UniProtKB - P07713 (DECA_DROME)
Protein
Protein decapentaplegic
Gene
dpp
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Required during oogenesis for eggshell patterning and dorsal/ventral patterning of the embryo. Acts as a morphogen during embryogenesis to pattern the dorsal/ventral axis, specifying dorsal ectoderm and amnioserosa cell fate within the dorsal half of the embryo; this activity is antagonized by binding to sog and tsg. Induces the formation of visceral mesoderm and the heart in early embryos. Required later in embryogenesis for dorsal closure and patterning of the hindgut. Also functions postembryonically as a long-range morphogen during imaginal disk development; is responsible for the progression of the morphogenetic furrow during eye development. Patterns the wing imaginal disk along its anterior/posterior axis and has a role in positioning pro-veins. Also required to subdivide the wing disk along the proximal/distal axis into body wall (notum) and wing. Ensures the correct architecture of wing epithelial cells. Has multiple roles in the developing tracheal system, controlling directed tracheal cell migration during embryogenesis and later specifying the fate of fusion cells in the tracheal branches. Required for viability of larvae. Essential for the maintenance and division of germline stem cells in the ovary. Signals via the type I receptor tkv, the type II receptor punt, and in some tissues via the type I receptor sax, in a signaling cascade that leads to activation and repression of target genes.15 Publications
GO - Molecular functioni
- BMP receptor binding Source: FlyBase
- collagen binding Source: FlyBase
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- heparin binding Source: FlyBase
- morphogen activity Source: FlyBase
- protein heterodimerization activity Source: UniProtKB
- protein homodimerization activity Source: FlyBase
- receptor ligand activity Source: FlyBase
GO - Biological processi
- amnioserosa formation Source: FlyBase
- anterior Malpighian tubule development Source: FlyBase
- BMP signaling pathway Source: FlyBase
- cardioblast differentiation Source: FlyBase
- cell chemotaxis involved in Malpighian tubule morphogenesis Source: FlyBase
- chorion-containing eggshell formation Source: FlyBase
- compound eye morphogenesis Source: FlyBase
- dorsal/ventral axis specification Source: UniProtKB
- dorsal/ventral pattern formation Source: FlyBase
- dorsal appendage formation Source: FlyBase
- dorsal closure Source: FlyBase
- ectodermal cell fate specification Source: FlyBase
- embryonic hindgut morphogenesis Source: UniProtKB
- epithelial cell migration, open tracheal system Source: UniProtKB
- eye-antennal disc development Source: FlyBase
- eye-antennal disc morphogenesis Source: FlyBase
- female germ-line stem cell population maintenance Source: FlyBase
- fusion cell fate specification Source: UniProtKB
- genital disc anterior/posterior pattern formation Source: FlyBase
- genital disc development Source: FlyBase
- genital disc sexually dimorphic development Source: FlyBase
- germ cell development Source: FlyBase
- germ cell migration Source: FlyBase
- germ-line stem cell division Source: FlyBase
- germ-line stem cell population maintenance Source: FlyBase
- head morphogenesis Source: FlyBase
- heart development Source: UniProtKB
- hemocyte development Source: FlyBase
- hindgut morphogenesis Source: FlyBase
- imaginal disc-derived wing morphogenesis Source: FlyBase
- imaginal disc-derived wing vein morphogenesis Source: FlyBase
- imaginal disc-derived wing vein specification Source: FlyBase
- imaginal disc development Source: FlyBase
- labial disc development Source: FlyBase
- larval lymph gland hemocyte differentiation Source: FlyBase
- lymph gland development Source: FlyBase
- male germ-line stem cell population maintenance Source: UniProtKB
- Malpighian tubule morphogenesis Source: FlyBase
