AAFI02000005 Genomic DNA Translation: EAL71967.1
AAFI02000008 Genomic DNA Translation: EAL71184.1
AAFI02000008 Genomic DNA Translation: EAL71276.1
AAFI02000012 Genomic DNA Translation: EAL69957.1
AAFI02000012 Genomic DNA Translation: EAL69959.1
AAFI02000012 Genomic DNA Translation: EAL69960.1
AAFI02000012 Genomic DNA Translation: EAL69961.1
AAFI02000012 Genomic DNA Translation: EAL70035.1
AAFI02000012 Genomic DNA Translation: EAL70173.1
AAFI02000012 Genomic DNA Translation: EAL70192.1
AAFI02000012 Genomic DNA Translation: EAL70193.1
AAFI02000012 Genomic DNA Translation: EAL70256.1
AAFI02000037 Genomic DNA Translation: EAL67074.1
AAFI02000126 Genomic DNA Translation: EAL62963.1
AAFI02000129 Genomic DNA Translation: EAL62918.1
AAFI02000142 Genomic DNA Translation: EAL62666.1
AAFI02000148 Genomic DNA Translation: EAL62543.1
U25660 Genomic DNA Translation: AAA74186.1
V00183 Genomic DNA Translation: CAA23479.1
V00186 Genomic DNA Translation: CAA23482.1
V00188 mRNA Translation: CAA23484.1
J01267 Genomic DNA Translation: AAA33147.1
J01273 Genomic DNA Translation: AAA33151.1
J01274 Genomic DNA Translation: AAA33153.1
J01276 Genomic DNA Translation: AAA51618.1
J01279 Genomic DNA Translation: AAA33146.1
J01265 mRNA Translation: AAA33158.1
J01270 mRNA Translation: AAA33159.1
J01272 Genomic DNA Translation: AAA33160.1
K02954 Genomic DNA Translation: AAA33148.1
K02958 Genomic DNA Translation: AAA33152.1
K02960 Genomic DNA Translation: AAA51619.1
J01278 mRNA Translation: AAA33157.1
PIRiA25084
A39239
A93223 ATDO
B23412
RefSeqiXP_636088.1, XM_630996.1
XP_636169.1, XM_631077.1
XP_636425.1, XM_631333.1
XP_636507.1, XM_631415.1
XP_641146.1, XM_636054.1
XP_643986.1, XM_638894.1
XP_643988.1, XM_638896.1
XP_643989.1, XM_638897.1
XP_643990.1, XM_638898.1
XP_644132.1, XM_639040.1
XP_644146.1, XM_639054.1
XP_644157.1, XM_639065.1
XP_644244.1, XM_639152.1
XP_644246.1, XM_639154.1
XP_645099.1, XM_640007.1
XP_645262.1, XM_640170.1
XP_646688.1, XM_641596.1

Genome annotation databases

EnsemblProtistsiEAL62543; EAL62543; DDB_G0289663
EAL62666; EAL62666; DDB_G0289553
EAL62918; EAL62918; DDB_G0289005
EAL62963; EAL62963; DDB_G0288879
EAL67074; EAL67074; DDB_G0280545
EAL69957; EAL69957; DDB_G0274129
EAL69959; EAL69959; DDB_G0274133
EAL69960; EAL69960; DDB_G0274135
EAL69961; EAL69961; DDB_G0274137
EAL70035; EAL70035; DDB_G0274285
EAL70173; EAL70173; DDB_G0274561
EAL70192; EAL70192; DDB_G0274599
EAL70193; EAL70193; DDB_G0274601
EAL70256; EAL70256; DDB_G0274727
EAL71184; EAL71184; DDB_G0272520
EAL71276; EAL71276; DDB_G0272248
EAL71967; EAL71967; DDB_G0269234
GeneIDi8617663
8618428
8618493
8619412
8619414
8619415
8619416
8619562
8619575
8619586
8619672
8619674
8622703
8626890
8626916
8627198
8627300
KEGGiddi:DDB_G0269234
ddi:DDB_G0272248
ddi:DDB_G0272520
ddi:DDB_G0274129
ddi:DDB_G0274133
ddi:DDB_G0274135
ddi:DDB_G0274137
ddi:DDB_G0274285
ddi:DDB_G0274561
ddi:DDB_G0274599
ddi:DDB_G0274601
ddi:DDB_G0274727
ddi:DDB_G0280545
ddi:DDB_G0288879
ddi:DDB_G0289005
ddi:DDB_G0289553
ddi:DDB_G0289663

