PFN1

Functionⁱ

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.1 Publication

GO - Molecular functionⁱ

actin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17914456
- 7758455
actin monomer binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18573880
adenyl-nucleotide exchange factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 7758455
cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
phosphatidylinositol-4,5-bisphosphate binding
Source: UniProtKB
Inferred from direct assayⁱ
- 7758455
proline-rich region binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17914456
Rho GTPase binding Source: Ensembl
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22681889

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin cytoskeleton organization Source: InterPro
modification of postsynaptic actin cytoskeleton Source: Ensembl
negative regulation of actin filament bundle assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23153535
negative regulation of actin filament polymerization
Source: UniProtKB
Inferred from direct assayⁱ
- 7758455
negative regulation of stress fiber assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23153535
neural tube closure Source: Ensembl
positive regulation of actin filament bundle assembly
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of actin filament polymerization
Source: UniProtKB
Inferred from genetic interactionⁱ
- 23153535
positive regulation of ATPase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 7758455
positive regulation of epithelial cell migration
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23153535
positive regulation of ruffle assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23153535
protein stabilization
Source: UniProtKB
Inferred from direct assayⁱ
- 18573880
regulation of actin filament polymerization
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of transcription by RNA polymerase II Source: Ensembl
synapse maturation Source: Ensembl
Wnt signaling pathway, planar cell polarity pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin-binding

Molecular function

Actin-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-114608 Platelet degranulation R-HSA-376176 Signaling by ROBO receptors R-HSA-4086400 PCP/CE pathway R-HSA-5663220 RHO GTPases Activate Formins
SIGNORⁱ	P07737

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Profilin-1 Alternative name(s): Epididymis tissue protein Li 184a Profilin I
Gene namesⁱ	Name:PFN1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000108518.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8881 PFN1
MIMⁱ	176610 gene
neXtProtⁱ	NX_P07737

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Amyotrophic lateral sclerosis 18 (ALS18)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.

Keywords - Diseaseⁱ

Amyotrophic lateral sclerosis, Disease mutation, Neurodegeneration

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5216
GeneReviewsⁱ	PFN1
MalaCards human disease database More...MalaCardsⁱ	PFN1
MIMⁱ	614808 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000108518
Orphanetⁱ	803 Amyotrophic lateral sclerosis
PharmGKBⁱ	PA33219

Protein family/group databases

Allergomeⁱ	907 Hom s Profilin

Allergomeⁱ

907 Hom s Profilin

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB07908 7-HYDROXY-4-METHYL-3-(2-HYDROXY-ETHYL)COUMARIN

DrugBankⁱ

DB07908 7-HYDROXY-4-METHYL-3-(2-HYDROXY-ETHYL)COUMARIN

Polymorphism and mutation databases

BioMutaⁱ	PFN1
DMDMⁱ	130979

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000199571	2 – 140	Profilin-1Add BLAST		139

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources1 Publication	1
Modified residueⁱ	28	PhosphoserineBy similarity	1
Cross-linkⁱ	54	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linkⁱ	54	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
Modified residueⁱ	57	PhosphoserineCombined sources	1
Modified residueⁱ	85	PhosphoserineCombined sources	1
Modified residueⁱ	105	N6-acetyllysineCombined sources	1
Modified residueⁱ	108	N6-acetyllysineCombined sources	1
Modified residueⁱ	129	PhosphotyrosineCombined sources	1
Modified residueⁱ	138	Phosphoserine; by ROCK11 Publication	1

Post-translational modificationⁱ

Phosphorylation at Ser-138 reduces its affinity for G-actin and blocks its interaction with HTT, reducing its ability to inhibit androgen receptor (AR) and HTT aggregation.1 Publication

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P07737
PaxDbⁱ	P07737
PeptideAtlas More...PeptideAtlasⁱ	P07737
PRIDEⁱ	P07737
ProteomicsDBⁱ	52024
TopDownProteomicsⁱ	P07737

2D gel databases

DOSAC-COBS 2D-PAGE database More...DOSAC-COBS-2DPAGEⁱ	P07737
USC-OGP 2-DE database More...OGPⁱ	P07737
REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00216691
UCD-2DPAGEⁱ	P07737

