Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serum albumin

Gene

Alb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi27Copper1
Metal bindingi91ZincBy similarity1
Metal bindingi123ZincBy similarity1
Metal bindingi271ZincBy similarity1
Metal bindingi273ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCopper, Lipid-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-159418 Recycling of bile acids and salts
R-MMU-2168880 Scavenging of heme from plasma
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-879518 Transport of organic anions
R-MMU-8957275 Post-translational protein phosphorylation
R-MMU-8964058 HDL remodeling

Names & Taxonomyi

Protein namesi
Recommended name:
Serum albumin
Gene namesi
Name:Alb
Synonyms:Alb-1, Alb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:87991 Alb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei755 Mus m 4

Chemistry databases

ChEMBLiCHEMBL1075271

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000000107319 – 246
ChainiPRO_000000107425 – 608Serum albuminAdd BLAST584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphoserineBy similarity1
Disulfide bondi77 ↔ 86PROSITE-ProRule annotation
Modified residuei82PhosphoserineBy similarity1
Modified residuei89PhosphoserineBy similarity1
Disulfide bondi99 ↔ 115PROSITE-ProRule annotation
Disulfide bondi114 ↔ 125PROSITE-ProRule annotation
Disulfide bondi148 ↔ 193PROSITE-ProRule annotation
Disulfide bondi192 ↔ 201PROSITE-ProRule annotation
Disulfide bondi224 ↔ 270PROSITE-ProRule annotation
Modified residuei229N6-succinyllysineCombined sources1
Disulfide bondi269 ↔ 277PROSITE-ProRule annotation
Disulfide bondi289 ↔ 303PROSITE-ProRule annotation
Modified residuei297PhosphoserineCombined sources1
Disulfide bondi302 ↔ 313PROSITE-ProRule annotation
Disulfide bondi340 ↔ 385PROSITE-ProRule annotation
Disulfide bondi384 ↔ 393PROSITE-ProRule annotation
Disulfide bondi416 ↔ 462PROSITE-ProRule annotation
Modified residuei443PhosphoserineCombined sources1
Modified residuei444PhosphothreonineBy similarity1
Modified residuei446PhosphothreonineBy similarity1
Modified residuei460N6-succinyllysineCombined sources1
Disulfide bondi461 ↔ 472PROSITE-ProRule annotation
Disulfide bondi485 ↔ 501PROSITE-ProRule annotation
Disulfide bondi500 ↔ 511PROSITE-ProRule annotation
Modified residuei513PhosphoserineBy similarity1
Disulfide bondi538 ↔ 583PROSITE-ProRule annotation
Modified residuei543N6-succinyllysineCombined sources1
Modified residuei558N6-methyllysineBy similarity1
Modified residuei570PhosphothreonineBy similarity1
Disulfide bondi582 ↔ 591PROSITE-ProRule annotation
Modified residuei588N6-succinyllysineCombined sources1

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP07724
PeptideAtlasiP07724
PRIDEiP07724

2D gel databases

REPRODUCTION-2DPAGEiIPI00131695
P07724
Q8CG74
SWISS-2DPAGEiP07724
UCD-2DPAGEiP07724

PTM databases

CarbonylDBiP07724
iPTMnetiP07724
PhosphoSitePlusiP07724
SwissPalmiP07724

Expressioni

Tissue specificityi

Plasma.

Gene expression databases

BgeeiENSMUSG00000029368 Expressed in 119 organ(s), highest expression level in diaphragm
CleanExiMM_ALB
ExpressionAtlasiP07724 baseline and differential
GenevisibleiP07724 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198060, 8 interactors
IntActiP07724, 12 interactors
MINTiP07724
STRINGi10090.ENSMUSP00000031314

Chemistry databases

BindingDBiP07724

Structurei

3D structure databases

ProteinModelPortaliP07724
SMRiP07724
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 211Albumin 1PROSITE-ProRule annotationAdd BLAST193
Domaini212 – 403Albumin 2PROSITE-ProRule annotationAdd BLAST192
Domaini404 – 601Albumin 3PROSITE-ProRule annotationAdd BLAST198

Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIRZ Eukaryota
ENOG410Z40H LUCA
GeneTreeiENSGT00390000000113
HOGENOMiHOG000293137
HOVERGENiHBG004207
InParanoidiP07724
KOiK16141
OMAiHKECCHG
OrthoDBiEOG091G0F5F
PhylomeDBiP07724
TreeFamiTF335561

Family and domain databases

CDDicd00015 ALBUMIN, 3 hits
InterProiView protein in InterPro
IPR000264 ALB/AFP/VDB
IPR020858 Serum_albumin-like
IPR021177 Serum_albumin/AFP/Afamin
IPR020857 Serum_albumin_CS
IPR014760 Serum_albumin_N
PANTHERiPTHR11385 PTHR11385, 1 hit
PfamiView protein in Pfam
PF00273 Serum_albumin, 3 hits
PIRSFiPIRSF002520 Serum_albumin_subgroup, 1 hit
PRINTSiPR00802 SERUMALBUMIN
SMARTiView protein in SMART
SM00103 ALBUMIN, 3 hits
SUPFAMiSSF48552 SSF48552, 3 hits
PROSITEiView protein in PROSITE
PS00212 ALBUMIN_1, 3 hits
PS51438 ALBUMIN_2, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07724-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKWVTFLLLL FVSGSAFSRG VFRREAHKSE IAHRYNDLGE QHFKGLVLIA
60 70 80 90 100
FSQYLQKCSY DEHAKLVQEV TDFAKTCVAD ESAANCDKSL HTLFGDKLCA
110 120 130 140 150
IPNLRENYGE LADCCTKQEP ERNECFLQHK DDNPSLPPFE RPEAEAMCTS
160 170 180 190 200
FKENPTTFMG HYLHEVARRH PYFYAPELLY YAEQYNEILT QCCAEADKES
210 220 230 240 250
CLTPKLDGVK EKALVSSVRQ RMKCSSMQKF GERAFKAWAV ARLSQTFPNA
260 270 280 290 300
DFAEITKLAT DLTKVNKECC HGDLLECADD RAELAKYMCE NQATISSKLQ
310 320 330 340 350
TCCDKPLLKK AHCLSEVEHD TMPADLPAIA ADFVEDQEVC KNYAEAKDVF
360 370 380 390 400
LGTFLYEYSR RHPDYSVSLL LRLAKKYEAT LEKCCAEANP PACYGTVLAE
410 420 430 440 450
FQPLVEEPKN LVKTNCDLYE KLGEYGFQNA ILVRYTQKAP QVSTPTLVEA
460 470 480 490 500
ARNLGRVGTK CCTLPEDQRL PCVEDYLSAI LNRVCLLHEK TPVSEHVTKC
510 520 530 540 550
CSGSLVERRP CFSALTVDET YVPKEFKAET FTFHSDICTL PEKEKQIKKQ
560 570 580 590 600
TALAELVKHK PKATAEQLKT VMDDFAQFLD TCCKAADKDT CFSTEGPNLV

TRCKDALA
Length:608
Mass (Da):68,693
Last modified:July 15, 1999 - v3
Checksum:i292F7C7EED3A61B4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27H → D AA sequence (PubMed:1286668).Curated1
Sequence conflicti33H → D AA sequence (PubMed:1286668).Curated1
Sequence conflicti33H → N in BAC34360 (PubMed:16141072).Curated1
Sequence conflicti41Q → I AA sequence (PubMed:1286668).Curated1
Sequence conflicti561P → H in BAE35818 (PubMed:16141072).Curated1
Sequence conflicti606A → T in BAC34145 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011413 mRNA Translation: CAA09617.1
AJ277794 Genomic DNA Translation: CAC81903.1
AK010025 mRNA Translation: BAB26650.1
AK050248 mRNA Translation: BAC34145.1
AK050644 mRNA Translation: BAC34360.1
AK160487 mRNA Translation: BAE35818.1
BC024643 mRNA Translation: AAH24643.1
BC049971 mRNA Translation: AAH49971.1
M16111 mRNA Translation: AAA37190.1
X13060 Genomic DNA Translation: CAA31458.1
CCDSiCCDS19412.1
PIRiA05139
RefSeqiNP_033784.2, NM_009654.4
UniGeneiMm.16773

