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Protein

Period circadian protein

Gene

per

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition. Required for binding of cwo to the E box regions in the promoters of target genes of the transcriptional activator Clock, probably by binding to Clock-cycle heterodimers, reducing their affinity for E box binding and allowing cwo to bind instead (PubMed:27814361).1 Publication

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein heterodimerization activity Source: FlyBase
  • protein homodimerization activity Source: FlyBase
  • transcription coregulator activity Source: FlyBase
  • transcription corepressor activity Source: FlyBase
  • transcription corepressor binding Source: GO_Central
  • transcription factor binding Source: FlyBase
  • transcription regulatory region sequence-specific DNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processBiological rhythms

Enzyme and pathway databases

ReactomeiR-DME-432395 Degradation of TIM
R-DME-432490 Nuclear import of PER and TIM
R-DME-432501 Transcription repression by PER and activation by PDP1
R-DME-432524 Degradation of PER
R-DME-432553 Phosphorylation of PER and TIM
R-DME-432620 Dephosphorylation of PER
R-DME-538898 Dephosphorylation of TIM

Names & Taxonomyi

Protein namesi
Recommended name:
Period circadian protein
Alternative name(s):
Protein clock-6
Short name:
CLK-6
Gene namesi
Name:per
ORF Names:CG2647
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0003068 per

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001625961 – 1224Period circadian proteinAdd BLAST1224

Post-translational modificationi

Phosphorylated with a circadian rhythmicity, probably by the double-time protein (dbt). Phosphorylation could be implicated in the stability of per monomer and in the formation of heterodimer per-tim.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP07663
PRIDEiP07663

PTM databases

iPTMnetiP07663

Expressioni

Tissue specificityi

Expressed in neural tissues and in several nonneural tissues of the abdomen. Malpighian tubules contain a circadian pacemaker that functions independently of the brain. Expression oscillates in all tissues studied except for the ovary. PER-A isoforms are mainly expressed in adult's head.

Inductioni

Expression is sensitive to temperature but not to light.

Gene expression databases

BgeeiFBgn0003068 Expressed in 24 organ(s), highest expression level in head capsule
ExpressionAtlasiP07663 baseline and differential
GenevisibleiP07663 DM

Interactioni

Subunit structurei

Forms a heterodimer with timeless (TIM); the complex then translocates into the nucleus. A proportion of the protein exists as homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
timP490212EBI-15718452,EBI-266295

GO - Molecular functioni

Protein-protein interaction databases

BioGridi57782, 29 interactors
DIPiDIP-29426N
IntActiP07663, 5 interactors
STRINGi7227.FBpp0070455

Structurei

Secondary structure

11224
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP07663
SMRiP07663
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07663

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini238 – 373PAS 1PROSITE-ProRule annotationAdd BLAST136
Domaini391 – 497PAS 2PROSITE-ProRule annotationAdd BLAST107
Repeati694 – 69512
Repeati697 – 69822
Repeati699 – 70032
Repeati701 – 70242
Repeati703 – 70452
Repeati705 – 70662
Repeati707 – 70872
Repeati709 – 71082
Repeati711 – 71292
Repeati713 – 714102
Repeati715 – 716112
Repeati717 – 718122
Repeati719 – 720132
Repeati721 – 722142
Repeati723 – 724152
Repeati725 – 726162
Repeati727 – 728172
Repeati729 – 730182
Repeati731 – 732192
Repeati733 – 734202
Repeati735 – 736212
Repeati737 – 738222
Repeati739 – 740232
Repeati741 – 742242
Repeati743 – 744252
Repeati745 – 746262
Repeati747 – 74827; approximate2
Repeati749 – 750282
Repeati751 – 752292
Repeati753 – 754302

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni694 – 75430 X 2 AA approximate tandem repeats of G-[TN]Add BLAST61
Regioni749 – 868Regulates the rhythm of species-specific courtship songAdd BLAST120

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi66 – 79Nuclear localization signalSequence analysisAdd BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi74 – 79Poly-Lys6
Compositional biasi143 – 146Poly-Glu4
Compositional biasi223 – 226Poly-Ala4
Compositional biasi872 – 879Poly-Gly8
Compositional biasi898 – 905Poly-Gly8
Compositional biasi906 – 914Poly-Ala9
Compositional biasi1006 – 1013Poly-Ala8
Compositional biasi1035 – 1041Poly-Ala7

Domaini

Contains a remarkable run of alternating Gly-Thr residues which is polymorphic in length. At least three types of Gly-Thr length exist in the natural population, (Gly-Thr)23 (shown here), and two major variants (Gly-Thr)17 and (Gly-Thr)20. This Gly-Thr stretch is implicated in the maintenance of circadian period at different temperatures. Deletion of the repeat leads to a shortening of the courtship song cycle period, and thus could be important for determining features of species-specific mating behavior.
Mutations in the PAS domain result in longer circadian rhythms and courtship song (PERL mutation) or makes the flies arrhythmic (PER01 mutation).