PTM databases

iPTMnetⁱ	P07737
PhosphoSitePlusⁱ	P07737
SwissPalmⁱ	P07737

Miscellaneous databases

PMAP-CutDBⁱ	P07737

PMAP-CutDBⁱ

P07737

Expressionⁱ

Tissue specificityⁱ

Expressed in epididymis (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000108518 Expressed in 231 organ(s), highest expression level in blood
CleanExⁱ	HS_PFN1
ExpressionAtlasⁱ	P07737 baseline and differential
Genevisibleⁱ	P07737 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB037134 CAB037140

HPAⁱ

CAB037134
CAB037140

Interactionⁱ

Subunit structureⁱ

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio. Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with VASP. Interacts with HTT.4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
act21	P07830	3	EBI-713780,EBI-7195234	From Dictyostelium discoideum.
ACTA1	P68135	2	EBI-713780,EBI-367540	From Oryctolagus cuniculus.
ACTB	P60709	2	EBI-713780,EBI-353944
WASF1	Q92558	2	EBI-713780,EBI-1548747
Wasl	O08816	4	EBI-713780,EBI-6142604	From Rattus norvegicus.

GO - Molecular functionⁱ

actin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17914456
- 7758455
actin monomer binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18573880
cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
proline-rich region binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17914456
Rho GTPase binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111237, 78 interactors
CORUMⁱ	P07737
Database of interacting proteins More...DIPⁱ	DIP-30N
IntActⁱ	P07737, 57 interactors
Molecular INTeraction database More...MINTⁱ	P07737
STRINGⁱ	9606.ENSP00000225655

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	5 – 12	Combined sources	8
Beta strandⁱ	13 – 15	Combined sources	3
Beta strandⁱ	17 – 28	Combined sources	12
Beta strandⁱ	30 – 34	Combined sources	5
Helixⁱ	40 – 42	Combined sources	3
Helixⁱ	45 – 52	Combined sources	8
Helixⁱ	58 – 60	Combined sources	3
Beta strandⁱ	64 – 66	Combined sources	3
Beta strandⁱ	69 – 77	Combined sources	9
Beta strandⁱ	78 – 80	Combined sources	3
Turnⁱ	81 – 83	Combined sources	3
Beta strandⁱ	85 – 90	Combined sources	6
Beta strandⁱ	93 – 96	Combined sources	4
Beta strandⁱ	100 – 105	Combined sources	6
Beta strandⁱ	107 – 115	Combined sources	9
Helixⁱ	121 – 137	Combined sources	17

Show more details

3D structure databases

ProteinModelPortalⁱ	P07737
SMRⁱ	P07737
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P07737

EvolutionaryTraceⁱ

P07737

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the profilin family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1755 Eukaryota ENOG41126PD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000010143
HOGENOMⁱ	HOG000171592
HOVERGENⁱ	HBG053683
InParanoidⁱ	P07737
KEGG Orthology (KO) More...KOⁱ	K05759
OMAⁱ	HLRRAQY
PhylomeDBⁱ	P07737
TreeFamⁱ	TF331744

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00148 PROF, 1 hit
InterProⁱ	View protein in InterPro IPR005455 PFN IPR036140 PFN_sf IPR005454 Profilin1/2/3_vertebrate IPR027310 Profilin_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00235 Profilin, 1 hit
PRINTSⁱ	PR01639 PROFILINMAML
SMARTⁱ	View protein in SMART SM00392 PROF, 1 hit
SUPFAMⁱ	SSF55770 SSF55770, 1 hit
PROSITEⁱ	View protein in PROSITE PS00414 PROFILIN, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

P07737-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAGWNAYIDN LMADGTCQDA AIVGYKDSPS VWAAVPGKTF VNITPAEVGV 
        60         70         80         90        100
LVGKDRSSFY VNGLTLGGQK CSVIRDSLLQ DGEFSMDLRT KSTGGAPTFN 
       110        120        130        140
VTVTKTDKTL VLLMGKEGVH GGLINKKCYE MASHLRRSQY

