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Protein

Fructose-bisphosphate aldolase

Gene

Ald

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May take part in developmental stage-specific or tissue -specific sugar-phosphate metabolisms. Protein acts on two substrates fructose 1,6-bisphosphate and fructose 1-phosphate (like other class I aldolases).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH is 7.2-7.8 for isozyme alpha, and 7.2-7.5 for isozymes beta and gamma.1 Publication

Temperature dependencei

Thermostability of the isozymes, calculated as the temperature causing half maximal stability, is 42-43 degrees Celsius for isozymes alpha and beta and 45 degrees Celsius for isozyme gamma.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (Pgi)
  3. ATP-dependent 6-phosphofructokinase (Pfk), ATP-dependent 6-phosphofructokinase (Pfk-RB), ATP-dependent 6-phosphofructokinase (Pfk-RC), ATP-dependent 6-phosphofructokinase (Pfk), ATP-dependent 6-phosphofructokinase (Pfk-RB), ATP-dependent 6-phosphofructokinase (Pfk)
  4. Fructose-bisphosphate aldolase (Ald), Fructose-bisphosphate aldolase (Ald), Fructose-bisphosphate aldolase (Ald), Fructose-bisphosphate aldolase (Ald-RH), Fructose-bisphosphate aldolase (Ald-RI), Fructose-bisphosphate aldolase (Ald)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei56Substrate1
Binding sitei147Substrate1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei188Proton acceptorBy similarity1
Active sitei230Schiff-base intermediate with dihydroxyacetone-P1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei361Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • fructose-bisphosphate aldolase activity Source: FlyBase

GO - Biological processi

  • glucose homeostasis Source: FlyBase
  • glycolytic process Source: FlyBase
  • mesoderm development Source: FlyBase

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandSchiff base

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-114608 Platelet degranulation
R-DME-6798695 Neutrophil degranulation
R-DME-70171 Glycolysis
R-DME-70263 Gluconeogenesis
R-DME-70350 Fructose catabolism

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P07764

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00109;UER00183

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ald
ORF Names:CG6058
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0000064 Ald

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved2 Publications
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002169272 – 361Fructose-bisphosphate aldolaseAdd BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylthreonine2 Publications1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P07764

PRoteomics IDEntifications database

More...
PRIDEi
P07764

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P07764

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isozyme gamma is mainly expressed in the heads and partly in the thoraxes of adult flies. Isozyme alpha is expressed in all adult tissues. Isozyme beta is mainly expressed in adult abdominal regions and is also expressed in lesser amounts in other parts of the body and in earlier developmental stages. Isozyme alpha-beta shows strong expression in the abdomens of adults. Isozyme beta-gamma is expressed in adult heads.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isozyme gamma is first detected during late embryogenesis, is present through larval stages, declines in abundance during pupal stages and is maximum at eclosion. Isozyme beta is abundant during the earliest stages of embryogenesis, declines in amount and increases prior to hatching. Isozyme alpha is found only during the adult stage. Expression correlates to dietary behavior: high dietary activity in the larvae and adults causes active glycolysis and high expression levels. Isozyme alpha-beta is detected in the pupae and adults and isozyme beta-gamma in the adult.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0000064 Expressed in 33 organ(s), highest expression level in arthropod fat body

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P07764 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P07764 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
68080, 93 interactors

Protein interaction database and analysis system

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IntActi
P07764, 67 interactors

STRING: functional protein association networks

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STRINGi
7227.FBpp0302781

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1361
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P07764

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P07764

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P07764

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1557 Eukaryota
COG3588 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000010235

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P07764

KEGG Orthology (KO)

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KOi
K01623

Identification of Orthologs from Complete Genome Data

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OMAi
DYREMLF

Database of Orthologous Groups

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OrthoDBi
EOG091G0A9T

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P07764

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.70, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029768 Aldolase_I_AS
IPR013785 Aldolase_TIM
IPR000741 FBA_I

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00274 Glycolytic, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00158 ALDOLASE_CLASS_I, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Two additional mRNAs also exist (Alpha-beta and Beta-gamma). The translation product of Alpha-beta mRNA is isoform Alpha.

