Il4

Functionⁱ

Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3083412). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells (PubMed:3498301). It enhances both secretion and cell surface expression of IgE and IgG1 (PubMed:3498301). It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (PubMed:25847241). Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4 (PubMed:26416964).4 Publications

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

autophagy Source: UniProtKB-KW
B cell activation
Source: MGI
Inferred from direct assayⁱ
- 16129705
- 9798653
B cell costimulation
Source: MGI
Inferred from direct assayⁱ
- 18762567
cholesterol metabolic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 11971948
defense response to protozoan
Source: MGI
Inferred from mutant phenotypeⁱ
- 7927664
dendritic cell differentiation Source: MGI
extrinsic apoptotic signaling pathway in absence of ligand
Source: MGI
Inferred from direct assayⁱ
- 12115603
innate immune response in mucosa
Source: BHF-UCL
Inferred from direct assayⁱ
- 9973465
microglial cell activation Source: MGI
myeloid dendritic cell differentiation Source: MGI
negative regulation of acute inflammatory response Source: MGI
negative regulation of chronic inflammatory response Source: MGI
negative regulation of complement-dependent cytotoxicity Source: MGI
negative regulation of endothelial cell apoptotic process Source: MGI
negative regulation of epithelial cell migration Source: MGI
negative regulation of extrinsic apoptotic signaling pathway
Source: MGI
Inferred from direct assayⁱ
- 10429671
negative regulation of macrophage activation Source: MGI
negative regulation of nitric oxide biosynthetic process Source: MGI
negative regulation of osteoclast differentiation
Source: MGI
Inferred from direct assayⁱ
- 12941478
- 17442941
negative regulation of T cell activation
Source: MGI
Inferred from direct assayⁱ
- 18997793
negative regulation of T-helper 17 cell differentiation
Source: MGI
Inferred from direct assayⁱ
- 18792410
negative regulation of transcription, DNA-templated Source: MGI
negative regulation of white fat cell proliferation
Source: CACAO
Inferred from direct assayⁱ
- 24347527
positive regulation of activated T cell proliferation
Source: MGI
Inferred from direct assayⁱ
- 10485657
- 9841920
positive regulation of B cell activation
Source: MGI
Inferred from direct assayⁱ
- 8566034
positive regulation of B cell proliferation
Source: MGI
Inferred from direct assayⁱ
- 10979977
- 14607964
positive regulation of cell proliferation Source: MGI
positive regulation of chemokine biosynthetic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 9013979
positive regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from mutant phenotypeⁱ
- 24906148
positive regulation of defense response to virus by host Source: MGI
positive regulation of DNA-binding transcription factor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 7749983
positive regulation of eosinophil chemotaxis Source: MGI
positive regulation of immunoglobulin production
Source: MGI
Inferred from mutant phenotypeⁱ
- 15944273
positive regulation of interleukin-10 production Source: MGI
positive regulation of interleukin-13 production Source: MGI
positive regulation of isotype switching to IgE isotypes
Source: MGI
Inferred from direct assayⁱ
- 14988498
positive regulation of isotype switching to IgG isotypes
Source: MGI
Inferred from direct assayⁱ
- 12882831
- 14988498
positive regulation of macroautophagy
Source: UniProtKB
Inferred from direct assayⁱ
- 26416964
positive regulation of mast cell degranulation
Source: MGI
Inferred from mutant phenotypeⁱ
- 15944273
positive regulation of MHC class II biosynthetic process
Source: MGI
Inferred from direct assayⁱ
- 10549626
- 11027433
positive regulation of mononuclear cell migration Source: MGI
positive regulation of myoblast fusion
Source: MGI
Inferred from direct assayⁱ
- 12757709
positive regulation of peptidyl-tyrosine phosphorylation
Source: MGI
Inferred from direct assayⁱ
- 8022486
positive regulation of protein phosphorylation
Source: MGI
Inferred from direct assayⁱ
- 12115603
positive regulation of reactive oxygen species biosynthetic process Source: MGI
positive regulation of T cell differentiation Source: MGI
positive regulation of T cell proliferation
Source: MGI
Inferred from direct assayⁱ
- 1588041
- 18997793
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 20696860
positive regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from direct assayⁱ
- 15187136
positive regulation of tyrosine phosphorylation of STAT protein
Source: MGI
Inferred from direct assayⁱ
- 10485657
regulation of immune response
Source: MGI
Inferred from direct assayⁱ
- 12882831
regulation of inflammatory response Source: MGI
regulation of proton transport Source: MGI
T cell activation Source: MGI
T-helper 1 cell lineage commitment
Source: MGI
Inferred from genetic interactionⁱ
- 20706986
T-helper 2 cell cytokine production Source: MGI
T-helper 2 cell differentiation
Source: MGI
Inferred from direct assayⁱ
- 20706986

