UniProtKB - P07585 (PGS2_HUMAN)
Decorin
DCN
Functioni
May affect the rate of fibrils formation.
GO - Molecular functioni
- collagen binding Source: InterPro
- extracellular matrix binding Source: Ensembl
- extracellular matrix structural constituent conferring compression resistance Source: BHF-UCL
- glycosaminoglycan binding Source: Ensembl
- RNA binding Source: UniProtKB
GO - Biological processi
- animal organ morphogenesis Source: ProtInc
- negative regulation of angiogenesis Source: MGI
- negative regulation of endothelial cell migration Source: MGI
- negative regulation of vascular endothelial growth factor signaling pathway Source: MGI
- peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan Source: Ensembl
- positive regulation of autophagy Source: CACAO
- positive regulation of macroautophagy Source: MGI
- positive regulation of mitochondrial depolarization Source: MGI
- positive regulation of mitochondrial fission Source: MGI
- positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
Enzyme and pathway databases
PathwayCommonsi | P07585 |
Reactomei | R-HSA-1474228, Degradation of the extracellular matrix R-HSA-1971475, A tetrasaccharide linker sequence is required for GAG synthesis R-HSA-2022870, Chondroitin sulfate biosynthesis R-HSA-2022923, Dermatan sulfate biosynthesis R-HSA-2024101, CS/DS degradation R-HSA-3000178, ECM proteoglycans R-HSA-3560783, Defective B4GALT7 causes EDS, progeroid type R-HSA-3560801, Defective B3GAT3 causes JDSSDHD R-HSA-3595172, Defective CHST3 causes SEDCJD R-HSA-3595174, Defective CHST14 causes EDS, musculocontractural type R-HSA-3595177, Defective CHSY1 causes TPBS R-HSA-4420332, Defective B3GALT6 causes EDSP2 and SEMDJL1 |
SignaLinki | P07585 |
SIGNORi | P07585 |
Names & Taxonomyi
Protein namesi | Recommended name: DecorinAlternative name(s): Bone proteoglycan II PG-S2 PG40 |
Gene namesi | Name:DCN Synonyms:SLRR1B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2705, DCN |
MIMi | 125255, gene |
neXtProti | NX_P07585 |
VEuPathDBi | HostDB:ENSG00000011465 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: BHF-UCL
- extracellular space Source: BHF-UCL
Golgi apparatus
- Golgi lumen Source: Reactome
Lysosome
- lysosomal lumen Source: Reactome
Other locations
- collagen-containing extracellular matrix Source: BHF-UCL
Keywords - Cellular componenti
Extracellular matrix, SecretedPathology & Biotechi
Involvement in diseasei
Corneal dystrophy, congenital stromal (CSCD)1 Publication
Keywords - Diseasei
Corneal dystrophyOrganism-specific databases
DisGeNETi | 1634 |
GeneReviewsi | DCN |
MalaCardsi | DCN |
MIMi | 610048, phenotype |
OpenTargetsi | ENSG00000011465 |
Orphaneti | 101068, Congenital stromal corneal dystrophy |
PharmGKBi | PA27177 |
Miscellaneous databases
Pharosi | P07585, Tbio |
Genetic variation databases
BioMutai | DCN |
DMDMi | 129951 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | By similarityAdd BLAST | 16 | |
PropeptideiPRO_0000032709 | 17 – 30 | 2 PublicationsAdd BLAST | 14 | |
ChainiPRO_0000032710 | 31 – 359 | DecorinAdd BLAST | 329 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 34 | O-linked (Xyl...) (glycosaminoglycan) serine1 Publication | 1 | |
Disulfide bondi | 54 ↔ 60 | By similarity | ||
Disulfide bondi | 58 ↔ 67 | By similarity | ||
Glycosylationi | 211 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 262 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 303 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 313 ↔ 346 | By similarity |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, ProteoglycanProteomic databases
EPDi | P07585 |
jPOSTi | P07585 |
MassIVEi | P07585 |
PaxDbi | P07585 |
PeptideAtlasi | P07585 |
PRIDEi | P07585 |
ProteomicsDBi | 52014 [P07585-1] 52015 [P07585-2] 52016 [P07585-3] 52017 [P07585-4] 52018 [P07585-5] |
PTM databases
GlyConnecti | 1169, 69 N-Linked glycans (3 sites) |
GlyGeni | P07585, 6 sites, 68 N-linked glycans (3 sites) |
iPTMneti | P07585 |
PhosphoSitePlusi | P07585 |
Expressioni
Gene expression databases
Bgeei | ENSG00000011465, Expressed in decidua and 239 other tissues |
ExpressionAtlasi | P07585, baseline and differential |
Genevisiblei | P07585, HS |
Organism-specific databases
HPAi | ENSG00000011465, Low tissue specificity |
Interactioni
Subunit structurei
Binds to type I and type II collagen, fibronectin and TGF-beta.
Forms a ternary complex with MFAP2 and ELN.
