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UniProtKB - P07663 (PER_DROME)

Entry version 193 (03 Jul 2019)
Sequence version 2 (15 Dec 1998)
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Protein

Period circadian protein

Gene

per

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential for biological clock functions. Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms. Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition. Required for binding of cwo to the E box regions in the promoters of target genes of the transcriptional activator Clock, probably by binding to Clock-cycle heterodimers, reducing their affinity for E box binding and allowing cwo to bind instead (PubMed:27814361).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBiological rhythms

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-432395 Degradation of TIM
R-DME-432490 Nuclear import of PER and TIM
R-DME-432501 Transcription repression by PER and activation by PDP1
R-DME-432524 Degradation of PER
R-DME-432553 Phosphorylation of PER and TIM
R-DME-432620 Dephosphorylation of PER
R-DME-538898 Dephosphorylation of TIM

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Period circadian protein
Alternative name(s):
Protein clock-6
Short name:
CLK-6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:per
ORF Names:CG2647
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0003068 per

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001625961 – 1224Period circadian proteinAdd BLAST1224

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated with a circadian rhythmicity, probably by the double-time protein (dbt). Phosphorylation could be implicated in the stability of per monomer and in the formation of heterodimer per-tim.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P07663

PRoteomics IDEntifications database

More...PRIDEi		P07663

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P07663

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in neural tissues and in several nonneural tissues of the abdomen. Malpighian tubules contain a circadian pacemaker that functions independently of the brain. Expression oscillates in all tissues studied except for the ovary. PER-A isoforms are mainly expressed in adult's head.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is sensitive to temperature but not to light.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0003068 Expressed in 24 organ(s), highest expression level in head capsule

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P07663 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a heterodimer with timeless (TIM); the complex then translocates into the nucleus. A proportion of the protein exists as homodimer.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
timP490212EBI-15718452,EBI-266295

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		57782, 35 interactors

Database of interacting proteins

More...DIPi		DIP-29426N

Protein interaction database and analysis system

More...IntActi		P07663, 5 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0070455

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11224
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P07663

Database of comparative protein structure models

More...ModBasei		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P07663

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini238 – 373PAS 1PROSITE-ProRule annotationAdd BLAST136
Domaini391 – 497PAS 2PROSITE-ProRule annotationAdd BLAST107
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati694 – 69512
Repeati697 – 69822
Repeati699 – 70032
Repeati701 – 70242
Repeati703 – 70452
Repeati705 – 70662
Repeati707 – 70872
Repeati709 – 71082
Repeati711 – 71292
Repeati713 – 714102
Repeati715 – 716112
Repeati717 – 718122
Repeati719 – 720132
Repeati721 – 722142
Repeati723 – 724152
Repeati725 – 726162
Repeati727 – 728172
Repeati729 – 730182
Repeati731 – 732192
Repeati733 – 734202
Repeati735 – 736212
Repeati737 – 738222
Repeati739 – 740232
Repeati741 – 742242
Repeati743 – 744252
Repeati745 – 746262
Repeati747 – 74827; approximate2
Repeati749 – 750282
Repeati751 – 752292
Repeati753 – 754302

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni694 – 75430 X 2 AA approximate tandem repeats of G-[TN]Add BLAST61
Regioni749 – 868Regulates the rhythm of species-specific courtship songAdd BLAST120

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi66 – 79Nuclear localization signalSequence analysisAdd BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi74 – 79Poly-Lys6
Compositional biasi143 – 146Poly-Glu4
Compositional biasi223 – 226Poly-Ala4
Compositional biasi872 – 879Poly-Gly8
Compositional biasi898 – 905Poly-Gly8
Compositional biasi906 – 914Poly-Ala9
Compositional biasi1006 – 1013Poly-Ala8
Compositional biasi1035 – 1041Poly-Ala7

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains a remarkable run of alternating Gly-Thr residues which is polymorphic in length. At least three types of Gly-Thr length exist in the natural population, (Gly-Thr)23 (shown here), and two major variants (Gly-Thr)17 and (Gly-Thr)20. This Gly-Thr stretch is implicated in the maintenance of circadian period at different temperatures. Deletion of the repeat leads to a shortening of the courtship song cycle period, and thus could be important for determining features of species-specific mating behavior.
Mutations in the PAS domain result in longer circadian rhythms and courtship song (PERL mutation) or makes the flies arrhythmic (PER01 mutation).

