per

Functionⁱ

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition. Required for binding of cwo to the E box regions in the promoters of target genes of the transcriptional activator Clock, probably by binding to Clock-cycle heterodimers, reducing their affinity for E box binding and allowing cwo to bind instead (PubMed:27814361).1 Publication

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 19402744
- 19402751
protein heterodimerization activity
Source: FlyBase
Inferred from physical interactionⁱ
- 10409723
protein homodimerization activity
Source: FlyBase
Inferred from physical interactionⁱ
- 19402744
transcription coregulator activity
Source: FlyBase
Non-traceable author statementⁱ
- 11715043
transcription corepressor activity
Source: FlyBase
Traceable author statementⁱ
- 12486701
transcription corepressor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription factor binding
Source: FlyBase
Inferred from physical interactionⁱ
- 10409723
transcription regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

age-dependent response to oxidative stress
Source: FlyBase
Inferred from mutant phenotypeⁱ
- 20157575
behavioral response to cocaine
Source: FlyBase
Non-traceable author statementⁱ
- 11715043
circadian behavior
Source: FlyBase
Inferred from mutant phenotypeⁱ
- 10677013
circadian regulation of gene expression
Source: FlyBase
Inferred from mutant phenotypeⁱ
- 29174887
circadian rhythm
Source: FlyBase
Inferred from mutant phenotypeⁱ
circadian sleep/wake cycle
Source: FlyBase
Traceable author statementⁱ
- 12111533
circadian temperature homeostasis
Source: FlyBase
Inferred from mutant phenotypeⁱ
- 22981774
copulation
Source: FlyBase
Inferred from mutant phenotypeⁱ
- 15324667
courtship behavior
Source: FlyBase
Non-traceable author statementⁱ
- 11715043
determination of adult lifespan
Source: FlyBase
Inferred from mutant phenotypeⁱ
- 20157575
eclosion rhythm
Source: FlyBase
Inferred from mutant phenotypeⁱ
- 11264660
entrainment of circadian clock
Source: FlyBase
Inferred from mutant phenotypeⁱ
- 16085487
entrainment of circadian clock by photoperiod
Source: FlyBase
Inferred from mutant phenotypeⁱ
- 16361445
locomotor rhythm
Source: FlyBase
Inferred from mutant phenotypeⁱ
long-term memory
Source: FlyBase
Inferred from mutant phenotypeⁱ
- 15522971
- 22323813
male courtship behavior, veined wing generated song production
Source: FlyBase
Traceable author statementⁱ
- 12486700
mating behavior
Source: FlyBase
Inferred from mutant phenotypeⁱ
- 11470898
negative regulation of transcription, DNA-templated
Source: FlyBase
Inferred from direct assayⁱ
- 17452449
- 19402744
negative regulation of transcription by RNA polymerase II
Source: FlyBase
Inferred from direct assayⁱ
negative regulation of transcription regulatory region DNA binding
Source: FlyBase
Inferred from direct assayⁱ
- 10409723
regulation of circadian rhythm
Source: FlyBase
Inferred from mutant phenotypeⁱ
regulation of circadian sleep/wake cycle, sleep
Source: FlyBase
Inferred from mutant phenotypeⁱ
- 12015603
- 25325457
regulation of locomotor rhythm
Source: FlyBase
Inferred from mutant phenotypeⁱ
- 24086144
regulation of protein phosphorylation
Source: FlyBase
Inferred from mutant phenotypeⁱ
- 24086144
response to light stimulus
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to oxidative stress
Source: FlyBase
Inferred from mutant phenotypeⁱ
- 18627767
response to temperature stimulus
Source: FlyBase
Traceable author statementⁱ
- 12626480
rhythmic behavior
Source: FlyBase
Traceable author statementⁱ
- 12486701

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Biological rhythms

Biological process

Biological rhythms

Enzyme and pathway databases

Reactomeⁱ	R-DME-432395 Degradation of TIM R-DME-432490 Nuclear import of PER and TIM R-DME-432501 Transcription repression by PER and activation by PDP1 R-DME-432524 Degradation of PER R-DME-432553 Phosphorylation of PER and TIM R-DME-432620 Dephosphorylation of PER R-DME-538898 Dephosphorylation of TIM

Reactomeⁱ

R-DME-432395 Degradation of TIM
R-DME-432490 Nuclear import of PER and TIM
R-DME-432501 Transcription repression by PER and activation by PDP1
R-DME-432524 Degradation of PER
R-DME-432553 Phosphorylation of PER and TIM
R-DME-432620 Dephosphorylation of PER
R-DME-538898 Dephosphorylation of TIM

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Period circadian protein Alternative name(s): Protein clock-6 Short name: CLK-6
Gene namesⁱ	Name:per ORF Names:CG2647
Organismⁱ	Drosophila melanogaster (Fruit fly)
Taxonomic identifierⁱ	7227 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophila › Sophophora › melanogaster group › melanogaster subgroup
Proteomesⁱ	UP000000803 Componentⁱ: Chromosome X

Organism-specific databases

Drosophila genome database More...FlyBaseⁱ	FBgn0003068 per

FlyBaseⁱ

FBgn0003068 per

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000162596	1 – 1224	Period circadian proteinAdd BLAST		1224

Post-translational modificationⁱ

Phosphorylated with a circadian rhythmicity, probably by the double-time protein (dbt). Phosphorylation could be implicated in the stability of per monomer and in the formation of heterodimer per-tim.1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	P07663
PRIDEⁱ	P07663

PTM databases

iPTMnetⁱ	P07663

iPTMnetⁱ

P07663

Expressionⁱ

Tissue specificityⁱ

Expressed in neural tissues and in several nonneural tissues of the abdomen. Malpighian tubules contain a circadian pacemaker that functions independently of the brain. Expression oscillates in all tissues studied except for the ovary. PER-A isoforms are mainly expressed in adult's head.

Inductionⁱ

Expression is sensitive to temperature but not to light.

Gene expression databases

Bgeeⁱ	FBgn0003068 Expressed in 24 organ(s), highest expression level in head capsule
ExpressionAtlasⁱ	P07663 baseline and differential
Genevisibleⁱ	P07663 DM

Interactionⁱ

Subunit structureⁱ

Forms a heterodimer with timeless (TIM); the complex then translocates into the nucleus. A proportion of the protein exists as homodimer.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
tim	P49021	2	EBI-15718452,EBI-266295

With

Entry

#Exp.

