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UniProtKB - P07713 (DECA_DROME)

Entry version 190 (02 Dec 2020)
Sequence version 2 (13 Sep 2005)
Previous versions | rss
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Protein

Protein decapentaplegic

Gene

dpp

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required during oogenesis for eggshell patterning and dorsal/ventral patterning of the embryo. Acts as a morphogen during embryogenesis to pattern the dorsal/ventral axis, specifying dorsal ectoderm and amnioserosa cell fate within the dorsal half of the embryo; this activity is antagonized by binding to sog and tsg. Induces the formation of visceral mesoderm and the heart in early embryos. Required later in embryogenesis for dorsal closure and patterning of the hindgut. Also functions postembryonically as a long-range morphogen during imaginal disk development; is responsible for the progression of the morphogenetic furrow during eye development. Patterns the wing imaginal disk along its anterior/posterior axis and has a role in positioning pro-veins. Also required to subdivide the wing disk along the proximal/distal axis into body wall (notum) and wing. Ensures the correct architecture of wing epithelial cells. Has multiple roles in the developing tracheal system, controlling directed tracheal cell migration during embryogenesis and later specifying the fate of fusion cells in the tracheal branches. Required for viability of larvae. Essential for the maintenance and division of germline stem cells in the ovary. Signals via the type I receptor tkv, the type II receptor punt, and in some tissues via the type I receptor sax, in a signaling cascade that leads to activation and repression of target genes.15 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Growth factor
Biological processDifferentiation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-201451, Signaling by BMP
R-DME-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-DME-8957275, Post-translational protein phosphorylation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P07713

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein decapentaplegic
Short name:
Protein DPP-C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dpp
ORF Names:CG9885
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0000490, dpp

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000003366424 – 4561 PublicationAdd BLAST433
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000033665457 – 588Protein decapentaplegicAdd BLAST132

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi342N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi377N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi487 ↔ 553By similarity
Disulfide bondi516 ↔ 585By similarity
Disulfide bondi520 ↔ 587By similarity
Glycosylationi529N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi552InterchainBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei456Cleavage1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P07713

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the dorsal region of the embryo, and becomes enriched in a dorsal midline stripe just prior to gastrulation. Expressed in midgut mesoderm and in two overlapping regions of the embryonic large intestine. Expressed in a long-range concentration gradient in the wing imaginal disk.4 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically. First detected during stages 8 to 10 of oogenesis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0000490, Expressed in crop (Drosophila) and 65 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P07713, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimers of scw/dpp are the active subunit, dpp/dpp homodimers elicit a basal response and scw/scw homodimers alone are ineffective in specifying a dorsal pattern.

Component of a complex composed of dpp, sog and tsg.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		59659, 97 interactors

Database of interacting proteins

More...DIPi		DIP-19N

Protein interaction database and analysis system

More...IntActi		P07713, 3 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0077451

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3900, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000174461

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_020515_4_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P07713

Identification of Orthologs from Complete Genome Data

More...OMAi		DSWPQAR

Database of Orthologous Groups

More...OrthoDBi		1063560at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P07713

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.10.90.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029034, Cystine-knot_cytokine
IPR001839, TGF-b_C
IPR001111, TGF-b_propeptide
IPR015615, TGF-beta-rel
IPR017948, TGFb_CS