Length:140

Mass (Da):15,054

Last modified:January 23, 2007 - v2

Checksum:ⁱF725119E55A289EB

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

I3L3D5	I3L3D5_HUMAN	Profilin Profilin	PFN1	165	Annotation score:
K7EJ44	K7EJ44_HUMAN	Profilin Profilin	PFN1 hCG_32691	104	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_068925	71	C → G in ALS18; the mutant protein is detected in the insoluble fraction of cells. 1 PublicationCorresponds to variant dbSNP:rs387907264EnsemblClinVar.	1
Natural variantⁱVAR_068926	114	M → T in ALS18; the mutant protein is detected in the insoluble fraction of cells. 1 PublicationCorresponds to variant dbSNP:rs387907265EnsemblClinVar.	1
Natural variantⁱVAR_068927	117	E → G in ALS18; unknown pathological significance; like the wild-type the mutant protein is detected in the soluble fraction of cells. 1 PublicationCorresponds to variant dbSNP:rs140547520EnsemblClinVar.	1
Natural variantⁱVAR_068928	118	G → V in ALS18; the mutant protein is detected in the insoluble fraction of cells. 1 PublicationCorresponds to variant dbSNP:rs387907266EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J03191 mRNA Translation: AAA36486.1 GU727630 mRNA Translation: ADU87632.1 BT007001 mRNA Translation: AAP35647.1 AK312168 mRNA Translation: BAG35102.1 CR407670 mRNA Translation: CAG28598.1 CH471108 Genomic DNA Translation: EAW90381.1 CH471108 Genomic DNA Translation: EAW90383.1 CH471108 Genomic DNA Translation: EAW90384.1 BC002475 mRNA Translation: AAH02475.1 BC006768 mRNA Translation: AAH06768.1 BC013439 mRNA Translation: AAH13439.1 BC015164 mRNA Translation: AAH15164.1 BC057828 mRNA Translation: AAH57828.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11061.1
PIRⁱ	A28622
NCBI Reference Sequences More...RefSeqⁱ	NP_005013.1, NM_005022.3
UniGeneⁱ	Hs.494691

Genome annotation databases

Ensemblⁱ	ENST00000225655; ENSP00000225655; ENSG00000108518
GeneIDⁱ	5216
KEGGⁱ	hsa:5216
UCSC genome browser More...UCSCⁱ	uc002gaa.5 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P07737	Profilin		PANTR		140	UniRef100_P07737
Profilin		MACMU		140
Profilin		COLAP		140
Profilin		PONAB		140
Profilin		CERAT		140
+11

Protein	Similar proteins		Species	Score	Length	Source
P07737	Profilin		PANTR		140	UniRef90_P07737
Profilin		MACMU		140
Profilin		COLAP		140
Profilin		PONAB		140
Profilin		CERAT		140
+12

Protein	Similar proteins		Species	Score	Length	Source
P07737	Profilin		PANTR		140	UniRef50_P07737
Profilin		MACMU		140
Profilin		COLAP		140
Profilin		PONAB		140
Profilin		CERAT		140
+16

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J03191 mRNA Translation: AAA36486.1 GU727630 mRNA Translation: ADU87632.1 BT007001 mRNA Translation: AAP35647.1 AK312168 mRNA Translation: BAG35102.1 CR407670 mRNA Translation: CAG28598.1 CH471108 Genomic DNA Translation: EAW90381.1 CH471108 Genomic DNA Translation: EAW90383.1 CH471108 Genomic DNA Translation: EAW90384.1 BC002475 mRNA Translation: AAH02475.1 BC006768 mRNA Translation: AAH06768.1 BC013439 mRNA Translation: AAH13439.1 BC015164 mRNA Translation: AAH15164.1 BC057828 mRNA Translation: AAH57828.1
CCDSⁱ	CCDS11061.1
PIRⁱ	A28622
RefSeqⁱ	NP_005013.1, NM_005022.3
UniGeneⁱ	Hs.494691

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1AWI	X-ray	2.20	A/B	3-140	[»]
	1CF0	X-ray	2.20	A/B	3-140	[»]
	1CJF	X-ray	2.30	A/B	2-140	[»]
	1FIK	X-ray	2.30	A	2-140	[»]
	1FIL	X-ray	2.00	A	2-140	[»]
	1PFL	NMR	-	A	2-140	[»]
	2PAV	X-ray	1.80	P	2-140	[»]
	2PBD	X-ray	1.50	P	2-140	[»]
	3CHW	X-ray	2.30	P	2-140	[»]
	4X1L	X-ray	2.16	A	1-140	[»]
	4X1M	X-ray	2.17	A	1-140	[»]
	4X25	X-ray	2.23	A/B	1-140	[»]
ProteinModelPortalⁱ	P07737
SMRⁱ	P07737
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111237, 78 interactors
CORUMⁱ	P07737
DIPⁱ	DIP-30N
IntActⁱ	P07737, 57 interactors
MINTⁱ	P07737
STRINGⁱ	9606.ENSP00000225655