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3753 Eukaryota
ENOG410Y118 LUCA
InParanoidiP07663
KOiK02633
OrthoDBiEOG091G01SQ

Family and domain databases

CDDicd00130 PAS, 2 hits
InterProiView protein in InterPro
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
PfamiView protein in Pfam
PF00989 PAS, 1 hit
SMARTiView protein in SMART
SM00091 PAS, 2 hits
SUPFAMiSSF55785 SSF55785, 2 hits
PROSITEiView protein in PROSITE
PS50112 PAS, 2 hits

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform PER-A-long (identifier: P07663-1) [UniParc]FASTAAdd to basket
Also known as: perA

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGGESTEST HNTKVSDSAY SNSCSNSQSQ RSGSSKSRLS GSHSSGSSGY
60 70 80 90 100
GGKPSTQASS SDMIIKRNKD KSRKKKKNKG AGQGAGQAQT LISASTSLEG
110 120 130 140 150
RDEEKPRPSG TGCVEQQICR ELQDQQHGED HSEPQAIEQL QQEEEEDQSG
160 170 180 190 200
SESEADRVEG VAKSEAAQSF PIPSPLSVTI VPPSMGGCGG VGHAAGLDSG
210 220 230 240 250
LAKFDKTWEA GPGKLESMTG VGAAAAGTGQ RGERVKEDSF CCVISMHDGI
260 270 280 290 300
VLYTTPSITD VLGYPRDMWL GRSFIDFVHL KDRATFASQI TTGIPIAESR
310 320 330 340 350
GSVPKDAKST FCVMLRRYRG LKSGGFGVIG RPVSYEPFRL GLTFREAPEE
360 370 380 390 400
ARPDNYMVSN GTNMLLVICA TPIKSSYKVP DEILSQKSPK FAIRHTATGI
410 420 430 440 450
ISHVDSAAVS ALGYLPQDLI GRSIMDFYHH EDLSVMKETY ETVMKKGQTA
460 470 480 490 500
GASFCSKPYR FLIQNGCYVL LETEWTSFVN PWSRKLEFVV GHHRVFQGPK
510 520 530 540 550
QCNVFEAAPT CKLKISEEAQ SRNTRIKEDI VKRLAETVSR PSDTVKQEVS
560 570 580 590 600
RRCQALASFM ETLMDEVSRA DLKLELPHEN ELTVSERDSV MLGEISPHHD
610 620 630 640 650
YYDSKSSTET PPSYNQLNYN ENLLRFFNSK PVTAPAELDP PKTEPPEPRG
660 670 680 690 700
TCVSGASGPM SPVHEGSGGS GSSGNFTTAS NIHMSSVTNT SIAGTGGTGT
710 720 730 740 750
GTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTGNGTNSGT
760 770 780 790 800
GTGTASSSKG GTAAIPPVTL TESLLNKHND EMEKFMLKKH RESRGRTGEK
810 820 830 840 850
SKKSANDTLK MLEYSGPGHG IKRGGSHSWE GEANKPKQQL TLGTDAIKGA
860 870 880 890 900
AGSAGGAVGT GGVGSGGAGV AGGGGSGTGV AGTPEGRATT TSGTGTPGGA
910 920 930 940 950
GGGGGAGAAA AAGASSSVGS STPGPSSYPT CTQNINLWPP FSVGITPPVH
960 970 980 990 1000
STHTAMAQSS FSSAGLFPTF YYIPASLTPT SPTRSPRMHK HPHKGGTDMP
1010 1020 1030 1040 1050
TTSQQAAAAA AQAMPLQYMA GVMYPHPSLF YTHPAAAAAT AMMYQPMPFP
1060 1070 1080 1090 1100
GMANALQIPE RPLGSQSAYN KSVYTTTPAS MTKKVPGAFH SVTTPAQVQR
1110 1120 1130 1140 1150
PSSQSASVKT EPGSSAAVSD PCKKEVPDSS PIPSVMGDYN SDPPCSSSNP
1160 1170 1180 1190 1200
ANNKKYTDSN GNSDDMDGSS FSSFYSSFIK TTDGSESPPD TEKDPKHRKL
1210 1220
KSMSTSESKI MEHPEEDQTQ HGDG
Length:1,224
Mass (Da):127,852
Last modified:December 15, 1998 - v2
Checksum:i71FA54ECF3E90F4A
GO
Isoform PER-A-short (identifier: P07663-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.

