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Protein

Decorin

Gene

DCN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May affect the rate of fibrils formation.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022870 Chondroitin sulfate biosynthesis
R-HSA-2022923 Dermatan sulfate biosynthesis
R-HSA-2024101 CS/DS degradation
R-HSA-3000178 ECM proteoglycans
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD
R-HSA-3595172 Defective CHST3 causes SEDCJD
R-HSA-3595174 Defective CHST14 causes EDS, musculocontractural type
R-HSA-3595177 Defective CHSY1 causes TPBS
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1
SIGNORiP07585

Names & Taxonomyi

Protein namesi
Recommended name:
Decorin
Alternative name(s):
Bone proteoglycan II
PG-S2
PG40
Gene namesi
Name:DCN
Synonyms:SLRR1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000011465.16
HGNCiHGNC:2705 DCN
MIMi125255 gene
neXtProtiNX_P07585

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Involvement in diseasei

Corneal dystrophy, congenital stromal (CSCD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA corneal dystrophy characterized by congenital corneal opacification consisting of a large number of flakes and spots throughout all layers of the stroma. It results in progressive, painless visual loss. Corneal erosions and photophobia are absent.
See also OMIM:610048

Keywords - Diseasei

Corneal dystrophy

Organism-specific databases

DisGeNETi1634
GeneReviewsiDCN
MalaCardsiDCN
MIMi610048 phenotype
OpenTargetsiENSG00000011465
Orphaneti101068 Congenital stromal corneal dystrophy
PharmGKBiPA27177

Chemistry databases

DrugBankiDB03754 Tris

Polymorphism and mutation databases

BioMutaiDCN
DMDMi129951

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16By similarityAdd BLAST16
PropeptideiPRO_000003270917 – 302 PublicationsAdd BLAST14
ChainiPRO_000003271031 – 359DecorinAdd BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34O-linked (Xyl...) (glycosaminoglycan) serine1 Publication1
Disulfide bondi54 ↔ 60By similarity
Disulfide bondi58 ↔ 67By similarity
Glycosylationi211N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi262N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi303N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi313 ↔ 346By similarity

Post-translational modificationi

The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

EPDiP07585
PaxDbiP07585
PeptideAtlasiP07585
PRIDEiP07585
ProteomicsDBi52014
52015 [P07585-2]
52016 [P07585-3]
52017 [P07585-4]
52018 [P07585-5]

PTM databases

GlyConnecti1169
iPTMnetiP07585
PhosphoSitePlusiP07585

Miscellaneous databases

PMAP-CutDBiP07585

Expressioni

Gene expression databases

BgeeiENSG00000011465 Expressed in 228 organ(s), highest expression level in decidua
CleanExiHS_DCN
ExpressionAtlasiP07585 baseline and differential
GenevisibleiP07585 HS

Organism-specific databases

HPAiCAB017118
CAB068930
HPA003315
HPA064736

Interactioni

Subunit structurei

Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108002, 20 interactors
IntActiP07585, 14 interactors
STRINGi9606.ENSP00000052754

Structurei

3D structure databases

ProteinModelPortaliP07585
SMRiP07585
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati73 – 93LRR 1Add BLAST21
Repeati94 – 117LRR 2Add BLAST24
Repeati118 – 141LRR 3Add BLAST24
Repeati142 – 162LRR 4Add BLAST21
Repeati163 – 186LRR 5Add BLAST24
Repeati187 – 212LRR 6Add BLAST26
Repeati213 – 233LRR 7Add BLAST21
Repeati234 – 257LRR 8Add BLAST24
Repeati258 – 281LRR 9Add BLAST24
Repeati282 – 304LRR 10Add BLAST23
Repeati305 – 334LRR 11Add BLAST30
Repeati335 – 359LRR 12Add BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi54 – 67Cys-richAdd BLAST14

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118969
HOGENOMiHOG000261690
HOVERGENiHBG016052
InParanoidiP07585
KOiK04660
OMAiPLGPVCP
OrthoDBiEOG091G044B
PhylomeDBiP07585
TreeFamiTF334562

