UniProtKB - P07663 (PER_DROME)
Period circadian protein
per
Functioni
Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition. Required for binding of cwo to the E box regions in the promoters of target genes of the transcriptional activator Clock, probably by binding to Clock-cycle heterodimers, reducing their affinity for E box binding and allowing cwo to bind instead (PubMed:27814361).
1 PublicationGO - Molecular functioni
- identical protein binding Source: IntAct
- protein heterodimerization activity Source: FlyBase
- protein homodimerization activity Source: FlyBase
- transcription cis-regulatory region binding Source: GO_Central
- transcription coregulator activity Source: FlyBase
- transcription corepressor activity Source: FlyBase
- transcription corepressor binding Source: GO_Central
- transcription factor binding Source: FlyBase
GO - Biological processi
- age-dependent response to oxidative stress Source: FlyBase
- behavioral response to cocaine Source: FlyBase
- circadian behavior Source: FlyBase
- circadian regulation of gene expression Source: FlyBase
- circadian rhythm Source: FlyBase
- circadian sleep/wake cycle Source: FlyBase
- circadian temperature homeostasis Source: FlyBase
- copulation Source: FlyBase
- courtship behavior Source: FlyBase
- determination of adult lifespan Source: FlyBase
- eclosion rhythm Source: FlyBase
- entrainment of circadian clock Source: FlyBase
- entrainment of circadian clock by photoperiod Source: FlyBase
- locomotor rhythm Source: FlyBase
- long-term memory Source: FlyBase
- male courtship behavior, veined wing generated song production Source: FlyBase
- mating behavior Source: FlyBase
- negative regulation of transcription, DNA-templated Source: FlyBase
- negative regulation of transcription by RNA polymerase II Source: FlyBase
- negative regulation of transcription regulatory region DNA binding Source: FlyBase
- regulation of circadian rhythm Source: FlyBase
- regulation of circadian sleep/wake cycle, sleep Source: FlyBase
- regulation of locomotor rhythm Source: FlyBase
- regulation of protein phosphorylation Source: FlyBase
- response to light stimulus Source: FlyBase
- response to oxidative stress Source: FlyBase
- response to temperature stimulus Source: FlyBase
- rhythmic behavior Source: FlyBase
Keywordsi
Biological process | Biological rhythms |
Enzyme and pathway databases
Reactomei | R-DME-432395, Degradation of TIM R-DME-432490, Nuclear import of PER and TIM R-DME-432501, Transcription repression by PER and activation by PDP1 R-DME-432524, Degradation of PER R-DME-432553, Phosphorylation of PER and TIM R-DME-432620, Dephosphorylation of PER R-DME-538898, Dephosphorylation of TIM |
SignaLinki | P07663 |
Names & Taxonomyi
Protein namesi | Recommended name: Period circadian proteinAlternative name(s): Protein clock-6 Short name: CLK-6 |
Gene namesi | Name:per ORF Names:CG2647 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0003068, per |
VEuPathDBi | VectorBase:FBgn0003068 |
Subcellular locationi
Nucleus
Other locations
Note: Nuclear at specific periods of the day. First accumulates in the perinuclear region about one hour before translocation into the nucleus. Interaction with Tim is required for nuclear localization.
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: FlyBase
Other locations
- cell body Source: FlyBase
- cytoplasm Source: FlyBase
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000162596 | 1 – 1224 | Period circadian proteinAdd BLAST | 1224 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P07663 |
PTM databases
iPTMneti | P07663 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | FBgn0003068, Expressed in head capsule and 30 other tissues |
ExpressionAtlasi | P07663, baseline and differential |
Genevisiblei | P07663, DM |
Interactioni
Subunit structurei
Forms a heterodimer with timeless (TIM); the complex then translocates into the nucleus. A proportion of the protein exists as homodimer.
