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UniProtKB - P07737 (PROF1_HUMAN)

Entry version 223 (07 Oct 2020)
Sequence version 2 (23 Jan 2007)
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Protein

Profilin-1

Gene

PFN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P07737

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-114608, Platelet degranulation
R-HSA-376176, Signaling by ROBO receptors
R-HSA-4086400, PCP/CE pathway
R-HSA-5663220, RHO GTPases Activate Formins

SIGNOR Signaling Network Open Resource

More...SIGNORi		P07737

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Profilin-1
Alternative name(s):
Epididymis tissue protein Li 184a
Profilin I
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PFN1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000108518.7

Human Gene Nomenclature Database

More...HGNCi		HGNC:8881, PFN1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		176610, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P07737

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Amyotrophic lateral sclerosis 18 (ALS18)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06892571C → G in ALS18; the mutant protein is detected in the insoluble fraction of cells. 1 PublicationCorresponds to variant dbSNP:rs387907264EnsemblClinVar.1
Natural variantiVAR_068926114M → T in ALS18; the mutant protein is detected in the insoluble fraction of cells. 1 PublicationCorresponds to variant dbSNP:rs387907265EnsemblClinVar.1
Natural variantiVAR_068927117E → G in ALS18; unknown pathological significance; like the wild-type the mutant protein is detected in the soluble fraction of cells. 1 PublicationCorresponds to variant dbSNP:rs140547520EnsemblClinVar.1
Natural variantiVAR_068928118G → V in ALS18; the mutant protein is detected in the insoluble fraction of cells. 1 PublicationCorresponds to variant dbSNP:rs387907266EnsemblClinVar.1

Keywords - Diseasei

Amyotrophic lateral sclerosis, Disease mutation, Neurodegeneration

Organism-specific databases

DisGeNET

More...DisGeNETi		5216

MalaCards human disease database

More...MalaCardsi		PFN1
MIMi614808, phenotype

Open Targets

More...OpenTargetsi		ENSG00000108518

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		803, Amyotrophic lateral sclerosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33219

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P07737, Tbio

Protein family/group databases

Allergome; a platform for allergen knowledge

More...Allergomei		907, Hom s Profilin

Chemistry databases

Drug and drug target database

More...DrugBanki		DB07908, 7-HYDROXY-4-METHYL-3-(2-HYDROXY-ETHYL)COUMARIN
DB11638, Artenimol

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PFN1

Domain mapping of disease mutations (DMDM)

More...DMDMi		130979

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001995712 – 140Profilin-1Add BLAST139

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei28PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki54Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki54Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
Modified residuei57PhosphoserineCombined sources1
Modified residuei85PhosphoserineCombined sources1
Modified residuei105N6-acetyllysineCombined sources1
Modified residuei108N6-acetyllysineCombined sources1
Modified residuei129PhosphotyrosineCombined sources1
Modified residuei138Phosphoserine; by ROCK11 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-138 reduces its affinity for G-actin and blocks its interaction with HTT, reducing its ability to inhibit androgen receptor (AR) and HTT aggregation.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-253
CPTAC-254

Encyclopedia of Proteome Dynamics

More...EPDi		P07737

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P07737

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P07737

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P07737

PeptideAtlas

More...PeptideAtlasi		P07737

PRoteomics IDEntifications database

More...PRIDEi		P07737

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52024

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P07737

2D gel databases

DOSAC-COBS 2D-PAGE database

More...DOSAC-COBS-2DPAGEi		P07737

USC-OGP 2-DE database

More...OGPi		P07737

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00216691

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		P07737

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P07737, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P07737

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P07737

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P07737

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P07737

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in epididymis (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000108518, Expressed in granulocyte and 243 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P07737, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P07737, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000108518, Tissue enhanced (blood)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

Found in a complex with XPO6, Ran, ACTB and PFN1.

Interacts with VASP.