Genome annotation databases

EnsembliENSMUST00000031314; ENSMUSP00000031314; ENSMUSG00000029368
GeneIDi11657
KEGGimmu:11657
UCSCiuc008yaz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011413 mRNA Translation: CAA09617.1
AJ277794 Genomic DNA Translation: CAC81903.1
AK010025 mRNA Translation: BAB26650.1
AK050248 mRNA Translation: BAC34145.1
AK050644 mRNA Translation: BAC34360.1
AK160487 mRNA Translation: BAE35818.1
BC024643 mRNA Translation: AAH24643.1
BC049971 mRNA Translation: AAH49971.1
M16111 mRNA Translation: AAA37190.1
X13060 Genomic DNA Translation: CAA31458.1
CCDSiCCDS19412.1
PIRiA05139
RefSeqiNP_033784.2, NM_009654.4
UniGeneiMm.16773

3D structure databases

ProteinModelPortaliP07724
SMRiP07724
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198060, 8 interactors
IntActiP07724, 12 interactors
MINTiP07724
STRINGi10090.ENSMUSP00000031314

Chemistry databases

BindingDBiP07724
ChEMBLiCHEMBL1075271

Protein family/group databases

Allergomei755 Mus m 4

PTM databases

CarbonylDBiP07724
iPTMnetiP07724
PhosphoSitePlusiP07724
SwissPalmiP07724

2D gel databases

REPRODUCTION-2DPAGEiIPI00131695
P07724
Q8CG74
SWISS-2DPAGEiP07724
UCD-2DPAGEiP07724

Proteomic databases

PaxDbiP07724
PeptideAtlasiP07724
PRIDEiP07724

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031314; ENSMUSP00000031314; ENSMUSG00000029368
GeneIDi11657
KEGGimmu:11657
UCSCiuc008yaz.2 mouse

Organism-specific databases

CTDi213
MGIiMGI:87991 Alb

Phylogenomic databases

eggNOGiENOG410IIRZ Eukaryota
ENOG410Z40H LUCA
GeneTreeiENSGT00390000000113
HOGENOMiHOG000293137
HOVERGENiHBG004207
InParanoidiP07724
KOiK16141
OMAiHKECCHG
OrthoDBiEOG091G0F5F
PhylomeDBiP07724
TreeFamiTF335561

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-159418 Recycling of bile acids and salts
R-MMU-2168880 Scavenging of heme from plasma
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-879518 Transport of organic anions
R-MMU-8957275 Post-translational protein phosphorylation
R-MMU-8964058 HDL remodeling

Miscellaneous databases

ChiTaRSiAlb mouse
PROiPR:P07724
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029368 Expressed in 119 organ(s), highest expression level in diaphragm
CleanExiMM_ALB
ExpressionAtlasiP07724 baseline and differential
GenevisibleiP07724 MM

Family and domain databases

CDDicd00015 ALBUMIN, 3 hits
InterProiView protein in InterPro
IPR000264 ALB/AFP/VDB
IPR020858 Serum_albumin-like
IPR021177 Serum_albumin/AFP/Afamin
IPR020857 Serum_albumin_CS
IPR014760 Serum_albumin_N
PANTHERiPTHR11385 PTHR11385, 1 hit
PfamiView protein in Pfam
PF00273 Serum_albumin, 3 hits
PIRSFiPIRSF002520 Serum_albumin_subgroup, 1 hit
PRINTSiPR00802 SERUMALBUMIN
SMARTiView protein in SMART
SM00103 ALBUMIN, 3 hits
SUPFAMiSSF48552 SSF48552, 3 hits
PROSITEiView protein in PROSITE
PS00212 ALBUMIN_1, 3 hits
PS51438 ALBUMIN_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiALBU_MOUSE
AccessioniPrimary (citable) accession number: P07724
Secondary accession number(s): Q3TV03
, Q61802, Q8C7C7, Q8C7H3, Q8CG74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: July 15, 1999
Last modified: November 7, 2018
This is version 186 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again