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3753 Eukaryota
ENOG410Y118 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P07663

KEGG Orthology (KO)

More...KOi		K02633

Family and domain databases

Conserved Domains Database

More...CDDi		cd00130 PAS, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00989 PAS, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00091 PAS, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55785 SSF55785, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50112 PAS, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform PER-A-long (identifier: P07663-1) [UniParc]FASTAAdd to basket
Also known as: perA

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGGESTEST HNTKVSDSAY SNSCSNSQSQ RSGSSKSRLS GSHSSGSSGY 
        60         70         80         90        100
GGKPSTQASS SDMIIKRNKD KSRKKKKNKG AGQGAGQAQT LISASTSLEG 
       110        120        130        140        150
RDEEKPRPSG TGCVEQQICR ELQDQQHGED HSEPQAIEQL QQEEEEDQSG 
       160        170        180        190        200
SESEADRVEG VAKSEAAQSF PIPSPLSVTI VPPSMGGCGG VGHAAGLDSG 
       210        220        230        240        250
LAKFDKTWEA GPGKLESMTG VGAAAAGTGQ RGERVKEDSF CCVISMHDGI 
       260        270        280        290        300
VLYTTPSITD VLGYPRDMWL GRSFIDFVHL KDRATFASQI TTGIPIAESR 
       310        320        330        340        350
GSVPKDAKST FCVMLRRYRG LKSGGFGVIG RPVSYEPFRL GLTFREAPEE 
       360        370        380        390        400
ARPDNYMVSN GTNMLLVICA TPIKSSYKVP DEILSQKSPK FAIRHTATGI 
       410        420        430        440        450
ISHVDSAAVS ALGYLPQDLI GRSIMDFYHH EDLSVMKETY ETVMKKGQTA 
       460        470        480        490        500
GASFCSKPYR FLIQNGCYVL LETEWTSFVN PWSRKLEFVV GHHRVFQGPK 
       510        520        530        540        550
QCNVFEAAPT CKLKISEEAQ SRNTRIKEDI VKRLAETVSR PSDTVKQEVS 
       560        570        580        590        600
RRCQALASFM ETLMDEVSRA DLKLELPHEN ELTVSERDSV MLGEISPHHD 
       610        620        630        640        650
YYDSKSSTET PPSYNQLNYN ENLLRFFNSK PVTAPAELDP PKTEPPEPRG 
       660        670        680        690        700
TCVSGASGPM SPVHEGSGGS GSSGNFTTAS NIHMSSVTNT SIAGTGGTGT 
       710        720        730        740        750
GTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GTGNGTNSGT 
       760        770        780        790        800
GTGTASSSKG GTAAIPPVTL TESLLNKHND EMEKFMLKKH RESRGRTGEK 
       810        820        830        840        850
SKKSANDTLK MLEYSGPGHG IKRGGSHSWE GEANKPKQQL TLGTDAIKGA 
       860        870        880        890        900
AGSAGGAVGT GGVGSGGAGV AGGGGSGTGV AGTPEGRATT TSGTGTPGGA 
       910        920        930        940        950
GGGGGAGAAA AAGASSSVGS STPGPSSYPT CTQNINLWPP FSVGITPPVH 
       960        970        980        990       1000
STHTAMAQSS FSSAGLFPTF YYIPASLTPT SPTRSPRMHK HPHKGGTDMP 
      1010       1020       1030       1040       1050
TTSQQAAAAA AQAMPLQYMA GVMYPHPSLF YTHPAAAAAT AMMYQPMPFP 
      1060       1070       1080       1090       1100
GMANALQIPE RPLGSQSAYN KSVYTTTPAS MTKKVPGAFH SVTTPAQVQR 
      1110       1120       1130       1140       1150
PSSQSASVKT EPGSSAAVSD PCKKEVPDSS PIPSVMGDYN SDPPCSSSNP 
      1160       1170       1180       1190       1200
ANNKKYTDSN GNSDDMDGSS FSSFYSSFIK TTDGSESPPD TEKDPKHRKL 
      1210       1220 
KSMSTSESKI MEHPEEDQTQ HGDG
Length:1,224
Mass (Da):127,852
Last modified:December 15, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i71FA54ECF3E90F4A
GO
Isoform PER-A-short (identifier: P07663-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.