Interacts with HTT.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111237, 110 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P07737

Database of interacting proteins

More...DIPi		DIP-30N

Protein interaction database and analysis system

More...IntActi		P07737, 67 interactors

Molecular INTeraction database

More...MINTi		P07737

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000225655

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P07737, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1140
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P07737

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P07737

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P07737

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the profilin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1755, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153664

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_123405_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P07737

KEGG Orthology (KO)

More...KOi		K05759

Identification of Orthologs from Complete Genome Data

More...OMAi		KKCFEMA

Database of Orthologous Groups

More...OrthoDBi		1428600at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P07737

TreeFam database of animal gene trees

More...TreeFami		TF331744

Family and domain databases

Conserved Domains Database

More...CDDi		cd00148, PROF, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005455, PFN
IPR036140, PFN_sf
IPR005454, Profilin1/2/3_vertebrate
IPR027310, Profilin_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00235, Profilin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01639, PROFILINMAML

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00392, PROF, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55770, SSF55770, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00414, PROFILIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P07737-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGWNAYIDN LMADGTCQDA AIVGYKDSPS VWAAVPGKTF VNITPAEVGV 
        60         70         80         90        100
LVGKDRSSFY VNGLTLGGQK CSVIRDSLLQ DGEFSMDLRT KSTGGAPTFN 
       110        120        130        140
VTVTKTDKTL VLLMGKEGVH GGLINKKCYE MASHLRRSQY
Length:140
Mass (Da):15,054
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF725119E55A289EB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L3D5I3L3D5_HUMAN
Profilin
PFN1
165Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJ44K7EJ44_HUMAN
Profilin
PFN1 hCG_32691
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06892571C → G in ALS18; the mutant protein is detected in the insoluble fraction of cells. 1 PublicationCorresponds to variant dbSNP:rs387907264EnsemblClinVar.1
Natural variantiVAR_068926114M → T in ALS18; the mutant protein is detected in the insoluble fraction of cells. 1 PublicationCorresponds to variant dbSNP:rs387907265EnsemblClinVar.1
Natural variantiVAR_068927117E → G in ALS18; unknown pathological significance; like the wild-type the mutant protein is detected in the soluble fraction of cells. 1 PublicationCorresponds to variant dbSNP:rs140547520EnsemblClinVar.1
Natural variantiVAR_068928118G → V in ALS18; the mutant protein is detected in the insoluble fraction of cells. 1 PublicationCorresponds to variant dbSNP:rs387907266EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J03191 mRNA Translation: AAA36486.1
GU727630 mRNA Translation: ADU87632.1
BT007001 mRNA Translation: AAP35647.1
AK312168 mRNA Translation: BAG35102.1
CR407670 mRNA Translation: CAG28598.1
CH471108 Genomic DNA Translation: EAW90381.1
CH471108 Genomic DNA Translation: EAW90383.1
CH471108 Genomic DNA Translation: EAW90384.1
BC002475 mRNA Translation: AAH02475.1
BC006768 mRNA Translation: AAH06768.1
BC013439 mRNA Translation: AAH13439.1
BC015164 mRNA Translation: AAH15164.1
BC057828 mRNA Translation: AAH57828.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11061.1

Protein sequence database of the Protein Information Resource

More...PIRi		A28622

NCBI Reference Sequences

More...RefSeqi		NP_005013.1, NM_005022.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000225655; ENSP00000225655; ENSG00000108518

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5216

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5216

UCSC genome browser

More...UCSCi		uc002gaa.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03191 mRNA Translation: AAA36486.1
GU727630 mRNA Translation: ADU87632.1
BT007001 mRNA Translation: AAP35647.1
AK312168 mRNA Translation: BAG35102.1
CR407670 mRNA Translation: CAG28598.1
CH471108 Genomic DNA Translation: EAW90381.1
CH471108 Genomic DNA Translation: EAW90383.1
CH471108 Genomic DNA Translation: EAW90384.1
BC002475 mRNA Translation: AAH02475.1
BC006768 mRNA Translation: AAH06768.1
BC013439 mRNA Translation: AAH13439.1
BC015164 mRNA Translation: AAH15164.1
BC057828 mRNA Translation: AAH57828.1
CCDSiCCDS11061.1
PIRiA28622
RefSeqiNP_005013.1, NM_005022.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AWIX-ray2.20A/B3-140[»]
1CF0X-ray2.20A/B3-140[»]
1CJFX-ray2.30A/B2-140[»]
1FIKX-ray2.30A2-140[»]
1FILX-ray2.00A2-140[»]
1PFLNMR-A2-140[»]
2PAVX-ray1.80P2-140[»]
2PBDX-ray1.50P2-140[»]
3CHWX-ray2.30P2-140[»]
4X1LX-ray2.16A1-140[»]
4X1MX-ray2.17A1-140[»]
4X25X-ray2.23A/B1-140[»]
6NASX-ray2.90P1-140[»]
6NBEX-ray2.00P1-140[»]
6NBWX-ray2.50P1-140[»]
BMRBiP07737
SMRiP07737
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111237, 110 interactors
CORUMiP07737
DIPiDIP-30N
IntActiP07737, 67 interactors
MINTiP07737
STRINGi9606.ENSP00000225655