1 PublicationBinary interactionsi
per - isoform PER-A-long [P07663-1]
With | #Exp. | IntAct |
---|---|---|
itself | 3 | EBI-15718452,EBI-15718452 |
tim [P49021] | 2 | EBI-15718452,EBI-266295 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein heterodimerization activity Source: FlyBase
- protein homodimerization activity Source: FlyBase
- transcription corepressor binding Source: GO_Central
- transcription factor binding Source: FlyBase
Protein-protein interaction databases
BioGRIDi | 57782, 38 interactors |
DIPi | DIP-29426N |
IntActi | P07663, 4 interactors |
STRINGi | 7227.FBpp0070455 |
Structurei
Secondary structure
3D structure databases
SMRi | P07663 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P07663 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 238 – 373 | PAS 1PROSITE-ProRule annotationAdd BLAST | 136 | |
Domaini | 391 – 497 | PAS 2PROSITE-ProRule annotationAdd BLAST | 107 | |
Repeati | 694 – 695 | 1 | 2 | |
Repeati | 697 – 698 | 2 | 2 | |
Repeati | 699 – 700 | 3 | 2 | |
Repeati | 701 – 702 | 4 | 2 | |
Repeati | 703 – 704 | 5 | 2 | |
Repeati | 705 – 706 | 6 | 2 | |
Repeati | 707 – 708 | 7 | 2 | |
Repeati | 709 – 710 | 8 | 2 | |
Repeati | 711 – 712 | 9 | 2 | |
Repeati | 713 – 714 | 10 | 2 | |
Repeati | 715 – 716 | 11 | 2 | |
Repeati | 717 – 718 | 12 | 2 | |
Repeati | 719 – 720 | 13 | 2 | |
Repeati | 721 – 722 | 14 | 2 | |
Repeati | 723 – 724 | 15 | 2 | |
Repeati | 725 – 726 | 16 | 2 | |
Repeati | 727 – 728 | 17 | 2 | |
Repeati | 729 – 730 | 18 | 2 | |
Repeati | 731 – 732 | 19 | 2 | |
Repeati | 733 – 734 | 20 | 2 | |
Repeati | 735 – 736 | 21 | 2 | |
Repeati | 737 – 738 | 22 | 2 | |
Repeati | 739 – 740 | 23 | 2 | |
Repeati | 741 – 742 | 24 | 2 | |
Repeati | 743 – 744 | 25 | 2 | |
Repeati | 745 – 746 | 26 | 2 | |
Repeati | 747 – 748 | 27; approximate | 2 | |
Repeati | 749 – 750 | 28 | 2 | |
Repeati | 751 – 752 | 29 | 2 | |
Repeati | 753 – 754 | 30 | 2 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 175 | DisorderedSequence analysisAdd BLAST | 175 | |
Regioni | 632 – 764 | DisorderedSequence analysisAdd BLAST | 133 | |
Regioni | 694 – 754 | 30 X 2 AA approximate tandem repeats of G-[TN]Add BLAST | 61 | |
Regioni | 749 – 868 | Regulates the rhythm of species-specific courtship songAdd BLAST | 120 | |
Regioni | 788 – 807 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 814 – 833 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 874 – 927 | DisorderedSequence analysisAdd BLAST | 54 | |
Regioni | 978 – 1008 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 1094 – 1224 | DisorderedSequence analysisAdd BLAST | 131 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 66 – 79 | Nuclear localization signalSequence analysisAdd BLAST | 14 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 63 | Polar residuesSequence analysisAdd BLAST | 63 | |
Compositional biasi | 83 – 97 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 122 – 138 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 666 – 764 | Polar residuesSequence analysisAdd BLAST | 99 | |