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR028549 Decorin
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR016352 SLRP_I_decor/aspor/byglycan
PANTHERiPTHR44053:SF2 PTHR44053:SF2, 1 hit
PfamiView protein in Pfam
PF13855 LRR_8, 3 hits
PF01462 LRRNT, 1 hit
PIRSFiPIRSF002490 SLRP_I, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 6 hits
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 8 hits

Sequences (5+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: P07585-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKATIILLLL AQVSWAGPFQ QRGLFDFMLE DEASGIGPEV PDDRDFEPSL
60 70 80 90 100
GPVCPFRCQC HLRVVQCSDL GLDKVPKDLP PDTTLLDLQN NKITEIKDGD
110 120 130 140 150
FKNLKNLHAL ILVNNKISKV SPGAFTPLVK LERLYLSKNQ LKELPEKMPK
160 170 180 190 200
TLQELRAHEN EITKVRKVTF NGLNQMIVIE LGTNPLKSSG IENGAFQGMK
210 220 230 240 250
KLSYIRIADT NITSIPQGLP PSLTELHLDG NKISRVDAAS LKGLNNLAKL
260 270 280 290 300
GLSFNSISAV DNGSLANTPH LRELHLDNNK LTRVPGGLAE HKYIQVVYLH
310 320 330 340 350
NNNISVVGSS DFCPPGHNTK KASYSGVSLF SNPVQYWEIQ PSTFRCVYVR

SAIQLGNYK
Length:359
Mass (Da):39,747
Last modified:April 1, 1988 - v1
Checksum:iFF511E871A1A52DD
GO
Isoform B (identifier: P07585-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-179: Missing.

Show »
Length:250
Mass (Da):27,353
Checksum:i5AA599BE479F68D9
GO
Isoform C (identifier: P07585-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-219: Missing.

Show »
Length:212
Mass (Da):23,278
Checksum:i0BCF8BC8CBA92CA9
GO
Isoform D (identifier: P07585-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-295: Missing.

Show »
Length:172
Mass (Da):19,243
Checksum:i7EA011E351163971
GO
Isoform E (identifier: P07585-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-75: LDKV → CLPS
     76-359: Missing.

Show »
Length:75
Mass (Da):8,266
Checksum:i781856DC9E377479
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VWU0F8VWU0_HUMAN
Decorin
DCN
179Annotation score:
F8VUF6F8VUF6_HUMAN
Decorin
DCN
178Annotation score:
F8VXZ8F8VXZ8_HUMAN
Decorin
DCN
174Annotation score:
F8VNV6F8VNV6_HUMAN
Decorin
DCN
177Annotation score:
F8VX58F8VX58_HUMAN
Decorin
DCN
119Annotation score:
F8VNW0F8VNW0_HUMAN
Decorin
DCN
88Annotation score:
F8VSI3F8VSI3_HUMAN
Decorin
DCN
100Annotation score:
F8VU58F8VU58_HUMAN
Decorin
DCN
98Annotation score:
H0YIH3H0YIH3_HUMAN
Decorin
DCN
95Annotation score:
H0YI87H0YI87_HUMAN
Decorin
DCN
52Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37G → A AA sequence (PubMed:3597437).Curated1
Sequence conflicti45D → P AA sequence (PubMed:3597437).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014351268T → M1 PublicationCorresponds to variant dbSNP:rs3138268EnsemblClinVar.1
Natural variantiVAR_011975273E → Q. Corresponds to variant dbSNP:rs1803344Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00617271 – 179Missing in isoform B. 1 PublicationAdd BLAST109
Alternative sequenceiVSP_00617572 – 75LDKV → CLPS in isoform E. 1 Publication4
Alternative sequenceiVSP_00617373 – 219Missing in isoform C. 1 PublicationAdd BLAST147
Alternative sequenceiVSP_00617676 – 359Missing in isoform E. 1 PublicationAdd BLAST284
Alternative sequenceiVSP_006174109 – 295Missing in isoform D. 1 PublicationAdd BLAST187