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine, Growth factor
Biological process	Autophagy, B-cell activation

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6785807 Interleukin-4 and Interleukin-13 signaling

Reactomeⁱ

R-MMU-6785807 Interleukin-4 and Interleukin-13 signaling

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interleukin-4 Short name: IL-4 Alternative name(s): B-cell IgG differentiation factor B-cell growth factor 1 B-cell stimulatory factor 1 Short name: BSF-1 IGG1 induction factor Lymphocyte stimulatory factor 1
Gene namesⁱ	Name:Il4 Synonyms:Il-4
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:96556 Il4

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	Add BLAST		20
ChainⁱPRO_0000015538	21 – 140	Interleukin-4Add BLAST		120

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	25 ↔ 107	1 Publication
Disulfide bondⁱ	47 ↔ 87	1 Publication
Glycosylationⁱ	61	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	69 ↔ 114	1 Publication
Glycosylationⁱ	91	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	117	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P07750
PRIDEⁱ	P07750

PTM databases

PhosphoSitePlusⁱ	P07750

PhosphoSitePlusⁱ

P07750

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000000869 Expressed in 34 organ(s), highest expression level in brain
CleanExⁱ	MM_IL4
ExpressionAtlasⁱ	P07750 baseline and differential
Genevisibleⁱ	P07750 MM

Interactionⁱ

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	P07750, 1 interactor
STRINGⁱ	10090.ENSMUSP00000000889

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P07750
SMRⁱ	P07750
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the IL-4/IL-13 family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG3886 Eukaryota ENOG410XQ0R LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013108
HOGENOMⁱ	HOG000254781
HOVERGENⁱ	HBG000290
InParanoidⁱ	P07750
KEGG Orthology (KO) More...KOⁱ	K05430
OMAⁱ	LACTSNF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0WDE
PhylomeDBⁱ	P07750
TreeFamⁱ	TF336383

Family and domain databases

InterProⁱ	View protein in InterPro IPR009079 4_helix_cytokine-like_core IPR002354 IL-4 IPR001325 IL-4/IL-13 IPR018096 IL-4/IL-13_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00727 IL4, 1 hit
PIRSFⁱ	PIRSF001941 Interleukin_4, 1 hit
PRINTSⁱ	PR00431 INTERLEUKIN4
SMARTⁱ	View protein in SMART SM00190 IL4_13, 1 hit
SUPFAMⁱ	SSF47266 SSF47266, 1 hit
PROSITEⁱ	View protein in PROSITE PS00838 INTERLEUKIN_4_13, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P07750-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGLNPQLVVI LLFFLECTRS HIHGCDKNHL REIIGILNEV TGEGTPCTEM 
        60         70         80         90        100
DVPNVLTATK NTTESELVCR ASKVLRIFYL KHGKTPCLKK NSSVLMELQR 
       110        120        130        140
LFRAFRCLDS SISCTMNESK STSLKDFLES LKSIMQMDYS

Length:140

Mass (Da):15,834

Last modified:August 1, 1988 - v1

Checksum:ⁱE43CE16195DE051F

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	G3UXB0	G3UXB0_MOUSE		Interleukin 4, isoform CRA_b Interleukin 4, isoform CRA_b (Interleukin-4)	Il4 mCG_13773	45	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X03532 mRNA Translation: CAA27233.1 X05064 Genomic DNA Translation: CAA28731.1 X05252 Genomic DNA Translation: CAA28873.1 Sequence problems. X05253 Genomic DNA Translation: CAA28874.1 Sequence problems. M13238 mRNA Translation: AAA39307.1 M25892 mRNA Translation: AAA39298.1 BC027514 mRNA Translation: AAH27514.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS24682.1
PIRⁱ	A25870 IIMSG1
NCBI Reference Sequences More...RefSeqⁱ	NP_067258.1, NM_021283.2
UniGeneⁱ	Mm.276360

