DCN

Functionⁱ

May affect the rate of fibrils formation.

GO - Molecular functionⁱ

collagen binding Source: Ensembl
extracellular matrix binding Source: Ensembl
extracellular matrix structural constituent conferring compression resistance
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
glycosaminoglycan binding Source: Ensembl
protein N-terminus binding Source: Ensembl
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

aging Source: Ensembl
animal organ morphogenesis
Source: ProtInc
Traceable author statementⁱ
- 7961765
chondroitin sulfate biosynthetic process Source: Reactome
chondroitin sulfate catabolic process Source: Reactome
dermatan sulfate biosynthetic process Source: Reactome
extracellular matrix organization Source: Reactome
kidney development Source: Ensembl
negative regulation of angiogenesis
Source: MGI
Inferred from direct assayⁱ
- 23978385
negative regulation of endothelial cell migration
Source: MGI
Inferred from direct assayⁱ
- 23798385
negative regulation of vascular endothelial growth factor signaling pathway
Source: MGI
Inferred from direct assayⁱ
- 23798385
peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan Source: Ensembl
placenta development Source: Ensembl
positive regulation of autophagy
Source: CACAO
Inferred from direct assayⁱ
- 23798385
positive regulation of macroautophagy
Source: MGI
Inferred from direct assayⁱ
- 23798385
positive regulation of mitochondrial depolarization
Source: MGI
Inferred from genetic interactionⁱ
- 23798385
positive regulation of mitochondrial fission
Source: MGI
Inferred from genetic interactionⁱ
- 23798385
positive regulation of phosphatidylinositol 3-kinase signaling
Source: MGI
Inferred from direct assayⁱ
- 23798385
positive regulation of transcription by RNA polymerase II
Source: MGI
Inferred from genetic interactionⁱ
- 23798385
response to lipopolysaccharide Source: Ensembl
response to mechanical stimulus Source: Ensembl
skeletal muscle tissue development Source: Ensembl
wound healing Source: Ensembl

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1474228 Degradation of the extracellular matrix R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis R-HSA-2022870 Chondroitin sulfate biosynthesis R-HSA-2022923 Dermatan sulfate biosynthesis R-HSA-2024101 CS/DS degradation R-HSA-3000178 ECM proteoglycans R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type R-HSA-3560801 Defective B3GAT3 causes JDSSDHD R-HSA-3595172 Defective CHST3 causes SEDCJD R-HSA-3595174 Defective CHST14 causes EDS, musculocontractural type R-HSA-3595177 Defective CHSY1 causes TPBS R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1
SIGNORⁱ	P07585

Reactomeⁱ

R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022870 Chondroitin sulfate biosynthesis
R-HSA-2022923 Dermatan sulfate biosynthesis
R-HSA-2024101 CS/DS degradation
R-HSA-3000178 ECM proteoglycans
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD
R-HSA-3595172 Defective CHST3 causes SEDCJD
R-HSA-3595174 Defective CHST14 causes EDS, musculocontractural type
R-HSA-3595177 Defective CHSY1 causes TPBS
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1

SIGNORⁱ

P07585

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Decorin Alternative name(s): Bone proteoglycan II PG-S2 PG40
Gene namesⁱ	Name:DCN Synonyms:SLRR1B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000011465.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2705 DCN
MIMⁱ	125255 gene
neXtProtⁱ	NX_P07585

Keywords - Cellular componentⁱ

Extracellular matrix, Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Corneal dystrophy, congenital stromal (CSCD)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA corneal dystrophy characterized by congenital corneal opacification consisting of a large number of flakes and spots throughout all layers of the stroma. It results in progressive, painless visual loss. Corneal erosions and photophobia are absent.

