UniProtKB - P07825 (SYPH_RAT)
Protein
Synaptophysin
Gene
Syp
Organism
Rattus norvegicus (Rat)
Status
Functioni
Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).By similarity
GO - Molecular functioni
- cholesterol binding Source: RGD
- identical protein binding Source: RGD
- protein-containing complex binding Source: RGD
- protein domain specific binding Source: RGD
- SH2 domain binding Source: RGD
- SNARE binding Source: UniProtKB
- syntaxin-1 binding Source: MGI
GO - Biological processi
- cellular response to organic substance Source: RGD
- endocytosis Source: UniProtKB
- regulation of long-term neuronal synaptic plasticity Source: RGD
- regulation of neuronal synaptic plasticity Source: GO_Central
- regulation of opioid receptor signaling pathway Source: UniProtKB
- regulation of short-term neuronal synaptic plasticity Source: RGD
- regulation of synaptic vesicle exocytosis Source: RGD
- response to amyloid-beta Source: RGD
- synaptic vesicle endocytosis Source: RGD
Keywordsi
Ligand | Calcium |
Names & Taxonomyi
Protein namesi | Recommended name: SynaptophysinAlternative name(s): Major synaptic vesicle protein p38 |
Gene namesi | Name:Syp |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3802, Syp |
Subcellular locationi
Other locations
- synaptic vesicle membrane By similarity; Multi-pass membrane protein Sequence analysis
- synaptosome By similarity
Plasma Membrane
- presynaptic membrane Source: RGD
Other locations
- excitatory synapse Source: BHF-UCL
- integral component of synaptic vesicle membrane Source: SynGO
- intracellular organelle Source: RGD
- membrane Source: RGD
- neuromuscular junction Source: RGD
- neuron projection Source: RGD
- neuron projection terminus Source: RGD
- neuron spine Source: UniProtKB
- perinuclear region of cytoplasm Source: RGD
- postsynaptic density Source: UniProtKB
- presynaptic active zone Source: MGI
- protein-containing complex Source: RGD
- Schaffer collateral - CA1 synapse Source: RGD
- synapse Source: RGD
- synaptic vesicle Source: ParkinsonsUK-UCL
- synaptic vesicle membrane Source: CAFA
- terminal bouton Source: ParkinsonsUK-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 19 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 20 – 43 | HelicalSequence analysisAdd BLAST | 24 | |
Topological domaini | 44 – 101 | VesicularSequence analysisAdd BLAST | 58 | |
Transmembranei | 102 – 125 | HelicalSequence analysisAdd BLAST | 24 | |
Topological domaini | 126 – 132 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 133 – 156 | HelicalSequence analysisAdd BLAST | 24 | |
Topological domaini | 157 – 194 | VesicularSequence analysisAdd BLAST | 38 | |
Transmembranei | 195 – 218 | HelicalSequence analysisAdd BLAST | 24 | |
Topological domaini | 219 – 307 | CytoplasmicSequence analysisAdd BLAST | 89 |
Keywords - Cellular componenti
Cell junction, Cytoplasmic vesicle, Membrane, Synapse, SynaptosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000179163 | 1 – 307 | SynaptophysinAdd BLAST | 307 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 53 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 75 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 221 | PhosphothreonineSequence analysis | 1 | |
Modified residuei | 273 | PhosphotyrosineSequence analysis | 1 | |
Modified residuei | 289 | PhosphotyrosineSequence analysis | 1 |
Post-translational modificationi
Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
Keywords - PTMi
Glycoprotein, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | P07825 |
PaxDbi | P07825 |
PRIDEi | P07825 |
PTM databases
GlyGeni | P07825, 1 site |
iPTMneti | P07825 |
PhosphoSitePlusi | P07825 |
Expressioni
Tissue specificityi
Expressed in the brain with expression in the cerebrum and the cerebellum.1 Publication
Developmental stagei
Expressed in the spinal cord of newborn animals.1 Publication
Interactioni
Subunit structurei
Homohexamer or homotetramer.
Interacts with SRCIN1 (By similarity).
Interacts with VAMP2; the interaction is inhibit by interaction of VAPM2 with SEPT8 (PubMed:19196426).
By similarity1 PublicationBinary interactionsi
Hide detailsP07825
With | #Exp. | IntAct |
---|---|---|
Itm2b [Q5XIE8] | 4 | EBI-976085,EBI-15348306 |
Oprm1 [P33535] | 8 | EBI-976085,EBI-4392569 |
Srcin1 - isoform 2 [Q9QWI6-2] from Mus musculus. | 2 | EBI-976085,EBI-775607 |
GO - Molecular functioni
- identical protein binding Source: RGD
- protein domain specific binding Source: RGD
- SH2 domain binding Source: RGD
- SNARE binding Source: UniProtKB
- syntaxin-1 binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 246927, 7 interactors |
IntActi | P07825, 14 interactors |
MINTi | P07825 |
STRINGi | 10116.ENSRNOP00000013724 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 15 – 222 | MARVELPROSITE-ProRule annotationAdd BLAST | 208 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 249 – 298 | Repeats, Gly-richAdd BLAST | 50 |
Domaini
The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.