IntAct

Notes

tim

P49021

2

EBI-15718452,EBI-266295

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 19402744
- 19402751
protein heterodimerization activity
Source: FlyBase
Inferred from physical interactionⁱ
- 10409723
protein homodimerization activity
Source: FlyBase
Inferred from physical interactionⁱ
- 19402744
transcription corepressor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription factor binding
Source: FlyBase
Inferred from physical interactionⁱ
- 10409723

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	57782, 29 interactors
Database of interacting proteins More...DIPⁱ	DIP-29426N
IntActⁱ	P07663, 5 interactors
STRINGⁱ	7227.FBpp0070455

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	240 – 245	Combined sources	6
Turnⁱ	246 – 248	Combined sources	3
Beta strandⁱ	250 – 254	Combined sources	5
Helixⁱ	258 – 262	Combined sources	5
Helixⁱ	274 – 277	Combined sources	4
Helixⁱ	280 – 282	Combined sources	3
Helixⁱ	283 – 291	Combined sources	9
Beta strandⁱ	310 – 316	Combined sources	7
Beta strandⁱ	326 – 328	Combined sources	3
Beta strandⁱ	335 – 346	Combined sources	12
Beta strandⁱ	352 – 354	Combined sources	3
Beta strandⁱ	364 – 372	Combined sources	9
Beta strandⁱ	390 – 396	Combined sources	7
Beta strandⁱ	400 – 404	Combined sources	5
Helixⁱ	408 – 412	Combined sources	5
Helixⁱ	416 – 419	Combined sources	4
Helixⁱ	424 – 427	Combined sources	4
Helixⁱ	430 – 432	Combined sources	3
Helixⁱ	433 – 446	Combined sources	14
Beta strandⁱ	459 – 462	Combined sources	4
Beta strandⁱ	468 – 479	Combined sources	12
Turnⁱ	481 – 483	Combined sources	3
Beta strandⁱ	485 – 497	Combined sources	13
Beta strandⁱ	500 – 502	Combined sources	3
Beta strandⁱ	504 – 507	Combined sources	4
Helixⁱ	516 – 535	Combined sources	20
Turnⁱ	544 – 550	Combined sources	7
Helixⁱ	554 – 573	Combined sources	20

Show more details

3D structure databases

ProteinModelPortalⁱ	P07663
SMRⁱ	P07663
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P07663

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	238 – 373	PAS 1PROSITE-ProRule annotationAdd BLAST	136
Domainⁱ	391 – 497	PAS 2PROSITE-ProRule annotationAdd BLAST	107
Repeatⁱ	694 – 695	1	2
Repeatⁱ	697 – 698	2	2
Repeatⁱ	699 – 700	3	2
Repeatⁱ	701 – 702	4	2
Repeatⁱ	703 – 704	5	2
Repeatⁱ	705 – 706	6	2
Repeatⁱ	707 – 708	7	2
Repeatⁱ	709 – 710	8	2
Repeatⁱ	711 – 712	9	2
Repeatⁱ	713 – 714	10	2
Repeatⁱ	715 – 716	11	2
Repeatⁱ	717 – 718	12	2
Repeatⁱ	719 – 720	13	2
Repeatⁱ	721 – 722	14	2
Repeatⁱ	723 – 724	15	2
Repeatⁱ	725 – 726	16	2
Repeatⁱ	727 – 728	17	2
Repeatⁱ	729 – 730	18	2
Repeatⁱ	731 – 732	19	2
Repeatⁱ	733 – 734	20	2
Repeatⁱ	735 – 736	21	2
Repeatⁱ	737 – 738	22	2
Repeatⁱ	739 – 740	23	2
Repeatⁱ	741 – 742	24	2
Repeatⁱ	743 – 744	25	2
Repeatⁱ	745 – 746	26	2
Repeatⁱ	747 – 748	27; approximate	2
Repeatⁱ	749 – 750	28	2
Repeatⁱ	751 – 752	29	2
Repeatⁱ	753 – 754	30	2

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	694 – 754	30 X 2 AA approximate tandem repeats of G-[TN]Add BLAST		61
Regionⁱ	749 – 868	Regulates the rhythm of species-specific courtship songAdd BLAST		120

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	66 – 79	Nuclear localization signalSequence analysisAdd BLAST		14

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	74 – 79	Poly-Lys	6
Compositional biasⁱ	143 – 146	Poly-Glu	4
Compositional biasⁱ	223 – 226	Poly-Ala	4
Compositional biasⁱ	872 – 879	Poly-Gly	8
Compositional biasⁱ	898 – 905	Poly-Gly	8
Compositional biasⁱ	906 – 914	Poly-Ala	9
Compositional biasⁱ	1006 – 1013	Poly-Ala	8
Compositional biasⁱ	1035 – 1041	Poly-Ala	7

Domainⁱ

Contains a remarkable run of alternating Gly-Thr residues which is polymorphic in length. At least three types of Gly-Thr length exist in the natural population, (Gly-Thr)23 (shown here), and two major variants (Gly-Thr)17 and (Gly-Thr)20. This Gly-Thr stretch is implicated in the maintenance of circadian period at different temperatures. Deletion of the repeat leads to a shortening of the courtship song cycle period, and thus could be important for determining features of species-specific mating behavior.

Mutations in the PAS domain result in longer circadian rhythms and courtship song (PERL mutation) or makes the flies arrhythmic (PER01 mutation).

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG3753 Eukaryota ENOG410Y118 LUCA
InParanoidⁱ	P07663
KEGG Orthology (KO) More...KOⁱ	K02633
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01SQ

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00130 PAS, 2 hits
InterProⁱ	View protein in InterPro IPR000014 PAS IPR035965 PAS-like_dom_sf IPR013767 PAS_fold
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00989 PAS, 1 hit
SMARTⁱ	View protein in SMART SM00091 PAS, 2 hits
SUPFAMⁱ	SSF55785 SSF55785, 2 hits
PROSITEⁱ	View protein in PROSITE PS50112 PAS, 2 hits

Sequences (6+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist.

