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Protein

Serine protease inhibitor A3K

Gene

Serpina3k

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Contrapsin inhibits trypsin-like proteases.2 Publications

Miscellaneous

The single human alpha1-antichymotrypsin gene (SERPINA3) is represented by a cluster of 14 individual murine paralogs.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei384 – 385Reactive bond2

GO - Molecular functioni

  • serine-type endopeptidase inhibitor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.029

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease inhibitor A3K
Short name:
Serpin A3K
Alternative name(s):
Contrapsin
SPI-2
Gene namesi
Name:Serpina3k
Synonyms:Mcm2, Spi2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:98377 Serpina3k

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000003241722 – 418Serine protease inhibitor A3KAdd BLAST397

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi185N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi270N-linked (GlcNAc...) asparagine2 Publications1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP07759
PaxDbiP07759
PeptideAtlasiP07759
PRIDEiP07759

PTM databases

GlyConnecti781
iPTMnetiP07759
PhosphoSitePlusiP07759

Expressioni

Tissue specificityi

Expressed in liver and secreted in plasma.4 Publications

Interactioni

Protein-protein interaction databases

BioGridi203440, 3 interactors
IntActiP07759, 5 interactors
MINTiP07759
STRINGi10090.ENSMUSP00000042095

Structurei

3D structure databases

ProteinModelPortaliP07759
SMRiP07759
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni369 – 394RCLAdd BLAST26

Domaini

The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the serpin reactive site and the protease. The resulting inactive serpin-protease complex is highly stable (By similarity). Variability within the reactive center loop (RCL) sequences of Serpina3 paralogs may determine target protease specificity.By similarity

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
HOGENOMiHOG000238521
HOVERGENiHBG005957
InParanoidiP07759
KOiK04525
PhylomeDBiP07759
TreeFamiTF343201

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P07759-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFIVAMGMI LMAGICPAVL CFPDGTKEMD IVFHEHQDNG TQDDSLTLAS
60 70 80 90 100
VNTDFAFSLY KKLALKNPDT NIVFSPLSIS AALALVSLGA KGKTMEEILE
110 120 130 140 150
GLKFNLTETP EADIHQGFGN LLQSLSQPED QDQINIGNAM FIEKDLQILA
160 170 180 190 200
EFHEKTRALY QTEAFTADFQ QPTEAKNLIN DYVSNQTQGM IKELISELDE
210 220 230 240 250
RTLMVLVNYI YFKGKWKISF DPQDTFESEF YLDEKRSVKV PMMKMKLLTT
260 270 280 290 300
RHFRDEELSC SVLELKYTGN ASALLILPDQ GRMQQVEASL QPETLRKWRK
310 320 330 340 350
TLFPSQIEEL NLPKFSIASN YRLEEDVLPE MGIKEVFTEQ ADLSGITETK
360 370 380 390 400
KLSVSQVVHK AVLDVAETGT EAAAATGVIG GIRKAILPAV HFNRPFLFVI
410
YHTSAQSILF MAKVNNPK
Length:418
Mass (Da):46,880
Last modified:November 1, 1991 - v2
Checksum:i761A6F986C5B5CCD
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J0I1A0A0R4J0I1_MOUSE
MCG1051009
Serpina3k mCG_1051009
418Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15I → V in AAH19802 (PubMed:15489334).Curated1
Sequence conflicti15I → V in AAH11217 (PubMed:15489334).Curated1
Sequence conflicti15I → V in AAH16407 (PubMed:15489334).Curated1
Sequence conflicti68 – 70PDT → QDK in CAA40106 (PubMed:11916263).Curated3
Sequence conflicti68 – 70PDT → QDK in BAE28874 (PubMed:16141072).Curated3
Sequence conflicti72I → F in AAH16407 (PubMed:15489334).Curated1
Sequence conflicti84A → R in CAA38948 (PubMed:2049065).Curated1
Sequence conflicti193E → K in CAA40106 (PubMed:11916263).Curated1
Sequence conflicti193E → K in BAE28874 (PubMed:16141072).Curated1
Sequence conflicti200 – 201ER → DG in CAA40106 (PubMed:11916263).Curated2
Sequence conflicti200 – 201ER → DG in BAE28874 (PubMed:16141072).Curated2
Sequence conflicti204M → V in CAA25458 (PubMed:6547997).Curated1
Sequence conflicti250T → A in CAA40106 (PubMed:11916263).Curated1
Sequence conflicti250T → A in BAE28874 (PubMed:16141072).Curated1
Sequence conflicti304P → S in CAA40106 (PubMed:11916263).Curated1
Sequence conflicti304P → S in BAE28874 (PubMed:16141072).Curated1
Sequence conflicti320N → D in CAA40106 (PubMed:11916263).Curated1
Sequence conflicti320N → D in BAE28874 (PubMed:16141072).Curated1
Sequence conflicti347T → I in CAA25458 (PubMed:6547997).Curated1
Sequence conflicti349T → A in CAA40106 (PubMed:11916263).Curated1
Sequence conflicti349T → A in BAE28874 (PubMed:16141072).Curated1
Sequence conflicti386I → V in CAA40106 (PubMed:11916263).Curated1
Sequence conflicti386I → V in BAE28874 (PubMed:16141072).Curated1
Sequence conflicti389A → G in AAH19802 (PubMed:15489334).Curated1
Sequence conflicti391H → C in CAA40106 (PubMed:11916263).Curated1
Sequence conflicti391H → C in BAE28874 (PubMed:16141072).Curated1
Sequence conflicti398F → I in CAA40106 (PubMed:11916263).Curated1
Sequence conflicti398F → I in BAE28874 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00725 mRNA Translation: BAA00627.1
X55147 mRNA Translation: CAA38948.1
X56786 mRNA Translation: CAA40106.1
AK149436 mRNA Translation: BAE28874.1
BC011217 mRNA Translation: AAH11217.1
BC016407 mRNA Translation: AAH16407.1
BC019802 mRNA Translation: AAH19802.1
X00946 Genomic DNA Translation: CAA25458.1
CCDSiCCDS36537.1
PIRiJX0129
RefSeqiNP_035588.2, NM_011458.2
UniGeneiMm.291569