Sequence similaritiesi
Belongs to the synaptophysin/synaptobrevin family.Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QT4W, Eukaryota |
InParanoidi | P07825 |
OrthoDBi | 1446480at2759 |
PhylomeDBi | P07825 |
Family and domain databases
InterProi | View protein in InterPro IPR008253, Marvel IPR001285, Synaptophysin/porin IPR028714, SYP |
PANTHERi | PTHR10306, PTHR10306, 1 hit PTHR10306:SF10, PTHR10306:SF10, 1 hit |
Pfami | View protein in Pfam PF01284, MARVEL, 1 hit |
PRINTSi | PR00220, SYNAPTOPHYSN |
PROSITEi | View protein in PROSITE PS51225, MARVEL, 1 hit PS00604, SYNAPTOP, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P07825-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDVVNQLVAG GQFRVVKEPL GFVKVLQWVF AIFAFATCGS YTGELRLSVE
60 70 80 90 100
CANKTESALN IEVEFEYPFR LHQVYFDAPS CVKGGTTKIF LVGDYSSSAE
110 120 130 140 150
FFVTVAVFAF LYSMGALATY IFLQNKYREN NKGPMMDFLA TAVFAFMWLV
160 170 180 190 200
SSSAWAKGLS DVKMATDPEN IIKEMPMCRQ TGNTCKELRD PVTSGLNTSV
210 220 230 240 250
VFGFLNLVLW VGNLWFVFKE TGWAAPFMRA PPGAPEKQPA PGDAYGDAGY
260 270 280 290 300
GQGPGGYGPQ DSYGPQGGYQ PDYGQPASGG GGYGPQGDYG QQGYGQQGAP
TSFSNQM
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2KAD8 | A0A0G2KAD8_RAT | Synaptophysin | Syp | 283 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X06177 mRNA Translation: CAA29543.1 X06388 mRNA Translation: CAA29685.1 M58396 , M58402, M58401, M58399 Genomic DNA Translation: AAA42196.1 BC099798 mRNA Translation: AAH99798.1 X06655 mRNA Translation: CAA29854.1 |
PIRi | JU0464, B27287 |
RefSeqi | NP_036796.1, NM_012664.3 |
Genome annotation databases
GeneIDi | 24804 |
KEGGi | rno:24804 |
UCSCi | RGD:3802, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X06177 mRNA Translation: CAA29543.1 X06388 mRNA Translation: CAA29685.1 M58396 , M58402, M58401, M58399 Genomic DNA Translation: AAA42196.1 BC099798 mRNA Translation: AAH99798.1 X06655 mRNA Translation: CAA29854.1 |
PIRi | JU0464, B27287 |
RefSeqi | NP_036796.1, NM_012664.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 246927, 7 interactors |
IntActi | P07825, 14 interactors |
MINTi | P07825 |
STRINGi | 10116.ENSRNOP00000013724 |
PTM databases
GlyGeni | P07825, 1 site |
iPTMneti | P07825 |
PhosphoSitePlusi | P07825 |
Proteomic databases
jPOSTi | P07825 |
PaxDbi | P07825 |
PRIDEi | P07825 |
Genome annotation databases
GeneIDi | 24804 |
KEGGi | rno:24804 |
UCSCi | RGD:3802, rat |
Organism-specific databases
CTDi | 6855 |
RGDi | 3802, Syp |
Phylogenomic databases
eggNOGi | ENOG502QT4W, Eukaryota |
InParanoidi | P07825 |
OrthoDBi | 1446480at2759 |
PhylomeDBi | P07825 |
Miscellaneous databases
PROi | PR:P07825 |
Family and domain databases
InterProi | View protein in InterPro IPR008253, Marvel IPR001285, Synaptophysin/porin IPR028714, SYP |
PANTHERi | PTHR10306, PTHR10306, 1 hit PTHR10306:SF10, PTHR10306:SF10, 1 hit |
Pfami | View protein in Pfam PF01284, MARVEL, 1 hit |
PRINTSi | PR00220, SYNAPTOPHYSN |
PROSITEi | View protein in PROSITE PS51225, MARVEL, 1 hit PS00604, SYNAPTOP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SYPH_RAT | |
Accessioni | P07825Primary (citable) accession number: P07825 Secondary accession number(s): Q499R3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | August 1, 1988 | |
Last modified: | April 7, 2021 | |
This is version 170 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families