UniProtKB - P07751 (SPTN1_CHICK)
Protein
Spectrin alpha chain, non-erythrocytic 1
Gene
SPTAN1
Organism
Gallus gallus (Chicken)
Status
Functioni
Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 2341 – 2352 | 1PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 2384 – 2395 | 2PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- calcium ion binding Source: InterPro
- calmodulin binding Source: UniProtKB-KW
GO - Biological processi
- actin filament capping Source: UniProtKB-KW
Keywordsi
Molecular function | Actin capping, Actin-binding, Calmodulin-binding |
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Spectrin alpha chain, non-erythrocytic 1Alternative name(s): Alpha-II spectrin Fodrin alpha chain |
Gene namesi | Name:SPTAN1 Synonyms:SPTA2 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Cytoskeleton
Other locations
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Other locations
- cell cortex Source: UniProtKB-SubCell
- costamere Source: AgBase
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000073454 | 1 – 2477 | Spectrin alpha chain, non-erythrocytic 1Add BLAST | 2477 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1176 | PhosphotyrosineBy similarity | 1 |
Post-translational modificationi
Phosphorylation of Tyr-1176 decreases sensitivity to cleavage by calpain in vitro.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 1176 – 1177 | Cleavage; by mu-calpainBy similarity | 2 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P07751 |
PRIDEi | P07751 |
Interactioni
Subunit structurei
Like erythrocyte spectrin, the spectrin-like proteins are capable of forming dimers which can further associate to tetramers.
Interacts with ACP1 (By similarity).
By similarityGO - Molecular functioni
- actin binding Source: UniProtKB-KW
- calmodulin binding Source: UniProtKB-KW
Protein-protein interaction databases
MINTi | P07751 |
STRINGi | 9031.ENSGALP00000038979 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P07751 |
SASBDBi | P07751 |
SMRi | P07751 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P07751 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 45 – 146 | Spectrin 1Sequence analysisAdd BLAST | 102 | |
Repeati | 150 – 251 | Spectrin 2Sequence analysisAdd BLAST | 102 | |
Repeati | 256 – 358 | Spectrin 3Sequence analysisAdd BLAST | 103 | |
Repeati | 361 – 465 | Spectrin 4Sequence analysisAdd BLAST | 105 | |
Repeati | 468 – 570 | Spectrin 5Sequence analysisAdd BLAST | 103 | |
Repeati | 574 – 676 | Spectrin 6Sequence analysisAdd BLAST | 103 | |
Repeati | 679 – 781 | Spectrin 7Sequence analysisAdd BLAST | 103 | |
Repeati | 785 – 888 | Spectrin 8Sequence analysisAdd BLAST | 104 | |
Repeati | 891 – 969 | Spectrin 9Sequence analysisAdd BLAST | 79 | |
Domaini | 967 – 1026 | SH3PROSITE-ProRule annotationAdd BLAST | 60 | |
Repeati | 1096 – 1162 | Spectrin 10Sequence analysisAdd BLAST | 67 | |
Repeati | 1234 – 1336 | Spectrin 11Sequence analysisAdd BLAST | 103 | |
Repeati | 1339 – 1442 | Spectrin 12Sequence analysisAdd BLAST | 104 | |
Repeati | 1446 – 1549 | Spectrin 13Sequence analysisAdd BLAST | 104 | |
Repeati | 1552 – 1661 | Spectrin 14Sequence analysisAdd BLAST | 110 | |
Repeati | 1664 – 1767 | Spectrin 15Sequence analysis1 PublicationAdd BLAST | 104 | |
Repeati | 1769 – 1873 | Spectrin 16Sequence analysis3 PublicationsAdd BLAST | 105 | |
Repeati | 1876 – 1979 | Spectrin 17Sequence analysisAdd BLAST | 104 | |
Repeati | 1983 – 2086 | Spectrin 18Sequence analysisAdd BLAST | 104 | |
Repeati | 2097 – 2199 | Spectrin 19Sequence analysisAdd BLAST | 103 | |
Repeati | 2211 – 2315 | Spectrin 20Sequence analysisAdd BLAST | 105 | |
Domaini | 2328 – 2363 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 2371 – 2406 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 2409 – 2444 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 36 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 14 | N-terminal domainAdd BLAST | 14 | |
Regioni | 2257 – 2477 | C-terminal domainAdd BLAST | 221 |
Sequence similaritiesi
Belongs to the spectrin family.Curated
Keywords - Domaini
Repeat, SH3 domainPhylogenomic databases
eggNOGi | KOG0040, Eukaryota |
InParanoidi | P07751 |
OrthoDBi | 543832at2759 |
PhylomeDBi | P07751 |
Family and domain databases
CDDi | cd00051, EFh, 1 hit cd11808, SH3_Alpha_Spectrin, 1 hit |
InterProi | View protein in InterPro IPR035825, Alpha_Spectrin_SH3 IPR011992, EF-hand-dom_pair IPR014837, EF-hand_Ca_insen IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR018159, Spectrin/alpha-actinin IPR002017, Spectrin_repeat |
Pfami | View protein in Pfam PF13499, EF-hand_7, 1 hit PF08726, EFhand_Ca_insen, 1 hit PF00018, SH3_1, 1 hit PF00435, Spectrin, 20 hits |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00054, EFh, 2 hits SM00326, SH3, 1 hit SM00150, SPEC, 20 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 3 hits PS50002, SH3, 1 hit |
i Sequence
Sequence statusi: Complete.
