UniProtKB - P07750 (IL4_MOUSE)
Interleukin-4
Il4
Functioni
Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3083412).
It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells (PubMed:3498301).
It enhances both secretion and cell surface expression of IgE and IgG1 (PubMed:3498301).
It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (PubMed:25847241).
Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4 (PubMed:26416964).
4 PublicationsGO - Molecular functioni
- cytokine activity Source: MGI
- growth factor activity Source: UniProtKB-KW
- interleukin-4 receptor binding Source: InterPro
GO - Biological processi
- activation of Janus kinase activity Source: MGI
- autophagy Source: UniProtKB-KW
- B cell activation Source: UniProtKB-KW
- B cell costimulation Source: MGI
- cholesterol metabolic process Source: UniProtKB
- defense response to protozoan Source: MGI
- dendritic cell differentiation Source: MGI
- extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
- innate immune response in mucosa Source: BHF-UCL
- macrophage activation Source: MGI
- microglial cell activation Source: MGI
- myeloid dendritic cell differentiation Source: MGI
- negative regulation of acute inflammatory response Source: MGI
- negative regulation of cellular response to transforming growth factor beta stimulus Source: MGI
- negative regulation of chronic inflammatory response Source: MGI
- negative regulation of complement-dependent cytotoxicity Source: MGI
- negative regulation of endothelial cell apoptotic process Source: MGI
- negative regulation of epithelial cell migration Source: MGI
- negative regulation of extrinsic apoptotic signaling pathway Source: MGI
- negative regulation of inflammatory response Source: MGI
- negative regulation of macrophage activation Source: MGI
- negative regulation of nitric oxide biosynthetic process Source: MGI
- negative regulation of osteoclast differentiation Source: MGI
- negative regulation of T cell activation Source: MGI
- negative regulation of T-helper 17 cell differentiation Source: MGI
- negative regulation of transcription, DNA-templated Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- negative regulation of tumor necrosis factor production Source: ARUK-UCL
- negative regulation of white fat cell proliferation Source: CACAO
- neuroinflammatory response Source: MGI
- positive regulation of activated T cell proliferation Source: MGI
- positive regulation of amyloid-beta clearance Source: ARUK-UCL
- positive regulation of ATP biosynthetic process Source: ARUK-UCL
- positive regulation of B cell activation Source: MGI
- positive regulation of B cell proliferation Source: MGI
- positive regulation of cell migration Source: MGI
- positive regulation of cell population proliferation Source: MGI
- positive regulation of cellular respiration Source: ARUK-UCL
- positive regulation of chemokine production Source: BHF-UCL
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of defense response to virus by host Source: MGI
- positive regulation of DNA-binding transcription factor activity Source: BHF-UCL
- positive regulation of eosinophil chemotaxis Source: MGI
- positive regulation of gene expression Source: ARUK-UCL
- positive regulation of immunoglobulin production Source: MGI
- positive regulation of interleukin-10 production Source: MGI
- positive regulation of interleukin-13 production Source: MGI
- positive regulation of isotype switching to IgE isotypes Source: MGI
- positive regulation of isotype switching to IgG isotypes Source: MGI
- positive regulation of macroautophagy Source: UniProtKB
- positive regulation of mast cell degranulation Source: MGI
- positive regulation of MHC class II biosynthetic process Source: MGI
- positive regulation of mononuclear cell migration Source: MGI
- positive regulation of myoblast fusion Source: MGI
- positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
- positive regulation of protein phosphorylation Source: MGI
- positive regulation of reactive oxygen species biosynthetic process Source: MGI
- positive regulation of receptor-mediated endocytosis Source: ARUK-UCL
- positive regulation of T cell differentiation Source: MGI
- positive regulation of T cell proliferation Source: MGI
- positive regulation of T-helper 2 cell cytokine production Source: MGI
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of tyrosine phosphorylation of STAT protein Source: MGI
- regulation of immune response Source: MGI
- regulation of inflammatory response Source: MGI
- regulation of proton transport Source: MGI
- T cell activation Source: MGI
- T-helper 1 cell lineage commitment Source: MGI
- T-helper 2 cell differentiation Source: MGI
Keywordsi
Molecular function | Cytokine, Growth factor |
Biological process | Autophagy, B-cell activation |
Enzyme and pathway databases
Reactomei | R-MMU-6785807, Interleukin-4 and Interleukin-13 signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-4Short name: IL-4 Alternative name(s): B-cell IgG differentiation factor B-cell growth factor 1 B-cell stimulatory factor 1 Short name: BSF-1 IGG1 induction factor Lymphocyte stimulatory factor 1 |
Gene namesi | Name:Il4 Synonyms:Il-4 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96556, Il4 |
VEuPathDBi | HostDB:ENSMUSG00000000869 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: MGI
Plasma Membrane
- external side of plasma membrane Source: MGI