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform PER-A-long (identifier: P07663-1) [UniParc]FASTA Add to basket

Also known as: perA

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGGESTEST HNTKVSDSAY SNSCSNSQSQ RSGSSKSRLS GSHSSGSSGY 
        60         70         80         90        100
GGKPSTQASS SDMIIKRNKD KSRKKKKNKG AGQGAGQAQT LISASTSLEG 
       110        120        130        140        150
RDEEKPRPSG TGCVEQQICR ELQDQQHGED HSEPQAIEQL QQEEEEDQSG 
       160        170        180        190        200
SESEADRVEG VAKSEAAQSF PIPSPLSVTI VPPSMGGCGG VGHAAGLDSG 
       210        220        230        240        250
LAKFDKTWEA GPGKLESMTG VGAAAAGTGQ RGERVKEDSF CCVISMHDGI 
       260        270        280        290        300
VLYTTPSITD VLGYPRDMWL GRSFIDFVHL KDRATFASQI TTGIPIAESR 
       310        320        330        340        350
GSVPKDAKST FCVMLRRYRG LKSGGFGVIG RPVSYEPFRL GLTFREAPEE 
       360        370        380        390        400
ARPDNYMVSN GTNMLLVICA TPIKSSYKVP DEILSQKSPK FAIRHTATGI 
       410        420        430        440        450
ISHVDSAAVS ALGYLPQDLI GRSIMDFYHH EDLSVMKETY ETVMKKGQTA 
       460        470        480        490        500
GASFCSKPYR FLIQNGCYVL LETEWTSFVN PWSRKLEFVV GHHRVFQGPK 
       510        520        530        540        550
QCNVFEAAPT CKLKISEEAQ SRNTRIKEDI VKRLAETVSR PSDTVKQEVS 
       560        570        580        590        600
RRCQALASFM ETLMDEVSRA DLKLELPHEN ELTVSERDSV MLGEISPHHD 
       610        620        630        640        650
YYDSKSSTET PPSYNQLNYN ENLLRFFNSK PVTAPAELDP PKTEPPEPRG 
       660        670        680        690        700
TCVSGASGPM SPVHEGSGGS GSSGNFTTAS NIHMSSVTNT SIAGTGGTGT 
       710        720        730        740        750
GTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTGNGTNSGT 
       760        770        780        790        800
GTGTASSSKG GTAAIPPVTL TESLLNKHND EMEKFMLKKH RESRGRTGEK 
       810        820        830        840        850
SKKSANDTLK MLEYSGPGHG IKRGGSHSWE GEANKPKQQL TLGTDAIKGA 
       860        870        880        890        900
AGSAGGAVGT GGVGSGGAGV AGGGGSGTGV AGTPEGRATT TSGTGTPGGA 
       910        920        930        940        950
GGGGGAGAAA AAGASSSVGS STPGPSSYPT CTQNINLWPP FSVGITPPVH 
       960        970        980        990       1000
STHTAMAQSS FSSAGLFPTF YYIPASLTPT SPTRSPRMHK HPHKGGTDMP 
      1010       1020       1030       1040       1050
TTSQQAAAAA AQAMPLQYMA GVMYPHPSLF YTHPAAAAAT AMMYQPMPFP 
      1060       1070       1080       1090       1100
GMANALQIPE RPLGSQSAYN KSVYTTTPAS MTKKVPGAFH SVTTPAQVQR 
      1110       1120       1130       1140       1150
PSSQSASVKT EPGSSAAVSD PCKKEVPDSS PIPSVMGDYN SDPPCSSSNP 
      1160       1170       1180       1190       1200
ANNKKYTDSN GNSDDMDGSS FSSFYSSFIK TTDGSESPPD TEKDPKHRKL 
      1210       1220 
KSMSTSESKI MEHPEEDQTQ HGDG

Length:1,224

Mass (Da):127,852

Last modified:December 15, 1998 - v2

Checksum:ⁱ71FA54ECF3E90F4A

GO

Isoform PER-A-short (identifier: P07663-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-62: Missing.

« Hide

        10         20         30         40         50
MIIKRNKDKS RKKKKNKGAG QGAGQAQTLI SASTSLEGRD EEKPRPSGTG 
        60         70         80         90        100
CVEQQICREL QDQQHGEDHS EPQAIEQLQQ EEEEDQSGSE SEADRVEGVA 
       110        120        130        140        150
KSEAAQSFPI PSPLSVTIVP PSMGGCGGVG HAAGLDSGLA KFDKTWEAGP 
       160        170        180        190        200
GKLESMTGVG AAAAGTGQRG ERVKEDSFCC VISMHDGIVL YTTPSITDVL 
       210        220        230        240        250
GYPRDMWLGR SFIDFVHLKD RATFASQITT GIPIAESRGS VPKDAKSTFC 
       260        270        280        290        300
VMLRRYRGLK SGGFGVIGRP VSYEPFRLGL TFREAPEEAR PDNYMVSNGT 
       310        320        330        340        350
NMLLVICATP IKSSYKVPDE ILSQKSPKFA IRHTATGIIS HVDSAAVSAL 
       360        370        380        390        400
GYLPQDLIGR SIMDFYHHED LSVMKETYET VMKKGQTAGA SFCSKPYRFL 
       410        420        430        440        450
IQNGCYVLLE TEWTSFVNPW SRKLEFVVGH HRVFQGPKQC NVFEAAPTCK 
       460        470        480        490        500
LKISEEAQSR NTRIKEDIVK RLAETVSRPS DTVKQEVSRR CQALASFMET 
       510        520        530        540        550
LMDEVSRADL KLELPHENEL TVSERDSVML GEISPHHDYY DSKSSTETPP 
       560        570        580        590        600
SYNQLNYNEN LLRFFNSKPV TAPAELDPPK TEPPEPRGTC VSGASGPMSP 
       610        620        630        640        650
VHEGSGGSGS SGNFTTASNI HMSSVTNTSI AGTGGTGTGT GTGTGTGTGT 
       660        670        680        690        700
GTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GNGTNSGTGT GTASSSKGGT 
       710        720        730        740        750
AAIPPVTLTE SLLNKHNDEM EKFMLKKHRE SRGRTGEKSK KSANDTLKML 
       760        770        780        790        800
EYSGPGHGIK RGGSHSWEGE ANKPKQQLTL GTDAIKGAAG SAGGAVGTGG 
       810        820        830        840        850
VGSGGAGVAG GGGSGTGVAG TPEGRATTTS GTGTPGGAGG GGGAGAAAAA 
       860        870        880        890        900
GASSSVGSST PGPSSYPTCT QNINLWPPFS VGITPPVHST HTAMAQSSFS 
       910        920        930        940        950
SAGLFPTFYY IPASLTPTSP TRSPRMHKHP HKGGTDMPTT SQQAAAAAAQ 
       960        970        980        990       1000
AMPLQYMAGV MYPHPSLFYT HPAAAAATAM MYQPMPFPGM ANALQIPERP 
      1010       1020       1030       1040       1050
LGSQSAYNKS VYTTTPASMT KKVPGAFHSV TTPAQVQRPS SQSASVKTEP 
      1060       1070       1080       1090       1100
GSSAAVSDPC KKEVPDSSPI PSVMGDYNSD PPCSSSNPAN NKKYTDSNGN 
      1110       1120       1130       1140       1150
SDDMDGSSFS SFYSSFIKTT DGSESPPDTE KDPKHRKLKS MSTSESKIME 
      1160 
HPEEDQTQHG DG

Show »

Length:1,162

Mass (Da):121,661

Checksum:ⁱ7EF93EDE76EC5A5B

GO

Isoform PER-B (identifier: P07663-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
868-963: Missing.

