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Protein

Interleukin-4

Gene

Il4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3083412). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells (PubMed:3498301). It enhances both secretion and cell surface expression of IgE and IgG1 (PubMed:3498301). It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (PubMed:25847241). Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4 (PubMed:26416964).4 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor
Biological processAutophagy, B-cell activation

Enzyme and pathway databases

ReactomeiR-MMU-6785807 Interleukin-4 and Interleukin-13 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-4
Short name:
IL-4
Alternative name(s):
B-cell IgG differentiation factor
B-cell growth factor 1
B-cell stimulatory factor 1
Short name:
BSF-1
IGG1 induction factor
Lymphocyte stimulatory factor 1
Gene namesi
Name:Il4
Synonyms:Il-4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96556 Il4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000001553821 – 140Interleukin-4Add BLAST120

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 1071 Publication
Disulfide bondi47 ↔ 871 Publication
Glycosylationi61N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi69 ↔ 1141 Publication
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP07750
PRIDEiP07750

PTM databases

PhosphoSitePlusiP07750

Expressioni

Gene expression databases

BgeeiENSMUSG00000000869 Expressed in 34 organ(s), highest expression level in brain
CleanExiMM_IL4
ExpressionAtlasiP07750 baseline and differential
GenevisibleiP07750 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP07750, 1 interactor
STRINGi10090.ENSMUSP00000000889

Structurei

3D structure databases

ProteinModelPortaliP07750
SMRiP07750
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-4/IL-13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3886 Eukaryota
ENOG410XQ0R LUCA
GeneTreeiENSGT00390000013108
HOGENOMiHOG000254781
HOVERGENiHBG000290
InParanoidiP07750
KOiK05430
OMAiLACTSNF
OrthoDBiEOG091G0WDE
PhylomeDBiP07750
TreeFamiTF336383

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR002354 IL-4
IPR001325 IL-4/IL-13
IPR018096 IL-4/IL-13_CS
PfamiView protein in Pfam
PF00727 IL4, 1 hit
PIRSFiPIRSF001941 Interleukin_4, 1 hit
PRINTSiPR00431 INTERLEUKIN4
SMARTiView protein in SMART
SM00190 IL4_13, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00838 INTERLEUKIN_4_13, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P07750-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLNPQLVVI LLFFLECTRS HIHGCDKNHL REIIGILNEV TGEGTPCTEM
60 70 80 90 100
DVPNVLTATK NTTESELVCR ASKVLRIFYL KHGKTPCLKK NSSVLMELQR
110 120 130 140
LFRAFRCLDS SISCTMNESK STSLKDFLES LKSIMQMDYS
Length:140
Mass (Da):15,834
Last modified:August 1, 1988 - v1
Checksum:iE43CE16195DE051F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UXB0G3UXB0_MOUSE
Interleukin 4, isoform CRA_b
Il4 mCG_13773
45Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03532 mRNA Translation: CAA27233.1
X05064 Genomic DNA Translation: CAA28731.1
X05252 Genomic DNA Translation: CAA28873.1 Sequence problems.
X05253 Genomic DNA Translation: CAA28874.1 Sequence problems.
M13238 mRNA Translation: AAA39307.1
M25892 mRNA Translation: AAA39298.1
BC027514 mRNA Translation: AAH27514.1
CCDSiCCDS24682.1
PIRiA25870 IIMSG1
RefSeqiNP_067258.1, NM_021283.2
UniGeneiMm.276360

Genome annotation databases

EnsembliENSMUST00000000889; ENSMUSP00000000889; ENSMUSG00000000869
GeneIDi16189
KEGGimmu:16189
UCSCiuc007iwq.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03532 mRNA Translation: CAA27233.1
X05064 Genomic DNA Translation: CAA28731.1
X05252 Genomic DNA Translation: CAA28873.1 Sequence problems.
X05253 Genomic DNA Translation: CAA28874.1 Sequence problems.
M13238 mRNA Translation: AAA39307.1
M25892 mRNA Translation: AAA39298.1
BC027514 mRNA Translation: AAH27514.1
CCDSiCCDS24682.1
PIRiA25870 IIMSG1
RefSeqiNP_067258.1, NM_021283.2
UniGeneiMm.276360

3D structure databases

ProteinModelPortaliP07750
SMRiP07750
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP07750, 1 interactor
STRINGi10090.ENSMUSP00000000889

PTM databases

PhosphoSitePlusiP07750

Proteomic databases

PaxDbiP07750
PRIDEiP07750

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000889; ENSMUSP00000000889; ENSMUSG00000000869
GeneIDi16189
KEGGimmu:16189
UCSCiuc007iwq.2 mouse

Organism-specific databases

CTDi3565
MGIiMGI:96556 Il4

Phylogenomic databases

eggNOGiKOG3886 Eukaryota
ENOG410XQ0R LUCA
GeneTreeiENSGT00390000013108
HOGENOMiHOG000254781
HOVERGENiHBG000290
InParanoidiP07750
KOiK05430
OMAiLACTSNF
OrthoDBiEOG091G0WDE
PhylomeDBiP07750
TreeFamiTF336383

Enzyme and pathway databases

ReactomeiR-MMU-6785807 Interleukin-4 and Interleukin-13 signaling

Miscellaneous databases

PROiPR:P07750
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000869 Expressed in 34 organ(s), highest expression level in brain
CleanExiMM_IL4
ExpressionAtlasiP07750 baseline and differential
GenevisibleiP07750 MM

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR002354 IL-4
IPR001325 IL-4/IL-13
IPR018096 IL-4/IL-13_CS
PfamiView protein in Pfam
PF00727 IL4, 1 hit
PIRSFiPIRSF001941 Interleukin_4, 1 hit
PRINTSiPR00431 INTERLEUKIN4
SMARTiView protein in SMART
SM00190 IL4_13, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00838 INTERLEUKIN_4_13, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIL4_MOUSE
AccessioniPrimary (citable) accession number: P07750
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 7, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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