Show »
Length:1,162
Mass (Da):121,661
Checksum:i7EF93EDE76EC5A5B
GO
Isoform PER-B (identifier: P07663-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     868-963: Missing.

Show »
Length:1,128
Mass (Da):119,293
Checksum:iAE924CCDF4C5ADD9
GO
Isoform PER-C (identifier: P07663-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1076-1224: TTPASMTKKV...EEDQTQHGDG → VSQWPVVPHR...SRQQQGMLYE

Show »
Length:1,182
Mass (Da):123,485
Checksum:i434AC9036463909E
GO
Isoform PER-D (identifier: P07663-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     863-958: Missing.

Show »
Length:1,128
Mass (Da):119,431
Checksum:i5ED88CCD3FEE97B4
GO
Isoform PER-E (identifier: P07663-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     863-958: Missing.
     1155-1224: KYTDSNGNSD...EEDQTQHGDG → VCYTNEVHW

Show »
Length:1,067
Mass (Da):112,804
Checksum:iBD72A8EC731BFD31
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PGJ3M9PGJ3_DROME
Period, isoform B
per Clk, clk-6, Dmel\CG2647, dmper, dPER
1,218Annotation score:

Sequence cautioni

The sequence CAA27285 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti211G → V in AAA28777 (PubMed:8436278).Curated1
Sequence conflicti498 – 499GP → A in AAA28777 (PubMed:8436278).Curated2
Sequence conflicti637E → A (PubMed:3087625).Curated1
Sequence conflicti733 – 767Missing (PubMed:3081818).CuratedAdd BLAST35
Sequence conflicti762 – 764TAA → RR (PubMed:3081818).Curated3
Sequence conflicti762 – 764TAA → RR (PubMed:3087625).Curated3
Sequence conflicti1029L → V (PubMed:3087625).Curated1
Sequence conflicti1038A → P (PubMed:3087625).Curated1
Sequence conflicti1075T → TVSQWPV in CAA19677 (PubMed:10731137).Curated1
Sequence conflicti1114S → F (PubMed:3102970).Curated1
Sequence conflicti1215E → D (PubMed:3102970).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti697 – 708Missing in (Gly-Thr)17. Add BLAST12
Natural varianti697 – 702Missing in (Gly-Thr)20. 6
Natural varianti748S → F in strain: U79. 1
Natural varianti762T → S in strain: Berkeley, L18, Oregon-R, SP1 and U79. 1
Natural varianti846A → T in strain: U79. 1
Natural varianti858V → A in strain: L18 and U79. 1
Natural varianti1176S → P in strain: L18. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0046571 – 62Missing in isoform PER-A-short. CuratedAdd BLAST62
Alternative sequenceiVSP_004659863 – 958Missing in isoform PER-D and isoform PER-E. CuratedAdd BLAST96
Alternative sequenceiVSP_004658868 – 963Missing in isoform PER-B. CuratedAdd BLAST96
Alternative sequenceiVSP_0046601076 – 1224TTPAS…QHGDG → VSQWPVVPHRTVLTPTPTPY SSIDHAGVHDEEGAGCIPLG HHSCPGAASLLAERIRQDGA GLQCSGIRSLQEGGAGLLAH SLRDGRLQLRPALQQQQSRQ QQGMLYE in isoform PER-C. CuratedAdd BLAST149
Alternative sequenceiVSP_0046611155 – 1224KYTDS…QHGDG → VCYTNEVHW in isoform PER-E. CuratedAdd BLAST70

