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UniProtKB - P07751 (SPTN1_CHICK)

Entry version 166 (26 Feb 2020)
Sequence version 3 (01 Aug 1991)
Previous versions | rss
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Protein

Spectrin alpha chain, non-erythrocytic 1

Gene

SPTAN1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi2341 – 23521PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi2384 – 23952PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin capping, Actin-binding, Calmodulin-binding
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spectrin alpha chain, non-erythrocytic 1
Alternative name(s):
Alpha-II spectrin
Fodrin alpha chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPTAN1
Synonyms:SPTA2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000734541 – 2477Spectrin alpha chain, non-erythrocytic 1Add BLAST2477

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1176PhosphotyrosineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation of Tyr-1176 decreases sensitivity to cleavage by calpain in vitro.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1176 – 1177Cleavage; by mu-calpainBy similarity2

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P07751

PRoteomics IDEntifications database

More...PRIDEi		P07751

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Like erythrocyte spectrin, the spectrin-like proteins are capable of forming dimers which can further associate to tetramers.

Interacts with ACP1 (By similarity).

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Molecular INTeraction database

More...MINTi		P07751

STRING: functional protein association networks

More...STRINGi		9031.ENSGALP00000038979

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12477
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P07751

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P07751

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati45 – 146Spectrin 1Sequence analysisAdd BLAST102
Repeati150 – 251Spectrin 2Sequence analysisAdd BLAST102
Repeati256 – 358Spectrin 3Sequence analysisAdd BLAST103
Repeati361 – 465Spectrin 4Sequence analysisAdd BLAST105
Repeati468 – 570Spectrin 5Sequence analysisAdd BLAST103
Repeati574 – 676Spectrin 6Sequence analysisAdd BLAST103
Repeati679 – 781Spectrin 7Sequence analysisAdd BLAST103
Repeati785 – 888Spectrin 8Sequence analysisAdd BLAST104
Repeati891 – 969Spectrin 9Sequence analysisAdd BLAST79
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini967 – 1026SH3PROSITE-ProRule annotationAdd BLAST60
Repeati1096 – 1162Spectrin 10Sequence analysisAdd BLAST67
Repeati1234 – 1336Spectrin 11Sequence analysisAdd BLAST103
Repeati1339 – 1442Spectrin 12Sequence analysisAdd BLAST104
Repeati1446 – 1549Spectrin 13Sequence analysisAdd BLAST104
Repeati1552 – 1661Spectrin 14Sequence analysisAdd BLAST110
Repeati1664 – 1767Spectrin 15Sequence analysis1 PublicationAdd BLAST104
Repeati1769 – 1873Spectrin 16Sequence analysis3 PublicationsAdd BLAST105
Repeati1876 – 1979Spectrin 17Sequence analysisAdd BLAST104
Repeati1983 – 2086Spectrin 18Sequence analysisAdd BLAST104
Repeati2097 – 2199Spectrin 19Sequence analysisAdd BLAST103
Repeati2211 – 2315Spectrin 20Sequence analysisAdd BLAST105
Domaini2328 – 2363EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini2371 – 2406EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini2409 – 2444EF-hand 3PROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 14N-terminal domainAdd BLAST14
Regioni2257 – 2477C-terminal domainAdd BLAST221

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the spectrin family.Curated

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0035 Eukaryota
COG5069 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P07751

KEGG Orthology (KO)

More...KOi		K06114

Database of Orthologous Groups

More...OrthoDBi		543832at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P07751