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform Gamma (identifier: P07764-1) [UniParc]FASTAAdd to basket
Also known as: 4C, B, C, D

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTYFNYPSK ELQDELREIA QKIVAPGKGI LAADESGPTM GKRLQDIGVE
60 70 80 90 100
NTEDNRRAYR QLLFSTDPKL AENISGVILF HETLYQKADD GTPFAEILKK
110 120 130 140 150
KGIILGIKVD KGVVPLFGSE DEVTTQGLDD LAARCAQYKK DGCDFAKWRC
160 170 180 190 200
VLKIGKNTPS YQSILENANV LARYASICQS QRIVPIVEPE VLPDGDHDLD
210 220 230 240 250
RAQKVTETVL AAVYKALSDH HVYLEGTLLK PNMVTAGQSA KKNTPEEIAL
260 270 280 290 300
ATVQALRRTV PAAVTGVTFL SGGQSEEEAT VNLSAINNVP LIRPWALTFS
310 320 330 340 350
YGRALQASVL RAWAGKKENI AAGQNELLKR AKANGDAAQG KYVAGSAGAG
360
SGSLFVANHA Y
Length:361
Mass (Da):39,047
Last modified:January 23, 2007 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD8DA46E273668CE9
GO
Isoform Alpha (identifier: P07764-2) [UniParc]FASTAAdd to basket
Also known as: 4A, E

The sequence of this isoform differs from the canonical sequence as follows:
     336-361: DAAQGKYVAGSAGAGSGSLFVANHAY → EAACGNYTAGSVKGFAGKDTLHVDDHRY

Show »
Length:363
Mass (Da):39,561
Checksum:iE48CC61438C85B64
GO
Isoform Beta (identifier: P07764-3) [UniParc]FASTAAdd to basket
Also known as: 4B, H

The sequence of this isoform differs from the canonical sequence as follows:
     335-361: GDAAQGKYVAGSAGAGSGSLFVANHAY → SQACQGIYVPGSIPSFAGNANLFVAQHKY

Show »
Length:363
Mass (Da):39,589
Checksum:i7B326172746BF31D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C8VV14C8VV14_DROME
Fructose-bisphosphate aldolase
Ald ALD, ald, Ald-RC, BcDNA:LP07735, dALDOA
361Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F3YDE2F3YDE2_DROME
Fructose-bisphosphate aldolase
Ald ALD, ald, Ald-RH, BcDNA:LP07735, dALDOA
363Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A4V3G1A4V3G1_DROME
Fructose-bisphosphate aldolase
Ald ALD, ald, Ald-RE, BcDNA:LP07735, dALDOA
363Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM75045 differs from that shown. Reason: Frameshift at positions 267 and 333.Curated
The sequence ABH06768 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence ABH06769 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence ABH06770 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence ABH06771 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence ABH06772 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence ABH06773 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence ABH06774 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence ABH06775 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence ABH06776 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence ABH06777 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence ABH06778 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence ABH06779 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA42666 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti40M → H in BAA01236 (PubMed:1339430).Curated1
Sequence conflicti40M → H in BAA01237 (PubMed:1339430).Curated1
Sequence conflicti40M → H in BAA01238 (PubMed:1339430).Curated1
Sequence conflicti40M → H in BAA01592 (PubMed:7487099).Curated1
Sequence conflicti111K → E in CAA42666 (PubMed:1732743).Curated1
Sequence conflicti111K → E in CAA42667 (PubMed:1732743).Curated1
Sequence conflicti181Q → E in BAA01236 (PubMed:1339430).Curated1
Sequence conflicti181Q → E in BAA01237 (PubMed:1339430).Curated1
Sequence conflicti181Q → E in BAA01238 (PubMed:1339430).Curated1
Sequence conflicti181Q → E in BAA01592 (PubMed:7487099).Curated1
Sequence conflicti201R → G in CAA42666 (PubMed:1732743).Curated1
Sequence conflicti201R → G in CAA42667 (PubMed:1732743).Curated1
Sequence conflicti251A → T in CAA42666 (PubMed:1732743).Curated1
Sequence conflicti251A → T in CAA42667 (PubMed:1732743).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000221335 – 361GDAAQ…ANHAY → SQACQGIYVPGSIPSFAGNA NLFVAQHKY in isoform Beta. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_000223336 – 361DAAQG…ANHAY → EAACGNYTAGSVKGFAGKDT LHVDDHRY in isoform Alpha. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D10446 Genomic DNA Translation: BAA01236.1
D10446 Genomic DNA Translation: BAA01237.1
D10446 Genomic DNA Translation: BAA01238.1
M98351 Genomic DNA Translation: AAA99426.1
M98351 Genomic DNA Translation: AAA99427.1
M98351 Genomic DNA Translation: AAA99428.1
X60064 Genomic DNA Translation: CAA42666.1 Sequence problems.
X60064 Genomic DNA Translation: CAA42667.1
X60064 Genomic DNA Translation: CAA42668.1
D10762 mRNA Translation: BAA01592.1
DQ864133 Genomic DNA Translation: ABH06768.1 Sequence problems.
DQ864134 Genomic DNA Translation: ABH06769.1 Sequence problems.
DQ864135 Genomic DNA Translation: ABH06770.1 Sequence problems.
DQ864136 Genomic DNA Translation: ABH06771.1 Sequence problems.
DQ864137 Genomic DNA Translation: ABH06772.1 Sequence problems.
DQ864138 Genomic DNA Translation: ABH06773.1 Sequence problems.
DQ864139 Genomic DNA Translation: ABH06774.1 Sequence problems.
DQ864140 Genomic DNA Translation: ABH06775.1 Sequence problems.
DQ864141 Genomic DNA Translation: ABH06776.1 Sequence problems.
DQ864142 Genomic DNA Translation: ABH06777.1 Sequence problems.
DQ864143 Genomic DNA Translation: ABH06778.1 Sequence problems.
DQ864144 Genomic DNA Translation: ABH06779.1 Sequence problems.
AE014297 Genomic DNA Translation: AAF56579.1
AE014297 Genomic DNA Translation: AAN14381.1
AE014297 Genomic DNA Translation: AAN14382.1
AE014297 Genomic DNA Translation: AAN14384.1
AE014297 Genomic DNA Translation: AAS65220.1
AY058667 mRNA Translation: AAL13896.1
AY128452 mRNA Translation: AAM75045.1 Frameshift.