Show »
Length:1,162
Mass (Da):121,661
Checksum:i7EF93EDE76EC5A5B
GO
Isoform PER-B (identifier: P07663-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     868-963: Missing.

Show »
Length:1,128
Mass (Da):119,293
Checksum:iAE924CCDF4C5ADD9
GO
Isoform PER-C (identifier: P07663-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1076-1224: TTPASMTKKV...EEDQTQHGDG → VSQWPVVPHR...SRQQQGMLYE

Show »
Length:1,182
Mass (Da):123,485
Checksum:i434AC9036463909E
GO
Isoform PER-D (identifier: P07663-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     863-958: Missing.

Show »
Length:1,128
Mass (Da):119,431
Checksum:i5ED88CCD3FEE97B4
GO
Isoform PER-E (identifier: P07663-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     863-958: Missing.
     1155-1224: KYTDSNGNSD...EEDQTQHGDG → VCYTNEVHW

Show »
Length:1,067
Mass (Da):112,804
Checksum:iBD72A8EC731BFD31
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PGJ3M9PGJ3_DROME
Period, isoform B
per Clk, clk-6, Dmel\CG2647, dmper, dPER
1,218Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA27285 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti211G → V in AAA28777 (PubMed:8436278).Curated1
Sequence conflicti498 – 499GP → A in AAA28777 (PubMed:8436278).Curated2
Sequence conflicti637E → A (PubMed:3087625).Curated1
Sequence conflicti733 – 767Missing (PubMed:3081818).CuratedAdd BLAST35
Sequence conflicti762 – 764TAA → RR (PubMed:3081818).Curated3
Sequence conflicti762 – 764TAA → RR (PubMed:3087625).Curated3
Sequence conflicti1029L → V (PubMed:3087625).Curated1
Sequence conflicti1038A → P (PubMed:3087625).Curated1
Sequence conflicti1075T → TVSQWPV in CAA19677 (PubMed:10731137).Curated1
Sequence conflicti1114S → F (PubMed:3102970).Curated1
Sequence conflicti1215E → D (PubMed:3102970).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti697 – 708Missing in (Gly-Thr)17. Add BLAST12
Natural varianti697 – 702Missing in (Gly-Thr)20. 6
Natural varianti748S → F in strain: U79. 1
Natural varianti762T → S in strain: Berkeley, L18, Oregon-R, SP1 and U79. 1
Natural varianti846A → T in strain: U79. 1
Natural varianti858V → A in strain: L18 and U79. 1
Natural varianti1176S → P in strain: L18. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0046571 – 62Missing in isoform PER-A-short. CuratedAdd BLAST62
Alternative sequenceiVSP_004659863 – 958Missing in isoform PER-D and isoform PER-E. CuratedAdd BLAST96
Alternative sequenceiVSP_004658868 – 963Missing in isoform PER-B. CuratedAdd BLAST96
Alternative sequenceiVSP_0046601076 – 1224TTPAS…QHGDG → VSQWPVVPHRTVLTPTPTPY SSIDHAGVHDEEGAGCIPLG HHSCPGAASLLAERIRQDGA GLQCSGIRSLQEGGAGLLAH SLRDGRLQLRPALQQQQSRQ QQGMLYE in isoform PER-C. CuratedAdd BLAST149
Alternative sequenceiVSP_0046611155 – 1224KYTDS…QHGDG → VCYTNEVHW in isoform PER-E. CuratedAdd BLAST70