Keywords - Diseaseⁱ

Corneal dystrophy

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1634
GeneReviewsⁱ	DCN
MalaCards human disease database More...MalaCardsⁱ	DCN
MIMⁱ	610048 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000011465
Orphanetⁱ	101068 Congenital stromal corneal dystrophy
PharmGKBⁱ	PA27177

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB03754 Tris

DrugBankⁱ

DB03754 Tris

Polymorphism and mutation databases

BioMutaⁱ	DCN
DMDMⁱ	129951

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 16	By similarityAdd BLAST	16
PropeptideⁱPRO_0000032709	17 – 30	2 PublicationsAdd BLAST	14
ChainⁱPRO_0000032710	31 – 359	DecorinAdd BLAST	329

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	34	O-linked (Xyl...) (glycosaminoglycan) serine1 Publication	1
Disulfide bondⁱ	54 ↔ 60	By similarity
Disulfide bondⁱ	58 ↔ 67	By similarity
Glycosylationⁱ	211	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	262	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	303	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	313 ↔ 346	By similarity

Post-translational modificationⁱ

The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

EPDⁱ	P07585
PaxDbⁱ	P07585
PeptideAtlas More...PeptideAtlasⁱ	P07585
PRIDEⁱ	P07585
ProteomicsDBⁱ	52014 52015 [P07585-2] 52016 [P07585-3] 52017 [P07585-4] 52018 [P07585-5]

PTM databases

GlyConnectⁱ	1169
iPTMnetⁱ	P07585
PhosphoSitePlusⁱ	P07585

Miscellaneous databases

PMAP-CutDBⁱ	P07585

PMAP-CutDBⁱ

P07585

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000011465 Expressed in 228 organ(s), highest expression level in decidua
CleanExⁱ	HS_DCN
ExpressionAtlasⁱ	P07585 baseline and differential
Genevisibleⁱ	P07585 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB017118 CAB068930 HPA003315 HPA064736

HPAⁱ

CAB017118
CAB068930
HPA003315
HPA064736

Interactionⁱ

Subunit structureⁱ

Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
BMP1	P13497-2	2	EBI-9663608,EBI-12509497
FAM20B	O75063	4	EBI-9663608,EBI-11090967
FN1	P02751	9	EBI-9663608,EBI-1220319

GO - Molecular functionⁱ

protein N-terminus binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108002, 20 interactors
IntActⁱ	P07585, 14 interactors
STRINGⁱ	9606.ENSP00000052754

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P07585
SMRⁱ	P07585
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	73 – 93	LRR 1Add BLAST	21
Repeatⁱ	94 – 117	LRR 2Add BLAST	24
Repeatⁱ	118 – 141	LRR 3Add BLAST	24
Repeatⁱ	142 – 162	LRR 4Add BLAST	21
Repeatⁱ	163 – 186	LRR 5Add BLAST	24
Repeatⁱ	187 – 212	LRR 6Add BLAST	26
Repeatⁱ	213 – 233	LRR 7Add BLAST	21
Repeatⁱ	234 – 257	LRR 8Add BLAST	24
Repeatⁱ	258 – 281	LRR 9Add BLAST	24
Repeatⁱ	282 – 304	LRR 10Add BLAST	23
Repeatⁱ	305 – 334	LRR 11Add BLAST	30
Repeatⁱ	335 – 359	LRR 12Add BLAST	25

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	54 – 67	Cys-richAdd BLAST		14

Sequence similaritiesⁱ

Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.Curated

Keywords - Domainⁱ

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGⁱ	KOG0619 Eukaryota COG4886 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118969
HOGENOMⁱ	HOG000261690
HOVERGENⁱ	HBG016052
InParanoidⁱ	P07585
KEGG Orthology (KO) More...KOⁱ	K04660
OMAⁱ	PLGPVCP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G044B
PhylomeDBⁱ	P07585
TreeFamⁱ	TF334562

