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UniProtKB - P07585 (PGS2_HUMAN)

Entry version 218 (22 Apr 2020)
Sequence version 1 (01 Apr 1988)
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Protein

Decorin

Gene

DCN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May affect the rate of fibrils formation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022870 Chondroitin sulfate biosynthesis
R-HSA-2022923 Dermatan sulfate biosynthesis
R-HSA-2024101 CS/DS degradation
R-HSA-3000178 ECM proteoglycans
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD
R-HSA-3595172 Defective CHST3 causes SEDCJD
R-HSA-3595174 Defective CHST14 causes EDS, musculocontractural type
R-HSA-3595177 Defective CHSY1 causes TPBS
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1

SIGNOR Signaling Network Open Resource

More...SIGNORi		P07585

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Decorin
Alternative name(s):
Bone proteoglycan II
PG-S2
PG40
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DCN
Synonyms:SLRR1B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2705 DCN

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		125255 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P07585

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Corneal dystrophy, congenital stromal (CSCD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA corneal dystrophy characterized by congenital corneal opacification consisting of a large number of flakes and spots throughout all layers of the stroma. It results in progressive, painless visual loss. Corneal erosions and photophobia are absent.
Related information in OMIM

Keywords - Diseasei

Corneal dystrophy

Organism-specific databases

DisGeNET

More...DisGeNETi		1634

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		DCN

MalaCards human disease database

More...MalaCardsi		DCN
MIMi610048 phenotype

Open Targets

More...OpenTargetsi		ENSG00000011465

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		101068 Congenital stromal corneal dystrophy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27177

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P07585 Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB03754 Tromethamine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DCN

Domain mapping of disease mutations (DMDM)

More...DMDMi		129951

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16By similarityAdd BLAST16
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000003270917 – 302 PublicationsAdd BLAST14
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003271031 – 359DecorinAdd BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi34O-linked (Xyl...) (glycosaminoglycan) serine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi54 ↔ 60By similarity
Disulfide bondi58 ↔ 67By similarity
Glycosylationi211N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi262N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi303N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi313 ↔ 346By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P07585

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P07585

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P07585

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P07585

PeptideAtlas

More...PeptideAtlasi		P07585

PRoteomics IDEntifications database

More...PRIDEi		P07585

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52014 [P07585-1]
52015 [P07585-2]
52016 [P07585-3]
52017 [P07585-4]
52018 [P07585-5]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1169

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P07585

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P07585

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000011465 Expressed in decidua and 227 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P07585 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P07585 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000011465 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to type I and type II collagen, fibronectin and TGF-beta.

Forms a ternary complex with MFAP2 and ELN.

Interacts with DPT (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		108002, 20 interactors

Protein interaction database and analysis system

More...IntActi		P07585, 16 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000052754

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P07585 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P07585

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati73 – 93LRR 1Add BLAST21
Repeati94 – 117LRR 2Add BLAST24
Repeati118 – 141LRR 3Add BLAST24
Repeati142 – 162LRR 4Add BLAST21
Repeati163 – 186LRR 5Add BLAST24
Repeati187 – 212LRR 6Add BLAST26
Repeati213 – 233LRR 7Add BLAST21
Repeati234 – 257LRR 8Add BLAST24
Repeati258 – 281LRR 9Add BLAST24
Repeati282 – 304LRR 10Add BLAST23
Repeati305 – 334LRR 11Add BLAST30
Repeati335 – 359LRR 12Add BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi54 – 67Cys-richAdd BLAST14

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0619 Eukaryota
COG4886 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158382

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000288_186_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P07585

KEGG Orthology (KO)

More...KOi		K04660

Identification of Orthologs from Complete Genome Data

More...OMAi		GLADHKY

Database for complete collections of gene phylogenies

More...PhylomeDBi		P07585

TreeFam database of animal gene trees

More...TreeFami		TF334562

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028549 Decorin
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR016352 SLRP_I_decor/aspor/byglycan

The PANTHER Classification System

More...PANTHERi		PTHR45712:SF14 PTHR45712:SF14, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13855 LRR_8, 3 hits
PF01462 LRRNT, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF002490 SLRP_I, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00369 LRR_TYP, 6 hits
SM00013 LRRNT, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51450 LRR, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: P07585-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKATIILLLL AQVSWAGPFQ QRGLFDFMLE DEASGIGPEV PDDRDFEPSL 
        60         70         80         90        100
GPVCPFRCQC HLRVVQCSDL GLDKVPKDLP PDTTLLDLQN NKITEIKDGD 
       110        120        130        140        150
FKNLKNLHAL ILVNNKISKV SPGAFTPLVK LERLYLSKNQ LKELPEKMPK 
       160        170        180        190        200
TLQELRAHEN EITKVRKVTF NGLNQMIVIE LGTNPLKSSG IENGAFQGMK 
       210        220        230        240        250
KLSYIRIADT NITSIPQGLP PSLTELHLDG NKISRVDAAS LKGLNNLAKL 
       260        270        280        290        300
GLSFNSISAV DNGSLANTPH LRELHLDNNK LTRVPGGLAE HKYIQVVYLH 
       310        320        330        340        350
NNNISVVGSS DFCPPGHNTK KASYSGVSLF SNPVQYWEIQ PSTFRCVYVR 

SAIQLGNYK
Length:359
Mass (Da):39,747
Last modified:April 1, 1988 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFF511E871A1A52DD
GO
Isoform B (identifier: P07585-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-179: Missing.