Chemistry databases

DrugBankⁱ	DB07908 7-HYDROXY-4-METHYL-3-(2-HYDROXY-ETHYL)COUMARIN

DrugBankⁱ

DB07908 7-HYDROXY-4-METHYL-3-(2-HYDROXY-ETHYL)COUMARIN

Protein family/group databases

Allergomeⁱ	907 Hom s Profilin

Allergomeⁱ

907 Hom s Profilin

PTM databases

iPTMnetⁱ	P07737
PhosphoSitePlusⁱ	P07737
SwissPalmⁱ	P07737

Polymorphism and mutation databases

BioMutaⁱ	PFN1
DMDMⁱ	130979

2D gel databases

DOSAC-COBS-2DPAGEⁱ	P07737
OGPⁱ	P07737
REPRODUCTION-2DPAGEⁱ	IPI00216691
UCD-2DPAGEⁱ	P07737

Proteomic databases

EPDⁱ	P07737
PaxDbⁱ	P07737
PeptideAtlasⁱ	P07737
PRIDEⁱ	P07737
ProteomicsDBⁱ	52024
TopDownProteomicsⁱ	P07737

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5216
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000225655; ENSP00000225655; ENSG00000108518
GeneIDⁱ	5216
KEGGⁱ	hsa:5216
UCSCⁱ	uc002gaa.5 human

Organism-specific databases

CTDⁱ	5216
DisGeNETⁱ	5216
EuPathDBⁱ	HostDB:ENSG00000108518.7
GeneCardsⁱ	PFN1
GeneReviewsⁱ	PFN1
HGNCⁱ	HGNC:8881 PFN1
HPAⁱ	CAB037134 CAB037140
MalaCardsⁱ	PFN1
MIMⁱ	176610 gene 614808 phenotype
neXtProtⁱ	NX_P07737
OpenTargetsⁱ	ENSG00000108518
Orphanetⁱ	803 Amyotrophic lateral sclerosis
PharmGKBⁱ	PA33219
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1755 Eukaryota ENOG41126PD LUCA
GeneTreeⁱ	ENSGT00390000010143
HOGENOMⁱ	HOG000171592
HOVERGENⁱ	HBG053683
InParanoidⁱ	P07737
KOⁱ	K05759
OMAⁱ	HLRRAQY
PhylomeDBⁱ	P07737
TreeFamⁱ	TF331744

Enzyme and pathway databases

Reactomeⁱ	R-HSA-114608 Platelet degranulation R-HSA-376176 Signaling by ROBO receptors R-HSA-4086400 PCP/CE pathway R-HSA-5663220 RHO GTPases Activate Formins
SIGNORⁱ	P07737

Miscellaneous databases

ChiTaRSⁱ	PFN1 human
EvolutionaryTraceⁱ	P07737
GeneWikiⁱ	Profilin_1
GenomeRNAiⁱ	5216
PMAP-CutDBⁱ	P07737
Protein Ontology More...PROⁱ	PR:P07737
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000108518 Expressed in 231 organ(s), highest expression level in blood
CleanExⁱ	HS_PFN1
ExpressionAtlasⁱ	P07737 baseline and differential
Genevisibleⁱ	P07737 HS

Family and domain databases

CDDⁱ	cd00148 PROF, 1 hit
InterProⁱ	View protein in InterPro IPR005455 PFN IPR036140 PFN_sf IPR005454 Profilin1/2/3_vertebrate IPR027310 Profilin_CS
Pfamⁱ	View protein in Pfam PF00235 Profilin, 1 hit
PRINTSⁱ	PR01639 PROFILINMAML
SMARTⁱ	View protein in SMART SM00392 PROF, 1 hit
SUPFAMⁱ	SSF55770 SSF55770, 1 hit
PROSITEⁱ	View protein in PROSITE PS00414 PROFILIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PROF1_HUMAN
Accessionⁱ	P07737Primary (citable) accession number: P07737 Secondary accession number(s): Q53Y44
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 207 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P07737 (PROF1_HUMAN)

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Profilin-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytoskeleton

Cytosol

Extracellular region or secreted

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Protein family/group databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