Family and domain databases

Gene3Dⁱ	3.80.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR028549 Decorin IPR001611 Leu-rich_rpt IPR003591 Leu-rich_rpt_typical-subtyp IPR032675 LRR_dom_sf IPR000372 LRRNT IPR016352 SLRP_I_decor/aspor/byglycan
PANTHERⁱ	PTHR44053:SF2 PTHR44053:SF2, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13855 LRR_8, 3 hits PF01462 LRRNT, 1 hit
PIRSFⁱ	PIRSF002490 SLRP_I, 1 hit
SMARTⁱ	View protein in SMART SM00369 LRR_TYP, 6 hits SM00013 LRRNT, 1 hit
PROSITEⁱ	View protein in PROSITE PS51450 LRR, 8 hits

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 10 potential isoforms that are computationally mapped.Show all Align All

Isoform A (identifier: P07585-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKATIILLLL AQVSWAGPFQ QRGLFDFMLE DEASGIGPEV PDDRDFEPSL 
        60         70         80         90        100
GPVCPFRCQC HLRVVQCSDL GLDKVPKDLP PDTTLLDLQN NKITEIKDGD 
       110        120        130        140        150
FKNLKNLHAL ILVNNKISKV SPGAFTPLVK LERLYLSKNQ LKELPEKMPK 
       160        170        180        190        200
TLQELRAHEN EITKVRKVTF NGLNQMIVIE LGTNPLKSSG IENGAFQGMK 
       210        220        230        240        250
KLSYIRIADT NITSIPQGLP PSLTELHLDG NKISRVDAAS LKGLNNLAKL 
       260        270        280        290        300
GLSFNSISAV DNGSLANTPH LRELHLDNNK LTRVPGGLAE HKYIQVVYLH 
       310        320        330        340        350
NNNISVVGSS DFCPPGHNTK KASYSGVSLF SNPVQYWEIQ PSTFRCVYVR 

SAIQLGNYK

Length:359

Mass (Da):39,747

Last modified:April 1, 1988 - v1

Checksum:ⁱFF511E871A1A52DD

GO

Isoform B (identifier: P07585-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
71-179: Missing.

« Hide

        10         20         30         40         50
MKATIILLLL AQVSWAGPFQ QRGLFDFMLE DEASGIGPEV PDDRDFEPSL 
        60         70         80         90        100
GPVCPFRCQC HLRVVQCSDL ELGTNPLKSS GIENGAFQGM KKLSYIRIAD 
       110        120        130        140        150
TNITSIPQGL PPSLTELHLD GNKISRVDAA SLKGLNNLAK LGLSFNSISA 
       160        170        180        190        200
VDNGSLANTP HLRELHLDNN KLTRVPGGLA EHKYIQVVYL HNNNISVVGS 
       210        220        230        240        250
SDFCPPGHNT KKASYSGVSL FSNPVQYWEI QPSTFRCVYV RSAIQLGNYK

Show »

Length:250

Mass (Da):27,353

Checksum:ⁱ5AA599BE479F68D9

GO

Isoform C (identifier: P07585-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
73-219: Missing.

« Hide

        10         20         30         40         50
MKATIILLLL AQVSWAGPFQ QRGLFDFMLE DEASGIGPEV PDDRDFEPSL 
        60         70         80         90        100
GPVCPFRCQC HLRVVQCSDL GLPPSLTELH LDGNKISRVD AASLKGLNNL 
       110        120        130        140        150
AKLGLSFNSI SAVDNGSLAN TPHLRELHLD NNKLTRVPGG LAEHKYIQVV 
       160        170        180        190        200
YLHNNNISVV GSSDFCPPGH NTKKASYSGV SLFSNPVQYW EIQPSTFRCV 
       210 
YVRSAIQLGN YK

Show »

Length:212

Mass (Da):23,278

Checksum:ⁱ0BCF8BC8CBA92CA9

GO

Isoform D (identifier: P07585-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
109-295: Missing.