Compositional biasi | 883 – 897 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1094 – 1114 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 1134 – 1185 | Polar residuesSequence analysisAdd BLAST | 52 | |
Compositional biasi | 1186 – 1224 | Basic and acidic residuesSequence analysisAdd BLAST | 39 |
Domaini
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3753, Eukaryota |
GeneTreei | ENSGT00940000174107 |
HOGENOMi | CLU_002704_0_0_1 |
InParanoidi | P07663 |
Family and domain databases
CDDi | cd00130, PAS, 2 hits |
IDEALi | IID50270 |
InterProi | View protein in InterPro IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold |
Pfami | View protein in Pfam PF00989, PAS, 1 hit |
SMARTi | View protein in SMART SM00091, PAS, 2 hits |
SUPFAMi | SSF55785, SSF55785, 2 hits |
PROSITEi | View protein in PROSITE PS50112, PAS, 2 hits |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEGGESTEST HNTKVSDSAY SNSCSNSQSQ RSGSSKSRLS GSHSSGSSGY
60 70 80 90 100
GGKPSTQASS SDMIIKRNKD KSRKKKKNKG AGQGAGQAQT LISASTSLEG
110 120 130 140 150
RDEEKPRPSG TGCVEQQICR ELQDQQHGED HSEPQAIEQL QQEEEEDQSG
160 170 180 190 200
SESEADRVEG VAKSEAAQSF PIPSPLSVTI VPPSMGGCGG VGHAAGLDSG
210 220 230 240 250
LAKFDKTWEA GPGKLESMTG VGAAAAGTGQ RGERVKEDSF CCVISMHDGI
260 270 280 290 300
VLYTTPSITD VLGYPRDMWL GRSFIDFVHL KDRATFASQI TTGIPIAESR
310 320 330 340 350
GSVPKDAKST FCVMLRRYRG LKSGGFGVIG RPVSYEPFRL GLTFREAPEE
360 370 380 390 400
ARPDNYMVSN GTNMLLVICA TPIKSSYKVP DEILSQKSPK FAIRHTATGI
410 420 430 440 450
ISHVDSAAVS ALGYLPQDLI GRSIMDFYHH EDLSVMKETY ETVMKKGQTA
460 470 480 490 500
GASFCSKPYR FLIQNGCYVL LETEWTSFVN PWSRKLEFVV GHHRVFQGPK
510 520 530 540 550
QCNVFEAAPT CKLKISEEAQ SRNTRIKEDI VKRLAETVSR PSDTVKQEVS
560 570 580 590 600
RRCQALASFM ETLMDEVSRA DLKLELPHEN ELTVSERDSV MLGEISPHHD
610 620 630 640 650
YYDSKSSTET PPSYNQLNYN ENLLRFFNSK PVTAPAELDP PKTEPPEPRG
660 670 680 690 700
TCVSGASGPM SPVHEGSGGS GSSGNFTTAS NIHMSSVTNT SIAGTGGTGT
710 720 730 740 750
GTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTGNGTNSGT
760 770 780 790 800
GTGTASSSKG GTAAIPPVTL TESLLNKHND EMEKFMLKKH RESRGRTGEK
810 820 830 840 850
SKKSANDTLK MLEYSGPGHG IKRGGSHSWE GEANKPKQQL TLGTDAIKGA
860 870 880 890 900
AGSAGGAVGT GGVGSGGAGV AGGGGSGTGV AGTPEGRATT TSGTGTPGGA
910 920 930 940 950
GGGGGAGAAA AAGASSSVGS STPGPSSYPT CTQNINLWPP FSVGITPPVH
960 970 980 990 1000
STHTAMAQSS FSSAGLFPTF YYIPASLTPT SPTRSPRMHK HPHKGGTDMP
1010 1020 1030 1040 1050
TTSQQAAAAA AQAMPLQYMA GVMYPHPSLF YTHPAAAAAT AMMYQPMPFP
1060 1070 1080 1090 1100
GMANALQIPE RPLGSQSAYN KSVYTTTPAS MTKKVPGAFH SVTTPAQVQR
1110 1120 1130 1140 1150
PSSQSASVKT EPGSSAAVSD PCKKEVPDSS PIPSVMGDYN SDPPCSSSNP
1160 1170 1180 1190 1200
ANNKKYTDSN GNSDDMDGSS FSSFYSSFIK TTDGSESPPD TEKDPKHRKL
1210 1220
KSMSTSESKI MEHPEEDQTQ HGDG
The sequence of this isoform differs from the canonical sequence as follows:
1-62: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
868-963: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1076-1224: TTPASMTKKV...EEDQTQHGDG → VSQWPVVPHR...SRQQQGMLYE
The sequence of this isoform differs from the canonical sequence as follows:
863-958: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
863-958: Missing.