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30114 Genomic DNA Translation: AAA28752.1
M30114 Genomic DNA Translation: AAA28753.1
M30114 Genomic DNA Translation: AAA28754.1
AF033029 mRNA Translation: AAB87476.1
X03636 Genomic DNA Translation: CAA27285.1 Sequence problems.
AE014298 Genomic DNA Translation: AAF45804.1
AL024485 Genomic DNA Translation: CAA19677.1
AL024485 Genomic DNA Translation: CAA19678.1
AL024485 Genomic DNA Translation: CAA19679.1
AL024485 Genomic DNA Translation: CAA19680.1
AY575847 Genomic DNA Translation: AAS89667.1
L07817 Genomic DNA Translation: AAA28777.1
L07818 Genomic DNA Translation: AAA28776.1
L07819 Genomic DNA Translation: AAA28775.1
L07821 Genomic DNA Translation: AAA28773.1
L07823 Genomic DNA Translation: AAA28771.1
L07825 Genomic DNA Translation: AAA28769.1
AB029194 Genomic DNA Translation: BAB15868.1
AB029195 Genomic DNA Translation: BAB15869.1
AB029196 Genomic DNA Translation: BAB15870.1
AB029222 Genomic DNA Translation: BAB15896.1
AB029223 Genomic DNA Translation: BAB15897.1
AB029224 Genomic DNA Translation: BAB15898.1
AB029250 Genomic DNA Translation: BAB15924.1
AB029251 Genomic DNA Translation: BAB15925.1
AB029252 Genomic DNA Translation: BAB15926.1
D00009 Genomic DNA Translation: BAA00007.1
AF251241 Genomic DNA Translation: AAG44573.1
AY047980 Genomic DNA Translation: AAN02289.1
AY047981 Genomic DNA Translation: AAN02291.1
AY047982 Genomic DNA Translation: AAN02293.1
AY047983 Genomic DNA Translation: AAN02295.1
AY047984 Genomic DNA Translation: AAN02297.1
AY047985 Genomic DNA Translation: AAN02299.1
AY047986 Genomic DNA Translation: AAN02301.1
AY047987 Genomic DNA Translation: AAN02303.1
AY047988 Genomic DNA Translation: AAN02305.1
AY047989 Genomic DNA Translation: AAN02307.1
AY047990 Genomic DNA Translation: AAN02309.1
AY047991 Genomic DNA Translation: AAN02311.1
AY047992 Genomic DNA Translation: AAN02313.1
AY047993 Genomic DNA Translation: AAN02315.1
AY047994 Genomic DNA Translation: AAN02317.1
AY047995 Genomic DNA Translation: AAN02319.1
AY047996 Genomic DNA Translation: AAN02321.1
AY047997 Genomic DNA Translation: AAN02323.1
AY047998 Genomic DNA Translation: AAN02325.1
AY047999 Genomic DNA Translation: AAN02327.1
AY048000 Genomic DNA Translation: AAN02329.1
AY048001 Genomic DNA Translation: AAN02331.1
AY048002 Genomic DNA Translation: AAN02333.1
AY048003 Genomic DNA Translation: AAN02335.1
AY048004 Genomic DNA Translation: AAN02337.1
AY048005 Genomic DNA Translation: AAN02339.1
AY048006 Genomic DNA Translation: AAN02341.1
AY048007 Genomic DNA Translation: AAN02343.1
AY048008 Genomic DNA Translation: AAN02345.1
AY048009 Genomic DNA Translation: AAN02347.1
AY048010 Genomic DNA Translation: AAN02349.1
AY048011 Genomic DNA Translation: AAN02351.1
AY048012 Genomic DNA Translation: AAN02353.1
AY048013 Genomic DNA Translation: AAN02355.1
AY048014 Genomic DNA Translation: AAN02357.1
AY048015 Genomic DNA Translation: AAN02359.1
AY048016 Genomic DNA Translation: AAN02361.1
AY048017 Genomic DNA Translation: AAN02363.1
AY048018 Genomic DNA Translation: AAN02365.1
AY048019 Genomic DNA Translation: AAN02367.1
AY048020 Genomic DNA Translation: AAN02369.1
AY048021 Genomic DNA Translation: AAN02371.1
AY048022 Genomic DNA Translation: AAN02373.1
AY048023 Genomic DNA Translation: AAN02375.1
AY048024 Genomic DNA Translation: AAN02377.1
AY048025 Genomic DNA Translation: AAN02379.1
AY048026 Genomic DNA Translation: AAN02381.1
AY048027 Genomic DNA Translation: AAN02383.1
AY048028 Genomic DNA Translation: AAN02385.1
AY048029 Genomic DNA Translation: AAN02387.1
AY048030 Genomic DNA Translation: AAN02389.1
AY048031 Genomic DNA Translation: AAN02391.1
AY048032 Genomic DNA Translation: AAN02393.1
AY048033 Genomic DNA Translation: AAN02395.1
AY048034 Genomic DNA Translation: AAN02397.1
AY048035 Genomic DNA Translation: AAN02399.1
AY048036 Genomic DNA Translation: AAN02401.1
AY048037 Genomic DNA Translation: AAN02403.1
AY048038 Genomic DNA Translation: AAN02405.1
AY048040 Genomic DNA Translation: AAN02407.1
AY048041 Genomic DNA Translation: AAN02409.1
AY048042 Genomic DNA Translation: AAN02411.1
PIRiA23932 UMFF
A26427
A26588
B26427
C26427
S52943
RefSeqiNP_001259194.1, NM_001272265.1
NP_525056.2, NM_080317.2
UniGeneiDm.65