« Hide

        10         20         30         40         50
MKATIILLLL AQVSWAGPFQ QRGLFDFMLE DEASGIGPEV PDDRDFEPSL 
        60         70         80         90        100
GPVCPFRCQC HLRVVQCSDL GLDKVPKDLP PDTTLLDLQN NKITEIKDGD 
       110        120        130        140        150
FKNLKNLHVV YLHNNNISVV GSSDFCPPGH NTKKASYSGV SLFSNPVQYW 
       160        170 
EIQPSTFRCV YVRSAIQLGN YK

Show »

Length:172

Mass (Da):19,243

Checksum:ⁱ7EA011E351163971

GO

Isoform E (identifier: P07585-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
72-75: LDKV → CLPS
76-359: Missing.

« Hide

        10         20         30         40         50
MKATIILLLL AQVSWAGPFQ QRGLFDFMLE DEASGIGPEV PDDRDFEPSL 
        60         70 
GPVCPFRCQC HLRVVQCSDL GCLPS

Show »

Length:75

Mass (Da):8,266

Checksum:ⁱ781856DC9E377479

GO

Computationally mapped potential isoform sequencesⁱ

There are 10 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8VWU0	F8VWU0_HUMAN	Decorin Decorin (Bone proteoglycan II)	DCN	179	Annotation score:
F8VUF6	F8VUF6_HUMAN	Decorin Decorin (Bone proteoglycan II)	DCN	178	Annotation score:
F8VXZ8	F8VXZ8_HUMAN	Decorin Decorin (Bone proteoglycan II)	DCN	174	Annotation score:
F8VNV6	F8VNV6_HUMAN	Decorin Decorin (Bone proteoglycan II)	DCN	177	Annotation score:
F8VX58	F8VX58_HUMAN	Decorin Decorin (Bone proteoglycan II)	DCN	119	Annotation score:
F8VNW0	F8VNW0_HUMAN	Decorin Decorin (Bone proteoglycan II)	DCN	88	Annotation score:
F8VSI3	F8VSI3_HUMAN	Decorin Decorin (Bone proteoglycan II)	DCN	100	Annotation score:
F8VU58	F8VU58_HUMAN	Decorin Decorin (Bone proteoglycan II)	DCN	98	Annotation score:
H0YIH3	H0YIH3_HUMAN	Decorin Decorin (Bone proteoglycan II)	DCN	95	Annotation score:
H0YI87	H0YI87_HUMAN	Decorin Decorin (Bone proteoglycan II)	DCN	52	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	37	G → A AA sequence (PubMed:3597437).Curated		1
Sequence conflictⁱ	45	D → P AA sequence (PubMed:3597437).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_014351	268	T → M1 PublicationCorresponds to variant dbSNP:rs3138268EnsemblClinVar.		1
Natural variantⁱVAR_011975	273	E → Q. Corresponds to variant dbSNP:rs1803344Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_006172	71 – 179	Missing in isoform B. 1 PublicationAdd BLAST	109
Alternative sequenceⁱVSP_006175	72 – 75	LDKV → CLPS in isoform E. 1 Publication	4
Alternative sequenceⁱVSP_006173	73 – 219	Missing in isoform C. 1 PublicationAdd BLAST	147
Alternative sequenceⁱVSP_006176	76 – 359	Missing in isoform E. 1 PublicationAdd BLAST	284
Alternative sequenceⁱVSP_006174	109 – 295	Missing in isoform D. 1 PublicationAdd BLAST	187