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Add BLAST | 20 | |
ChainiPRO_0000015538 | 21 – 140 | Interleukin-4Add BLAST | 120 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 25 ↔ 107 | 1 Publication | ||
Disulfide bondi | 47 ↔ 87 | 1 Publication | ||
Glycosylationi | 61 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 69 ↔ 114 | 1 Publication | ||
Glycosylationi | 91 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 117 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P07750 |
PRIDEi | P07750 |
PTM databases
GlyGeni | P07750, 3 sites |
PhosphoSitePlusi | P07750 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000000869, Expressed in midbrain and 85 other tissues |
ExpressionAtlasi | P07750, baseline and differential |
Genevisiblei | P07750, MM |
Interactioni
GO - Molecular functioni
- cytokine activity Source: MGI
- growth factor activity Source: UniProtKB-KW
- interleukin-4 receptor binding Source: InterPro
Protein-protein interaction databases
IntActi | P07750, 1 interactor |
STRINGi | 10090.ENSMUSP00000000889 |
Miscellaneous databases
RNActi | P07750, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3886, Eukaryota |
GeneTreei | ENSGT00390000013108 |
HOGENOMi | CLU_154691_0_0_1 |
InParanoidi | P07750 |
OMAi | SCMELTV |
OrthoDBi | 1495672at2759 |
PhylomeDBi | P07750 |
TreeFami | TF336383 |
Family and domain databases
Gene3Di | 1.20.1250.10, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR002354, IL-4 IPR001325, IL-4/IL-13 IPR018096, IL-4/IL-13_CS |
PANTHERi | PTHR47401, PTHR47401, 1 hit |
Pfami | View protein in Pfam PF00727, IL4, 1 hit |
PIRSFi | PIRSF001941, Interleukin_4, 1 hit |
PRINTSi | PR00431, INTERLEUKIN4 |
SMARTi | View protein in SMART SM00190, IL4_13, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00838, INTERLEUKIN_4_13, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MGLNPQLVVI LLFFLECTRS HIHGCDKNHL REIIGILNEV TGEGTPCTEM
60 70 80 90 100
DVPNVLTATK NTTESELVCR ASKVLRIFYL KHGKTPCLKK NSSVLMELQR
110 120 130 140
LFRAFRCLDS SISCTMNESK STSLKDFLES LKSIMQMDYS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3UXB0 | G3UXB0_MOUSE | Interleukin-4 | Il4 | 45 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X03532 mRNA Translation: CAA27233.1 X05064 Genomic DNA Translation: CAA28731.1 X05252 Genomic DNA Translation: CAA28873.1 Sequence problems. X05253 Genomic DNA Translation: CAA28874.1 Sequence problems. M13238 mRNA Translation: AAA39307.1 M25892 mRNA Translation: AAA39298.1 BC027514 mRNA Translation: AAH27514.1 |
CCDSi | CCDS24682.1 |
PIRi | A25870, IIMSG1 |
RefSeqi | NP_067258.1, NM_021283.2 |
Genome annotation databases
Ensembli | ENSMUST00000000889; ENSMUSP00000000889; ENSMUSG00000000869 |
GeneIDi | 16189 |
KEGGi | mmu:16189 |
UCSCi | uc007iwq.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X03532 mRNA Translation: CAA27233.1 X05064 Genomic DNA Translation: CAA28731.1 X05252 Genomic DNA Translation: CAA28873.1 Sequence problems. X05253 Genomic DNA Translation: CAA28874.1 Sequence problems. M13238 mRNA Translation: AAA39307.1 M25892 mRNA Translation: AAA39298.1 BC027514 mRNA Translation: AAH27514.1 |
CCDSi | CCDS24682.1 |
PIRi | A25870, IIMSG1 |
RefSeqi | NP_067258.1, NM_021283.2 |
3D structure databases
AlphaFoldDBi | P07750 |
SMRi | P07750 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P07750, 1 interactor |
STRINGi | 10090.ENSMUSP00000000889 |
PTM databases
GlyGeni | P07750, 3 sites |
PhosphoSitePlusi | P07750 |
Proteomic databases
PaxDbi | P07750 |
PRIDEi | P07750 |
Protocols and materials databases
ABCDi | P07750, 2 sequenced antibodies |
Antibodypediai | 14502, 1821 antibodies from 47 providers |
DNASUi | 16189 |
Genome annotation databases
Ensembli | ENSMUST00000000889; ENSMUSP00000000889; ENSMUSG00000000869 |
GeneIDi | 16189 |
KEGGi | mmu:16189 |
UCSCi | uc007iwq.2, mouse |
Organism-specific databases
CTDi | 3565 |
MGIi | MGI:96556, Il4 |
VEuPathDBi | HostDB:ENSMUSG00000000869 |
Phylogenomic databases
eggNOGi | KOG3886, Eukaryota |
GeneTreei | ENSGT00390000013108 |
HOGENOMi | CLU_154691_0_0_1 |
InParanoidi | P07750 |
OMAi | SCMELTV |
OrthoDBi | 1495672at2759 |
PhylomeDBi | P07750 |
TreeFami | TF336383 |
Enzyme and pathway databases
Reactomei | R-MMU-6785807, Interleukin-4 and Interleukin-13 signaling |
Miscellaneous databases
BioGRID-ORCSi | 16189, 0 hits in 108 CRISPR screens |
ChiTaRSi | Il4, mouse |
PROi | PR:P07750 |
RNActi | P07750, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000000869, Expressed in midbrain and 85 other tissues |
ExpressionAtlasi | P07750, baseline and differential |
Genevisiblei | P07750, MM |
Family and domain databases
Gene3Di | 1.20.1250.10, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR002354, IL-4 IPR001325, IL-4/IL-13 IPR018096, IL-4/IL-13_CS |
PANTHERi | PTHR47401, PTHR47401, 1 hit |
Pfami | View protein in Pfam PF00727, IL4, 1 hit |
PIRSFi | PIRSF001941, Interleukin_4, 1 hit |
PRINTSi | PR00431, INTERLEUKIN4 |
SMARTi | View protein in SMART SM00190, IL4_13, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00838, INTERLEUKIN_4_13, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | IL4_MOUSE | |
Accessioni | P07750Primary (citable) accession number: P07750 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | August 1, 1988 | |
Last modified: | May 25, 2022 | |
This is version 181 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families