P07751-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDPSGVKVLE TAEDIQERRQ QVLDRYHRFK ELSSLRRQKL EDSYRFQFFQ
60 70 80 90 100
RDADELGKWI QEKLQIASDE NYKDPSNLQG KLQKHQAFEA EVQANSGAIV
110 120 130 140 150
KLDETGNQMI NEGHFASETI RTRLQELHRL WELLLEKMRE KGVKLLQAQK
160 170 180 190 200
LVQFLRECED VMDWINDKEA IVTSEELGQD LEHVEVLQKK FEEFQTDLAA
210 220 230 240 250
HEERVNEVNQ FAGKLIQEQH PEEELIKSKQ DEVNASWQRL KGLAQQRQGK
260 270 280 290 300
LFGAAEVQRF NRDVDETISW IKEKGQLMAS DDFGRDLASV QALLRKHEGL
310 320 330 340 350
ERDLAAFHHK VKALCAEADR LQQSHPINAS QIQVKREELI ANWEQIRTLA
360 370 380 390 400
AERHARLNDS YRLQRFLADF RDLTSWVTEM KALINADELA NDVAGAEALL
410 420 430 440 450
DRHQEHKGEI DAHEDSFRSA DESGQALLAA GHYASDEVKE KLTILSDERS
460 470 480 490 500
ALLELWELRR QQYEQCMDLQ LFYRDTEQVD NWMSKQEAFL LNEDLGDSLD
510 520 530 540 550
SVEALLKKHE DFEKSLSAQE EKITALDEFA TKLIQNNHYA MDDVATRRDA
560 570 580 590 600
LLSRRNALHE RAMKRRAQLA DSFHLQQFFR DSDELKSWVN EKMKTATDEA
610 620 630 640 650
YKDPSNLQGK VQKHQAFEAE LSANQSRIDA LEKAGQKLID VNHYASDEVA
660 670 680 690 700
ARMNEVISLW KKLLEATELK GIKLREANQQ QQFNRNVEDI ELWLYEVEGH
710 720 730 740 750
LASDDYGKDL TSVQNLQKKH ALLEADVAAH QDPIDGITIQ ARQFQDAGHF
760 770 780 790 800
DADNIKKKQE ALVARYEALK DPMVARKQKL ADSLRLQQLF RDIEDEETWI
810 820 830 840 850
REKEPIAAST NRGKDLIGVQ NLLKKHQALQ AEIAGHEPRI KAVTQKGNAM
860 870 880 890 900
VEEGHFAAED VKIKLNELNQ KWDSLKAKAS QRRQDLEDSL QAQQYFADAN
910 920 930 940 950
EAQSWMREKE PIVGSTDYGK DEDSAEALLK KHEALMSDLS AYGSSIQALR
960 970 980 990 1000
EQAQSCRQQV APTDDETGKE LVLALYDYQE KSPREVTMKK GDILTLLNST
1010 1020 1030 1040 1050
NKDWWKVEVN DRQGFVPAAY VKKLDPAQSA SRENLLEEQG SIALRQEQID
1060 1070 1080 1090 1100
NQTLITKEVG SVSLRMKQVE ELYHSLLELG EKRKGMLEKS CKKFMLFREA
1110 1120 1130 1140 1150
NELQQWINEK EAALTNEEVG ADLEQVEVLQ KKFDDFQKDL KANESRLKDI
1160 1170 1180 1190 1200
NKVANDLESE GLMAEEVQAV EHQEVYGMMP RDETDSKTVS PWKSARMMVH
1210 1220 1230 1240 1250
TVATFNSIKE LNERWRSLQQ LAEERSQLLG SADEVQRFHR DADETKEWIE
1260 1270 1280 1290 1300
EKNQALNTDN YGHDLASVQA LQRNDEGFER DLAALGDKVN SLGETAQRLI
1310 1320 1330 1340 1350
QSHPELAEDL QEKCTELNQA WSSLGKRADQ RKEKLGDSHD LQRFLSDFRD
1360 1370 1380 1390 1400
LMSWINGIRG LVSSDELAKD VTGAEALLER HQEHRTEIDA RAGTFQAFEQ
1410 1420 1430 1440 1450
FGQQLLARGH YASPEIKEKL DILDQERTDL EKAWVQRRMM LDQCLELQLF
1460 1470 1480 1490 1500
HRDCEQAENW MAAREAFLNT EDKGDSLDSV EALIKKHEDF DKAINVQEEK
1510 1520 1530 1540 1550
IAVLQSFADQ LIAADHYAKG VIANRRNEVL DRWRRLKAQM IEKRSKLGES
1560 1570 1580 1590 1600
QTLQQFSRDV DEIEAWISEK LQTASDESYK DPTNIQLSKL LSKHQKHQAF
1610 1620 1630 1640 1650
EAELHANADR IRGVIEMGNP LIERGACAGS EDAVKARLAA LADQWEFLVQ
1660 1670 1680 1690 1700
KSSEKSQKLK EANKQQNFNT GIKDFDFWLS EVEALLASED YGKDLASVNN
1710 1720 1730 1740 1750
LLKKHQLLEA DISAHEDRLK DLNSQADSLM TSSAFDTSQV KDKRETINGR
1760 1770 1780 1790 1800