Show »
Length:250
Mass (Da):27,353
Checksum:i5AA599BE479F68D9
GO
Isoform C (identifier: P07585-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-219: Missing.

Show »
Length:212
Mass (Da):23,278
Checksum:i0BCF8BC8CBA92CA9
GO
Isoform D (identifier: P07585-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-295: Missing.

Show »
Length:172
Mass (Da):19,243
Checksum:i7EA011E351163971
GO
Isoform E (identifier: P07585-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-75: LDKV → CLPS
     76-359: Missing.

Show »
Length:75
Mass (Da):8,266
Checksum:i781856DC9E377479
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VNV6F8VNV6_HUMAN
Decorin
DCN
177Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VUF6F8VUF6_HUMAN
Decorin
DCN
178Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VWU0F8VWU0_HUMAN
Decorin
DCN
179Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VX58F8VX58_HUMAN
Decorin
DCN
119Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VXZ8F8VXZ8_HUMAN
Decorin
DCN
174Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VNW0F8VNW0_HUMAN
Decorin
DCN
88Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VSI3F8VSI3_HUMAN
Decorin
DCN
100Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VU58F8VU58_HUMAN
Decorin
DCN
98Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIH3H0YIH3_HUMAN
Decorin
DCN
95Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YI87H0YI87_HUMAN
Decorin
DCN
52Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti37G → A AA sequence (PubMed:3597437).Curated1
Sequence conflicti45D → P AA sequence (PubMed:3597437).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_014351268T → M1 PublicationCorresponds to variant dbSNP:rs3138268EnsemblClinVar.1
Natural variantiVAR_011975273E → Q. Corresponds to variant dbSNP:rs1803344Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00617271 – 179Missing in isoform B. 1 PublicationAdd BLAST109
Alternative sequenceiVSP_00617572 – 75LDKV → CLPS in isoform E. 1 Publication4
Alternative sequenceiVSP_00617373 – 219Missing in isoform C. 1 PublicationAdd BLAST147
Alternative sequenceiVSP_00617676 – 359Missing in isoform E. 1 PublicationAdd BLAST284
Alternative sequenceiVSP_006174109 – 295Missing in isoform D. 1 PublicationAdd BLAST187

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M14219 mRNA Translation: AAB00774.1
L01131 L01130 Genomic DNA Translation: AAA52301.1 Sequence problems.
AH005442 Genomic DNA Translation: AAB60901.1
AF138300 mRNA Translation: AAD44713.1
AF138301 mRNA Translation: AAF61437.1
AF138302 mRNA Translation: AAD44714.1
AF138303 mRNA Translation: AAF61438.1
AF138304 mRNA Translation: AAD44715.1
BT019800 mRNA Translation: AAV38603.1
AF491944 Genomic DNA Translation: AAL92176.1
BC005322 mRNA Translation: AAH05322.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44951.1 [P07585-5]
CCDS9039.1 [P07585-1]
CCDS9040.1 [P07585-2]
CCDS9041.1 [P07585-3]
CCDS9042.1 [P07585-4]

Protein sequence database of the Protein Information Resource

More...PIRi		A45016 NBHUC8
B28457

NCBI Reference Sequences

More...RefSeqi		NP_001911.1, NM_001920.4 [P07585-1]
NP_598010.1, NM_133503.3 [P07585-1]
NP_598011.1, NM_133504.3 [P07585-2]
NP_598012.1, NM_133505.3 [P07585-3]
NP_598013.1, NM_133506.3 [P07585-4]
NP_598014.1, NM_133507.3 [P07585-5]
XP_005268750.1, XM_005268693.1
XP_006719333.1, XM_006719270.1
XP_016874406.1, XM_017018917.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000052754; ENSP00000052754; ENSG00000011465 [P07585-1]
ENST00000393155; ENSP00000376862; ENSG00000011465 [P07585-1]
ENST00000420120; ENSP00000413723; ENSG00000011465 [P07585-2]
ENST00000425043; ENSP00000401021; ENSG00000011465 [P07585-3]
ENST00000441303; ENSP00000399815; ENSG00000011465 [P07585-4]
ENST00000456569; ENSP00000398514; ENSG00000011465 [P07585-5]
ENST00000547568; ENSP00000447674; ENSG00000011465 [P07585-3]
ENST00000552962; ENSP00000447654; ENSG00000011465 [P07585-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1634