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M30114 Genomic DNA Translation: AAA28752.1
M30114 Genomic DNA Translation: AAA28753.1
M30114 Genomic DNA Translation: AAA28754.1
AF033029 mRNA Translation: AAB87476.1
X03636 Genomic DNA Translation: CAA27285.1 Sequence problems.
AE014298 Genomic DNA Translation: AAF45804.1
AL024485 Genomic DNA Translation: CAA19677.1
AL024485 Genomic DNA Translation: CAA19678.1
AL024485 Genomic DNA Translation: CAA19679.1
AL024485 Genomic DNA Translation: CAA19680.1
AY575847 Genomic DNA Translation: AAS89667.1
L07817 Genomic DNA Translation: AAA28777.1
L07818 Genomic DNA Translation: AAA28776.1
L07819 Genomic DNA Translation: AAA28775.1
L07821 Genomic DNA Translation: AAA28773.1
L07823 Genomic DNA Translation: AAA28771.1
L07825 Genomic DNA Translation: AAA28769.1
AB029194 Genomic DNA Translation: BAB15868.1
AB029195 Genomic DNA Translation: BAB15869.1
AB029196 Genomic DNA Translation: BAB15870.1
AB029222 Genomic DNA Translation: BAB15896.1
AB029223 Genomic DNA Translation: BAB15897.1
AB029224 Genomic DNA Translation: BAB15898.1
AB029250 Genomic DNA Translation: BAB15924.1
AB029251 Genomic DNA Translation: BAB15925.1
AB029252 Genomic DNA Translation: BAB15926.1
D00009 Genomic DNA Translation: BAA00007.1
AF251241 Genomic DNA Translation: AAG44573.1
AY047980 Genomic DNA Translation: AAN02289.1
AY047981 Genomic DNA Translation: AAN02291.1
AY047982 Genomic DNA Translation: AAN02293.1
AY047983 Genomic DNA Translation: AAN02295.1
AY047984 Genomic DNA Translation: AAN02297.1
AY047985 Genomic DNA Translation: AAN02299.1
AY047986 Genomic DNA Translation: AAN02301.1
AY047987 Genomic DNA Translation: AAN02303.1
AY047988 Genomic DNA Translation: AAN02305.1
AY047989 Genomic DNA Translation: AAN02307.1
AY047990 Genomic DNA Translation: AAN02309.1
AY047991 Genomic DNA Translation: AAN02311.1
AY047992 Genomic DNA Translation: AAN02313.1
AY047993 Genomic DNA Translation: AAN02315.1
AY047994 Genomic DNA Translation: AAN02317.1
AY047995 Genomic DNA Translation: AAN02319.1
AY047996 Genomic DNA Translation: AAN02321.1
AY047997 Genomic DNA Translation: AAN02323.1
AY047998 Genomic DNA Translation: AAN02325.1
AY047999 Genomic DNA Translation: AAN02327.1
AY048000 Genomic DNA Translation: AAN02329.1
AY048001 Genomic DNA Translation: AAN02331.1
AY048002 Genomic DNA Translation: AAN02333.1
AY048003 Genomic DNA Translation: AAN02335.1
AY048004 Genomic DNA Translation: AAN02337.1
AY048005 Genomic DNA Translation: AAN02339.1
AY048006 Genomic DNA Translation: AAN02341.1
AY048007 Genomic DNA Translation: AAN02343.1
AY048008 Genomic DNA Translation: AAN02345.1
AY048009 Genomic DNA Translation: AAN02347.1
AY048010 Genomic DNA Translation: AAN02349.1
AY048011 Genomic DNA Translation: AAN02351.1
AY048012 Genomic DNA Translation: AAN02353.1
AY048013 Genomic DNA Translation: AAN02355.1
AY048014 Genomic DNA Translation: AAN02357.1
AY048015 Genomic DNA Translation: AAN02359.1
AY048016 Genomic DNA Translation: AAN02361.1
AY048017 Genomic DNA Translation: AAN02363.1
AY048018 Genomic DNA Translation: AAN02365.1
AY048019 Genomic DNA Translation: AAN02367.1
AY048020 Genomic DNA Translation: AAN02369.1
AY048021 Genomic DNA Translation: AAN02371.1
AY048022 Genomic DNA Translation: AAN02373.1
AY048023 Genomic DNA Translation: AAN02375.1
AY048024 Genomic DNA Translation: AAN02377.1
AY048025 Genomic DNA Translation: AAN02379.1
AY048026 Genomic DNA Translation: AAN02381.1
AY048027 Genomic DNA Translation: AAN02383.1
AY048028 Genomic DNA Translation: AAN02385.1
AY048029 Genomic DNA Translation: AAN02387.1
AY048030 Genomic DNA Translation: AAN02389.1
AY048031 Genomic DNA Translation: AAN02391.1
AY048032 Genomic DNA Translation: AAN02393.1
AY048033 Genomic DNA Translation: AAN02395.1
AY048034 Genomic DNA Translation: AAN02397.1
AY048035 Genomic DNA Translation: AAN02399.1
AY048036 Genomic DNA Translation: AAN02401.1
AY048037 Genomic DNA Translation: AAN02403.1
AY048038 Genomic DNA Translation: AAN02405.1
AY048040 Genomic DNA Translation: AAN02407.1
AY048041 Genomic DNA Translation: AAN02409.1
AY048042 Genomic DNA Translation: AAN02411.1