Family and domain databases

Conserved Domains Database

More...CDDi		cd00051 EFh, 1 hit
cd11808 SH3_Alpha_Spectrin, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035825 Alpha_Spectrin_SH3
IPR011992 EF-hand-dom_pair
IPR014837 EF-hand_Ca_insen
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13499 EF-hand_7, 1 hit
PF08726 EFhand_Ca_insen, 1 hit
PF00018 SH3_1, 1 hit
PF00435 Spectrin, 20 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00452 SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00054 EFh, 2 hits
SM00326 SH3, 1 hit
SM00150 SPEC, 20 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473 SSF47473, 1 hit
SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 3 hits
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P07751-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPSGVKVLE TAEDIQERRQ QVLDRYHRFK ELSSLRRQKL EDSYRFQFFQ 
        60         70         80         90        100
RDADELGKWI QEKLQIASDE NYKDPSNLQG KLQKHQAFEA EVQANSGAIV 
       110        120        130        140        150
KLDETGNQMI NEGHFASETI RTRLQELHRL WELLLEKMRE KGVKLLQAQK 
       160        170        180        190        200
LVQFLRECED VMDWINDKEA IVTSEELGQD LEHVEVLQKK FEEFQTDLAA 
       210        220        230        240        250
HEERVNEVNQ FAGKLIQEQH PEEELIKSKQ DEVNASWQRL KGLAQQRQGK 
       260        270        280        290        300
LFGAAEVQRF NRDVDETISW IKEKGQLMAS DDFGRDLASV QALLRKHEGL 
       310        320        330        340        350
ERDLAAFHHK VKALCAEADR LQQSHPINAS QIQVKREELI ANWEQIRTLA 
       360        370        380        390        400
AERHARLNDS YRLQRFLADF RDLTSWVTEM KALINADELA NDVAGAEALL 
       410        420        430        440        450
DRHQEHKGEI DAHEDSFRSA DESGQALLAA GHYASDEVKE KLTILSDERS 
       460        470        480        490        500
ALLELWELRR QQYEQCMDLQ LFYRDTEQVD NWMSKQEAFL LNEDLGDSLD 
       510        520        530        540        550
SVEALLKKHE DFEKSLSAQE EKITALDEFA TKLIQNNHYA MDDVATRRDA 
       560        570        580        590        600
LLSRRNALHE RAMKRRAQLA DSFHLQQFFR DSDELKSWVN EKMKTATDEA 
       610        620        630        640        650
YKDPSNLQGK VQKHQAFEAE LSANQSRIDA LEKAGQKLID VNHYASDEVA 
       660        670        680        690        700
ARMNEVISLW KKLLEATELK GIKLREANQQ QQFNRNVEDI ELWLYEVEGH 
       710        720        730        740        750
LASDDYGKDL TSVQNLQKKH ALLEADVAAH QDPIDGITIQ ARQFQDAGHF 
       760        770        780        790        800
DADNIKKKQE ALVARYEALK DPMVARKQKL ADSLRLQQLF RDIEDEETWI 
       810        820        830        840        850
REKEPIAAST NRGKDLIGVQ NLLKKHQALQ AEIAGHEPRI KAVTQKGNAM 
       860        870        880        890        900
VEEGHFAAED VKIKLNELNQ KWDSLKAKAS QRRQDLEDSL QAQQYFADAN 
       910        920        930        940        950
EAQSWMREKE PIVGSTDYGK DEDSAEALLK KHEALMSDLS AYGSSIQALR 
       960        970        980        990       1000
EQAQSCRQQV APTDDETGKE LVLALYDYQE KSPREVTMKK GDILTLLNST 
      1010       1020       1030       1040       1050
NKDWWKVEVN DRQGFVPAAY VKKLDPAQSA SRENLLEEQG SIALRQEQID 
      1060       1070       1080       1090       1100
NQTLITKEVG SVSLRMKQVE ELYHSLLELG EKRKGMLEKS CKKFMLFREA 
      1110       1120       1130       1140       1150
NELQQWINEK EAALTNEEVG ADLEQVEVLQ KKFDDFQKDL KANESRLKDI 
