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Protein

Cytochrome b-c1 complex subunit 10

Gene

UQCR11

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain.
This protein may be closely linked to the iron-sulfur protein in the complex and function as an iron-sulfur protein binding factor.

GO - Molecular functioni

  • ubiquinol-cytochrome-c reductase activity Source: GO_Central

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-BTA-611105 Respiratory electron transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 10
Alternative name(s):
Complex III subunit 10
Complex III subunit XI
Ubiquinol-cytochrome c reductase complex 6.4 kDa protein
Gene namesi
Name:UQCR11
Synonyms:UQCR
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001935591 – 56Cytochrome b-c1 complex subunit 10Add BLAST56

Proteomic databases

PaxDbiP07552
PRIDEiP07552

Expressioni

Gene expression databases

BgeeiENSBTAG00000008692 Expressed in 10 organ(s), highest expression level in heart

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Protein-protein interaction databases

CORUMiP07552
DIPiDIP-61255N
IntActiP07552, 1 interactor
STRINGi9913.ENSBTAP00000011458

Structurei

Secondary structure

156
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP07552
SMRiP07552
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07552

Family & Domainsi

Sequence similaritiesi

Belongs to the UQCR11/QCR10 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J5Z0 Eukaryota
ENOG410XVMI LUCA
GeneTreeiENSGT00390000018299
HOGENOMiHOG000030914
HOVERGENiHBG105467
InParanoidiP07552
KOiK00420
OMAiRELAKNW
OrthoDBiEOG091G1ATB
TreeFamiTF105034

Family and domain databases

InterProiView protein in InterPro
IPR029027 Single_a-helix_sf
IPR015089 UQCR
PANTHERiPTHR15420 PTHR15420, 1 hit
PfamiView protein in Pfam
PF08997 UCR_6-4kD, 1 hit
SUPFAMiSSF81518 SSF81518, 1 hit

Sequencei

Sequence statusi: Complete.

P07552-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTRFLGPRY RQLARNWVPT ASLWGAVGAV GLVWATDWRL ILDWVPYING

KFKKDD
Length:56
Mass (Da):6,520
Last modified:December 15, 1998 - v2
Checksum:iA412EA7EB58F45FE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22S → Q AA sequence (PubMed:2995132).Curated1
Sequence conflicti34W → S AA sequence (PubMed:2995132).Curated1
Sequence conflicti38W → S AA sequence (PubMed:2995132).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D55637 mRNA Translation: BAA21747.1
BC102080 mRNA Translation: AAI02081.1
BC126774 mRNA Translation: AAI26775.1
PIRiA24096 CBBOC6
RefSeqiNP_776640.1, NM_174215.2
UniGeneiBt.5040

Genome annotation databases

EnsembliENSBTAT00000011458; ENSBTAP00000011458; ENSBTAG00000008692
GeneIDi281570
KEGGibta:281570

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D55637 mRNA Translation: BAA21747.1
BC102080 mRNA Translation: AAI02081.1
BC126774 mRNA Translation: AAI26775.1
PIRiA24096 CBBOC6
RefSeqiNP_776640.1, NM_174215.2
UniGeneiBt.5040

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BE3X-ray3.00K1-56[»]
1BGYX-ray3.00K/W1-56[»]
1L0LX-ray2.35K1-56[»]
1L0NX-ray2.60K1-56[»]
1NTKX-ray2.60K1-56[»]
1NTMX-ray2.40K1-56[»]
1NTZX-ray2.60K1-56[»]
1NU1X-ray3.20K1-56[»]
1QCRX-ray2.70K1-45[»]
1SQBX-ray2.69K1-56[»]
1SQPX-ray2.70K1-56[»]
1SQQX-ray3.00K1-56[»]
1SQVX-ray2.85K1-56[»]
1SQXX-ray2.60K1-56[»]
2FYUX-ray2.26K1-56[»]
2YBBelectron microscopy19.00K/k1-56[»]
5GPNelectron microscopy5.40K/V1-56[»]
5KLVX-ray2.65K2-56[»]
5LUFelectron microscopy9.10k/w1-56[»]
5NMIX-ray3.50K/X15-36[»]
ProteinModelPortaliP07552
SMRiP07552
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiP07552
DIPiDIP-61255N
IntActiP07552, 1 interactor
STRINGi9913.ENSBTAP00000011458

Proteomic databases

PaxDbiP07552
PRIDEiP07552

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000011458; ENSBTAP00000011458; ENSBTAG00000008692
GeneIDi281570
KEGGibta:281570

Organism-specific databases

CTDi10975

Phylogenomic databases

eggNOGiENOG410J5Z0 Eukaryota
ENOG410XVMI LUCA
GeneTreeiENSGT00390000018299
HOGENOMiHOG000030914
HOVERGENiHBG105467
InParanoidiP07552
KOiK00420
OMAiRELAKNW
OrthoDBiEOG091G1ATB
TreeFamiTF105034

Enzyme and pathway databases

ReactomeiR-BTA-611105 Respiratory electron transport

Miscellaneous databases

EvolutionaryTraceiP07552

Gene expression databases

BgeeiENSBTAG00000008692 Expressed in 10 organ(s), highest expression level in heart

Family and domain databases

InterProiView protein in InterPro
IPR029027 Single_a-helix_sf
IPR015089 UQCR
PANTHERiPTHR15420 PTHR15420, 1 hit
PfamiView protein in Pfam
PF08997 UCR_6-4kD, 1 hit
SUPFAMiSSF81518 SSF81518, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQCR10_BOVIN
AccessioniPrimary (citable) accession number: P07552
Secondary accession number(s): A1A4P1, O18996, Q3T176
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: December 15, 1998
Last modified: November 7, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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