Chemistry databases

DrugBankiDB07908, 7-HYDROXY-4-METHYL-3-(2-HYDROXY-ETHYL)COUMARIN
DB11638, Artenimol

Protein family/group databases

Allergomei907, Hom s Profilin

PTM databases

GlyGeniP07737, 1 site
iPTMnetiP07737
MetOSiteiP07737
PhosphoSitePlusiP07737
SwissPalmiP07737

Polymorphism and mutation databases

BioMutaiPFN1
DMDMi130979

2D gel databases

DOSAC-COBS-2DPAGEiP07737
OGPiP07737
REPRODUCTION-2DPAGEiIPI00216691
UCD-2DPAGEiP07737

Proteomic databases

CPTACiCPTAC-253
CPTAC-254
EPDiP07737
jPOSTiP07737
MassIVEiP07737
PaxDbiP07737
PeptideAtlasiP07737
PRIDEiP07737
ProteomicsDBi52024
TopDownProteomicsiP07737

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23487, 427 antibodies

The DNASU plasmid repository

More...DNASUi		5216

Genome annotation databases

EnsembliENST00000225655; ENSP00000225655; ENSG00000108518
GeneIDi5216
KEGGihsa:5216
UCSCiuc002gaa.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5216
DisGeNETi5216
EuPathDBiHostDB:ENSG00000108518.7

GeneCards: human genes, protein and diseases

More...GeneCardsi		PFN1
HGNCiHGNC:8881, PFN1
HPAiENSG00000108518, Tissue enhanced (blood)
MalaCardsiPFN1
MIMi176610, gene
614808, phenotype
neXtProtiNX_P07737
OpenTargetsiENSG00000108518
Orphaneti803, Amyotrophic lateral sclerosis
PharmGKBiPA33219

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1755, Eukaryota
GeneTreeiENSGT00940000153664
HOGENOMiCLU_123405_1_0_1
InParanoidiP07737
KOiK05759
OMAiKKCFEMA
OrthoDBi1428600at2759
PhylomeDBiP07737
TreeFamiTF331744

Enzyme and pathway databases

PathwayCommonsiP07737
ReactomeiR-HSA-114608, Platelet degranulation
R-HSA-376176, Signaling by ROBO receptors
R-HSA-4086400, PCP/CE pathway
R-HSA-5663220, RHO GTPases Activate Formins
SIGNORiP07737

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5216, 547 hits in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PFN1, human
EvolutionaryTraceiP07737

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Profilin_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5216
PharosiP07737, Tbio

Protein Ontology

More...PROi		PR:P07737
RNActiP07737, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000108518, Expressed in granulocyte and 243 other tissues
ExpressionAtlasiP07737, baseline and differential
GenevisibleiP07737, HS

Family and domain databases

CDDicd00148, PROF, 1 hit
InterProiView protein in InterPro
IPR005455, PFN
IPR036140, PFN_sf
IPR005454, Profilin1/2/3_vertebrate
IPR027310, Profilin_CS
PfamiView protein in Pfam
PF00235, Profilin, 1 hit
PRINTSiPR01639, PROFILINMAML
SMARTiView protein in SMART
SM00392, PROF, 1 hit
SUPFAMiSSF55770, SSF55770, 1 hit
PROSITEiView protein in PROSITE
PS00414, PROFILIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPROF1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07737
Secondary accession number(s): Q53Y44
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: October 7, 2020
This is version 223 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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