      1160       1170       1180       1190       1200
NKVANDLESE GLMAEEVQAV EHQEVYGMMP RDETDSKTVS PWKSARMMVH 
      1210       1220       1230       1240       1250
TVATFNSIKE LNERWRSLQQ LAEERSQLLG SADEVQRFHR DADETKEWIE 
      1260       1270       1280       1290       1300
EKNQALNTDN YGHDLASVQA LQRNDEGFER DLAALGDKVN SLGETAQRLI 
      1310       1320       1330       1340       1350
QSHPELAEDL QEKCTELNQA WSSLGKRADQ RKEKLGDSHD LQRFLSDFRD 
      1360       1370       1380       1390       1400
LMSWINGIRG LVSSDELAKD VTGAEALLER HQEHRTEIDA RAGTFQAFEQ 
      1410       1420       1430       1440       1450
FGQQLLARGH YASPEIKEKL DILDQERTDL EKAWVQRRMM LDQCLELQLF 
      1460       1470       1480       1490       1500
HRDCEQAENW MAAREAFLNT EDKGDSLDSV EALIKKHEDF DKAINVQEEK 
      1510       1520       1530       1540       1550
IAVLQSFADQ LIAADHYAKG VIANRRNEVL DRWRRLKAQM IEKRSKLGES 
      1560       1570       1580       1590       1600
QTLQQFSRDV DEIEAWISEK LQTASDESYK DPTNIQLSKL LSKHQKHQAF 
      1610       1620       1630       1640       1650
EAELHANADR IRGVIEMGNP LIERGACAGS EDAVKARLAA LADQWEFLVQ 
      1660       1670       1680       1690       1700
KSSEKSQKLK EANKQQNFNT GIKDFDFWLS EVEALLASED YGKDLASVNN 
      1710       1720       1730       1740       1750
LLKKHQLLEA DISAHEDRLK DLNSQADSLM TSSAFDTSQV KDKRETINGR 
      1760       1770       1780       1790       1800
FQRIKSMAAA RRAKLNESHR LHQFFRDMDD EESWIKEKKL LVSSEDYGRD 
      1810       1820       1830       1840       1850
LTGVQNLRKK HKRLEAELAA HEPAIQGVLD TGKKLSDDNT IGKEEIQQRL 
      1860       1870       1880       1890       1900
AQFVDHWKEL KQLAAARGQR LEESLEYQQF VANVEEEEAW INEKMTLVAS 
      1910       1920       1930       1940       1950
EDYGDTLAAI QGLLKKHEAF ETDFTVHKDR VNDVCANGED LIKKNNHHVE 
      1960       1970       1980       1990       2000
NITAKMKGLK GKVSDLEKAA AQRKAKLDEN SAFLQFNWKA DVVESWIGEK 
      2010       2020       2030       2040       2050
ENSLKTDDYG RDLSSVQTLL TKQETFDAGL QAFQQEGIAN ITALKDQLLA 
      2060       2070       2080       2090       2100
AKHIQSKAIE VRHASLMKRW NQLLANSAAR KKKLLEAQEH FRKVEDLFLT 
      2110       2120       2130       2140       2150
FAKKASAFNS WFENAEEDLT DPVRCNSLEE IKALREAHDA FRSSLSSAQA 
      2160       2170       2180       2190       2200
DFNQLAELDR QIKSFRVASN PYTWFTMEAL EETWRNLQKI IKERELELQK 
      2210       2220       2230       2240       2250
EQRRQEENDK LRQEFAQHAN AFHQWIQETR TYLLDGSCMV EESGTLESQL 
      2260       2270       2280       2290       2300
EATKRKHQEI RAMRSQLKKI EDLGAAMEEA LILDNKYTEH STVGLAQQWD 
      2310       2320       2330       2340       2350
QLDQLGMRMQ HNLEQQIQAR NTTGVTEEAL KEFSMMFKHF DKDKSGRLNH 
      2360       2370       2380       2390       2400
QEFKSCLRSL GYDLPMVEEG EPDPEFESIL DTVDPNRDGH VSLQEYMAFM 
      2410       2420       2430       2440       2450
ISRETENVKS SEEIESAFRA LSSERKPYVT KEELYQNLTR EQADYCISHM 
      2460       2470 
KPYMDGKGRE LPSAYDYIEF TRSLFVN
Length:2,477
Mass (Da):285,363
Last modified:August 1, 1991 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAD4C876994E6AB39
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X14518 Genomic DNA Translation: CAA32662.1
X14519 mRNA Translation: CAA32663.1 Sequence problems.
X02593 mRNA Translation: CAB51571.1 Sequence problems.