Interacts with DPT (By similarity).
By similarityBinary interactionsi
P07585
With | #Exp. | IntAct |
---|---|---|
BMP1 - isoform BMP1-1 [P13497-2] | 2 | EBI-9663608,EBI-12509497 |
FAM20B [O75063] | 4 | EBI-9663608,EBI-11090967 |
FN1 [P02751] | 9 | EBI-9663608,EBI-1220319 |
Protein-protein interaction databases
BioGRIDi | 108002, 24 interactors |
IntActi | P07585, 16 interactors |
STRINGi | 9606.ENSP00000052754 |
Miscellaneous databases
RNActi | P07585, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 73 – 93 | LRR 1Add BLAST | 21 | |
Repeati | 94 – 117 | LRR 2Add BLAST | 24 | |
Repeati | 118 – 141 | LRR 3Add BLAST | 24 | |
Repeati | 142 – 162 | LRR 4Add BLAST | 21 | |
Repeati | 163 – 186 | LRR 5Add BLAST | 24 | |
Repeati | 187 – 212 | LRR 6Add BLAST | 26 | |
Repeati | 213 – 233 | LRR 7Add BLAST | 21 | |
Repeati | 234 – 257 | LRR 8Add BLAST | 24 | |
Repeati | 258 – 281 | LRR 9Add BLAST | 24 | |
Repeati | 282 – 304 | LRR 10Add BLAST | 23 | |
Repeati | 305 – 334 | LRR 11Add BLAST | 30 | |
Repeati | 335 – 359 | LRR 12Add BLAST | 25 |
Sequence similaritiesi
Keywords - Domaini
Leucine-rich repeat, Repeat, SignalPhylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000158382 |
HOGENOMi | CLU_000288_186_0_1 |
InParanoidi | P07585 |
OMAi | MSQVIVM |
PhylomeDBi | P07585 |
TreeFami | TF334562 |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR028549, Decorin IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR000372, LRRNT IPR016352, SLRP_I_decor/aspor/byglycan |
PANTHERi | PTHR45712:SF14, PTHR45712:SF14, 1 hit |
Pfami | View protein in Pfam PF13855, LRR_8, 3 hits PF01462, LRRNT, 1 hit |
PIRSFi | PIRSF002490, SLRP_I, 1 hit |
SMARTi | View protein in SMART SM00369, LRR_TYP, 6 hits SM00013, LRRNT, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 8 hits |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKATIILLLL AQVSWAGPFQ QRGLFDFMLE DEASGIGPEV PDDRDFEPSL
60 70 80 90 100
GPVCPFRCQC HLRVVQCSDL GLDKVPKDLP PDTTLLDLQN NKITEIKDGD
110 120 130 140 150
FKNLKNLHAL ILVNNKISKV SPGAFTPLVK LERLYLSKNQ LKELPEKMPK
160 170 180 190 200
TLQELRAHEN EITKVRKVTF NGLNQMIVIE LGTNPLKSSG IENGAFQGMK
210 220 230 240 250
KLSYIRIADT NITSIPQGLP PSLTELHLDG NKISRVDAAS LKGLNNLAKL
260 270 280 290 300
GLSFNSISAV DNGSLANTPH LRELHLDNNK LTRVPGGLAE HKYIQVVYLH
310 320 330 340 350
NNNISVVGSS DFCPPGHNTK KASYSGVSLF SNPVQYWEIQ PSTFRCVYVR
SAIQLGNYK
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8VUF6 | F8VUF6_HUMAN | Decorin | DCN | 178 | Annotation score: | ||
F8VWU0 | F8VWU0_HUMAN | Decorin | DCN | 179 | Annotation score: | ||
F8VX58 | F8VX58_HUMAN | Decorin | DCN | 119 | Annotation score: | ||
F8VXZ8 | F8VXZ8_HUMAN | Decorin | DCN | 174 | Annotation score: | ||
F8VNV6 | F8VNV6_HUMAN | Decorin | DCN | 177 | Annotation score: | ||
F8VSI3 | F8VSI3_HUMAN | Decorin | DCN | 100 | Annotation score: | ||
F8VNW0 | F8VNW0_HUMAN | Decorin | DCN | 88 | Annotation score: | ||
F8VU58 | F8VU58_HUMAN | Decorin | DCN | 98 | Annotation score: | ||
A0A7I2PRI8 | A0A7I2PRI8_HUMAN | Decorin | DCN | 77 | Annotation score: | ||
H0YIH3 | H0YIH3_HUMAN | Decorin | DCN | 95 | Annotation score: | ||
There is more potential isoformShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 37 | G → A AA sequence (PubMed:3597437).Curated | 1 | |
Sequence conflicti | 45 | D → P AA sequence (PubMed:3597437).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_014351 | 268 | T → M1 PublicationCorresponds to variant dbSNP:rs3138268EnsemblClinVar. | 1 | |
Natural variantiVAR_011975 | 273 | E → Q. Corresponds to variant dbSNP:rs1803344Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006172 | 71 – 179 | Missing in isoform B. 1 PublicationAdd BLAST | 109 | |
Alternative sequenceiVSP_006175 | 72 – 75 | LDKV → CLPS in isoform E. 1 Publication | 4 | |