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03281 Genomic DNA Translation: CAA27031.1
X03282 Genomic DNA Translation: CAA27032.1
M14146 Genomic DNA Translation: AAA33145.1
AAFI02000005 Genomic DNA Translation: EAL71967.1
AAFI02000008 Genomic DNA Translation: EAL71184.1
AAFI02000008 Genomic DNA Translation: EAL71276.1
AAFI02000012 Genomic DNA Translation: EAL69957.1
AAFI02000012 Genomic DNA Translation: EAL69959.1
AAFI02000012 Genomic DNA Translation: EAL69960.1
AAFI02000012 Genomic DNA Translation: EAL69961.1
AAFI02000012 Genomic DNA Translation: EAL70035.1
AAFI02000012 Genomic DNA Translation: EAL70173.1
AAFI02000012 Genomic DNA Translation: EAL70192.1
AAFI02000012 Genomic DNA Translation: EAL70193.1
AAFI02000012 Genomic DNA Translation: EAL70256.1
AAFI02000037 Genomic DNA Translation: EAL67074.1
AAFI02000126 Genomic DNA Translation: EAL62963.1
AAFI02000129 Genomic DNA Translation: EAL62918.1
AAFI02000142 Genomic DNA Translation: EAL62666.1
AAFI02000148 Genomic DNA Translation: EAL62543.1
U25660 Genomic DNA Translation: AAA74186.1
V00183 Genomic DNA Translation: CAA23479.1
V00186 Genomic DNA Translation: CAA23482.1
V00188 mRNA Translation: CAA23484.1
J01267 Genomic DNA Translation: AAA33147.1
J01273 Genomic DNA Translation: AAA33151.1
J01274 Genomic DNA Translation: AAA33153.1
J01276 Genomic DNA Translation: AAA51618.1
J01279 Genomic DNA Translation: AAA33146.1
J01265 mRNA Translation: AAA33158.1
J01270 mRNA Translation: AAA33159.1
J01272 Genomic DNA Translation: AAA33160.1
K02954 Genomic DNA Translation: AAA33148.1
K02958 Genomic DNA Translation: AAA33152.1
K02960 Genomic DNA Translation: AAA51619.1
J01278 mRNA Translation: AAA33157.1
PIRiA25084
A39239
A93223 ATDO
B23412
RefSeqiXP_636088.1, XM_630996.1
XP_636169.1, XM_631077.1
XP_636425.1, XM_631333.1
XP_636507.1, XM_631415.1
XP_641146.1, XM_636054.1
XP_643986.1, XM_638894.1
XP_643988.1, XM_638896.1
XP_643989.1, XM_638897.1
XP_643990.1, XM_638898.1
XP_644132.1, XM_639040.1
XP_644146.1, XM_639054.1
XP_644157.1, XM_639065.1
XP_644244.1, XM_639152.1
XP_644246.1, XM_639154.1
XP_645099.1, XM_640007.1
XP_645262.1, XM_640170.1
XP_646688.1, XM_641596.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1C0FX-ray2.40A2-376[»]
1C0GX-ray2.00A2-376[»]
1DEJX-ray2.40A2-376[»]
1NLVX-ray1.80A2-376[»]
1NM1X-ray1.80A2-376[»]
1NMDX-ray1.90A2-376[»]
3A5LX-ray2.40C2-376[»]
3A5MX-ray2.40C2-376[»]
3A5NX-ray2.36C2-376[»]
3A5OX-ray2.40C2-376[»]
3CHWX-ray2.30A2-376[»]
3CI5X-ray1.70A2-376[»]
3CIPX-ray1.60A2-376[»]
ProteinModelPortaliP07830
SMRiP07830
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-40989N
IntActiP07830, 3 interactors
MINTiP07830
STRINGi44689.DDB0220456

PTM databases

iPTMnetiP07830

2D gel databases

SWISS-2DPAGEiP07830

Proteomic databases

PaxDbiP07830
PRIDEiP07830

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL62543; EAL62543; DDB_G0289663
EAL62666; EAL62666; DDB_G0289553
EAL62918; EAL62918; DDB_G0289005
EAL62963; EAL62963; DDB_G0288879
EAL67074; EAL67074; DDB_G0280545
EAL69957; EAL69957; DDB_G0274129
EAL69959; EAL69959; DDB_G0274133
EAL69960; EAL69960; DDB_G0274135
EAL69961; EAL69961; DDB_G0274137
EAL70035; EAL70035; DDB_G0274285
EAL70173; EAL70173; DDB_G0274561
EAL70192; EAL70192; DDB_G0274599
EAL70193; EAL70193; DDB_G0274601
EAL70256; EAL70256; DDB_G0274727
EAL71184; EAL71184; DDB_G0272520
EAL71276; EAL71276; DDB_G0272248
EAL71967; EAL71967; DDB_G0269234
GeneIDi8617663
8618428
8618493
8619412
8619414
8619415
8619416
8619562
8619575
8619586
8619672
8619674
8622703
8626890
8626916
8627198
8627300
KEGGiddi:DDB_G0269234
ddi:DDB_G0272248
ddi:DDB_G0272520
ddi:DDB_G0274129
ddi:DDB_G0274133
ddi:DDB_G0274135
ddi:DDB_G0274137
ddi:DDB_G0274285
ddi:DDB_G0274561
ddi:DDB_G0274599
ddi:DDB_G0274601
ddi:DDB_G0274727
ddi:DDB_G0280545
ddi:DDB_G0288879
ddi:DDB_G0289005
ddi:DDB_G0289553
ddi:DDB_G0289663

Organism-specific databases

dictyBaseiDDB_G0289553 act1
DDB_G0288879 act11
DDB_G0274129 act12
DDB_G0274599 act13
DDB_G0274137 act14
DDB_G0272520 act15
DDB_G0272248 act16
DDB_G0274727 act19
DDB_G0274133 act2
DDB_G0274285 act20
DDB_G0274561 act21
DDB_G0289005 act4
DDB_G0289663 act5
DDB_G0274135 act6
DDB_G0280545 act7
DDB_G0269234 act8
DDB_G0274601 act9

Phylogenomic databases

eggNOGiKOG0676 Eukaryota
COG5277 LUCA
InParanoidiP07830
KOiK10355
OMAiKCDESIC
PhylomeDBiP07830

Enzyme and pathway databases

ReactomeiR-DDI-2029482 Regulation of actin dynamics for phagocytic cup formation
R-DDI-5626467 RHO GTPases activate IQGAPs
R-DDI-5663213 RHO GTPases Activate WASPs and WAVEs

Miscellaneous databases

EvolutionaryTraceiP07830
PROiPR:P07830

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
PANTHERiPTHR11937 PTHR11937, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS00406 ACTINS_1, 1 hit
PS00432 ACTINS_2, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACT1_DICDI
AccessioniPrimary (citable) accession number: P07830
Secondary accession number(s): P02577
, P07827, Q23856, Q23875, Q23877, Q23879, Q23880, Q54H30, Q7KWV6, Q94466
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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