The PANTHER Classification System

More...PANTHERi		PTHR11848, PTHR11848, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00019, TGF_beta, 1 hit
PF00688, TGFb_propeptide, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00204, TGFB, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57501, SSF57501, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00250, TGF_BETA_1, 1 hit
PS51362, TGF_BETA_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P07713-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRAWLLLLAV LATFQTIVRV ASTEDISQRF IAAIAPVAAH IPLASASGSG 
        60         70         80         90        100
SGRSGSRSVG ASTSTALAKA FNPFSEPASF SDSDKSHRSK TNKKPSKSDA 
       110        120        130        140        150
NRQFNEVHKP RTDQLENSKN KSKQLVNKPN HNKMAVKEQR SHHKKSHHHR 
       160        170        180        190        200
SHQPKQASAS TESHQSSSIE SIFVEEPTLV LDREVASINV PANAKAIIAE 
       210        220        230        240        250
QGPSTYSKEA LIKDKLKPDP STLVEIEKSL LSLFNMKRPP KIDRSKIIIP 
       260        270        280        290        300
EPMKKLYAEI MGHELDSVNI PKPGLLTKSA NTVRSFTHKD SKIDDRFPHH 
       310        320        330        340        350
HRFRLHFDVK SIPADEKLKA AELQLTRDAL SQQVVASRSS ANRTRYQVLV 
       360        370        380        390        400
YDITRVGVRG QREPSYLLLD TKTVRLNSTD TVSLDVQPAV DRWLASPQRN 
       410        420        430        440        450
YGLLVEVRTV RSLKPAPHHH VRLRRSADEA HERWQHKQPL LFTYTDDGRH 
       460        470        480        490        500
KARSIRDVSG GEGGGKGGRN KRQPRRPTRR KNHDDTCRRH SLYVDFSDVG 
       510        520        530        540        550
WDDWIVAPLG YDAYYCHGKC PFPLADHFNS TNHAVVQTLV NNMNPGKVPK 
       560        570        580 
ACCVPTQLDS VAMLYLNDQS TVVLKNYQEM TVVGCGCR
Length:588
Mass (Da):65,868
Last modified:September 13, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2C8166C1BD2F666B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti473 – 474QP → HA in AAA28482 (PubMed:3467201).Curated2
Sequence conflicti556T → K in AAT94456 (Ref. 5) Curated1
Sequence conflicti568D → G in AAT94456 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti59V → G in strain: dp cn bw. 1 Publication1
Natural varianti121K → M in strain: dp cn bw. 1 Publication1
Natural varianti439P → A1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M30116 mRNA Translation: AAA28482.1
U63857 Genomic DNA Translation: AAC47552.1
AE014134 Genomic DNA Translation: AAF51250.1
AE014134 Genomic DNA Translation: AAN10431.1
AE014134 Genomic DNA Translation: AAN10432.1
AE014134 Genomic DNA Translation: AAN10434.1
BT015227 mRNA Translation: AAT94456.1
AF459545 Genomic DNA Translation: AAN61361.1
AF459546 Genomic DNA Translation: AAN61362.1
AF459547 Genomic DNA Translation: AAN61363.1
AF459548 Genomic DNA Translation: AAN61364.1
AF459549 Genomic DNA Translation: AAN61365.1
AF459550 Genomic DNA Translation: AAN61366.1
AF459551 Genomic DNA Translation: AAN61367.1
AF459552 Genomic DNA Translation: AAN61368.1
AF459553 Genomic DNA Translation: AAN61369.1
AF459554 Genomic DNA Translation: AAN61370.1
AF459555 Genomic DNA Translation: AAN61371.1
AF459556 Genomic DNA Translation: AAN61372.1
AF459557 Genomic DNA Translation: AAN61373.1
AF459558 Genomic DNA Translation: AAN61374.1
AF459559 Genomic DNA Translation: AAN61375.1
AF459560 Genomic DNA Translation: AAN61376.1
AF459561 Genomic DNA Translation: AAN61377.1
AF459562 Genomic DNA Translation: AAN61378.1
AF459563 Genomic DNA Translation: AAN61379.1
AF459564 Genomic DNA Translation: AAN61380.1

Protein sequence database of the Protein Information Resource

More...PIRi		A26158

NCBI Reference Sequences

More...RefSeqi		NP_477311.1, NM_057963.5
NP_722810.1, NM_164485.2
NP_722811.1, NM_164486.2
NP_722813.1, NM_164488.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0077771; FBpp0077451; FBgn0000490
FBtr0077772; FBpp0077452; FBgn0000490
FBtr0077773; FBpp0077453; FBgn0000490
FBtr0077775; FBpp0077455; FBgn0000490