Genome annotation databases

GeneIDi31251
KEGGidme:Dmel_CG2647

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Protein Spotlight

The tale of a love song - Issue 6 of January 2001

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30114 Genomic DNA Translation: AAA28752.1
M30114 Genomic DNA Translation: AAA28753.1
M30114 Genomic DNA Translation: AAA28754.1
AF033029 mRNA Translation: AAB87476.1
X03636 Genomic DNA Translation: CAA27285.1 Sequence problems.
AE014298 Genomic DNA Translation: AAF45804.1
AL024485 Genomic DNA Translation: CAA19677.1
AL024485 Genomic DNA Translation: CAA19678.1
AL024485 Genomic DNA Translation: CAA19679.1
AL024485 Genomic DNA Translation: CAA19680.1
AY575847 Genomic DNA Translation: AAS89667.1
L07817 Genomic DNA Translation: AAA28777.1
L07818 Genomic DNA Translation: AAA28776.1
L07819 Genomic DNA Translation: AAA28775.1
L07821 Genomic DNA Translation: AAA28773.1
L07823 Genomic DNA Translation: AAA28771.1
L07825 Genomic DNA Translation: AAA28769.1
AB029194 Genomic DNA Translation: BAB15868.1
AB029195 Genomic DNA Translation: BAB15869.1
AB029196 Genomic DNA Translation: BAB15870.1
AB029222 Genomic DNA Translation: BAB15896.1
AB029223 Genomic DNA Translation: BAB15897.1
AB029224 Genomic DNA Translation: BAB15898.1
AB029250 Genomic DNA Translation: BAB15924.1
AB029251 Genomic DNA Translation: BAB15925.1
AB029252 Genomic DNA Translation: BAB15926.1
D00009 Genomic DNA Translation: BAA00007.1
AF251241 Genomic DNA Translation: AAG44573.1
AY047980 Genomic DNA Translation: AAN02289.1
AY047981 Genomic DNA Translation: AAN02291.1
AY047982 Genomic DNA Translation: AAN02293.1
AY047983 Genomic DNA Translation: AAN02295.1
AY047984 Genomic DNA Translation: AAN02297.1
AY047985 Genomic DNA Translation: AAN02299.1
AY047986 Genomic DNA Translation: AAN02301.1
AY047987 Genomic DNA Translation: AAN02303.1
AY047988 Genomic DNA Translation: AAN02305.1
AY047989 Genomic DNA Translation: AAN02307.1
AY047990 Genomic DNA Translation: AAN02309.1
AY047991 Genomic DNA Translation: AAN02311.1
AY047992 Genomic DNA Translation: AAN02313.1
AY047993 Genomic DNA Translation: AAN02315.1
AY047994 Genomic DNA Translation: AAN02317.1
AY047995 Genomic DNA Translation: AAN02319.1
AY047996 Genomic DNA Translation: AAN02321.1
AY047997 Genomic DNA Translation: AAN02323.1
AY047998 Genomic DNA Translation: AAN02325.1
AY047999 Genomic DNA Translation: AAN02327.1
AY048000 Genomic DNA Translation: AAN02329.1
AY048001 Genomic DNA Translation: AAN02331.1
AY048002 Genomic DNA Translation: AAN02333.1
AY048003 Genomic DNA Translation: AAN02335.1
AY048004 Genomic DNA Translation: AAN02337.1
AY048005 Genomic DNA Translation: AAN02339.1
AY048006 Genomic DNA Translation: AAN02341.1
AY048007 Genomic DNA Translation: AAN02343.1
AY048008 Genomic DNA Translation: AAN02345.1
AY048009 Genomic DNA Translation: AAN02347.1
AY048010 Genomic DNA Translation: AAN02349.1
AY048011 Genomic DNA Translation: AAN02351.1
AY048012 Genomic DNA Translation: AAN02353.1
AY048013 Genomic DNA Translation: AAN02355.1
AY048014 Genomic DNA Translation: AAN02357.1
AY048015 Genomic DNA Translation: AAN02359.1
AY048016 Genomic DNA Translation: AAN02361.1
AY048017 Genomic DNA Translation: AAN02363.1
AY048018 Genomic DNA Translation: AAN02365.1
AY048019 Genomic DNA Translation: AAN02367.1
AY048020 Genomic DNA Translation: AAN02369.1
AY048021 Genomic DNA Translation: AAN02371.1
AY048022 Genomic DNA Translation: AAN02373.1
AY048023 Genomic DNA Translation: AAN02375.1
AY048024 Genomic DNA Translation: AAN02377.1
AY048025 Genomic DNA Translation: AAN02379.1
AY048026 Genomic DNA Translation: AAN02381.1
AY048027 Genomic DNA Translation: AAN02383.1
AY048028 Genomic DNA Translation: AAN02385.1
AY048029 Genomic DNA Translation: AAN02387.1
AY048030 Genomic DNA Translation: AAN02389.1
AY048031 Genomic DNA Translation: AAN02391.1
AY048032 Genomic DNA Translation: AAN02393.1
AY048033 Genomic DNA Translation: AAN02395.1
AY048034 Genomic DNA Translation: AAN02397.1
AY048035 Genomic DNA Translation: AAN02399.1
AY048036 Genomic DNA Translation: AAN02401.1
AY048037 Genomic DNA Translation: AAN02403.1
AY048038 Genomic DNA Translation: AAN02405.1
AY048040 Genomic DNA Translation: AAN02407.1
AY048041 Genomic DNA Translation: AAN02409.1
AY048042 Genomic DNA Translation: AAN02411.1
PIRiA23932 UMFF
A26427
A26588
B26427
C26427
S52943
RefSeqiNP_001259194.1, NM_001272265.1
NP_525056.2, NM_080317.2
UniGeneiDm.65

