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Entry version 143 (07 Apr 2021)
Sequence version 2 (28 Jul 2009)
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Protein

Sucrose-6-phosphate hydrolase

Gene

sacA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides.PROSITE-ProRule annotation EC:3.2.1.26

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: sucrose metabolism

This protein is involved in the pathway sucrose metabolism, which is part of Glycan biosynthesis.
View all proteins of this organism that are known to be involved in the pathway sucrose metabolism and in Glycan biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei43PROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei59SubstrateBy similarity1
Binding sitei220SubstrateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BSUB:BSU38040-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00238

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GH32, Glycoside Hydrolase Family 32

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sucrose-6-phosphate hydrolase (EC:3.2.1.26)
Short name:
Sucrase
Alternative name(s):
Invertase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sacA
Ordered Locus Names:BSU38040
ORF Names:ipa-50d
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus subtilis (strain 168)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224308 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001570 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001698701 – 479Sucrose-6-phosphate hydrolaseAdd BLAST479

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P07819

PRoteomics IDEntifications database

More...
PRIDEi
P07819

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
224308.BSU38040

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P07819

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni40 – 43Substrate bindingBy similarity4
Regioni102 – 103Substrate bindingBy similarity2
Regioni161 – 162Substrate bindingBy similarity2

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 32 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1621, Bacteria

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P07819

Identification of Orthologs from Complete Genome Data

More...
OMAi
TTFFCQD

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P07819

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.115.10.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR001362, Glyco_hydro_32
IPR018053, Glyco_hydro_32_AS
IPR013189, Glyco_hydro_32_C
IPR013148, Glyco_hydro_32_N
IPR023296, Glyco_hydro_beta-prop_sf
IPR006232, Suc6P_hydrolase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08244, Glyco_hydro_32C, 1 hit
PF00251, Glyco_hydro_32N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00640, Glyco_32, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899, SSF49899, 1 hit
SSF75005, SSF75005, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01322, scrB_fam, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00609, GLYCOSYL_HYDROL_F32, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P07819-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAHDQELRR RAYEEVEKKE PIANSDPHRQ HFHIMPPVGL LNDPNGVIYW
60 70 80 90 100
KGSYHVFFQW QPFQTGHGAK FWGHYTTQDV VNWKREEIAL APSDWFDKNG
110 120 130 140 150
CYSGSAVTKD DRLYLFYTGN VRDQDGNRET YQCLAVSDDG LSFEKKGVVA
160 170 180 190 200
RLPEGYTAHF RDPKVWEHEG TWYMVIGAQT ENLKGQAVLF ASDNLTEWRF
210 220 230 240 250
LGPITGAGFN GLDDFGYMWE CPDLFSLQGS DVLIVSPQGL EADGFRYQNV
260 270 280 290 300
YQSGYFVGRL DYNKPELKHG EFTELDQGFD FYAPQTLEDD QGRRILFAWM
310 320 330 340 350
AVPDQDEGSH PTIDCHWIHC MTLPRQLTLS GQKLIQQPLP ELKAMRRNEK
360 370 380 390 400
KIHINMHGSS GALPVEKPER TEILLEDIHT ESGFSISIRG TATFSFHKDE
410 420 430 440 450
GIVTLERKSF DGKRTEARHC RIKDLHTVHM FLDASSVEIF INNGEEVLSA
460 470
RYFPFPGNHE VTASATGKSE MNVGIWTLM
Length:479
Mass (Da):54,814
Last modified:July 28, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i53D882B4772CB3CF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti155 – 156GY → AIL in AAA22723 (PubMed:3100393).Curated2
Sequence conflicti155 – 156GY → AIL in CAA51606 (PubMed:7934828).Curated2
Sequence conflicti161 – 164RDPK → SRSE in AAA22723 (PubMed:3100393).Curated4
Sequence conflicti161 – 164RDPK → SRSE in CAA51606 (PubMed:7934828).Curated4
Sequence conflicti448L → F in AAA22723 (PubMed:3100393).Curated1
Sequence conflicti448L → F in CAA51606 (PubMed:7934828).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M15662 Genomic DNA Translation: AAA22723.1
X73124 Genomic DNA Translation: CAA51606.1
AL009126 Genomic DNA Translation: CAB15830.2
J03006 Genomic DNA Translation: AAA22728.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A25562

NCBI Reference Sequences

More...
RefSeqi
NP_391683.2, NC_000964.3
WP_010886636.1, NZ_CP053102.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAB15830; CAB15830; BSU_38040

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
937277

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bsu:BSU38040

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|224308.179.peg.4118

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15662 Genomic DNA Translation: AAA22723.1
X73124 Genomic DNA Translation: CAA51606.1
AL009126 Genomic DNA Translation: CAB15830.2
J03006 Genomic DNA Translation: AAA22728.1
PIRiA25562
RefSeqiNP_391683.2, NC_000964.3
WP_010886636.1, NZ_CP053102.1

3D structure databases

SMRiP07819
ModBaseiSearch...

Protein-protein interaction databases

STRINGi224308.BSU38040

Protein family/group databases

CAZyiGH32, Glycoside Hydrolase Family 32

Proteomic databases

PaxDbiP07819
PRIDEiP07819

Genome annotation databases

EnsemblBacteriaiCAB15830; CAB15830; BSU_38040
GeneIDi937277
KEGGibsu:BSU38040
PATRICifig|224308.179.peg.4118

Phylogenomic databases

eggNOGiCOG1621, Bacteria
InParanoidiP07819
OMAiTTFFCQD
PhylomeDBiP07819

Enzyme and pathway databases

UniPathwayiUPA00238
BioCyciBSUB:BSU38040-MONOMER

Family and domain databases

Gene3Di2.115.10.20, 1 hit
InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR001362, Glyco_hydro_32
IPR018053, Glyco_hydro_32_AS
IPR013189, Glyco_hydro_32_C
IPR013148, Glyco_hydro_32_N
IPR023296, Glyco_hydro_beta-prop_sf
IPR006232, Suc6P_hydrolase
PfamiView protein in Pfam
PF08244, Glyco_hydro_32C, 1 hit
PF00251, Glyco_hydro_32N, 1 hit
SMARTiView protein in SMART
SM00640, Glyco_32, 1 hit
SUPFAMiSSF49899, SSF49899, 1 hit
SSF75005, SSF75005, 1 hit
TIGRFAMsiTIGR01322, scrB_fam, 1 hit
PROSITEiView protein in PROSITE
PS00609, GLYCOSYL_HYDROL_F32, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCRB_BACSU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07819
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: July 28, 2009
Last modified: April 7, 2021
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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