Protein sequence database of the Protein Information Resource

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PIRi
A42027 ADFFR
A42263
B42027 ADFF
B42263
C42263
JX0233
S68360

NCBI Reference Sequences

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RefSeqi
NP_001262985.1, NM_001276056.1 [P07764-3]
NP_001287541.1, NM_001300612.1 [P07764-1]
NP_524515.2, NM_079791.5 [P07764-2]
NP_733140.2, NM_170261.3 [P07764-3]
NP_733141.1, NM_170262.2 [P07764-1]
NP_733142.1, NM_170263.4 [P07764-1]
NP_733143.1, NM_170264.3 [P07764-1]
NP_733144.3, NM_170265.4 [P07764-1]
NP_733145.3, NM_170266.4 [P07764-2]
NP_996300.1, NM_206577.3 [P07764-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Dm.2349

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0084994; FBpp0084367; FBgn0000064 [P07764-1]
FBtr0084995; FBpp0084368; FBgn0000064 [P07764-1]
FBtr0084999; FBpp0084372; FBgn0000064 [P07764-1]
FBtr0085000; FBpp0084373; FBgn0000064 [P07764-2]
FBtr0085001; FBpp0089214; FBgn0000064 [P07764-3]
FBtr0114544; FBpp0113036; FBgn0000064 [P07764-2]
FBtr0306657; FBpp0297612; FBgn0000064 [P07764-3]
FBtr0310660; FBpp0302780; FBgn0000064 [P07764-1]
FBtr0310661; FBpp0302781; FBgn0000064 [P07764-3]
FBtr0339614; FBpp0308680; FBgn0000064 [P07764-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
43183

