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Entry version 165 (11 Dec 2019)
Sequence version 4 (23 Jan 2007)
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Protein

Homoserine O-succinyltransferase

Gene

metAS

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine (PubMed:10572016, PubMed:17442255, PubMed:17302437, PubMed:28581482). Utilizes a ping-pong kinetic mechanism in which the succinyl group of succinyl-CoA is initially transferred to the enzyme to form a succinyl-enzyme intermediate before subsequent transfer to homoserine to form the final product, O-succinylhomoserine (PubMed:10572016, PubMed:17442255, PubMed:17302437). Cannot use acetyl-CoA (PubMed:10572016).4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by iodoacetamide in a pH-dependent manner.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 24 sec(-1) with succinyl-CoA as substrate. kcat is 24 sec(-1) with L-homoserine as substrate. kcat is 5.23 sec(-1) with CoA as substrate. kcat is 5.23 sec(-1) with O-succinylhomoserine as substrate.1 Publication
  1. KM=0.17 mM for succinyl-CoA1 Publication
  2. KM=0.13 mM for succinyl-CoA1 Publication
  3. KM=0.28 mM for succinyl-CoA1 Publication
  4. KM=1.6 mM for L-homoserine1 Publication
  5. KM=0.72 mM for L-homoserine1 Publication
  6. KM=0.38 mM for L-homoserine1 Publication
  7. KM=0.64 mM for CoA1 Publication
  8. KM=3.5 mM for O-succinylhomoserine1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-methionine biosynthesis via de novo pathway

    This protein is involved in step 1 of the subpathway that synthesizes O-succinyl-L-homoserine from L-homoserine.UniRule annotation1 Publication
    Proteins known to be involved in this subpathway in this organism are:
    1. Homoserine O-succinyltransferase (metA), Homoserine O-succinyltransferase (metAS), Homoserine O-succinyltransferase (metA), Homoserine O-succinyltransferase (metA)
    This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes O-succinyl-L-homoserine from L-homoserine, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei111Important for acyl-CoA specificityUniRule annotation1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei142Acyl-thioester intermediateUniRule annotation3 Publications1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei163SubstrateUniRule annotation1
    Binding sitei192SubstrateUniRule annotation1
    Sitei192Important for substrate specificityUniRule annotation1
    Active sitei235Proton acceptorUniRule annotation2 Publications1
    Active sitei237UniRule annotation2 Publications1
    Binding sitei249SubstrateUniRule annotation1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • homoserine O-acetyltransferase activity Source: UniProtKB-UniRule
    • homoserine O-succinyltransferase activity Source: EcoCyc

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAcyltransferase, Transferase
    Biological processAmino-acid biosynthesis, Methionine biosynthesis

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    EcoCyc:HOMSUCTRAN-MONOMER
    ECOL316407:JW3973-MONOMER
    MetaCyc:HOMSUCTRAN-MONOMER

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00051;UER00075

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Homoserine O-succinyltransferase1 PublicationUniRule annotation (EC:2.3.1.464 Publications)
    Short name:
    HST1 PublicationUniRule annotation
    Alternative name(s):
    Homoserine transsuccinylase1 PublicationUniRule annotation
    Short name:
    HTS1 PublicationUniRule annotation
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:metAS1 PublicationUniRule annotation
    Synonyms:metA1 Publication
    Ordered Locus Names:b4013, JW3973
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
    • UP000000625 Componenti: Chromosome

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    GO - Cellular componenti

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi46 – 47KK → AA: Lack of activity. 3 Publications2
    Mutagenesisi46K → A: 16-fold decrease in Km for L-homoserine. 32-fold decrease in catalytic activity. 1 Publication1
    Mutagenesisi46K → L: 6-fold increase in Km for L-homoserine and in Km for succinyl-CoA. Slight increase in catalytic activity. 1 Publication1
    Mutagenesisi46K → R: Slight decrease in catalytic activity. 1 Publication1
    Mutagenesisi47K → A: 22-fold decrease in Km for L-homoserine. Almost loss of catalytic activity. 1 Publication1
    Mutagenesisi47K → L: 8-fold decrease in Km for L-homoserine and 10-fold increase in Km for succinyl-CoA. 20-fold decrease in catalytic activity. 1 Publication1
    Mutagenesisi47K → R: 14-fold decrease in Km for L-homoserine. 72-fold decrease in catalytic activity. 1 Publication1
    Mutagenesisi90C → A or S: No change in activity. 1 Publication1
    Mutagenesisi142C → A or S: Lack of activity. 2 Publications1
    Mutagenesisi157K → L: Lack of activity. 1 Publication1
    Mutagenesisi193R → A: 3-fold increase in Km for L-homoserine. 8-fold decrease in catalytic activity. 1 Publication1
    Mutagenesisi193R → K: 8-fold decrease in catalytic activity. 1 Publication1
    Mutagenesisi235H → A or N: Lack of activity. 2 Publications1
    Mutagenesisi237E → A: 32-fold decrease in catalytic activity. 1 Publication1
    Mutagenesisi237E → D: 3-fold decrease in catalytic activity. 1 Publication1
    Mutagenesisi238Y → F: 5-fold increase in Km for L-homoserine. 1 Publication1
    Mutagenesisi246E → A: 150-fold increase in Km for L-homoserine. 1 Publication1
    Mutagenesisi246E → D: 24-fold increase in Km for L-homoserine. 1 Publication1
    Mutagenesisi249R → K: 4-fold increase in Km for L-homoserine. 1 Publication1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001997482 – 309Homoserine O-succinyltransferaseAdd BLAST308

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    P07623

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P07623

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P07623

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Contains two transcription starting points, P1 and P2, which are 74 bp apart. P1 is under negative control by methionine, whereas P2 is independent of the intracellular methionine concentration.1 Publication

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.