FQRIKSMAAA RRAKLNESHR LHQFFRDMDD EESWIKEKKL LVSSEDYGRD
1810 1820 1830 1840 1850
LTGVQNLRKK HKRLEAELAA HEPAIQGVLD TGKKLSDDNT IGKEEIQQRL
1860 1870 1880 1890 1900
AQFVDHWKEL KQLAAARGQR LEESLEYQQF VANVEEEEAW INEKMTLVAS
1910 1920 1930 1940 1950
EDYGDTLAAI QGLLKKHEAF ETDFTVHKDR VNDVCANGED LIKKNNHHVE
1960 1970 1980 1990 2000
NITAKMKGLK GKVSDLEKAA AQRKAKLDEN SAFLQFNWKA DVVESWIGEK
2010 2020 2030 2040 2050
ENSLKTDDYG RDLSSVQTLL TKQETFDAGL QAFQQEGIAN ITALKDQLLA
2060 2070 2080 2090 2100
AKHIQSKAIE VRHASLMKRW NQLLANSAAR KKKLLEAQEH FRKVEDLFLT
2110 2120 2130 2140 2150
FAKKASAFNS WFENAEEDLT DPVRCNSLEE IKALREAHDA FRSSLSSAQA
2160 2170 2180 2190 2200
DFNQLAELDR QIKSFRVASN PYTWFTMEAL EETWRNLQKI IKERELELQK
2210 2220 2230 2240 2250
EQRRQEENDK LRQEFAQHAN AFHQWIQETR TYLLDGSCMV EESGTLESQL
2260 2270 2280 2290 2300
EATKRKHQEI RAMRSQLKKI EDLGAAMEEA LILDNKYTEH STVGLAQQWD
2310 2320 2330 2340 2350
QLDQLGMRMQ HNLEQQIQAR NTTGVTEEAL KEFSMMFKHF DKDKSGRLNH
2360 2370 2380 2390 2400
QEFKSCLRSL GYDLPMVEEG EPDPEFESIL DTVDPNRDGH VSLQEYMAFM
2410 2420 2430 2440 2450
ISRETENVKS SEEIESAFRA LSSERKPYVT KEELYQNLTR EQADYCISHM
2460 2470
KPYMDGKGRE LPSAYDYIEF TRSLFVN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14518 Genomic DNA Translation: CAA32662.1 X14519 mRNA Translation: CAA32663.1 Sequence problems. X02593 mRNA Translation: CAB51571.1 Sequence problems. |
PIRi | A30122, SJCHA |
RefSeqi | NP_001036003.1, NM_001042538.1 |
Genome annotation databases
GeneIDi | 374234 |
KEGGi | gga:374234 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14518 Genomic DNA Translation: CAA32662.1 X14519 mRNA Translation: CAA32663.1 Sequence problems. X02593 mRNA Translation: CAB51571.1 Sequence problems. |
PIRi | A30122, SJCHA |
RefSeqi | NP_001036003.1, NM_001042538.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AEY | NMR | - | A | 965-1025 | [»] | |
1AJ3 | NMR | - | A | 1763-1872 | [»] | |
1BK2 | X-ray | 2.01 | A | 969-1025 | [»] | |
1CUN | X-ray | 2.00 | A/B/C | 1770-1982 | [»] | |
1E6G | X-ray | 2.30 | A | 965-1025 | [»] | |
1E6H | X-ray | 2.01 | A | 965-1025 | [»] | |
1E7O | X-ray | 3.20 | A | 965-1025 | [»] | |
1G2B | X-ray | 1.12 | A | 967-1025 | [»] | |
1H8K | X-ray | 2.70 | A | 965-1025 | [»] | |
1HD3 | X-ray | 1.98 | A | 965-1025 | [»] | |
1M8M | NMR | - | A | 965-1025 | [»] | |
1NEG | X-ray | 2.30 | A | 965-1024 | [»] | |
1PWT | X-ray | 1.77 | A | 967-1025 | [»] | |
1QKW | X-ray | 2.00 | A | 964-1025 | [»] | |
1QKX | X-ray | 1.80 | A | 964-1025 | [»] | |
1SHG | X-ray | 1.80 | A | 965-1025 | [»] | |
1TUC | X-ray | 2.02 | A | 983-1026 | [»] | |
A | 1030-1090 | [»] | ||||
1TUD | X-ray | 1.77 | A | 964-1010 | [»] | |
1U06 | X-ray | 1.49 | A | 965-1025 | [»] | |
1U4Q | X-ray | 2.50 | A/B | 1662-1982 | [»] | |
1U5P | X-ray | 2.00 | A | 1662-1876 | [»] | |
1UUE | X-ray | 2.60 | A | 965-1025 | [»] | |