1155-1224: KYTDSNGNSD...EEDQTQHGDG → VCYTNEVHW
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM9PGJ3 | M9PGJ3_DROME | Period, isoform B | per Clk, clk-6, Dmel\CG2647, dmper, dPER | 1,218 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 211 | G → V in AAA28777 (PubMed:8436278).Curated | 1 | |
Sequence conflicti | 498 – 499 | GP → A in AAA28777 (PubMed:8436278).Curated | 2 | |
Sequence conflicti | 637 | E → A (PubMed:3087625).Curated | 1 | |
Sequence conflicti | 733 – 767 | Missing (PubMed:3081818).CuratedAdd BLAST | 35 | |
Sequence conflicti | 762 – 764 | TAA → RR (PubMed:3081818).Curated | 3 | |
Sequence conflicti | 762 – 764 | TAA → RR (PubMed:3087625).Curated | 3 | |
Sequence conflicti | 1029 | L → V (PubMed:3087625).Curated | 1 | |
Sequence conflicti | 1038 | A → P (PubMed:3087625).Curated | 1 | |
Sequence conflicti | 1075 | T → TVSQWPV in CAA19677 (PubMed:10731137).Curated | 1 | |
Sequence conflicti | 1114 | S → F (PubMed:3102970).Curated | 1 | |
Sequence conflicti | 1215 | E → D (PubMed:3102970).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 697 – 708 | Missing in (Gly-Thr)17. Add BLAST | 12 | |
Natural varianti | 697 – 702 | Missing in (Gly-Thr)20. | 6 | |
Natural varianti | 748 | S → F in strain: U79. | 1 | |
Natural varianti | 762 | T → S in strain: Berkeley, L18, Oregon-R, SP1 and U79. | 1 | |
Natural varianti | 846 | A → T in strain: U79. | 1 | |
Natural varianti | 858 | V → A in strain: L18 and U79. | 1 | |
Natural varianti | 1176 | S → P in strain: L18. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_004657 | 1 – 62 | Missing in isoform PER-A-short. CuratedAdd BLAST | 62 | |
Alternative sequenceiVSP_004659 | 863 – 958 | Missing in isoform PER-D and isoform PER-E. CuratedAdd BLAST | 96 | |
Alternative sequenceiVSP_004658 | 868 – 963 | Missing in isoform PER-B. CuratedAdd BLAST | 96 | |
Alternative sequenceiVSP_004660 | 1076 – 1224 | TTPAS…QHGDG → VSQWPVVPHRTVLTPTPTPY SSIDHAGVHDEEGAGCIPLG HHSCPGAASLLAERIRQDGA GLQCSGIRSLQEGGAGLLAH SLRDGRLQLRPALQQQQSRQ QQGMLYE in isoform PER-C. CuratedAdd BLAST | 149 | |
Alternative sequenceiVSP_004661 | 1155 – 1224 | KYTDS…QHGDG → VCYTNEVHW in isoform PER-E. CuratedAdd BLAST | 70 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M30114 Genomic DNA Translation: AAA28752.1 M30114 Genomic DNA Translation: AAA28753.1 M30114 Genomic DNA Translation: AAA28754.1 AF033029 mRNA Translation: AAB87476.1 X03636 Genomic DNA Translation: CAA27285.1 Sequence problems. AE014298 Genomic DNA Translation: AAF45804.1 AL024485 Genomic DNA Translation: CAA19677.1 AL024485 Genomic DNA Translation: CAA19678.1 AL024485 Genomic DNA Translation: CAA19679.1 AL024485 Genomic DNA Translation: CAA19680.1 AY575847 Genomic DNA Translation: AAS89667.1 L07817 Genomic DNA Translation: AAA28777.1 L07818 Genomic DNA Translation: AAA28776.1 L07819 Genomic DNA Translation: AAA28775.1 L07821 Genomic DNA Translation: AAA28773.1 L07823 Genomic DNA Translation: AAA28771.1 L07825 Genomic DNA Translation: AAA28769.1 AB029194 Genomic DNA Translation: BAB15868.1 AB029195 Genomic DNA Translation: BAB15869.1 AB029196 Genomic DNA Translation: BAB15870.1 AB029222 Genomic DNA Translation: BAB15896.1 AB029223 Genomic DNA Translation: BAB15897.1 AB029224 Genomic DNA Translation: BAB15898.1 AB029250 Genomic DNA