Genome annotation databases

GeneIDi20714
KEGGimmu:20714
UCSCiuc007oxd.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00725 mRNA Translation: BAA00627.1
X55147 mRNA Translation: CAA38948.1
X56786 mRNA Translation: CAA40106.1
AK149436 mRNA Translation: BAE28874.1
BC011217 mRNA Translation: AAH11217.1
BC016407 mRNA Translation: AAH16407.1
BC019802 mRNA Translation: AAH19802.1
X00946 Genomic DNA Translation: CAA25458.1
CCDSiCCDS36537.1
PIRiJX0129
RefSeqiNP_035588.2, NM_011458.2
UniGeneiMm.291569

3D structure databases

ProteinModelPortaliP07759
SMRiP07759
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203440, 3 interactors
IntActiP07759, 5 interactors
MINTiP07759
STRINGi10090.ENSMUSP00000042095

Protein family/group databases

MEROPSiI04.029

PTM databases

GlyConnecti781
iPTMnetiP07759
PhosphoSitePlusiP07759

Proteomic databases

MaxQBiP07759
PaxDbiP07759
PeptideAtlasiP07759
PRIDEiP07759

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi20714
KEGGimmu:20714
UCSCiuc007oxd.1 mouse

Organism-specific databases

CTDi20714
MGIiMGI:98377 Serpina3k

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
HOGENOMiHOG000238521
HOVERGENiHBG005957
InParanoidiP07759
KOiK04525
PhylomeDBiP07759
TreeFamiTF343201

Miscellaneous databases

ChiTaRSiMcm2 mouse
PROiPR:P07759
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPA3K_MOUSE
AccessioniPrimary (citable) accession number: P07759
Secondary accession number(s): Q62257
, Q8VCH3, Q91W80, Q91X80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: November 1, 1991
Last modified: November 7, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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