Database of genes from NCBI RefSeq genomes

More...GeneIDi		33432

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG9885

UCSC genome browser

More...UCSCi		CG9885-RB, d. melanogaster

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30116 mRNA Translation: AAA28482.1
U63857 Genomic DNA Translation: AAC47552.1
AE014134 Genomic DNA Translation: AAF51250.1
AE014134 Genomic DNA Translation: AAN10431.1
AE014134 Genomic DNA Translation: AAN10432.1
AE014134 Genomic DNA Translation: AAN10434.1
BT015227 mRNA Translation: AAT94456.1
AF459545 Genomic DNA Translation: AAN61361.1
AF459546 Genomic DNA Translation: AAN61362.1
AF459547 Genomic DNA Translation: AAN61363.1
AF459548 Genomic DNA Translation: AAN61364.1
AF459549 Genomic DNA Translation: AAN61365.1
AF459550 Genomic DNA Translation: AAN61366.1
AF459551 Genomic DNA Translation: AAN61367.1
AF459552 Genomic DNA Translation: AAN61368.1
AF459553 Genomic DNA Translation: AAN61369.1
AF459554 Genomic DNA Translation: AAN61370.1
AF459555 Genomic DNA Translation: AAN61371.1
AF459556 Genomic DNA Translation: AAN61372.1
AF459557 Genomic DNA Translation: AAN61373.1
AF459558 Genomic DNA Translation: AAN61374.1
AF459559 Genomic DNA Translation: AAN61375.1
AF459560 Genomic DNA Translation: AAN61376.1
AF459561 Genomic DNA Translation: AAN61377.1
AF459562 Genomic DNA Translation: AAN61378.1
AF459563 Genomic DNA Translation: AAN61379.1
AF459564 Genomic DNA Translation: AAN61380.1
PIRiA26158
RefSeqiNP_477311.1, NM_057963.5
NP_722810.1, NM_164485.2
NP_722811.1, NM_164486.2
NP_722813.1, NM_164488.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi59659, 97 interactors
DIPiDIP-19N
IntActiP07713, 3 interactors
STRINGi7227.FBpp0077451

Proteomic databases

PaxDbiP07713

Genome annotation databases

EnsemblMetazoaiFBtr0077771; FBpp0077451; FBgn0000490
FBtr0077772; FBpp0077452; FBgn0000490
FBtr0077773; FBpp0077453; FBgn0000490
FBtr0077775; FBpp0077455; FBgn0000490
GeneIDi33432
KEGGidme:Dmel_CG9885
UCSCiCG9885-RB, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		33432
FlyBaseiFBgn0000490, dpp

Phylogenomic databases

eggNOGiKOG3900, Eukaryota
GeneTreeiENSGT00940000174461
HOGENOMiCLU_020515_4_2_1
InParanoidiP07713
OMAiDSWPQAR
OrthoDBi1063560at2759
PhylomeDBiP07713

Enzyme and pathway databases

ReactomeiR-DME-201451, Signaling by BMP
R-DME-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-DME-8957275, Post-translational protein phosphorylation
SignaLinkiP07713

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		33432, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		33432

Protein Ontology

More...PROi		PR:P07713

Gene expression databases

BgeeiFBgn0000490, Expressed in crop (Drosophila) and 65 other tissues
GenevisibleiP07713, DM

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034, Cystine-knot_cytokine
IPR001839, TGF-b_C
IPR001111, TGF-b_propeptide
IPR015615, TGF-beta-rel
IPR017948, TGFb_CS
PANTHERiPTHR11848, PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019, TGF_beta, 1 hit
PF00688, TGFb_propeptide, 1 hit
SMARTiView protein in SMART
SM00204, TGFB, 1 hit
SUPFAMiSSF57501, SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250, TGF_BETA_1, 1 hit
PS51362, TGF_BETA_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDECA_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07713
Secondary accession number(s): A4V009
, P91651, Q6AWM1, Q8I0M7, Q8ITK4, Q9VQC6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: September 13, 2005
Last modified: December 2, 2020
This is version 190 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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