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14219 mRNA Translation: AAB00774.1
L01131
, L01125, L01126, L01127, L01129, L01130 Genomic DNA Translation: AAA52301.1 Sequence problems.
AH005442 Genomic DNA Translation: AAB60901.1
AF138300 mRNA Translation: AAD44713.1
AF138301 mRNA Translation: AAF61437.1
AF138302 mRNA Translation: AAD44714.1
AF138303 mRNA Translation: AAF61438.1
AF138304 mRNA Translation: AAD44715.1
BT019800 mRNA Translation: AAV38603.1
AF491944 Genomic DNA Translation: AAL92176.1
BC005322 mRNA Translation: AAH05322.1
CCDSiCCDS44951.1 [P07585-5]
CCDS9039.1 [P07585-1]
CCDS9040.1 [P07585-2]
CCDS9041.1 [P07585-3]
CCDS9042.1 [P07585-4]
PIRiA45016 NBHUC8
B28457
RefSeqiNP_001911.1, NM_001920.4 [P07585-1]
NP_598010.1, NM_133503.3 [P07585-1]
NP_598011.1, NM_133504.3 [P07585-2]
NP_598012.1, NM_133505.3 [P07585-3]
NP_598013.1, NM_133506.3 [P07585-4]
NP_598014.1, NM_133507.3 [P07585-5]
XP_005268750.1, XM_005268693.1 [P07585-1]
XP_006719333.1, XM_006719270.1 [P07585-1]
XP_016874406.1, XM_017018917.1 [P07585-1]
UniGeneiHs.156316
Hs.530910

Genome annotation databases

EnsembliENST00000052754; ENSP00000052754; ENSG00000011465 [P07585-1]
ENST00000393155; ENSP00000376862; ENSG00000011465 [P07585-1]
ENST00000420120; ENSP00000413723; ENSG00000011465 [P07585-2]
ENST00000425043; ENSP00000401021; ENSG00000011465 [P07585-3]
ENST00000441303; ENSP00000399815; ENSG00000011465 [P07585-4]
ENST00000456569; ENSP00000398514; ENSG00000011465 [P07585-5]
ENST00000547568; ENSP00000447674; ENSG00000011465 [P07585-3]
ENST00000552962; ENSP00000447654; ENSG00000011465 [P07585-1]
GeneIDi1634
KEGGihsa:1634
UCSCiuc001tbo.4 human [P07585-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14219 mRNA Translation: AAB00774.1
L01131
, L01125, L01126, L01127, L01129, L01130 Genomic DNA Translation: AAA52301.1 Sequence problems.
AH005442 Genomic DNA Translation: AAB60901.1
AF138300 mRNA Translation: AAD44713.1
AF138301 mRNA Translation: AAF61437.1
AF138302 mRNA Translation: AAD44714.1
AF138303 mRNA Translation: AAF61438.1
AF138304 mRNA Translation: AAD44715.1
BT019800 mRNA Translation: AAV38603.1
AF491944 Genomic DNA Translation: AAL92176.1
BC005322 mRNA Translation: AAH05322.1
CCDSiCCDS44951.1 [P07585-5]
CCDS9039.1 [P07585-1]
CCDS9040.1 [P07585-2]
CCDS9041.1 [P07585-3]
CCDS9042.1 [P07585-4]
PIRiA45016 NBHUC8
B28457
RefSeqiNP_001911.1, NM_001920.4 [P07585-1]
NP_598010.1, NM_133503.3 [P07585-1]
NP_598011.1, NM_133504.3 [P07585-2]
NP_598012.1, NM_133505.3 [P07585-3]
NP_598013.1, NM_133506.3 [P07585-4]
NP_598014.1, NM_133507.3 [P07585-5]
XP_005268750.1, XM_005268693.1 [P07585-1]
XP_006719333.1, XM_006719270.1 [P07585-1]
XP_016874406.1, XM_017018917.1 [P07585-1]
UniGeneiHs.156316
Hs.530910