Translation: BAB15924.1 AB029251 Genomic DNA Translation: BAB15925.1 AB029252 Genomic DNA Translation: BAB15926.1 D00009 Genomic DNA Translation: BAA00007.1 AF251241 Genomic DNA Translation: AAG44573.1 AY047980 Genomic DNA Translation: AAN02289.1 AY047981 Genomic DNA Translation: AAN02291.1 AY047982 Genomic DNA Translation: AAN02293.1 AY047983 Genomic DNA Translation: AAN02295.1 AY047984 Genomic DNA Translation: AAN02297.1 AY047985 Genomic DNA Translation: AAN02299.1 AY047986 Genomic DNA Translation: AAN02301.1 AY047987 Genomic DNA Translation: AAN02303.1 AY047988 Genomic DNA Translation: AAN02305.1 AY047989 Genomic DNA Translation: AAN02307.1 AY047990 Genomic DNA Translation: AAN02309.1 AY047991 Genomic DNA Translation: AAN02311.1 AY047992 Genomic DNA Translation: AAN02313.1 AY047993 Genomic DNA Translation: AAN02315.1 AY047994 Genomic DNA Translation: AAN02317.1 AY047995 Genomic DNA Translation: AAN02319.1 AY047996 Genomic DNA Translation: AAN02321.1 AY047997 Genomic DNA Translation: AAN02323.1 AY047998 Genomic DNA Translation: AAN02325.1 AY047999 Genomic DNA Translation: AAN02327.1 AY048000 Genomic DNA Translation: AAN02329.1 AY048001 Genomic DNA Translation: AAN02331.1 AY048002 Genomic DNA Translation: AAN02333.1 AY048003 Genomic DNA Translation: AAN02335.1 AY048004 Genomic DNA Translation: AAN02337.1 AY048005 Genomic DNA Translation: AAN02339.1 AY048006 Genomic DNA Translation: AAN02341.1 AY048007 Genomic DNA Translation: AAN02343.1 AY048008 Genomic DNA Translation: AAN02345.1 AY048009 Genomic DNA Translation: AAN02347.1 AY048010 Genomic DNA Translation: AAN02349.1 AY048011 Genomic DNA Translation: AAN02351.1 AY048012 Genomic DNA Translation: AAN02353.1 AY048013 Genomic DNA Translation: AAN02355.1 AY048014 Genomic DNA Translation: AAN02357.1 AY048015 Genomic DNA Translation: AAN02359.1 AY048016 Genomic DNA Translation: AAN02361.1 AY048017 Genomic DNA Translation: AAN02363.1 AY048018 Genomic DNA Translation: AAN02365.1 AY048019 Genomic DNA Translation: AAN02367.1 AY048020 Genomic DNA Translation: AAN02369.1 AY048021 Genomic DNA Translation: AAN02371.1 AY048022 Genomic DNA Translation: AAN02373.1 AY048023 Genomic DNA Translation: AAN02375.1 AY048024 Genomic DNA Translation: AAN02377.1 AY048025 Genomic DNA Translation: AAN02379.1 AY048026 Genomic DNA Translation: AAN02381.1 AY048027 Genomic DNA Translation: AAN02383.1 AY048028 Genomic DNA Translation: AAN02385.1 AY048029 Genomic DNA Translation: AAN02387.1 AY048030 Genomic DNA Translation: AAN02389.1 AY048031 Genomic DNA Translation: AAN02391.1 AY048032 Genomic DNA Translation: AAN02393.1 AY048033 Genomic DNA Translation: AAN02395.1 AY048034 Genomic DNA Translation: AAN02397.1 AY048035 Genomic DNA Translation: AAN02399.1 AY048036 Genomic DNA Translation: AAN02401.1 AY048037 Genomic DNA Translation: AAN02403.1 AY048038 Genomic DNA Translation: AAN02405.1 AY048040 Genomic DNA Translation: AAN02407.1 AY048041 Genomic DNA Translation: AAN02409.1 AY048042 Genomic DNA Translation: AAN02411.1 |
PIRi | A23932, UMFF A26427 A26588 B26427 C26427 S52943 |
RefSeqi | NP_001259194.1, NM_001272265.1 NP_525056.2, NM_080317.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0070477; FBpp0070455; FBgn0003068 |
GeneIDi | 31251 |