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M14219 mRNA Translation: AAB00774.1 L01131 L01130 Genomic DNA Translation: AAA52301.1 Sequence problems. AH005442 Genomic DNA Translation: AAB60901.1 AF138300 mRNA Translation: AAD44713.1 AF138301 mRNA Translation: AAF61437.1 AF138302 mRNA Translation: AAD44714.1 AF138303 mRNA Translation: AAF61438.1 AF138304 mRNA Translation: AAD44715.1 BT019800 mRNA Translation: AAV38603.1 AF491944 Genomic DNA Translation: AAL92176.1 BC005322 mRNA Translation: AAH05322.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44951.1 [P07585-5] CCDS9039.1 [P07585-1] CCDS9040.1 [P07585-2] CCDS9041.1 [P07585-3] CCDS9042.1 [P07585-4]
PIRⁱ	A45016 NBHUC8 B28457
NCBI Reference Sequences More...RefSeqⁱ	NP_001911.1, NM_001920.4 [P07585-1] NP_598010.1, NM_133503.3 [P07585-1] NP_598011.1, NM_133504.3 [P07585-2] NP_598012.1, NM_133505.3 [P07585-3] NP_598013.1, NM_133506.3 [P07585-4] NP_598014.1, NM_133507.3 [P07585-5] XP_005268750.1, XM_005268693.1 [P07585-1] XP_006719333.1, XM_006719270.1 [P07585-1] XP_016874406.1, XM_017018917.1 [P07585-1]
UniGeneⁱ	Hs.156316 Hs.530910

Genome annotation databases

Ensemblⁱ	ENST00000052754; ENSP00000052754; ENSG00000011465 [P07585-1] ENST00000393155; ENSP00000376862; ENSG00000011465 [P07585-1] ENST00000420120; ENSP00000413723; ENSG00000011465 [P07585-2] ENST00000425043; ENSP00000401021; ENSG00000011465 [P07585-3] ENST00000441303; ENSP00000399815; ENSG00000011465 [P07585-4] ENST00000456569; ENSP00000398514; ENSG00000011465 [P07585-5] ENST00000547568; ENSP00000447674; ENSG00000011465 [P07585-3] ENST00000552962; ENSP00000447654; ENSG00000011465 [P07585-1]
GeneIDⁱ	1634
KEGGⁱ	hsa:1634
UCSC genome browser More...UCSCⁱ	uc001tbo.4 human [P07585-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P07585	Decorin		PANTR		359	UniRef100_P07585
Decorin		HUMAN		359
Decorin		PANPA		359
Decorin (Fragment)		RAT		96
Decorin		PANTR		359
+8
P07585-2	Decorin		PANTR		250	UniRef100_P07585-2
Decorin		PANPA		250
P07585-3	Decorin		HUMAN		212	UniRef100_A0A024RBG6
Decorin		PANTR		212
Decorin		PANPA		212
Decorin (Fragment)		HUMAN		177
Decorin (Fragment)		PANTR		177
P07585-4	Decorin		PANTR		172	UniRef100_P07585-4
Decorin		PANPA		172
P07585-5	Decorin		PANTR		75	UniRef100_P07585-5
Decorin		PANPA		75

Protein	Similar proteins		Species	Score	Length	Source
P07585	Decorin		PANTR		359	UniRef90_P07585
Decorin		CANLF		360
Decorin		HORSE		360
Decorin		PIG		360
Decorin		RABIT		360
+84
P07585-2	Decorin		PANTR		250	UniRef90_P07585-2
Decorin		PANPA		250
Decorin		FELCA		251
Decorin		PONAB		250
Decorin		NOMLE		250
+5
P07585-3	Decorin		NOMLE		212	UniRef90_G1R0T7
Decorin		FELCA		213
Decorin		HUMAN		212
Decorin		PANTR		212
Decorin		PANPA		212
+10
P07585-4	Decorin		PANTR		172	UniRef90_P07585-4
Decorin		PANPA		172
Decorin		PROCO		173
Decorin		FELCA		173
Decorin		SAIBB		172
+19
P07585-5	Decorin		PANTR		75	UniRef90_P07585-5
Decorin		PANPA		75
Decorin		GORGO		75