    UniRule annotation1 Publication

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    4259289, 20 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    P07623, 2 interactors

    Molecular INTeraction database

    More...
    MINTi
    P07623

    STRING: functional protein association networks

    More...
    STRINGi
    511145.b4013

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1309
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P07623

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the MetA family.UniRule annotationCurated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG4105CVG Bacteria
    COG1897 LUCA

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000115049

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P07623

    KEGG Orthology (KO)

    More...
    KOi
    K00651

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P07623

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd03131 GATase1_HTS, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.50.880, 1 hit

    HAMAP database of protein families

    More...
    HAMAPi
    MF_00295 MetA_acyltransf, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR029062 Class_I_gatase-like
    IPR005697 HST_MetA
    IPR033752 MetA_family

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR20919 PTHR20919, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF04204 HTS, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF000450 H_ser_succinyltr, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52317 SSF52317, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR01001 metA, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    P07623-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MPIRVPDELP AVNFLREENV FVMTTSRASG QEIRPLKVLI LNLMPKKIET
    60 70 80 90 100
    ENQFLRLLSN SPLQVDIQLL RIDSRESRNT PAEHLNNFYC NFEDIQDQNF
    110 120 130 140 150
    DGLIVTGAPL GLVEFNDVAY WPQIKQVLEW SKDHVTSTLF VCWAVQAALN
    160 170 180 190 200
    ILYGIPKQTR TEKLSGVYEH HILHPHALLT RGFDDSFLAP HSRYADFPAA
    210 220 230 240 250
    LIRDYTDLEI LAETEEGDAY LFASKDKRIA FVTGHPEYDA QTLAQEFFRD
    260 270 280 290 300
    VEAGLDPDVP YNYFPHNDPQ NTPRASWRSH GNLLFTNWLN YYVYQITPYD

    LRHMNPTLD
    Length:309
    Mass (Da):35,727
    Last modified:January 23, 2007 - v4
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA2C395A9A9CFE2C0
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti67I → V (PubMed:2654885).Curated1
    Sequence conflicti67I → V (PubMed:6094503).Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    X14501 Genomic DNA Translation: CAA32654.1
    U00006 Genomic DNA Translation: AAC43107.1
    U00096 Genomic DNA Translation: AAC76983.1
    AP009048 Genomic DNA Translation: BAE78015.1
    M10210 Genomic DNA Translation: AAA24157.1
    X12431 Genomic DNA No translation available.

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    D65208 XYECM

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_418437.1, NC_000913.3
    WP_001122779.1, NZ_LN832404.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    AAC76983; AAC76983; b4013
    BAE78015; BAE78015; BAE78015

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    948513

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ecj:JW3973
    eco:b4013

    Pathosystems Resource Integration Center (PATRIC)

    More...
    PATRICi
    fig|1411691.4.peg.2700

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    X14501 Genomic DNA Translation: CAA32654.1
    U00006 Genomic DNA Translation: AAC43107.1
    U00096 Genomic DNA Translation: AAC76983.1
    AP009048 Genomic DNA Translation: BAE78015.1
    M10210 Genomic DNA Translation: AAA24157.1
    X12431 Genomic DNA No translation available.
    PIRiD65208 XYECM
    RefSeqiNP_418437.1, NC_000913.3
    WP_001122779.1, NZ_LN832404.1

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    6MTGX-ray1.85A/B1-296[»]
    SMRiP07623
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGridi4259289, 20 interactors
    IntActiP07623, 2 interactors
    MINTiP07623
    STRINGi511145.b4013

    Proteomic databases

    EPDiP07623
    PaxDbiP07623
    PRIDEiP07623

    Genome annotation databases

    EnsemblBacteriaiAAC76983; AAC76983; b4013
    BAE78015; BAE78015; BAE78015
    GeneIDi948513
    KEGGiecj:JW3973
    eco:b4013
    PATRICifig|1411691.4.peg.2700

    Organism-specific databases

    EchoBASE - an integrated post-genomic database for E. coli

    More...
    EchoBASEi
    EB0576

    Phylogenomic databases

    eggNOGiENOG4105CVG Bacteria
    COG1897 LUCA
    HOGENOMiHOG000115049
    InParanoidiP07623
    KOiK00651
    PhylomeDBiP07623

    Enzyme and pathway databases

    UniPathwayiUPA00051;UER00075
    BioCyciEcoCyc:HOMSUCTRAN-MONOMER
    ECOL316407:JW3973-MONOMER
    MetaCyc:HOMSUCTRAN-MONOMER

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:P07623

    Family and domain databases

    CDDicd03131 GATase1_HTS, 1 hit
    Gene3Di3.40.50.880, 1 hit
    HAMAPiMF_00295 MetA_acyltransf, 1 hit
    InterProiView protein in InterPro
    IPR029062 Class_I_gatase-like
    IPR005697 HST_MetA
    IPR033752 MetA_family
    PANTHERiPTHR20919 PTHR20919, 1 hit
    PfamiView protein in Pfam
    PF04204 HTS, 1 hit
    PIRSFiPIRSF000450 H_ser_succinyltr, 1 hit
    SUPFAMiSSF52317 SSF52317, 1 hit
    TIGRFAMsiTIGR01001 metA, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
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    MobiDB: a database of protein disorder and mobility annotations

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    MobiDBi
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    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMETAS_ECOLI
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07623
    Secondary accession number(s): Q2M6U1
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: January 23, 2007
    Last modified: December 11, 2019
    This is version 165 of the entry and version 4 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families
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