Alternative sequenceiVSP_006173 | 73 – 219 | Missing in isoform C. 1 PublicationAdd BLAST | 147 | |
Alternative sequenceiVSP_006176 | 76 – 359 | Missing in isoform E. 1 PublicationAdd BLAST | 284 | |
Alternative sequenceiVSP_006174 | 109 – 295 | Missing in isoform D. 1 PublicationAdd BLAST | 187 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
SeattleSNPs |
Sequence databases
3D structure databases
AlphaFoldDBi | P07585 |
SMRi | P07585 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 108002, 24 interactors |
IntActi | P07585, 16 interactors |
STRINGi | 9606.ENSP00000052754 |
PTM databases
GlyConnecti | 1169, 69 N-Linked glycans (3 sites) |
GlyGeni | P07585, 6 sites, 68 N-linked glycans (3 sites) |
iPTMneti | P07585 |
PhosphoSitePlusi | P07585 |
Genetic variation databases
BioMutai | DCN |
DMDMi | 129951 |
Proteomic databases
EPDi | P07585 |
jPOSTi | P07585 |
MassIVEi | P07585 |
PaxDbi | P07585 |
PeptideAtlasi | P07585 |
PRIDEi | P07585 |
ProteomicsDBi | 52014 [P07585-1] 52015 [P07585-2] 52016 [P07585-3] 52017 [P07585-4] 52018 [P07585-5] |
Protocols and materials databases
Antibodypediai | 754, 623 antibodies from 40 providers |
DNASUi | 1634 |
Genome annotation databases
Organism-specific databases
CTDi | 1634 |
DisGeNETi | 1634 |
GeneCardsi | DCN |
GeneReviewsi | DCN |
HGNCi | HGNC:2705, DCN |
HPAi | ENSG00000011465, Low tissue specificity |
MalaCardsi | DCN |
MIMi | 125255, gene 610048, phenotype |
neXtProti | NX_P07585 |
OpenTargetsi | ENSG00000011465 |
Orphaneti | 101068, Congenital stromal corneal dystrophy |
PharmGKBi | PA27177 |
VEuPathDBi | HostDB:ENSG00000011465 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000158382 |
HOGENOMi | CLU_000288_186_0_1 |
InParanoidi | P07585 |
OMAi | MSQVIVM |
PhylomeDBi | P07585 |
TreeFami | TF334562 |
Enzyme and pathway databases
PathwayCommonsi | P07585 |
Reactomei | R-HSA-1474228, Degradation of the extracellular matrix R-HSA-1971475, A tetrasaccharide linker sequence is required for GAG synthesis R-HSA-2022870, Chondroitin sulfate biosynthesis R-HSA-2022923, Dermatan sulfate biosynthesis R-HSA-2024101, CS/DS degradation R-HSA-3000178, ECM proteoglycans R-HSA-3560783, Defective B4GALT7 causes EDS, progeroid type R-HSA-3560801, Defective B3GAT3 causes JDSSDHD R-HSA-3595172, Defective CHST3 causes SEDCJD R-HSA-3595174, Defective CHST14 causes EDS, musculocontractural type R-HSA-3595177, Defective CHSY1 causes TPBS R-HSA-4420332, Defective B3GALT6 causes EDSP2 and SEMDJL1 |
SignaLinki | P07585 |
SIGNORi | P07585 |
Miscellaneous databases
BioGRID-ORCSi | 1634, 7 hits in 1077 CRISPR screens |
ChiTaRSi | DCN, human |
GeneWikii | Decorin |
GenomeRNAii | 1634 |
Pharosi | P07585, Tbio |
PROi | PR:P07585 |
RNActi | P07585, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000011465, Expressed in decidua and 239 other tissues |
ExpressionAtlasi | P07585, baseline and differential |
Genevisiblei | P07585, HS |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR028549, Decorin IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR000372, LRRNT IPR016352, SLRP_I_decor/aspor/byglycan |
PANTHERi | PTHR45712:SF14, PTHR45712:SF14, 1 hit |
Pfami | View protein in Pfam PF13855, LRR_8, 3 hits PF01462, LRRNT, 1 hit |
PIRSFi | PIRSF002490, SLRP_I, 1 hit |
SMARTi | View protein in SMART SM00369, LRR_TYP, 6 hits SM00013, LRRNT, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 8 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | PGS2_HUMAN | |
Accessioni | P07585Primary (citable) accession number: P07585 Secondary accession number(s): Q9P0Z0 Q9Y5N9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1988 |
Last sequence update: | April 1, 1988 | |
Last modified: | May 25, 2022 | |
This is version 227 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families