Protein	Similar proteins		Species	Score	Length	Source
P07585	Decorin		PANTR		359	UniRef50_P07585
Decorin		PIG		360
Decorin		RABIT		360
Decorin		HORSE		360
Decorin		CANLF		360
+635
P07585-2	Decorin		PANTR		250	UniRef50_P07585-2
Decorin		PANPA		250
Decorin		FELCA		251
Decorin		PONAB		250
Decorin		NOMLE		250
+28
P07585-3	Decorin		NOMLE		212	UniRef50_G1R0T7
Decorin		FELCA		213
Decorin		GORGO		212
Decorin		HUMAN		212
Decorin		PANTR		212
+35
P07585-4	Decorin		PANTR		172	UniRef50_P07585-4
Decorin		PANPA		172
Decorin		PROCO		173
Decorin		FELCA		173
Decorin		CERAT		172
+27
P07585-5	Decorin		PANTR		75	UniRef50_P07585-5
Decorin		PANPA		75
Decorin		GORGO		75
Decorin		SAIBB		75
Decorin		AOTNA		82
+9

Cross-referencesⁱ

Web resourcesⁱ

SeattleSNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M14219 mRNA Translation: AAB00774.1 L01131 L01130 Genomic DNA Translation: AAA52301.1 Sequence problems. AH005442 Genomic DNA Translation: AAB60901.1 AF138300 mRNA Translation: AAD44713.1 AF138301 mRNA Translation: AAF61437.1 AF138302 mRNA Translation: AAD44714.1 AF138303 mRNA Translation: AAF61438.1 AF138304 mRNA Translation: AAD44715.1 BT019800 mRNA Translation: AAV38603.1 AF491944 Genomic DNA Translation: AAL92176.1 BC005322 mRNA Translation: AAH05322.1
CCDSⁱ	CCDS44951.1 [P07585-5] CCDS9039.1 [P07585-1] CCDS9040.1 [P07585-2] CCDS9041.1 [P07585-3] CCDS9042.1 [P07585-4]
PIRⁱ	A45016 NBHUC8 B28457
RefSeqⁱ	NP_001911.1, NM_001920.4 [P07585-1] NP_598010.1, NM_133503.3 [P07585-1] NP_598011.1, NM_133504.3 [P07585-2] NP_598012.1, NM_133505.3 [P07585-3] NP_598013.1, NM_133506.3 [P07585-4] NP_598014.1, NM_133507.3 [P07585-5] XP_005268750.1, XM_005268693.1 [P07585-1] XP_006719333.1, XM_006719270.1 [P07585-1] XP_016874406.1, XM_017018917.1 [P07585-1]
UniGeneⁱ	Hs.156316 Hs.530910

3D structure databases

ProteinModelPortalⁱ	P07585
SMRⁱ	P07585
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108002, 20 interactors
IntActⁱ	P07585, 14 interactors
STRINGⁱ	9606.ENSP00000052754

Chemistry databases

DrugBankⁱ	DB03754 Tris

DrugBankⁱ

DB03754 Tris

PTM databases

GlyConnectⁱ	1169
iPTMnetⁱ	P07585
PhosphoSitePlusⁱ	P07585

Polymorphism and mutation databases

BioMutaⁱ	DCN
DMDMⁱ	129951

Proteomic databases

EPDⁱ	P07585
PaxDbⁱ	P07585
PeptideAtlasⁱ	P07585
PRIDEⁱ	P07585
ProteomicsDBⁱ	52014 52015 [P07585-2] 52016 [P07585-3] 52017 [P07585-4] 52018 [P07585-5]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1634
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000052754; ENSP00000052754; ENSG00000011465 [P07585-1] ENST00000393155; ENSP00000376862; ENSG00000011465 [P07585-1] ENST00000420120; ENSP00000413723; ENSG00000011465 [P07585-2] ENST00000425043; ENSP00000401021; ENSG00000011465 [P07585-3] ENST00000441303; ENSP00000399815; ENSG00000011465 [P07585-4] ENST00000456569; ENSP00000398514; ENSG00000011465 [P07585-5] ENST00000547568; ENSP00000447674; ENSG00000011465 [P07585-3] ENST00000552962; ENSP00000447654; ENSG00000011465 [P07585-1]
GeneIDⁱ	1634
KEGGⁱ	hsa:1634
UCSCⁱ	uc001tbo.4 human [P07585-1]