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1634

UCSC genome browser

More...UCSCi		uc001tbo.4 human [P07585-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14219 mRNA Translation: AAB00774.1
L01131 L01130 Genomic DNA Translation: AAA52301.1 Sequence problems.
AH005442 Genomic DNA Translation: AAB60901.1
AF138300 mRNA Translation: AAD44713.1
AF138301 mRNA Translation: AAF61437.1
AF138302 mRNA Translation: AAD44714.1
AF138303 mRNA Translation: AAF61438.1
AF138304 mRNA Translation: AAD44715.1
BT019800 mRNA Translation: AAV38603.1
AF491944 Genomic DNA Translation: AAL92176.1
BC005322 mRNA Translation: AAH05322.1
CCDSiCCDS44951.1 [P07585-5]
CCDS9039.1 [P07585-1]
CCDS9040.1 [P07585-2]
CCDS9041.1 [P07585-3]
CCDS9042.1 [P07585-4]
PIRiA45016 NBHUC8
B28457
RefSeqiNP_001911.1, NM_001920.4 [P07585-1]
NP_598010.1, NM_133503.3 [P07585-1]
NP_598011.1, NM_133504.3 [P07585-2]
NP_598012.1, NM_133505.3 [P07585-3]
NP_598013.1, NM_133506.3 [P07585-4]
NP_598014.1, NM_133507.3 [P07585-5]
XP_005268750.1, XM_005268693.1
XP_006719333.1, XM_006719270.1
XP_016874406.1, XM_017018917.1

3D structure databases

SMRiP07585
ModBaseiSearch...

Protein-protein interaction databases

BioGridi108002, 20 interactors
IntActiP07585, 16 interactors
STRINGi9606.ENSP00000052754

Chemistry databases

DrugBankiDB03754 Tromethamine

PTM databases

GlyConnecti1169
iPTMnetiP07585
PhosphoSitePlusiP07585

Polymorphism and mutation databases

BioMutaiDCN
DMDMi129951

Proteomic databases

EPDiP07585
jPOSTiP07585
MassIVEiP07585
PaxDbiP07585
PeptideAtlasiP07585
PRIDEiP07585
ProteomicsDBi52014 [P07585-1]
52015 [P07585-2]
52016 [P07585-3]
52017 [P07585-4]
52018 [P07585-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		754 586 antibodies

The DNASU plasmid repository

More...DNASUi		1634

Genome annotation databases

EnsembliENST00000052754; ENSP00000052754; ENSG00000011465 [P07585-1]
ENST00000393155; ENSP00000376862; ENSG00000011465 [P07585-1]
ENST00000420120; ENSP00000413723; ENSG00000011465 [P07585-2]
ENST00000425043; ENSP00000401021; ENSG00000011465 [P07585-3]
ENST00000441303; ENSP00000399815; ENSG00000011465 [P07585-4]
ENST00000456569; ENSP00000398514; ENSG00000011465 [P07585-5]
ENST00000547568; ENSP00000447674; ENSG00000011465 [P07585-3]
ENST00000552962; ENSP00000447654; ENSG00000011465 [P07585-1]
GeneIDi1634
KEGGihsa:1634
UCSCiuc001tbo.4 human [P07585-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1634
DisGeNETi1634

GeneCards: human genes, protein and diseases

More...GeneCardsi		DCN
GeneReviewsiDCN
HGNCiHGNC:2705 DCN
HPAiENSG00000011465 Low tissue specificity
MalaCardsiDCN
MIMi125255 gene
610048 phenotype
neXtProtiNX_P07585
OpenTargetsiENSG00000011465
Orphaneti101068 Congenital stromal corneal dystrophy
PharmGKBiPA27177

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000158382
HOGENOMiCLU_000288_186_0_1
InParanoidiP07585
KOiK04660
OMAiGLADHKY
PhylomeDBiP07585
TreeFamiTF334562

Enzyme and pathway databases

ReactomeiR-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022870 Chondroitin sulfate biosynthesis
R-HSA-2022923 Dermatan sulfate biosynthesis
R-HSA-2024101 CS/DS degradation
R-HSA-3000178 ECM proteoglycans
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD
R-HSA-3595172 Defective CHST3 causes SEDCJD
R-HSA-3595174 Defective CHST14 causes EDS, musculocontractural type
R-HSA-3595177 Defective CHSY1 causes TPBS
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1
SIGNORiP07585

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DCN human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Decorin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1634
PharosiP07585 Tbio

Protein Ontology

More...PROi		PR:P07585
RNActiP07585 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000011465 Expressed in decidua and 227 other tissues
ExpressionAtlasiP07585 baseline and differential
GenevisibleiP07585 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR028549 Decorin
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR016352 SLRP_I_decor/aspor/byglycan
PANTHERiPTHR45712:SF14 PTHR45712:SF14, 1 hit
PfamiView protein in Pfam
PF13855 LRR_8, 3 hits
PF01462 LRRNT, 1 hit
PIRSFiPIRSF002490 SLRP_I, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 6 hits
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 8 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPGS2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07585
Secondary accession number(s): Q9P0Z0
, Q9P0Z1, Q9Y5N8, Q9Y5N9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: April 22, 2020
This is version 218 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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