« Hide

        10         20         30         40         50
MEGGESTEST HNTKVSDSAY SNSCSNSQSQ RSGSSKSRLS GSHSSGSSGY 
        60         70         80         90        100
GGKPSTQASS SDMIIKRNKD KSRKKKKNKG AGQGAGQAQT LISASTSLEG 
       110        120        130        140        150
RDEEKPRPSG TGCVEQQICR ELQDQQHGED HSEPQAIEQL QQEEEEDQSG 
       160        170        180        190        200
SESEADRVEG VAKSEAAQSF PIPSPLSVTI VPPSMGGCGG VGHAAGLDSG 
       210        220        230        240        250
LAKFDKTWEA GPGKLESMTG VGAAAAGTGQ RGERVKEDSF CCVISMHDGI 
       260        270        280        290        300
VLYTTPSITD VLGYPRDMWL GRSFIDFVHL KDRATFASQI TTGIPIAESR 
       310        320        330        340        350
GSVPKDAKST FCVMLRRYRG LKSGGFGVIG RPVSYEPFRL GLTFREAPEE 
       360        370        380        390        400
ARPDNYMVSN GTNMLLVICA TPIKSSYKVP DEILSQKSPK FAIRHTATGI 
       410        420        430        440        450
ISHVDSAAVS ALGYLPQDLI GRSIMDFYHH EDLSVMKETY ETVMKKGQTA 
       460        470        480        490        500
GASFCSKPYR FLIQNGCYVL LETEWTSFVN PWSRKLEFVV GHHRVFQGPK 
       510        520        530        540        550
QCNVFEAAPT CKLKISEEAQ SRNTRIKEDI VKRLAETVSR PSDTVKQEVS 
       560        570        580        590        600
RRCQALASFM ETLMDEVSRA DLKLELPHEN ELTVSERDSV MLGEISPHHD 
       610        620        630        640        650
YYDSKSSTET PPSYNQLNYN ENLLRFFNSK PVTAPAELDP PKTEPPEPRG 
       660        670        680        690        700
TCVSGASGPM SPVHEGSGGS GSSGNFTTAS NIHMSSVTNT SIAGTGGTGT 
       710        720        730        740        750
GTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTGNGTNSGT 
       760        770        780        790        800
GTGTASSSKG GTAAIPPVTL TESLLNKHND EMEKFMLKKH RESRGRTGEK 
       810        820        830        840        850
SKKSANDTLK MLEYSGPGHG IKRGGSHSWE GEANKPKQQL TLGTDAIKGA 
       860        870        880        890        900
AGSAGGAVGT GGVGSGGAGL FPTFYYIPAS LTPTSPTRSP RMHKHPHKGG 
       910        920        930        940        950
TDMPTTSQQA AAAAAQAMPL QYMAGVMYPH PSLFYTHPAA AAATAMMYQP 
       960        970        980        990       1000
MPFPGMANAL QIPERPLGSQ SAYNKSVYTT TPASMTKKVP GAFHSVTTPA 
      1010       1020       1030       1040       1050
QVQRPSSQSA SVKTEPGSSA AVSDPCKKEV PDSSPIPSVM GDYNSDPPCS 
      1060       1070       1080       1090       1100
SSNPANNKKY TDSNGNSDDM DGSSFSSFYS SFIKTTDGSE SPPDTEKDPK 
      1110       1120 
HRKLKSMSTS ESKIMEHPEE DQTQHGDG

Show »

Length:1,128

Mass (Da):119,293

Checksum:ⁱAE924CCDF4C5ADD9

GO

Isoform PER-C (identifier: P07663-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1076-1224: TTPASMTKKV...EEDQTQHGDG → VSQWPVVPHR...SRQQQGMLYE

« Hide

        10         20         30         40         50
MEGGESTEST HNTKVSDSAY SNSCSNSQSQ RSGSSKSRLS GSHSSGSSGY 
        60         70         80         90        100
GGKPSTQASS SDMIIKRNKD KSRKKKKNKG AGQGAGQAQT LISASTSLEG 
       110        120        130        140        150
RDEEKPRPSG TGCVEQQICR ELQDQQHGED HSEPQAIEQL QQEEEEDQSG 
       160        170        180        190        200
SESEADRVEG VAKSEAAQSF PIPSPLSVTI VPPSMGGCGG VGHAAGLDSG 
       210        220        230        240        250
LAKFDKTWEA GPGKLESMTG VGAAAAGTGQ RGERVKEDSF CCVISMHDGI 
       260        270        280        290        300
VLYTTPSITD VLGYPRDMWL GRSFIDFVHL KDRATFASQI TTGIPIAESR 
       310        320        330        340        350
GSVPKDAKST FCVMLRRYRG LKSGGFGVIG RPVSYEPFRL GLTFREAPEE 
       360        370        380        390        400
ARPDNYMVSN GTNMLLVICA TPIKSSYKVP DEILSQKSPK FAIRHTATGI 
       410        420        430        440        450
ISHVDSAAVS ALGYLPQDLI GRSIMDFYHH EDLSVMKETY ETVMKKGQTA 
       460        470        480        490        500
GASFCSKPYR FLIQNGCYVL LETEWTSFVN PWSRKLEFVV GHHRVFQGPK 
       510        520        530        540        550
QCNVFEAAPT CKLKISEEAQ SRNTRIKEDI VKRLAETVSR PSDTVKQEVS 
       560        570        580        590        600
RRCQALASFM ETLMDEVSRA DLKLELPHEN ELTVSERDSV MLGEISPHHD 
       610        620        630        640        650
YYDSKSSTET PPSYNQLNYN ENLLRFFNSK PVTAPAELDP PKTEPPEPRG 
       660        670        680        690        700
TCVSGASGPM SPVHEGSGGS GSSGNFTTAS NIHMSSVTNT SIAGTGGTGT 
       710        720        730        740        750
GTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTGNGTNSGT 
       760        770        780        790        800
GTGTASSSKG GTAAIPPVTL TESLLNKHND EMEKFMLKKH RESRGRTGEK 
       810        820        830        840        850
SKKSANDTLK MLEYSGPGHG IKRGGSHSWE GEANKPKQQL TLGTDAIKGA 
       860        870        880        890        900
AGSAGGAVGT GGVGSGGAGV AGGGGSGTGV AGTPEGRATT TSGTGTPGGA 
       910        920        930        940        950
GGGGGAGAAA AAGASSSVGS STPGPSSYPT CTQNINLWPP FSVGITPPVH 
       960        970        980        990       1000
STHTAMAQSS FSSAGLFPTF YYIPASLTPT SPTRSPRMHK HPHKGGTDMP 
      1010       1020       1030       1040       1050
TTSQQAAAAA AQAMPLQYMA GVMYPHPSLF YTHPAAAAAT AMMYQPMPFP 
      1060       1070       1080       1090       1100
GMANALQIPE RPLGSQSAYN KSVYTVSQWP VVPHRTVLTP TPTPYSSIDH 
      1110       1120       1130       1140       1150
AGVHDEEGAG CIPLGHHSCP GAASLLAERI RQDGAGLQCS GIRSLQEGGA 
      1160       1170       1180 
GLLAHSLRDG RLQLRPALQQ QQSRQQQGML YE

Show »

Length:1,182

Mass (Da):123,485

Checksum:ⁱ434AC9036463909E

GO

Isoform PER-D (identifier: P07663-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
863-958: Missing.