- maternal specification of dorsal/ventral axis, oocyte, soma encoded Source: FlyBase
- mesoderm development Source: UniProtKB
- negative regulation of gene expression Source: FlyBase
- negative regulation of salivary gland boundary specification Source: FlyBase
- ovarian follicle cell development Source: FlyBase
- pericardial nephrocyte differentiation Source: FlyBase
- positive regulation of gene expression Source: UniProtKB
- positive regulation of imaginal disc growth Source: FlyBase
- positive regulation of muscle organ development Source: FlyBase
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
- positive regulation of SMAD protein signal transduction Source: FlyBase
- progression of morphogenetic furrow involved in compound eye morphogenesis Source: UniProtKB
- R8 cell fate specification Source: FlyBase
- regulation of cell differentiation Source: FlyBase
- regulation of cell shape Source: UniProtKB
- regulation of imaginal disc growth Source: FlyBase
- regulation of stem cell differentiation Source: FlyBase
- regulation of tube diameter, open tracheal system Source: FlyBase
- SMAD protein signal transduction Source: GO_Central
- spectrosome organization Source: FlyBase
- wing and notum subfield formation Source: UniProtKB
- wing disc pattern formation Source: UniProtKB
- zygotic specification of dorsal/ventral axis Source: UniProtKB
Keywordsi
Molecular function | Developmental protein, Growth factor |
Biological process | Differentiation |
Enzyme and pathway databases
Reactomei | R-DME-201451, Signaling by BMP R-DME-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-8957275, Post-translational protein phosphorylation |
SignaLinki | P07713 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein decapentaplegicShort name: Protein DPP-C |
Gene namesi | Name:dpp ORF Names:CG9885 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0000490, dpp |
Subcellular locationi
Extracellular region or secreted
- Secreted 3 Publications
Note: Is internalized by receptor-mediated endocytosis.
Extracellular region or secreted
- extracellular space Source: FlyBase
Other locations
- cell leading edge Source: UniProtKB
- cytoneme Source: FlyBase
- dense core granule lumen Source: FlyBase
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
PropeptideiPRO_0000033664 | 24 – 456 | 1 PublicationAdd BLAST | 433 | |
ChainiPRO_0000033665 | 457 – 588 | Protein decapentaplegicAdd BLAST | 132 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 120 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 342 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 377 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 487 ↔ 553 | By similarity | ||
Disulfide bondi | 516 ↔ 585 | By similarity | ||
Disulfide bondi | 520 ↔ 587 | By similarity | ||
Glycosylationi | 529 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 552 | InterchainBy similarity |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 456 | Cleavage1 Publication | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P07713 |
Expressioni
Tissue specificityi
Expressed in the dorsal region of the embryo, and becomes enriched in a dorsal midline stripe just prior to gastrulation. Expressed in midgut mesoderm and in two overlapping regions of the embryonic large intestine. Expressed in a long-range concentration gradient in the wing imaginal disk.4 Publications
Developmental stagei
Expressed both maternally and zygotically. First detected during stages 8 to 10 of oogenesis.1 Publication
Gene expression databases
Bgeei | FBgn0000490, Expressed in crop (Drosophila) and 65 other tissues |
Genevisiblei | P07713, DM |
Interactioni
Subunit structurei
Heterodimers of scw/dpp are the active subunit, dpp/dpp homodimers elicit a basal response and scw/scw homodimers alone are ineffective in specifying a dorsal pattern.
Component of a complex composed of dpp, sog and tsg.