Protein sequence database of the Protein Information Resource

More...PIRi		A30122 SJCHA

NCBI Reference Sequences

More...RefSeqi		NP_001036003.1, NM_001042538.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		374234

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		gga:374234

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14518 Genomic DNA Translation: CAA32662.1
X14519 mRNA Translation: CAA32663.1 Sequence problems.
X02593 mRNA Translation: CAB51571.1 Sequence problems.
PIRiA30122 SJCHA
RefSeqiNP_001036003.1, NM_001042538.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AEYNMR-A965-1025[»]
1AJ3NMR-A1763-1872[»]
1BK2X-ray2.01A969-1025[»]
1CUNX-ray2.00A/B/C1770-1982[»]
1E6GX-ray2.30A965-1025[»]
1E6HX-ray2.01A965-1025[»]
1E7OX-ray3.20A965-1025[»]
1G2BX-ray1.12A967-1025[»]
1H8KX-ray2.70A965-1025[»]
1HD3X-ray1.98A965-1025[»]
1M8MNMR-A965-1025[»]
1NEGX-ray2.30A965-1024[»]
1PWTX-ray1.77A967-1025[»]
1QKWX-ray2.00A964-1025[»]
1QKXX-ray1.80A964-1025[»]
1SHGX-ray1.80A965-1025[»]
1TUCX-ray2.02A983-1026[»]
A1030-1090[»]
1TUDX-ray1.77A964-1010[»]
1U06X-ray1.49A965-1025[»]
1U4QX-ray2.50A/B1662-1982[»]
1U5PX-ray2.00A1662-1876[»]
1UUEX-ray2.60A965-1025[»]
2CDTX-ray2.54A965-1025[»]
2F2VX-ray1.85A965-1025[»]
2F2WX-ray1.70A965-1025[»]
2F2XX-ray1.60A965-1025[»]
2JM8NMR-A965-1025[»]
2JM9NMR-A965-1025[»]
2JMANMR-A965-1025[»]
2JMCNMR-A983-1025[»]
2KR3NMR-A965-1025[»]
2KXDNMR-A967-1025[»]
2LJ3NMR-A965-1025[»]
2NUZX-ray1.85A965-1025[»]
2OAWX-ray1.90A/B/C/D969-1025[»]
2RMONMR-A965-1025[»]
2ROTNMR-A965-1025[»]
3I9QX-ray1.45A969-1025[»]
3M0PX-ray2.60A965-1025[»]
3M0QX-ray1.75A965-1025[»]
3M0RX-ray1.10A965-1025[»]
3M0SX-ray1.60A969-1025[»]
3M0TX-ray1.70A965-1025[»]
3M0UX-ray1.10A965-1025[»]
3NGPX-ray1.08A965-1025[»]
4F16X-ray1.93A965-1025[»]
4F17X-ray1.55A965-1025[»]
5IHIX-ray1.45A965-1025[»]
5IHKX-ray1.35A965-1025[»]
5IHNX-ray1.50A965-1025[»]
5M6Selectron microscopy4.80A1764-1872[»]
SMRiP07751
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

MINTiP07751
STRINGi9031.ENSGALP00000038979

Proteomic databases

PaxDbiP07751
PRIDEiP07751

Genome annotation databases

GeneIDi374234
KEGGigga:374234

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6709

Phylogenomic databases

eggNOGiKOG0035 Eukaryota
COG5069 LUCA
InParanoidiP07751
KOiK06114
OrthoDBi543832at2759
PhylomeDBiP07751

Miscellaneous databases

EvolutionaryTraceiP07751

Protein Ontology

More...PROi		PR:P07751

Family and domain databases

CDDicd00051 EFh, 1 hit
cd11808 SH3_Alpha_Spectrin, 1 hit
InterProiView protein in InterPro
IPR035825 Alpha_Spectrin_SH3
IPR011992 EF-hand-dom_pair
IPR014837 EF-hand_Ca_insen
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF08726 EFhand_Ca_insen, 1 hit
PF00018 SH3_1, 1 hit
PF00435 Spectrin, 20 hits
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SM00326 SH3, 1 hit
SM00150 SPEC, 20 hits
SUPFAMiSSF47473 SSF47473, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 3 hits
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPTN1_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07751
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1991
Last modified: February 26, 2020
This is version 166 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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