Organism-specific databases

CTDⁱ	1634
DisGeNETⁱ	1634
EuPathDBⁱ	HostDB:ENSG00000011465.16
GeneCardsⁱ	DCN
GeneReviewsⁱ	DCN
HGNCⁱ	HGNC:2705 DCN
HPAⁱ	CAB017118 CAB068930 HPA003315 HPA064736
MalaCardsⁱ	DCN
MIMⁱ	125255 gene 610048 phenotype
neXtProtⁱ	NX_P07585
OpenTargetsⁱ	ENSG00000011465
Orphanetⁱ	101068 Congenital stromal corneal dystrophy
PharmGKBⁱ	PA27177
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0619 Eukaryota COG4886 LUCA
GeneTreeⁱ	ENSGT00760000118969
HOGENOMⁱ	HOG000261690
HOVERGENⁱ	HBG016052
InParanoidⁱ	P07585
KOⁱ	K04660
OMAⁱ	PLGPVCP
OrthoDBⁱ	EOG091G044B
PhylomeDBⁱ	P07585
TreeFamⁱ	TF334562

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1474228 Degradation of the extracellular matrix R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis R-HSA-2022870 Chondroitin sulfate biosynthesis R-HSA-2022923 Dermatan sulfate biosynthesis R-HSA-2024101 CS/DS degradation R-HSA-3000178 ECM proteoglycans R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type R-HSA-3560801 Defective B3GAT3 causes JDSSDHD R-HSA-3595172 Defective CHST3 causes SEDCJD R-HSA-3595174 Defective CHST14 causes EDS, musculocontractural type R-HSA-3595177 Defective CHSY1 causes TPBS R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1
SIGNORⁱ	P07585

Reactomeⁱ

R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022870 Chondroitin sulfate biosynthesis
R-HSA-2022923 Dermatan sulfate biosynthesis
R-HSA-2024101 CS/DS degradation
R-HSA-3000178 ECM proteoglycans
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD
R-HSA-3595172 Defective CHST3 causes SEDCJD
R-HSA-3595174 Defective CHST14 causes EDS, musculocontractural type
R-HSA-3595177 Defective CHSY1 causes TPBS
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1

SIGNORⁱ

P07585

Miscellaneous databases

ChiTaRSⁱ	DCN human
GeneWikiⁱ	Decorin
GenomeRNAiⁱ	1634
PMAP-CutDBⁱ	P07585
Protein Ontology More...PROⁱ	PR:P07585
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000011465 Expressed in 228 organ(s), highest expression level in decidua
CleanExⁱ	HS_DCN
ExpressionAtlasⁱ	P07585 baseline and differential
Genevisibleⁱ	P07585 HS

Family and domain databases

Gene3Dⁱ	3.80.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR028549 Decorin IPR001611 Leu-rich_rpt IPR003591 Leu-rich_rpt_typical-subtyp IPR032675 LRR_dom_sf IPR000372 LRRNT IPR016352 SLRP_I_decor/aspor/byglycan
PANTHERⁱ	PTHR44053:SF2 PTHR44053:SF2, 1 hit
Pfamⁱ	View protein in Pfam PF13855 LRR_8, 3 hits PF01462 LRRNT, 1 hit
PIRSFⁱ	PIRSF002490 SLRP_I, 1 hit
SMARTⁱ	View protein in SMART SM00369 LRR_TYP, 6 hits SM00013 LRRNT, 1 hit
PROSITEⁱ	View protein in PROSITE PS51450 LRR, 8 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PGS2_HUMAN
Accessionⁱ	P07585Primary (citable) accession number: P07585 Secondary accession number(s): Q9P0Z0 , Q9P0Z1, Q9Y5N8, Q9Y5N9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
	Last sequence update:	April 1, 1988
	Last modified:	November 7, 2018
	This is version 208 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

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UniProtKB - P07585 (PGS2_HUMAN)

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Keywords - Diseaseⁱ

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Keywords - Technical termⁱ