« Hide

        10         20         30         40         50
MEGGESTEST HNTKVSDSAY SNSCSNSQSQ RSGSSKSRLS GSHSSGSSGY 
        60         70         80         90        100
GGKPSTQASS SDMIIKRNKD KSRKKKKNKG AGQGAGQAQT LISASTSLEG 
       110        120        130        140        150
RDEEKPRPSG TGCVEQQICR ELQDQQHGED HSEPQAIEQL QQEEEEDQSG 
       160        170        180        190        200
SESEADRVEG VAKSEAAQSF PIPSPLSVTI VPPSMGGCGG VGHAAGLDSG 
       210        220        230        240        250
LAKFDKTWEA GPGKLESMTG VGAAAAGTGQ RGERVKEDSF CCVISMHDGI 
       260        270        280        290        300
VLYTTPSITD VLGYPRDMWL GRSFIDFVHL KDRATFASQI TTGIPIAESR 
       310        320        330        340        350
GSVPKDAKST FCVMLRRYRG LKSGGFGVIG RPVSYEPFRL GLTFREAPEE 
       360        370        380        390        400
ARPDNYMVSN GTNMLLVICA TPIKSSYKVP DEILSQKSPK FAIRHTATGI 
       410        420        430        440        450
ISHVDSAAVS ALGYLPQDLI GRSIMDFYHH EDLSVMKETY ETVMKKGQTA 
       460        470        480        490        500
GASFCSKPYR FLIQNGCYVL LETEWTSFVN PWSRKLEFVV GHHRVFQGPK 
       510        520        530        540        550
QCNVFEAAPT CKLKISEEAQ SRNTRIKEDI VKRLAETVSR PSDTVKQEVS 
       560        570        580        590        600
RRCQALASFM ETLMDEVSRA DLKLELPHEN ELTVSERDSV MLGEISPHHD 
       610        620        630        640        650
YYDSKSSTET PPSYNQLNYN ENLLRFFNSK PVTAPAELDP PKTEPPEPRG 
       660        670        680        690        700
TCVSGASGPM SPVHEGSGGS GSSGNFTTAS NIHMSSVTNT SIAGTGGTGT 
       710        720        730        740        750
GTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTGNGTNSGT 
       760        770        780        790        800
GTGTASSSKG GTAAIPPVTL TESLLNKHND EMEKFMLKKH RESRGRTGEK 
       810        820        830        840        850
SKKSANDTLK MLEYSGPGHG IKRGGSHSWE GEANKPKQQL TLGTDAIKGA 
       860        870        880        890        900
AGSAGGAVGT GGSSFSSAGL FPTFYYIPAS LTPTSPTRSP RMHKHPHKGG 
       910        920        930        940        950
TDMPTTSQQA AAAAAQAMPL QYMAGVMYPH PSLFYTHPAA AAATAMMYQP 
       960        970        980        990       1000
MPFPGMANAL QIPERPLGSQ SAYNKSVYTT TPASMTKKVP GAFHSVTTPA 
      1010       1020       1030       1040       1050
QVQRPSSQSA SVKTEPGSSA AVSDPCKKEV PDSSPIPSVM GDYNSDPPCS 
      1060       1070       1080       1090       1100
SSNPANNKKY TDSNGNSDDM DGSSFSSFYS SFIKTTDGSE SPPDTEKDPK 
      1110       1120 
HRKLKSMSTS ESKIMEHPEE DQTQHGDG

Show »

Length:1,128

Mass (Da):119,431

Checksum:ⁱ5ED88CCD3FEE97B4

GO

Isoform PER-E (identifier: P07663-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
863-958: Missing.
1155-1224: KYTDSNGNSD...EEDQTQHGDG → VCYTNEVHW

« Hide

        10         20         30         40         50
MEGGESTEST HNTKVSDSAY SNSCSNSQSQ RSGSSKSRLS GSHSSGSSGY 
        60         70         80         90        100
GGKPSTQASS SDMIIKRNKD KSRKKKKNKG AGQGAGQAQT LISASTSLEG 
       110        120        130        140        150
RDEEKPRPSG TGCVEQQICR ELQDQQHGED HSEPQAIEQL QQEEEEDQSG 
       160        170        180        190        200
SESEADRVEG VAKSEAAQSF PIPSPLSVTI VPPSMGGCGG VGHAAGLDSG 
       210        220        230        240        250
LAKFDKTWEA GPGKLESMTG VGAAAAGTGQ RGERVKEDSF CCVISMHDGI 
       260        270        280        290        300
VLYTTPSITD VLGYPRDMWL GRSFIDFVHL KDRATFASQI TTGIPIAESR 
       310        320        330        340        350
GSVPKDAKST FCVMLRRYRG LKSGGFGVIG RPVSYEPFRL GLTFREAPEE 
       360        370        380        390        400
ARPDNYMVSN GTNMLLVICA TPIKSSYKVP DEILSQKSPK FAIRHTATGI 
       410        420        430        440        450
ISHVDSAAVS ALGYLPQDLI GRSIMDFYHH EDLSVMKETY ETVMKKGQTA 
       460        470        480        490        500
GASFCSKPYR FLIQNGCYVL LETEWTSFVN PWSRKLEFVV GHHRVFQGPK 
       510        520        530        540        550
QCNVFEAAPT CKLKISEEAQ SRNTRIKEDI VKRLAETVSR PSDTVKQEVS 
       560        570        580        590        600
RRCQALASFM ETLMDEVSRA DLKLELPHEN ELTVSERDSV MLGEISPHHD 
       610        620        630        640        650
YYDSKSSTET PPSYNQLNYN ENLLRFFNSK PVTAPAELDP PKTEPPEPRG 
       660        670        680        690        700
TCVSGASGPM SPVHEGSGGS GSSGNFTTAS NIHMSSVTNT SIAGTGGTGT 
       710        720        730        740        750
GTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTGNGTNSGT 
       760        770        780        790        800
GTGTASSSKG GTAAIPPVTL TESLLNKHND EMEKFMLKKH RESRGRTGEK 
       810        820        830        840        850
SKKSANDTLK MLEYSGPGHG IKRGGSHSWE GEANKPKQQL TLGTDAIKGA 
       860        870        880        890        900
AGSAGGAVGT GGSSFSSAGL FPTFYYIPAS LTPTSPTRSP RMHKHPHKGG 
       910        920        930        940        950
TDMPTTSQQA AAAAAQAMPL QYMAGVMYPH PSLFYTHPAA AAATAMMYQP 
       960        970        980        990       1000
MPFPGMANAL QIPERPLGSQ SAYNKSVYTT TPASMTKKVP GAFHSVTTPA 
      1010       1020       1030       1040       1050
QVQRPSSQSA SVKTEPGSSA AVSDPCKKEV PDSSPIPSVM GDYNSDPPCS 
      1060 
SSNPANNKVC YTNEVHW