Protein sequence database of the Protein Information Resource

More...PIRi		A23932 UMFF
A26427
A26588
B26427
C26427
S52943

NCBI Reference Sequences

More...RefSeqi		NP_001259194.1, NM_001272265.1
NP_525056.2, NM_080317.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		31251

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG2647

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

The tale of a love song - Issue 6 of January 2001

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30114 Genomic DNA Translation: AAA28752.1
M30114 Genomic DNA Translation: AAA28753.1
M30114 Genomic DNA Translation: AAA28754.1
AF033029 mRNA Translation: AAB87476.1
X03636 Genomic DNA Translation: CAA27285.1 Sequence problems.
AE014298 Genomic DNA Translation: AAF45804.1
AL024485 Genomic DNA Translation: CAA19677.1
AL024485 Genomic DNA Translation: CAA19678.1
AL024485 Genomic DNA Translation: CAA19679.1
AL024485 Genomic DNA Translation: CAA19680.1
AY575847 Genomic DNA Translation: AAS89667.1
L07817 Genomic DNA Translation: AAA28777.1
L07818 Genomic DNA Translation: AAA28776.1
L07819 Genomic DNA Translation: AAA28775.1
L07821 Genomic DNA Translation: AAA28773.1
L07823 Genomic DNA Translation: AAA28771.1
L07825 Genomic DNA Translation: AAA28769.1
AB029194 Genomic DNA Translation: BAB15868.1
AB029195 Genomic DNA Translation: BAB15869.1
AB029196 Genomic DNA Translation: BAB15870.1
AB029222 Genomic DNA Translation: BAB15896.1
AB029223 Genomic DNA Translation: BAB15897.1
AB029224 Genomic DNA Translation: BAB15898.1
AB029250 Genomic DNA Translation: BAB15924.1
AB029251 Genomic DNA Translation: BAB15925.1
AB029252 Genomic DNA Translation: BAB15926.1
D00009 Genomic DNA Translation: BAA00007.1
AF251241 Genomic DNA Translation: AAG44573.1
AY047980 Genomic DNA Translation: AAN02289.1
AY047981 Genomic DNA Translation: AAN02291.1
AY047982 Genomic DNA Translation: AAN02293.1
AY047983 Genomic DNA Translation: AAN02295.1
AY047984 Genomic DNA Translation: AAN02297.1
AY047985 Genomic DNA Translation: AAN02299.1
AY047986 Genomic DNA Translation: AAN02301.1
AY047987 Genomic DNA Translation: AAN02303.1
AY047988 Genomic DNA Translation: AAN02305.1
AY047989 Genomic DNA Translation: AAN02307.1
AY047990 Genomic DNA Translation: AAN02309.1
AY047991 Genomic DNA Translation: AAN02311.1
AY047992 Genomic DNA Translation: AAN02313.1
AY047993 Genomic DNA Translation: AAN02315.1
AY047994 Genomic DNA Translation: AAN02317.1
AY047995 Genomic DNA Translation: AAN02319.1
AY047996 Genomic DNA Translation: AAN02321.1
AY047997 Genomic DNA Translation: AAN02323.1
AY047998 Genomic DNA Translation: AAN02325.1
AY047999 Genomic DNA Translation: AAN02327.1
AY048000 Genomic DNA Translation: AAN02329.1
AY048001 Genomic DNA Translation: AAN02331.1
AY048002 Genomic DNA Translation: AAN02333.1
AY048003 Genomic DNA Translation: AAN02335.1
AY048004 Genomic DNA Translation: AAN02337.1
AY048005 Genomic DNA Translation: AAN02339.1
AY048006 Genomic DNA Translation: AAN02341.1
AY048007 Genomic DNA Translation: AAN02343.1
AY048008 Genomic DNA Translation: AAN02345.1
AY048009 Genomic DNA Translation: AAN02347.1
AY048010 Genomic DNA Translation: AAN02349.1
AY048011 Genomic DNA Translation: AAN02351.1
AY048012 Genomic DNA Translation: AAN02353.1
AY048013 Genomic DNA Translation: AAN02355.1
AY048014 Genomic DNA Translation: AAN02357.1
AY048015 Genomic DNA Translation: AAN02359.1
AY048016 Genomic DNA Translation: AAN02361.1
AY048017 Genomic DNA Translation: AAN02363.1
AY048018 Genomic DNA Translation: AAN02365.1
AY048019 Genomic DNA Translation: AAN02367.1
AY048020 Genomic DNA Translation: AAN02369.1
AY048021 Genomic DNA Translation: AAN02371.1
AY048022 Genomic DNA Translation: AAN02373.1
AY048023 Genomic DNA Translation: AAN02375.1
AY048024 Genomic DNA Translation: AAN02377.1
AY048025 Genomic DNA Translation: AAN02379.1
AY048026 Genomic DNA Translation: AAN02381.1
AY048027 Genomic DNA Translation: AAN02383.1
AY048028 Genomic DNA Translation: AAN02385.1
AY048029 Genomic DNA Translation: AAN02387.1
AY048030 Genomic DNA Translation: AAN02389.1
AY048031 Genomic DNA Translation: AAN02391.1
AY048032 Genomic DNA Translation: AAN02393.1
AY048033 Genomic DNA Translation: AAN02395.1
AY048034 Genomic DNA Translation: AAN02397.1
AY048035 Genomic DNA Translation: AAN02399.1
AY048036 Genomic DNA Translation: AAN02401.1
AY048037 Genomic DNA Translation: AAN02403.1
AY048038 Genomic DNA Translation: AAN02405.1
AY048040 Genomic DNA Translation: AAN02407.1
AY048041 Genomic DNA Translation: AAN02409.1
AY048042 Genomic DNA Translation: AAN02411.1
PIRiA23932 UMFF
A26427
A26588
B26427
C26427
S52943
RefSeqiNP_001259194.1, NM_001272265.1
NP_525056.2, NM_080317.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WA9X-ray3.15A/B232-599[»]
3GECX-ray4.00A232-538[»]
3RTYX-ray2.85A/B/C/D/E/F/G/H236-574[»]
SMRiP07663
ModBaseiSearch...

Protein-protein interaction databases

BioGridi57782, 35 interactors
DIPiDIP-29426N
IntActiP07663, 5 interactors
STRINGi7227.FBpp0070455

PTM databases

iPTMnetiP07663

Proteomic databases

PaxDbiP07663
PRIDEiP07663

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi31251
KEGGidme:Dmel_CG2647

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		31251
FlyBaseiFBgn0003068 per

Phylogenomic databases

eggNOGiKOG3753 Eukaryota
ENOG410Y118 LUCA
InParanoidiP07663
KOiK02633

Enzyme and pathway databases

ReactomeiR-DME-432395 Degradation of TIM
R-DME-432490 Nuclear import of PER and TIM
R-DME-432501 Transcription repression by PER and activation by PDP1
R-DME-432524 Degradation of PER
R-DME-432553 Phosphorylation of PER and TIM
R-DME-432620 Dephosphorylation of PER
R-DME-538898 Dephosphorylation of TIM

Miscellaneous databases

EvolutionaryTraceiP07663

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		31251

Protein Ontology

More...PROi		PR:P07663

Gene expression databases

BgeeiFBgn0003068 Expressed in 24 organ(s), highest expression level in head capsule
GenevisibleiP07663 DM

Family and domain databases

CDDicd00130 PAS, 2 hits
InterProiView protein in InterPro
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
PfamiView protein in Pfam
PF00989 PAS, 1 hit
SMARTiView protein in SMART
SM00091 PAS, 2 hits
SUPFAMiSSF55785 SSF55785, 2 hits
PROSITEiView protein in PROSITE
PS50112 PAS, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPER_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07663
Secondary accession number(s): O17483
, O76882, O76883, O76884, O76885, Q24446, Q24447, Q24448, Q24449, Q6PVA3, Q8MLY0, Q9GN20, Q9GN51, Q9GQH9, Q9GV48, Q9GV53, Q9GV54, Q9GV55, Q9W4X0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: December 15, 1998
Last modified: July 3, 2019
This is version 193 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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