1 PublicationBinary interactionsi
Hide detailsGO - Molecular functioni
- BMP receptor binding Source: FlyBase
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- morphogen activity Source: FlyBase
- protein heterodimerization activity Source: UniProtKB
- protein homodimerization activity Source: FlyBase
- receptor ligand activity Source: FlyBase
Protein-protein interaction databases
BioGRIDi | 59659, 97 interactors |
DIPi | DIP-19N |
IntActi | P07713, 3 interactors |
STRINGi | 7227.FBpp0077451 |
Family & Domainsi
Sequence similaritiesi
Belongs to the TGF-beta family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000174461 |
HOGENOMi | CLU_020515_4_2_1 |
InParanoidi | P07713 |
OMAi | DSWPQAR |
OrthoDBi | 1063560at2759 |
PhylomeDBi | P07713 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P07713-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRAWLLLLAV LATFQTIVRV ASTEDISQRF IAAIAPVAAH IPLASASGSG
60 70 80 90 100
SGRSGSRSVG ASTSTALAKA FNPFSEPASF SDSDKSHRSK TNKKPSKSDA
110 120 130 140 150
NRQFNEVHKP RTDQLENSKN KSKQLVNKPN HNKMAVKEQR SHHKKSHHHR
160 170 180 190 200
SHQPKQASAS TESHQSSSIE SIFVEEPTLV LDREVASINV PANAKAIIAE
210 220 230 240 250
QGPSTYSKEA LIKDKLKPDP STLVEIEKSL LSLFNMKRPP KIDRSKIIIP
260 270 280 290 300
EPMKKLYAEI MGHELDSVNI PKPGLLTKSA NTVRSFTHKD SKIDDRFPHH
310 320 330 340 350
HRFRLHFDVK SIPADEKLKA AELQLTRDAL SQQVVASRSS ANRTRYQVLV
360 370 380 390 400
YDITRVGVRG QREPSYLLLD TKTVRLNSTD TVSLDVQPAV DRWLASPQRN
410 420 430 440 450
YGLLVEVRTV RSLKPAPHHH VRLRRSADEA HERWQHKQPL LFTYTDDGRH
460 470 480 490 500
KARSIRDVSG GEGGGKGGRN KRQPRRPTRR KNHDDTCRRH SLYVDFSDVG
510 520 530 540 550
WDDWIVAPLG YDAYYCHGKC PFPLADHFNS TNHAVVQTLV NNMNPGKVPK
560 570 580
ACCVPTQLDS VAMLYLNDQS TVVLKNYQEM TVVGCGCR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 473 – 474 | QP → HA in AAA28482 (PubMed:3467201).Curated | 2 | |
Sequence conflicti | 556 | T → K in AAT94456 (Ref. 5) Curated | 1 | |
Sequence conflicti | 568 | D → G in AAT94456 (Ref. 5) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 59 | V → G in strain: dp cn bw. 1 Publication | 1 | |
Natural varianti | 121 | K → M in strain: dp cn bw. 1 Publication | 1 | |
Natural varianti | 439 | P → A1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M30116 mRNA Translation: AAA28482.1 U63857 Genomic DNA Translation: AAC47552.1 AE014134 Genomic DNA Translation: AAF51250.1 AE014134 Genomic DNA Translation: AAN10431.1 AE014134 Genomic DNA Translation: AAN10432.1 AE014134 Genomic DNA Translation: AAN10434.1 BT015227 mRNA Translation: AAT94456.1 AF459545 Genomic DNA Translation: AAN61361.1 AF459546 Genomic DNA Translation: AAN61362.1 AF459547 Genomic DNA Translation: AAN61363.1 AF459548 Genomic DNA Translation: AAN61364.1 AF459549 Genomic DNA Translation: AAN61365.1 AF459550 Genomic DNA Translation: AAN61366.1 AF459551 Genomic DNA Translation: AAN61367.1 AF459552 Genomic DNA Translation: AAN61368.1 AF459553 Genomic DNA Translation: AAN61369.1 AF459554 Genomic DNA Translation: AAN61370.1 AF459555 Genomic DNA Translation: AAN61371.1 AF459556 Genomic DNA Translation: AAN61372.1 AF459557 Genomic DNA Translation: AAN61373.1 AF459558 Genomic DNA Translation: AAN61374.1 AF459559 Genomic DNA Translation: AAN61375.1 AF459560 Genomic DNA Translation: AAN61376.1 AF459561 Genomic DNA Translation: AAN61377.1 AF459562 Genomic DNA Translation: AAN61378.1 AF459563 Genomic DNA Translation: AAN61379.1 AF459564 Genomic DNA Translation: AAN61380.1 |