Show »

Length:1,067

Mass (Da):112,804

Checksum:ⁱBD72A8EC731BFD31

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	M9PGJ3	M9PGJ3_DROME		Period, isoform B Period, isoform B	per Clk, clk-6, Dmel\CG2647, dmper, dPER	1,218	Annotation score:

Sequence cautionⁱ

The sequence CAA27285 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	211	G → V in AAA28777 (PubMed:8436278).Curated	1
Sequence conflictⁱ	498 – 499	GP → A in AAA28777 (PubMed:8436278).Curated	2
Sequence conflictⁱ	637	E → A (PubMed:3087625).Curated	1
Sequence conflictⁱ	733 – 767	Missing (PubMed:3081818).CuratedAdd BLAST	35
Sequence conflictⁱ	762 – 764	TAA → RR (PubMed:3081818).Curated	3
Sequence conflictⁱ	762 – 764	TAA → RR (PubMed:3087625).Curated	3
Sequence conflictⁱ	1029	L → V (PubMed:3087625).Curated	1
Sequence conflictⁱ	1038	A → P (PubMed:3087625).Curated	1
Sequence conflictⁱ	1075	T → TVSQWPV in CAA19677 (PubMed:10731137).Curated	1
Sequence conflictⁱ	1114	S → F (PubMed:3102970).Curated	1
Sequence conflictⁱ	1215	E → D (PubMed:3102970).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱ	697 – 708	Missing in (Gly-Thr)17. Add BLAST	12
Natural variantⁱ	697 – 702	Missing in (Gly-Thr)20.	6
Natural variantⁱ	748	S → F in strain: U79.	1
Natural variantⁱ	762	T → S in strain: Berkeley, L18, Oregon-R, SP1 and U79.	1
Natural variantⁱ	846	A → T in strain: U79.	1
Natural variantⁱ	858	V → A in strain: L18 and U79.	1
Natural variantⁱ	1176	S → P in strain: L18.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_004657	1 – 62	Missing in isoform PER-A-short. CuratedAdd BLAST	62
Alternative sequenceⁱVSP_004659	863 – 958	Missing in isoform PER-D and isoform PER-E. CuratedAdd BLAST	96
Alternative sequenceⁱVSP_004658	868 – 963	Missing in isoform PER-B. CuratedAdd BLAST	96
Alternative sequenceⁱVSP_004660	1076 – 1224	TTPAS…QHGDG → VSQWPVVPHRTVLTPTPTPY SSIDHAGVHDEEGAGCIPLG HHSCPGAASLLAERIRQDGA GLQCSGIRSLQEGGAGLLAH SLRDGRLQLRPALQQQQSRQ QQGMLYE in isoform PER-C. CuratedAdd BLAST	149
Alternative sequenceⁱVSP_004661	1155 – 1224	KYTDS…QHGDG → VCYTNEVHW in isoform PER-E. CuratedAdd BLAST	70