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG6058

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10446 Genomic DNA Translation: BAA01236.1
D10446 Genomic DNA Translation: BAA01237.1
D10446 Genomic DNA Translation: BAA01238.1
M98351 Genomic DNA Translation: AAA99426.1
M98351 Genomic DNA Translation: AAA99427.1
M98351 Genomic DNA Translation: AAA99428.1
X60064 Genomic DNA Translation: CAA42666.1 Sequence problems.
X60064 Genomic DNA Translation: CAA42667.1
X60064 Genomic DNA Translation: CAA42668.1
D10762 mRNA Translation: BAA01592.1
DQ864133 Genomic DNA Translation: ABH06768.1 Sequence problems.
DQ864134 Genomic DNA Translation: ABH06769.1 Sequence problems.
DQ864135 Genomic DNA Translation: ABH06770.1 Sequence problems.
DQ864136 Genomic DNA Translation: ABH06771.1 Sequence problems.
DQ864137 Genomic DNA Translation: ABH06772.1 Sequence problems.
DQ864138 Genomic DNA Translation: ABH06773.1 Sequence problems.
DQ864139 Genomic DNA Translation: ABH06774.1 Sequence problems.
DQ864140 Genomic DNA Translation: ABH06775.1 Sequence problems.
DQ864141 Genomic DNA Translation: ABH06776.1 Sequence problems.
DQ864142 Genomic DNA Translation: ABH06777.1 Sequence problems.
DQ864143 Genomic DNA Translation: ABH06778.1 Sequence problems.
DQ864144 Genomic DNA Translation: ABH06779.1 Sequence problems.
AE014297 Genomic DNA Translation: AAF56579.1
AE014297 Genomic DNA Translation: AAN14381.1
AE014297 Genomic DNA Translation: AAN14382.1
AE014297 Genomic DNA Translation: AAN14384.1
AE014297 Genomic DNA Translation: AAS65220.1
AY058667 mRNA Translation: AAL13896.1
AY128452 mRNA Translation: AAM75045.1 Frameshift.
PIRiA42027 ADFFR
A42263
B42027 ADFF
B42263
C42263
JX0233
S68360
RefSeqiNP_001262985.1, NM_001276056.1 [P07764-3]
NP_001287541.1, NM_001300612.1 [P07764-1]
NP_524515.2, NM_079791.5 [P07764-2]
NP_733140.2, NM_170261.3 [P07764-3]
NP_733141.1, NM_170262.2 [P07764-1]
NP_733142.1, NM_170263.4 [P07764-1]
NP_733143.1, NM_170264.3 [P07764-1]
NP_733144.3, NM_170265.4 [P07764-1]
NP_733145.3, NM_170266.4 [P07764-2]
NP_996300.1, NM_206577.3 [P07764-3]
UniGeneiDm.2349

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FBAX-ray1.90A/B/C/D2-361[»]
ProteinModelPortaliP07764
SMRiP07764
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi68080, 93 interactors
IntActiP07764, 67 interactors
STRINGi7227.FBpp0302781

PTM databases

iPTMnetiP07764

Proteomic databases

PaxDbiP07764
PRIDEiP07764

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0084994; FBpp0084367; FBgn0000064 [P07764-1]
FBtr0084995; FBpp0084368; FBgn0000064 [P07764-1]
FBtr0084999; FBpp0084372; FBgn0000064 [P07764-1]
FBtr0085000; FBpp0084373; FBgn0000064 [P07764-2]
FBtr0085001; FBpp0089214; FBgn0000064 [P07764-3]
FBtr0114544; FBpp0113036; FBgn0000064 [P07764-2]
FBtr0306657; FBpp0297612; FBgn0000064 [P07764-3]
FBtr0310660; FBpp0302780; FBgn0000064 [P07764-1]
FBtr0310661; FBpp0302781; FBgn0000064 [P07764-3]
FBtr0339614; FBpp0308680; FBgn0000064 [P07764-1]
GeneIDi43183
KEGGidme:Dmel_CG6058

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
43183
FlyBaseiFBgn0000064 Ald

Phylogenomic databases

eggNOGiKOG1557 Eukaryota
COG3588 LUCA
GeneTreeiENSGT00390000010235
InParanoidiP07764
KOiK01623
OMAiDYREMLF
OrthoDBiEOG091G0A9T
PhylomeDBiP07764

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00183

ReactomeiR-DME-114608 Platelet degranulation
R-DME-6798695 Neutrophil degranulation
R-DME-70171 Glycolysis
R-DME-70263 Gluconeogenesis
R-DME-70350 Fructose catabolism
SABIO-RKiP07764

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Ald fly
EvolutionaryTraceiP07764

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
43183

Protein Ontology

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PROi
PR:P07764

Gene expression databases

BgeeiFBgn0000064 Expressed in 33 organ(s), highest expression level in arthropod fat body
ExpressionAtlasiP07764 baseline and differential
GenevisibleiP07764 DM

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR029768 Aldolase_I_AS
IPR013785 Aldolase_TIM
IPR000741 FBA_I
PfamiView protein in Pfam
PF00274 Glycolytic, 1 hit
PROSITEiView protein in PROSITE
PS00158 ALDOLASE_CLASS_I, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiALF_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07764
Secondary accession number(s): A4V3F9
, A5XCY2, P29841, Q24236, Q24237, Q7KRY9, Q8IMS1, Q8MQQ4, Q9VBG2, Q9VBG3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 190 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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