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WA9X-ray3.15A/B232-599[»]
3GECX-ray4.00A232-538[»]
3RTYX-ray2.85A/B/C/D/E/F/G/H236-574[»]
ProteinModelPortaliP07663
SMRiP07663
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi57782, 29 interactors
DIPiDIP-29426N
IntActiP07663, 5 interactors
STRINGi7227.FBpp0070455

PTM databases

iPTMnetiP07663

Proteomic databases

PaxDbiP07663
PRIDEiP07663

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi31251
KEGGidme:Dmel_CG2647

Organism-specific databases

CTDi31251
FlyBaseiFBgn0003068 per

Phylogenomic databases

eggNOGiKOG3753 Eukaryota
ENOG410Y118 LUCA
InParanoidiP07663
KOiK02633
OrthoDBiEOG091G01SQ

Enzyme and pathway databases

ReactomeiR-DME-432395 Degradation of TIM
R-DME-432490 Nuclear import of PER and TIM
R-DME-432501 Transcription repression by PER and activation by PDP1
R-DME-432524 Degradation of PER
R-DME-432553 Phosphorylation of PER and TIM
R-DME-432620 Dephosphorylation of PER
R-DME-538898 Dephosphorylation of TIM

Miscellaneous databases

EvolutionaryTraceiP07663
GenomeRNAii31251
PROiPR:P07663

Gene expression databases

BgeeiFBgn0003068 Expressed in 24 organ(s), highest expression level in head capsule
ExpressionAtlasiP07663 baseline and differential
GenevisibleiP07663 DM

Family and domain databases

CDDicd00130 PAS, 2 hits
InterProiView protein in InterPro
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
PfamiView protein in Pfam
PF00989 PAS, 1 hit
SMARTiView protein in SMART
SM00091 PAS, 2 hits
SUPFAMiSSF55785 SSF55785, 2 hits
PROSITEiView protein in PROSITE
PS50112 PAS, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPER_DROME
AccessioniPrimary (citable) accession number: P07663
Secondary accession number(s): O17483
, O76882, O76883, O76884, O76885, Q24446, Q24447, Q24448, Q24449, Q6PVA3, Q8MLY0, Q9GN20, Q9GN51, Q9GQH9, Q9GV48, Q9GV53, Q9GV54, Q9GV55, Q9W4X0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: December 15, 1998
Last modified: November 7, 2018
This is version 188 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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