KEGGi | dme:Dmel_CG2647 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Protein Spotlight The tale of a love song - Issue 6 of January 2001 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M30114 Genomic DNA Translation: AAA28752.1 M30114 Genomic DNA Translation: AAA28753.1 M30114 Genomic DNA Translation: AAA28754.1 AF033029 mRNA Translation: AAB87476.1 X03636 Genomic DNA Translation: CAA27285.1 Sequence problems. AE014298 Genomic DNA Translation: AAF45804.1 AL024485 Genomic DNA Translation: CAA19677.1 AL024485 Genomic DNA Translation: CAA19678.1 AL024485 Genomic DNA Translation: CAA19679.1 AL024485 Genomic DNA Translation: CAA19680.1 AY575847 Genomic DNA Translation: AAS89667.1 L07817 Genomic DNA Translation: AAA28777.1 L07818 Genomic DNA Translation: AAA28776.1 L07819 Genomic DNA Translation: AAA28775.1 L07821 Genomic DNA Translation: AAA28773.1 L07823 Genomic DNA Translation: AAA28771.1 L07825 Genomic DNA Translation: AAA28769.1 AB029194 Genomic DNA Translation: BAB15868.1 AB029195 Genomic DNA Translation: BAB15869.1 AB029196 Genomic DNA Translation: BAB15870.1 AB029222 Genomic DNA Translation: BAB15896.1 AB029223 Genomic DNA Translation: BAB15897.1 AB029224 Genomic DNA Translation: BAB15898.1 AB029250 Genomic DNA Translation: BAB15924.1 AB029251 Genomic DNA Translation: BAB15925.1 AB029252 Genomic DNA Translation: BAB15926.1 D00009 Genomic DNA Translation: BAA00007.1 AF251241 Genomic DNA Translation: AAG44573.1 AY047980 Genomic DNA Translation: AAN02289.1 AY047981 Genomic DNA Translation: AAN02291.1 AY047982 Genomic DNA Translation: AAN02293.1 AY047983 Genomic DNA Translation: AAN02295.1 AY047984 Genomic DNA Translation: AAN02297.1 AY047985 Genomic DNA Translation: AAN02299.1 AY047986 Genomic DNA Translation: AAN02301.1 AY047987 Genomic DNA Translation: AAN02303.1 AY047988 Genomic DNA Translation: AAN02305.1 AY047989 Genomic DNA Translation: AAN02307.1 AY047990 Genomic DNA Translation: AAN02309.1 AY047991 Genomic DNA Translation: AAN02311.1 AY047992 Genomic DNA Translation: AAN02313.1 AY047993 Genomic DNA Translation: AAN02315.1 AY047994 Genomic DNA Translation: AAN02317.1 AY047995 Genomic DNA Translation: AAN02319.1 AY047996 Genomic DNA Translation: AAN02321.1 AY047997 Genomic DNA Translation: AAN02323.1 AY047998 Genomic DNA Translation: AAN02325.1 AY047999 Genomic DNA Translation: AAN02327.1 AY048000 Genomic DNA Translation: AAN02329.1 AY048001 Genomic DNA Translation: AAN02331.1 AY048002 Genomic DNA Translation: AAN02333.1 AY048003 Genomic DNA Translation: AAN02335.1 AY048004 Genomic DNA Translation: AAN02337.1 AY048005 Genomic DNA Translation: AAN02339.1 AY048006 Genomic DNA Translation: AAN02341.1 AY048007 Genomic DNA Translation: AAN02343.1 AY048008 Genomic DNA Translation: AAN02345.1 AY048009 Genomic DNA Translation: AAN02347.1 AY048010 Genomic DNA Translation: AAN02349.1 AY048011 Genomic DNA Translation: AAN02351.1 AY048012 Genomic DNA Translation: AAN02353.1 AY048013 Genomic DNA Translation: AAN02355.1 AY048014 Genomic DNA Translation: AAN02357.1 AY048015 Genomic DNA Translation: AAN02359.1 AY048016 Genomic DNA Translation: AAN02361.1 AY048017 Genomic DNA Translation: AAN02363.1 AY048018 Genomic DNA Translation: AAN02365.1 AY048019 Genomic DNA Translation: AAN02367.1 AY048020 Genomic DNA Translation: AAN02369.1 AY048021 Genomic DNA Translation: AAN02371.1 AY048022 Genomic DNA