3D structure databases

ProteinModelPortaliP07585
SMRiP07585
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108002, 20 interactors
IntActiP07585, 14 interactors
STRINGi9606.ENSP00000052754

Chemistry databases

DrugBankiDB03754 Tris

PTM databases

GlyConnecti1169
iPTMnetiP07585
PhosphoSitePlusiP07585

Polymorphism and mutation databases

BioMutaiDCN
DMDMi129951

Proteomic databases

EPDiP07585
PaxDbiP07585
PeptideAtlasiP07585
PRIDEiP07585
ProteomicsDBi52014
52015 [P07585-2]
52016 [P07585-3]
52017 [P07585-4]
52018 [P07585-5]

Protocols and materials databases

DNASUi1634
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000052754; ENSP00000052754; ENSG00000011465 [P07585-1]
ENST00000393155; ENSP00000376862; ENSG00000011465 [P07585-1]
ENST00000420120; ENSP00000413723; ENSG00000011465 [P07585-2]
ENST00000425043; ENSP00000401021; ENSG00000011465 [P07585-3]
ENST00000441303; ENSP00000399815; ENSG00000011465 [P07585-4]
ENST00000456569; ENSP00000398514; ENSG00000011465 [P07585-5]
ENST00000547568; ENSP00000447674; ENSG00000011465 [P07585-3]
ENST00000552962; ENSP00000447654; ENSG00000011465 [P07585-1]
GeneIDi1634
KEGGihsa:1634
UCSCiuc001tbo.4 human [P07585-1]

Organism-specific databases

CTDi1634
DisGeNETi1634
EuPathDBiHostDB:ENSG00000011465.16
GeneCardsiDCN
GeneReviewsiDCN
HGNCiHGNC:2705 DCN
HPAiCAB017118
CAB068930
HPA003315
HPA064736
MalaCardsiDCN
MIMi125255 gene
610048 phenotype
neXtProtiNX_P07585
OpenTargetsiENSG00000011465
Orphaneti101068 Congenital stromal corneal dystrophy
PharmGKBiPA27177
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118969
HOGENOMiHOG000261690
HOVERGENiHBG016052
InParanoidiP07585
KOiK04660
OMAiPLGPVCP
OrthoDBiEOG091G044B
PhylomeDBiP07585
TreeFamiTF334562

Enzyme and pathway databases

ReactomeiR-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022870 Chondroitin sulfate biosynthesis
R-HSA-2022923 Dermatan sulfate biosynthesis
R-HSA-2024101 CS/DS degradation
R-HSA-3000178 ECM proteoglycans
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD
R-HSA-3595172 Defective CHST3 causes SEDCJD
R-HSA-3595174 Defective CHST14 causes EDS, musculocontractural type
R-HSA-3595177 Defective CHSY1 causes TPBS
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1
SIGNORiP07585

Miscellaneous databases

ChiTaRSiDCN human
GeneWikiiDecorin
GenomeRNAii1634
PMAP-CutDBiP07585
PROiPR:P07585
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000011465 Expressed in 228 organ(s), highest expression level in decidua
CleanExiHS_DCN
ExpressionAtlasiP07585 baseline and differential
GenevisibleiP07585 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR028549 Decorin
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR016352 SLRP_I_decor/aspor/byglycan
PANTHERiPTHR44053:SF2 PTHR44053:SF2, 1 hit
PfamiView protein in Pfam
PF13855 LRR_8, 3 hits
PF01462 LRRNT, 1 hit
PIRSFiPIRSF002490 SLRP_I, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 6 hits
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 8 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPGS2_HUMAN
AccessioniPrimary (citable) accession number: P07585
Secondary accession number(s): Q9P0Z0
, Q9P0Z1, Q9Y5N8, Q9Y5N9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: November 7, 2018
This is version 208 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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