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M30114 Genomic DNA Translation: AAA28752.1 M30114 Genomic DNA Translation: AAA28753.1 M30114 Genomic DNA Translation: AAA28754.1 AF033029 mRNA Translation: AAB87476.1 X03636 Genomic DNA Translation: CAA27285.1 Sequence problems. AE014298 Genomic DNA Translation: AAF45804.1 AL024485 Genomic DNA Translation: CAA19677.1 AL024485 Genomic DNA Translation: CAA19678.1 AL024485 Genomic DNA Translation: CAA19679.1 AL024485 Genomic DNA Translation: CAA19680.1 AY575847 Genomic DNA Translation: AAS89667.1 L07817 Genomic DNA Translation: AAA28777.1 L07818 Genomic DNA Translation: AAA28776.1 L07819 Genomic DNA Translation: AAA28775.1 L07821 Genomic DNA Translation: AAA28773.1 L07823 Genomic DNA Translation: AAA28771.1 L07825 Genomic DNA Translation: AAA28769.1 AB029194 Genomic DNA Translation: BAB15868.1 AB029195 Genomic DNA Translation: BAB15869.1 AB029196 Genomic DNA Translation: BAB15870.1 AB029222 Genomic DNA Translation: BAB15896.1 AB029223 Genomic DNA Translation: BAB15897.1 AB029224 Genomic DNA Translation: BAB15898.1 AB029250 Genomic DNA Translation: BAB15924.1 AB029251 Genomic DNA Translation: BAB15925.1 AB029252 Genomic DNA Translation: BAB15926.1 D00009 Genomic DNA Translation: BAA00007.1 AF251241 Genomic DNA Translation: AAG44573.1 AY047980 Genomic DNA Translation: AAN02289.1 AY047981 Genomic DNA Translation: AAN02291.1 AY047982 Genomic DNA Translation: AAN02293.1 AY047983 Genomic DNA Translation: AAN02295.1 AY047984 Genomic DNA Translation: AAN02297.1 AY047985 Genomic DNA Translation: AAN02299.1 AY047986 Genomic DNA Translation: AAN02301.1 AY047987 Genomic DNA Translation: AAN02303.1 AY047988 Genomic DNA Translation: AAN02305.1 AY047989 Genomic DNA Translation: AAN02307.1 AY047990 Genomic DNA Translation: AAN02309.1 AY047991 Genomic DNA Translation: AAN02311.1 AY047992 Genomic DNA Translation: AAN02313.1 AY047993 Genomic DNA Translation: AAN02315.1 AY047994 Genomic DNA Translation: AAN02317.1 AY047995 Genomic DNA Translation: AAN02319.1 AY047996 Genomic DNA Translation: AAN02321.1 AY047997 Genomic DNA Translation: AAN02323.1 AY047998 Genomic DNA Translation: AAN02325.1 AY047999 Genomic DNA Translation: AAN02327.1 AY048000 Genomic DNA Translation: AAN02329.1 AY048001 Genomic DNA Translation: AAN02331.1 AY048002 Genomic DNA Translation: AAN02333.1 AY048003 Genomic DNA Translation: AAN02335.1 AY048004 Genomic DNA Translation: AAN02337.1 AY048005 Genomic DNA Translation: AAN02339.1 AY048006 Genomic DNA Translation: AAN02341.1 AY048007 Genomic DNA Translation: AAN02343.1 AY048008 Genomic DNA Translation: AAN02345.1 AY048009 Genomic DNA Translation: AAN02347.1 AY048010 Genomic DNA Translation: AAN02349.1 AY048011 Genomic DNA Translation: AAN02351.1 AY048012 Genomic DNA Translation: AAN02353.1 AY048013 Genomic DNA Translation: AAN02355.1 AY048014 Genomic DNA Translation: AAN02357.1 AY048015 Genomic DNA Translation: AAN02359.1 AY048016 Genomic DNA Translation: AAN02361.1 AY048017 Genomic DNA Translation: AAN02363.1 AY048018 Genomic DNA Translation: AAN02365.1 AY048019 Genomic DNA Translation: AAN02367.1 AY048020 Genomic DNA Translation: AAN02369.1 AY048021 Genomic DNA Translation: AAN02371.1 AY048022 Genomic DNA Translation: AAN02373.1 AY048023 Genomic DNA Translation: AAN02375.1 AY048024 Genomic DNA Translation: AAN02377.1 AY048025 Genomic DNA Translation: AAN02379.1 AY048026 Genomic DNA Translation: AAN02381.1 AY048027 Genomic DNA Translation: AAN02383.1 AY048028 Genomic DNA Translation: AAN02385.1 AY048029 Genomic DNA Translation: AAN02387.1 AY048030 Genomic DNA Translation: AAN02389.1 AY048031 Genomic DNA Translation: AAN02391.1 AY048032 Genomic DNA Translation: AAN02393.1 AY048033 Genomic DNA Translation: AAN02395.1 AY048034 Genomic DNA Translation: AAN02397.1 AY048035 Genomic DNA Translation: AAN02399.1 AY048036 Genomic DNA Translation: AAN02401.1 AY048037 Genomic DNA Translation: AAN02403.1 AY048038 Genomic DNA Translation: AAN02405.1 AY048040 Genomic DNA Translation: AAN02407.1 AY048041 Genomic DNA Translation: AAN02409.1 AY048042 Genomic DNA Translation: AAN02411.1
PIRⁱ	A23932 UMFF A26427 A26588 B26427 C26427 S52943
NCBI Reference Sequences More...RefSeqⁱ	NP_001259194.1, NM_001272265.1 NP_525056.2, NM_080317.2
UniGeneⁱ	Dm.65

Genome annotation databases

GeneIDⁱ	31251
KEGGⁱ	dme:Dmel_CG2647

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P07663	Isoform PER-A-short of Period circadian protein		DROME		1162	UniRef90_P07663
Period protein (Fragment)		DROSE		158
Period protein (Fragment)		DROMA		158
Period protein (Fragment)		DROSI		158
Period protein (Fragment)		DROMA		143
+3
P07663-3	Isoform PER-D of Period circadian protein		DROME		1128	UniRef90_P07663-3
Isoform PER-E of Period circadian protein		DROME		1067
P07663-4	Period circadian protein		DROYA		1208	UniRef90_P07663-4
Period		DROSE		1232
Period (Fragment)		DROSI		301
Period (Fragment)		DROME		230
Period protein (Fragment)		DROSE		177
+5
P07663-5	Isoform PER-B of Period circadian protein		DROME		1128	UniRef90_P07663-3
Isoform PER-E of Period circadian protein		DROME		1067
P07663-6	Isoform PER-B of Period circadian protein		DROME		1128	UniRef90_P07663-3
Isoform PER-D of Period circadian protein		DROME		1128

Protein	Similar proteins		Species	Score	Length	Source
P07663	Period circadian protein		DROYA		1208	UniRef50_P07663
Period circadian protein (Fragment)		DROER		110
Period circadian protein (Fragment)		DROAN		125
Isoform PER-A-short of Period circadian protein		DROME		1162
Period protein (Fragment)		DROSE		158
+34