Translation: AAN02373.1 AY048023 Genomic DNA Translation: AAN02375.1 AY048024 Genomic DNA Translation: AAN02377.1 AY048025 Genomic DNA Translation: AAN02379.1 AY048026 Genomic DNA Translation: AAN02381.1 AY048027 Genomic DNA Translation: AAN02383.1 AY048028 Genomic DNA Translation: AAN02385.1 AY048029 Genomic DNA Translation: AAN02387.1 AY048030 Genomic DNA Translation: AAN02389.1 AY048031 Genomic DNA Translation: AAN02391.1 AY048032 Genomic DNA Translation: AAN02393.1 AY048033 Genomic DNA Translation: AAN02395.1 AY048034 Genomic DNA Translation: AAN02397.1 AY048035 Genomic DNA Translation: AAN02399.1 AY048036 Genomic DNA Translation: AAN02401.1 AY048037 Genomic DNA Translation: AAN02403.1 AY048038 Genomic DNA Translation: AAN02405.1 AY048040 Genomic DNA Translation: AAN02407.1 AY048041 Genomic DNA Translation: AAN02409.1 AY048042 Genomic DNA Translation: AAN02411.1 |
PIRi | A23932, UMFF A26427 A26588 B26427 C26427 S52943 |
RefSeqi | NP_001259194.1, NM_001272265.1 NP_525056.2, NM_080317.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1WA9 | X-ray | 3.15 | A/B | 232-599 | [»] | |
3GEC | X-ray | 4.00 | A | 232-538 | [»] | |
3RTY | X-ray | 2.85 | A/B/C/D/E/F/G/H | 236-574 | [»] | |
SMRi | P07663 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 57782, 38 interactors |
DIPi | DIP-29426N |
IntActi | P07663, 4 interactors |
STRINGi | 7227.FBpp0070455 |
PTM databases
iPTMneti | P07663 |
Proteomic databases
PaxDbi | P07663 |
Genome annotation databases
EnsemblMetazoai | FBtr0070477; FBpp0070455; FBgn0003068 |
GeneIDi | 31251 |
KEGGi | dme:Dmel_CG2647 |
Organism-specific databases
CTDi | 31251 |
FlyBasei | FBgn0003068, per |
VEuPathDBi | VectorBase:FBgn0003068 |
Phylogenomic databases
eggNOGi | KOG3753, Eukaryota |
GeneTreei | ENSGT00940000174107 |
HOGENOMi | CLU_002704_0_0_1 |
InParanoidi | P07663 |
Enzyme and pathway databases
Reactomei | R-DME-432395, Degradation of TIM R-DME-432490, Nuclear import of PER and TIM R-DME-432501, Transcription repression by PER and activation by PDP1 R-DME-432524, Degradation of PER R-DME-432553, Phosphorylation of PER and TIM R-DME-432620, Dephosphorylation of PER R-DME-538898, Dephosphorylation of TIM |
SignaLinki | P07663 |
Miscellaneous databases
BioGRID-ORCSi | 31251, 0 hits in 3 CRISPR screens |
EvolutionaryTracei | P07663 |
GenomeRNAii | 31251 |
PROi | PR:P07663 |
Gene expression databases
Bgeei | FBgn0003068, Expressed in head capsule and 30 other tissues |
ExpressionAtlasi | P07663, baseline and differential |
Genevisiblei | P07663, DM |
Family and domain databases
CDDi | cd00130, PAS, 2 hits |
IDEALi | IID50270 |
InterProi | View protein in InterPro IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold |
Pfami | View protein in Pfam PF00989, PAS, 1 hit |
SMARTi | View protein in SMART SM00091, PAS, 2 hits |
SUPFAMi | SSF55785, SSF55785, 2 hits |
PROSITEi | View protein in PROSITE PS50112, PAS, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | PER_DROME | |
Accessioni | P07663Primary (citable) accession number: P07663 Secondary accession number(s): O17483 Q9W4X0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1988 |
Last sequence update: | December 15, 1998 | |
Last modified: | February 23, 2022 | |
This is version 206 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries