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UniProtKB - P07650 (TYPH_ECOLI)
Protein
Thymidine phosphorylase
Gene
deoA
Organism
Escherichia coli (strain K12)
Status
Functioni
The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
Catalytic activityi
- EC:2.4.2.4
: dTMP biosynthesis via salvage pathway Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes dTMP from thymine. This subpathway is part of the pathway dTMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes dTMP from thymine, the pathway dTMP biosynthesis via salvage pathway and in Pyrimidine metabolism.
GO - Molecular functioni
- 1,4-alpha-oligoglucan phosphorylase activity Source: InterPro
- pyrimidine-nucleoside phosphorylase activity Source: InterPro
- thymidine phosphorylase activity Source: EcoCyc
GO - Biological processi
- cellular response to DNA damage stimulus Source: EcoliWiki
- pyrimidine nucleobase metabolic process Source: InterPro
- pyrimidine nucleoside metabolic process Source: CAFA
- thymidine metabolic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Enzyme and pathway databases
BioCyci | EcoCyc:DEOA-MONOMER |
BRENDAi | 2.4.2.4, 2026 |
UniPathwayi | UPA00578;UER00638 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:deoA Synonyms:tpp, ttg Ordered Locus Names:b4382, JW4345 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Pathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL3726 |
DrugBanki | DB03462, Thymine |
DrugCentrali | P07650 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000059054 | 1 – 440 | Thymidine phosphorylaseAdd BLAST | 440 |
Proteomic databases
jPOSTi | P07650 |
PaxDbi | P07650 |
PRIDEi | P07650 |
Interactioni
Subunit structurei
Homodimer.
Protein-protein interaction databases
BioGRIDi | 4262779, 20 interactors |
DIPi | DIP-9426N |
IntActi | P07650, 2 interactors |
STRINGi | 511145.b4382 |
Chemistry databases
BindingDBi | P07650 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P07650 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P07650 |
Family & Domainsi
Sequence similaritiesi
Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.Curated
Phylogenomic databases
eggNOGi | COG0213, Bacteria |
HOGENOMi | CLU_025040_0_1_6 |
InParanoidi | P07650 |
PhylomeDBi | P07650 |
Family and domain databases
Gene3Di | 3.40.1030.10, 1 hit 3.90.1170.30, 1 hit |
HAMAPi | MF_01628, Thymid_phosp, 1 hit |
InterProi | View protein in InterPro IPR000312, Glycosyl_Trfase_fam3 IPR017459, Glycosyl_Trfase_fam3_N_dom IPR036320, Glycosyl_Trfase_fam3_N_dom)sf IPR035902, Nuc_phospho_transferase IPR036566, PYNP-like_C_sf IPR013102, PYNP_C IPR018090, Pyrmidine_PPas_bac/euk IPR017872, Pyrmidine_PPase_CS IPR000053, Thymidine/pyrmidine_PPase IPR013465, Thymidine_Pase |
PANTHERi | PTHR10515, PTHR10515, 1 hit |
Pfami | View protein in Pfam PF02885, Glycos_trans_3N, 1 hit PF00591, Glycos_transf_3, 1 hit PF07831, PYNP_C, 1 hit |
PIRSFi | PIRSF000478, TP_PyNP, 1 hit |
SMARTi | View protein in SMART SM00941, PYNP_C, 1 hit |
SUPFAMi | SSF47648, SSF47648, 1 hit SSF52418, SSF52418, 1 hit SSF54680, SSF54680, 1 hit |
TIGRFAMsi | TIGR02643, T_phosphoryl, 1 hit TIGR02644, Y_phosphoryl, 1 hit |
PROSITEi | View protein in PROSITE PS00647, THYMID_PHOSPHORYLASE, 1 hit |
i Sequence
Sequence statusi: Complete.
P07650-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFLAQEIIRK KRDGHALSDE EIRFFINGIR DNTISEGQIA ALAMTIFFHD
60 70 80 90 100
MTMPERVSLT MAMRDSGTVL DWKSLHLNGP IVDKHSTGGV GDVTSLMLGP
110 120 130 140 150
MVAACGGYIP MISGRGLGHT GGTLDKLESI PGFDIFPDDN RFREIIKDVG
160 170 180 190 200
VAIIGQTSSL APADKRFYAT RDITATVDSI PLITASILAK KLAEGLDALV
210 220 230 240 250
MDVKVGSGAF MPTYELSEAL AEAIVGVANG AGVRTTALLT DMNQVLASSA
260 270 280 290 300
GNAVEVREAV QFLTGEYRNP RLFDVTMALC VEMLISGKLA KDDAEARAKL
310 320 330 340 350
QAVLDNGKAA EVFGRMVAAQ KGPTDFVENY AKYLPTAMLT KAVYADTEGF
360 370 380 390 400
VSEMDTRALG MAVVAMGGGR RQASDTIDYS VGFTDMARLG DQVDGQRPLA
410 420 430 440
VIHAKDENNW QEAAKAVKAA IKLADKAPES TPTVYRRISE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U14003 Genomic DNA Translation: AAA97278.1 U00096 Genomic DNA Translation: AAC77335.1 AP009048 Genomic DNA Translation: BAE78371.1 X00742 Genomic DNA Translation: CAA25324.1 X03224 Genomic DNA Translation: CAA26975.1 |
PIRi | S56606 |
RefSeqi | NP_418799.1, NC_000913.3 WP_000477807.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC77335; AAC77335; b4382 BAE78371; BAE78371; BAE78371 |
GeneIDi | 948901 |
KEGGi | ecj:JW4345 eco:b4382 |
PATRICi | fig|1411691.4.peg.2303 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U14003 Genomic DNA Translation: AAA97278.1 U00096 Genomic DNA Translation: AAC77335.1 AP009048 Genomic DNA Translation: BAE78371.1 X00742 Genomic DNA Translation: CAA25324.1 X03224 Genomic DNA Translation: CAA26975.1 |
PIRi | S56606 |
RefSeqi | NP_418799.1, NC_000913.3 WP_000477807.1, NZ_LN832404.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AZY | X-ray | 3.00 | A/B | 2-440 | [»] | |
1OTP | X-ray | 2.80 | A | 2-440 | [»] | |
1TPT | X-ray | 2.80 | A | 2-440 | [»] | |
2TPT | X-ray | 2.60 | A | 2-440 | [»] | |
4EAD | X-ray | 1.50 | A | 2-440 | [»] | |
4EAF | X-ray | 1.55 | A | 2-440 | [»] | |
4LHM | X-ray | 1.52 | A | 2-440 | [»] | |
SMRi | P07650 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4262779, 20 interactors |
DIPi | DIP-9426N |
IntActi | P07650, 2 interactors |
STRINGi | 511145.b4382 |
Chemistry databases
BindingDBi | P07650 |
ChEMBLi | CHEMBL3726 |
DrugBanki | DB03462, Thymine |
DrugCentrali | P07650 |
Proteomic databases
jPOSTi | P07650 |
PaxDbi | P07650 |
PRIDEi | P07650 |
Genome annotation databases
EnsemblBacteriai | AAC77335; AAC77335; b4382 BAE78371; BAE78371; BAE78371 |
GeneIDi | 948901 |
KEGGi | ecj:JW4345 eco:b4382 |
PATRICi | fig|1411691.4.peg.2303 |
Organism-specific databases
EchoBASEi | EB0215 |
Phylogenomic databases
eggNOGi | COG0213, Bacteria |
HOGENOMi | CLU_025040_0_1_6 |
InParanoidi | P07650 |
PhylomeDBi | P07650 |
Enzyme and pathway databases
UniPathwayi | UPA00578;UER00638 |
BioCyci | EcoCyc:DEOA-MONOMER |
BRENDAi | 2.4.2.4, 2026 |
Miscellaneous databases
EvolutionaryTracei | P07650 |
PROi | PR:P07650 |
Family and domain databases
Gene3Di | 3.40.1030.10, 1 hit 3.90.1170.30, 1 hit |
HAMAPi | MF_01628, Thymid_phosp, 1 hit |
InterProi | View protein in InterPro IPR000312, Glycosyl_Trfase_fam3 IPR017459, Glycosyl_Trfase_fam3_N_dom IPR036320, Glycosyl_Trfase_fam3_N_dom)sf IPR035902, Nuc_phospho_transferase IPR036566, PYNP-like_C_sf IPR013102, PYNP_C IPR018090, Pyrmidine_PPas_bac/euk IPR017872, Pyrmidine_PPase_CS IPR000053, Thymidine/pyrmidine_PPase IPR013465, Thymidine_Pase |
PANTHERi | PTHR10515, PTHR10515, 1 hit |
Pfami | View protein in Pfam PF02885, Glycos_trans_3N, 1 hit PF00591, Glycos_transf_3, 1 hit PF07831, PYNP_C, 1 hit |
PIRSFi | PIRSF000478, TP_PyNP, 1 hit |
SMARTi | View protein in SMART SM00941, PYNP_C, 1 hit |
SUPFAMi | SSF47648, SSF47648, 1 hit SSF52418, SSF52418, 1 hit SSF54680, SSF54680, 1 hit |
TIGRFAMsi | TIGR02643, T_phosphoryl, 1 hit TIGR02644, Y_phosphoryl, 1 hit |
PROSITEi | View protein in PROSITE PS00647, THYMID_PHOSPHORYLASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TYPH_ECOLI | |
Accessioni | P07650Primary (citable) accession number: P07650 Secondary accession number(s): Q2M5T5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1988 |
Last sequence update: | February 1, 1995 | |
Last modified: | February 23, 2022 | |
This is version 193 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families