Genome annotation databases

Ensemblⁱ	ENSMUST00000000889; ENSMUSP00000000889; ENSMUSG00000000869
GeneIDⁱ	16189
KEGGⁱ	mmu:16189
UCSC genome browser More...UCSCⁱ	uc007iwq.2 mouse

Protein	Similar proteins		Species	Score	Length	Source
P07750	Interleukin-4		MOUSE		140	UniRef90_P07750
Interleukin-4		MUSMM		142
Interleukin 4, isoform CRA_b		MOUSE		45

Protein	Similar proteins		Species	Score	Length	Source
P07750	Interleukin-4		MOUSE		140	UniRef50_P07750
Interleukin-4		MUSMM		142
Interleukin 4, isoform CRA_b		MOUSE		45

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X03532 mRNA Translation: CAA27233.1 X05064 Genomic DNA Translation: CAA28731.1 X05252 Genomic DNA Translation: CAA28873.1 Sequence problems. X05253 Genomic DNA Translation: CAA28874.1 Sequence problems. M13238 mRNA Translation: AAA39307.1 M25892 mRNA Translation: AAA39298.1 BC027514 mRNA Translation: AAH27514.1
CCDSⁱ	CCDS24682.1
PIRⁱ	A25870 IIMSG1
RefSeqⁱ	NP_067258.1, NM_021283.2
UniGeneⁱ	Mm.276360

3D structure databases

ProteinModelPortalⁱ	P07750
SMRⁱ	P07750
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P07750, 1 interactor
STRINGⁱ	10090.ENSMUSP00000000889

PTM databases

PhosphoSitePlusⁱ	P07750

PhosphoSitePlusⁱ

P07750

Proteomic databases

PaxDbⁱ	P07750
PRIDEⁱ	P07750

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000000889; ENSMUSP00000000889; ENSMUSG00000000869
GeneIDⁱ	16189
KEGGⁱ	mmu:16189
UCSCⁱ	uc007iwq.2 mouse

Organism-specific databases

CTDⁱ	3565
MGIⁱ	MGI:96556 Il4

Phylogenomic databases

eggNOGⁱ	KOG3886 Eukaryota ENOG410XQ0R LUCA
GeneTreeⁱ	ENSGT00390000013108
HOGENOMⁱ	HOG000254781
HOVERGENⁱ	HBG000290
InParanoidⁱ	P07750
KOⁱ	K05430
OMAⁱ	LACTSNF
OrthoDBⁱ	EOG091G0WDE
PhylomeDBⁱ	P07750
TreeFamⁱ	TF336383

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6785807 Interleukin-4 and Interleukin-13 signaling

Reactomeⁱ

R-MMU-6785807 Interleukin-4 and Interleukin-13 signaling

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P07750
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000000869 Expressed in 34 organ(s), highest expression level in brain
CleanExⁱ	MM_IL4
ExpressionAtlasⁱ	P07750 baseline and differential
Genevisibleⁱ	P07750 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR009079 4_helix_cytokine-like_core IPR002354 IL-4 IPR001325 IL-4/IL-13 IPR018096 IL-4/IL-13_CS
Pfamⁱ	View protein in Pfam PF00727 IL4, 1 hit
PIRSFⁱ	PIRSF001941 Interleukin_4, 1 hit
PRINTSⁱ	PR00431 INTERLEUKIN4
SMARTⁱ	View protein in SMART SM00190 IL4_13, 1 hit
SUPFAMⁱ	SSF47266 SSF47266, 1 hit
PROSITEⁱ	View protein in PROSITE PS00838 INTERLEUKIN_4_13, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IL4_MOUSE
Accessionⁱ	P07750Primary (citable) accession number: P07750
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
	Last sequence update:	August 1, 1988
	Last modified:	November 7, 2018
	This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P07750 (IL4_MOUSE)

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Interleukin-4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Plasma Membrane

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