Cross-referencesⁱ

Web resourcesⁱ

Protein Spotlight

The tale of a love song - Issue 6 of January 2001

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M30114 Genomic DNA Translation: AAA28752.1 M30114 Genomic DNA Translation: AAA28753.1 M30114 Genomic DNA Translation: AAA28754.1 AF033029 mRNA Translation: AAB87476.1 X03636 Genomic DNA Translation: CAA27285.1 Sequence problems. AE014298 Genomic DNA Translation: AAF45804.1 AL024485 Genomic DNA Translation: CAA19677.1 AL024485 Genomic DNA Translation: CAA19678.1 AL024485 Genomic DNA Translation: CAA19679.1 AL024485 Genomic DNA Translation: CAA19680.1 AY575847 Genomic DNA Translation: AAS89667.1 L07817 Genomic DNA Translation: AAA28777.1 L07818 Genomic DNA Translation: AAA28776.1 L07819 Genomic DNA Translation: AAA28775.1 L07821 Genomic DNA Translation: AAA28773.1 L07823 Genomic DNA Translation: AAA28771.1 L07825 Genomic DNA Translation: AAA28769.1 AB029194 Genomic DNA Translation: BAB15868.1 AB029195 Genomic DNA Translation: BAB15869.1 AB029196 Genomic DNA Translation: BAB15870.1 AB029222 Genomic DNA Translation: BAB15896.1 AB029223 Genomic DNA Translation: BAB15897.1 AB029224 Genomic DNA Translation: BAB15898.1 AB029250 Genomic DNA Translation: BAB15924.1 AB029251 Genomic DNA Translation: BAB15925.1 AB029252 Genomic DNA Translation: BAB15926.1 D00009 Genomic DNA Translation: BAA00007.1 AF251241 Genomic DNA Translation: AAG44573.1 AY047980 Genomic DNA Translation: AAN02289.1 AY047981 Genomic DNA Translation: AAN02291.1 AY047982 Genomic DNA Translation: AAN02293.1 AY047983 Genomic DNA Translation: AAN02295.1 AY047984 Genomic DNA Translation: AAN02297.1 AY047985 Genomic DNA Translation: AAN02299.1 AY047986 Genomic DNA Translation: AAN02301.1 AY047987 Genomic DNA Translation: AAN02303.1 AY047988 Genomic DNA Translation: AAN02305.1 AY047989 Genomic DNA Translation: AAN02307.1 AY047990 Genomic DNA Translation: AAN02309.1 AY047991 Genomic DNA Translation: AAN02311.1 AY047992 Genomic DNA Translation: AAN02313.1 AY047993 Genomic DNA Translation: AAN02315.1 AY047994 Genomic DNA Translation: AAN02317.1 AY047995 Genomic DNA Translation: AAN02319.1 AY047996 Genomic DNA Translation: AAN02321.1 AY047997 Genomic DNA Translation: AAN02323.1 AY047998 Genomic DNA Translation: AAN02325.1 AY047999 Genomic DNA Translation: AAN02327.1 AY048000 Genomic DNA Translation: AAN02329.1 AY048001 Genomic DNA Translation: AAN02331.1 AY048002 Genomic DNA Translation: AAN02333.1 AY048003 Genomic DNA Translation: AAN02335.1 AY048004 Genomic DNA Translation: AAN02337.1 AY048005 Genomic DNA Translation: AAN02339.1 AY048006 Genomic DNA Translation: AAN02341.1 AY048007 Genomic DNA Translation: AAN02343.1 AY048008 Genomic DNA Translation: AAN02345.1 AY048009 Genomic DNA Translation: AAN02347.1 AY048010 Genomic DNA Translation: AAN02349.1 AY048011 Genomic DNA Translation: AAN02351.1 AY048012 Genomic DNA Translation: AAN02353.1 AY048013 Genomic DNA Translation: AAN02355.1 AY048014 Genomic DNA Translation: AAN02357.1 AY048015 Genomic DNA Translation: AAN02359.1 AY048016 Genomic DNA Translation: AAN02361.1 AY048017 Genomic DNA Translation: AAN02363.1 AY048018 Genomic DNA Translation: AAN02365.1 AY048019 Genomic DNA Translation: AAN02367.1 AY048020 Genomic DNA Translation: AAN02369.1 AY048021 Genomic DNA Translation: AAN02371.1 AY048022 Genomic DNA Translation: AAN02373.1 AY048023 Genomic DNA Translation: AAN02375.1 AY048024 Genomic DNA Translation: AAN02377.1 AY048025 Genomic DNA Translation: AAN02379.1 AY048026 Genomic DNA Translation: AAN02381.1 AY048027 Genomic DNA Translation: AAN02383.1 AY048028 Genomic DNA Translation: AAN02385.1 AY048029 Genomic DNA Translation: AAN02387.1 AY048030 Genomic DNA Translation: AAN02389.1 AY048031 Genomic DNA Translation: AAN02391.1 AY048032 Genomic DNA Translation: AAN02393.1 AY048033 Genomic DNA Translation: AAN02395.1 AY048034 Genomic DNA Translation: AAN02397.1 AY048035 Genomic DNA Translation: AAN02399.1 AY048036 Genomic DNA Translation: AAN02401.1 AY048037 Genomic DNA Translation: AAN02403.1 AY048038 Genomic DNA Translation: AAN02405.1 AY048040 Genomic DNA Translation: AAN02407.1 AY048041 Genomic DNA Translation: AAN02409.1 AY048042 Genomic DNA Translation: AAN02411.1
PIRⁱ	A23932 UMFF A26427 A26588 B26427 C26427 S52943
RefSeqⁱ	NP_001259194.1, NM_001272265.1 NP_525056.2, NM_080317.2
UniGeneⁱ	Dm.65

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1WA9	X-ray	3.15	A/B	232-599	[»]
	3GEC	X-ray	4.00	A	232-538	[»]
	3RTY	X-ray	2.85	A/B/C/D/E/F/G/H	236-574	[»]
ProteinModelPortalⁱ	P07663
SMRⁱ	P07663
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	57782, 29 interactors
DIPⁱ	DIP-29426N
IntActⁱ	P07663, 5 interactors
STRINGⁱ	7227.FBpp0070455

PTM databases

iPTMnetⁱ	P07663

iPTMnetⁱ

P07663

Proteomic databases

PaxDbⁱ	P07663
PRIDEⁱ	P07663

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	31251
KEGGⁱ	dme:Dmel_CG2647

Organism-specific databases

CTDⁱ	31251
FlyBaseⁱ	FBgn0003068 per

Phylogenomic databases

eggNOGⁱ	KOG3753 Eukaryota ENOG410Y118 LUCA
InParanoidⁱ	P07663
KOⁱ	K02633
OrthoDBⁱ	EOG091G01SQ

Enzyme and pathway databases

Reactomeⁱ	R-DME-432395 Degradation of TIM R-DME-432490 Nuclear import of PER and TIM R-DME-432501 Transcription repression by PER and activation by PDP1 R-DME-432524 Degradation of PER R-DME-432553 Phosphorylation of PER and TIM R-DME-432620 Dephosphorylation of PER R-DME-538898 Dephosphorylation of TIM

Reactomeⁱ

R-DME-432395 Degradation of TIM
R-DME-432490 Nuclear import of PER and TIM
R-DME-432501 Transcription repression by PER and activation by PDP1
R-DME-432524 Degradation of PER
R-DME-432553 Phosphorylation of PER and TIM
R-DME-432620 Dephosphorylation of PER
R-DME-538898 Dephosphorylation of TIM

Miscellaneous databases

EvolutionaryTraceⁱ	P07663
GenomeRNAiⁱ	31251
Protein Ontology More...PROⁱ	PR:P07663

Gene expression databases

Bgeeⁱ	FBgn0003068 Expressed in 24 organ(s), highest expression level in head capsule
ExpressionAtlasⁱ	P07663 baseline and differential
Genevisibleⁱ	P07663 DM

Family and domain databases

CDDⁱ	cd00130 PAS, 2 hits
InterProⁱ	View protein in InterPro IPR000014 PAS IPR035965 PAS-like_dom_sf IPR013767 PAS_fold
Pfamⁱ	View protein in Pfam PF00989 PAS, 1 hit
SMARTⁱ	View protein in SMART SM00091 PAS, 2 hits
SUPFAMⁱ	SSF55785 SSF55785, 2 hits
PROSITEⁱ	View protein in PROSITE PS50112 PAS, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PER_DROME
Accessionⁱ	P07663Primary (citable) accession number: P07663 Secondary accession number(s): O17483 Q9W4X0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
	Last sequence update:	December 15, 1998
	Last modified:	November 7, 2018
	This is version 188 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Drosophila annotation project

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Drosophila
Drosophila: entries, gene names and cross-references to FlyBase
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

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UniProtKB - P07663 (PER_DROME)

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Period circadian protein

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

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<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

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Keywords - Coding sequence diversityi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