PIRi | A26158 |
RefSeqi | NP_477311.1, NM_057963.5 NP_722810.1, NM_164485.2 NP_722811.1, NM_164486.2 NP_722813.1, NM_164488.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0077771; FBpp0077451; FBgn0000490 FBtr0077772; FBpp0077452; FBgn0000490 FBtr0077773; FBpp0077453; FBgn0000490 FBtr0077775; FBpp0077455; FBgn0000490 |
GeneIDi | 33432 |
KEGGi | dme:Dmel_CG9885 |
UCSCi | CG9885-RB, d. melanogaster |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M30116 mRNA Translation: AAA28482.1 U63857 Genomic DNA Translation: AAC47552.1 AE014134 Genomic DNA Translation: AAF51250.1 AE014134 Genomic DNA Translation: AAN10431.1 AE014134 Genomic DNA Translation: AAN10432.1 AE014134 Genomic DNA Translation: AAN10434.1 BT015227 mRNA Translation: AAT94456.1 AF459545 Genomic DNA Translation: AAN61361.1 AF459546 Genomic DNA Translation: AAN61362.1 AF459547 Genomic DNA Translation: AAN61363.1 AF459548 Genomic DNA Translation: AAN61364.1 AF459549 Genomic DNA Translation: AAN61365.1 AF459550 Genomic DNA Translation: AAN61366.1 AF459551 Genomic DNA Translation: AAN61367.1 AF459552 Genomic DNA Translation: AAN61368.1 AF459553 Genomic DNA Translation: AAN61369.1 AF459554 Genomic DNA Translation: AAN61370.1 AF459555 Genomic DNA Translation: AAN61371.1 AF459556 Genomic DNA Translation: AAN61372.1 AF459557 Genomic DNA Translation: AAN61373.1 AF459558 Genomic DNA Translation: AAN61374.1 AF459559 Genomic DNA Translation: AAN61375.1 AF459560 Genomic DNA Translation: AAN61376.1 AF459561 Genomic DNA Translation: AAN61377.1 AF459562 Genomic DNA Translation: AAN61378.1 AF459563 Genomic DNA Translation: AAN61379.1 AF459564 Genomic DNA Translation: AAN61380.1 |
PIRi | A26158 |
RefSeqi | NP_477311.1, NM_057963.5 NP_722810.1, NM_164485.2 NP_722811.1, NM_164486.2 NP_722813.1, NM_164488.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 59659, 97 interactors |
DIPi | DIP-19N |
IntActi | P07713, 3 interactors |
STRINGi | 7227.FBpp0077451 |
Proteomic databases
PaxDbi | P07713 |
Genome annotation databases
EnsemblMetazoai | FBtr0077771; FBpp0077451; FBgn0000490 FBtr0077772; FBpp0077452; FBgn0000490 FBtr0077773; FBpp0077453; FBgn0000490 FBtr0077775; FBpp0077455; FBgn0000490 |
GeneIDi | 33432 |
KEGGi | dme:Dmel_CG9885 |
UCSCi | CG9885-RB, d. melanogaster |
Organism-specific databases
CTDi | 33432 |
FlyBasei | FBgn0000490, dpp |
Phylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000174461 |
HOGENOMi | CLU_020515_4_2_1 |
InParanoidi | P07713 |
OMAi | DSWPQAR |
OrthoDBi | 1063560at2759 |
PhylomeDBi | P07713 |
Enzyme and pathway databases
Reactomei | R-DME-201451, Signaling by BMP R-DME-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-8957275, Post-translational protein phosphorylation |
SignaLinki | P07713 |
Miscellaneous databases
BioGRID-ORCSi | 33432, 0 hits in 3 CRISPR screens |
GenomeRNAii | 33432 |
PROi | PR:P07713 |
Gene expression databases
Bgeei | FBgn0000490, Expressed in crop (Drosophila) and 65 other tissues |
Genevisiblei | P07713, DM |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DECA_DROME | |
Accessioni | P07713Primary (citable) accession number: P07713 Secondary accession number(s): A4V009 Q9VQC6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1988 |
Last sequence update: | September 13, 2005 | |
Last modified: | December 2, 2020 | |
This is version 190 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families