2CDT | X-ray | 2.54 | A | 965-1025 | [»] | |
2F2V | X-ray | 1.85 | A | 965-1025 | [»] | |
2F2W | X-ray | 1.70 | A | 965-1025 | [»] | |
2F2X | X-ray | 1.60 | A | 965-1025 | [»] | |
2JM8 | NMR | - | A | 965-1025 | [»] | |
2JM9 | NMR | - | A | 965-1025 | [»] | |
2JMA | NMR | - | A | 965-1025 | [»] | |
2JMC | NMR | - | A | 983-1025 | [»] | |
2KR3 | NMR | - | A | 965-1025 | [»] | |
2KXD | NMR | - | A | 967-1025 | [»] | |
2LJ3 | NMR | - | A | 965-1025 | [»] | |
2NUZ | X-ray | 1.85 | A | 965-1025 | [»] | |
2OAW | X-ray | 1.90 | A/B/C/D | 969-1025 | [»] | |
2RMO | NMR | - | A | 965-1025 | [»] | |
2ROT | NMR | - | A | 965-1025 | [»] | |
3I9Q | X-ray | 1.45 | A | 969-1025 | [»] | |
3M0P | X-ray | 2.60 | A | 965-1025 | [»] | |
3M0Q | X-ray | 1.75 | A | 965-1025 | [»] | |
3M0R | X-ray | 1.10 | A | 965-1025 | [»] | |
3M0S | X-ray | 1.60 | A | 969-1025 | [»] | |
3M0T | X-ray | 1.70 | A | 965-1025 | [»] | |
3M0U | X-ray | 1.10 | A | 965-1025 | [»] | |
3NGP | X-ray | 1.08 | A | 965-1025 | [»] | |
4F16 | X-ray | 1.93 | A | 965-1025 | [»] | |
4F17 | X-ray | 1.55 | A | 965-1025 | [»] | |
5IHI | X-ray | 1.45 | A | 965-1025 | [»] | |
5IHK | X-ray | 1.35 | A | 965-1025 | [»] | |
5IHN | X-ray | 1.50 | A | 965-1025 | [»] | |
5M6S | electron microscopy | 4.80 | A | 1764-1872 | [»] | |
BMRBi | P07751 | |||||
SASBDBi | P07751 | |||||
SMRi | P07751 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
MINTi | P07751 |
STRINGi | 9031.ENSGALP00000038979 |
Proteomic databases
PaxDbi | P07751 |
PRIDEi | P07751 |
Genome annotation databases
GeneIDi | 374234 |
KEGGi | gga:374234 |
Organism-specific databases
CTDi | 6709 |
Phylogenomic databases
eggNOGi | KOG0040, Eukaryota |
InParanoidi | P07751 |
OrthoDBi | 543832at2759 |
PhylomeDBi | P07751 |
Miscellaneous databases
EvolutionaryTracei | P07751 |
PROi | PR:P07751 |
Family and domain databases
CDDi | cd00051, EFh, 1 hit cd11808, SH3_Alpha_Spectrin, 1 hit |
InterProi | View protein in InterPro IPR035825, Alpha_Spectrin_SH3 IPR011992, EF-hand-dom_pair IPR014837, EF-hand_Ca_insen IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR018159, Spectrin/alpha-actinin IPR002017, Spectrin_repeat |
Pfami | View protein in Pfam PF13499, EF-hand_7, 1 hit PF08726, EFhand_Ca_insen, 1 hit PF00018, SH3_1, 1 hit PF00435, Spectrin, 20 hits |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00054, EFh, 2 hits SM00326, SH3, 1 hit SM00150, SPEC, 20 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 3 hits PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SPTN1_CHICK | |
Accessioni | P07751Primary (citable) accession number: P07751 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | August 1, 1991 | |
Last modified: | April 7, 2021 | |
This is version 171 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families