UniProtKB - P07552 (QCR10_BOVIN)
Cytochrome b-c1 complex subunit 10
UQCR11
Functioni
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. QCR10 has a role in CIII assembly and RIP1 stability.
By similarityGO - Biological processi
- mitochondrial electron transport, ubiquinol to cytochrome c Source: InterPro
Keywordsi
Biological process | Electron transport, Respiratory chain, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome b-c1 complex subunit 10Alternative name(s): Complex III subunit 10 Complex III subunit XI Ubiquinol-cytochrome c reductase complex 6.4 kDa protein |
Gene namesi | Name:UQCR11 Synonyms:UQCR |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000008692 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Single-pass membrane protein By similarity
Mitochondrion
- mitochondrial respiratory chain complex III Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 12 | Mitochondrial matrix1 PublicationAdd BLAST | 12 | |
Transmembranei | 13 – 35 | Helical1 PublicationAdd BLAST | 23 | |
Topological domaini | 36 – 56 | Mitochondrial intermembrane1 PublicationAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000193559 | 1 – 56 | Cytochrome b-c1 complex subunit 10Add BLAST | 56 |
Proteomic databases
PaxDbi | P07552 |
PRIDEi | P07552 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000008692, Expressed in heart and 98 other tissues |
Interactioni
Subunit structurei
Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1 (PubMed:9651245). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI1III2IV1 and megacomplex MCI2III2IV2) (PubMed:27830641).
2 PublicationsProtein-protein interaction databases
CORUMi | P07552 |
DIPi | DIP-61255N |
IntActi | P07552, 1 interactor |
STRINGi | 9913.ENSBTAP00000011458 |
Structurei
Secondary structure
3D structure databases
SMRi | P07552 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P07552 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S9FZ, Eukaryota |
GeneTreei | ENSGT00390000018299 |
HOGENOMi | CLU_211742_0_0_1 |
InParanoidi | P07552 |
OMAi | LGPRYLQ |
OrthoDBi | 1621371at2759 |
TreeFami | TF105034 |
Family and domain databases
InterProi | View protein in InterPro IPR029027, Single_a-helix_sf IPR015089, UQCR |
PANTHERi | PTHR15420, PTHR15420, 1 hit |
Pfami | View protein in Pfam PF08997, UCR_6-4kD, 1 hit |
SUPFAMi | SSF81518, SSF81518, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MLTRFLGPRY RQLARNWVPT ASLWGAVGAV GLVWATDWRL ILDWVPYING
KFKKDD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 22 | S → Q AA sequence (PubMed:2995132).Curated | 1 | |
Sequence conflicti | 34 | W → S AA sequence (PubMed:2995132).Curated | 1 | |
Sequence conflicti | 38 | W → S AA sequence (PubMed:2995132).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D55637 mRNA Translation: BAA21747.1 BC102080 mRNA Translation: AAI02081.1 BC126774 mRNA Translation: AAI26775.1 |
PIRi | A24096, CBBOC6 |
RefSeqi | NP_776640.1, NM_174215.2 |
Genome annotation databases
Ensembli | ENSBTAT00000011458; ENSBTAP00000011458; ENSBTAG00000008692 |
GeneIDi | 281570 |
KEGGi | bta:281570 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D55637 mRNA Translation: BAA21747.1 BC102080 mRNA Translation: AAI02081.1 BC126774 mRNA Translation: AAI26775.1 |
PIRi | A24096, CBBOC6 |
RefSeqi | NP_776640.1, NM_174215.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1BE3 | X-ray | 3.00 | K | 1-56 | [»] | |
1BGY | X-ray | 3.00 | K/W | 1-56 | [»] | |
1L0L | X-ray | 2.35 | K | 1-56 | [»] | |
1L0N | X-ray | 2.60 | K | 1-56 | [»] | |
1NTK | X-ray | 2.60 | K | 1-56 | [»] | |
1NTM | X-ray | 2.40 | K | 1-56 | [»] | |
1NTZ | X-ray | 2.60 | K | 1-56 | [»] | |
1NU1 | X-ray | 3.20 | K | 1-56 | [»] | |
1QCR | X-ray | 2.70 | K | 1-45 | [»] | |
1SQB | X-ray | 2.69 | K | 1-56 | [»] | |
1SQP | X-ray | 2.70 | K | 1-56 | [»] | |
1SQQ | X-ray | 3.00 | K | 1-56 | [»] | |
1SQV | X-ray | 2.85 | K | 1-56 | [»] | |
1SQX | X-ray | 2.60 | K | 1-56 | [»] | |
2FYU | X-ray | 2.26 | K | 1-56 | [»] | |
2YBB | electron microscopy | 19.00 | K/k | 1-56 | [»] | |
5GPN | electron microscopy | 5.40 | K/V | 1-56 | [»] | |
5KLV | X-ray | 2.65 | K | 2-56 | [»] | |
5LUF | electron microscopy | 9.10 | k/w | 1-56 | [»] | |
5NMI | X-ray | 3.50 | K/X | 15-36 | [»] | |
6NHG | X-ray | 2.80 | K | 2-56 | [»] | |
SMRi | P07552 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
CORUMi | P07552 |
DIPi | DIP-61255N |
IntActi | P07552, 1 interactor |
STRINGi | 9913.ENSBTAP00000011458 |
Proteomic databases
PaxDbi | P07552 |
PRIDEi | P07552 |
Genome annotation databases
Ensembli | ENSBTAT00000011458; ENSBTAP00000011458; ENSBTAG00000008692 |
GeneIDi | 281570 |
KEGGi | bta:281570 |
Organism-specific databases
CTDi | 10975 |
VEuPathDBi | HostDB:ENSBTAG00000008692 |
Phylogenomic databases
eggNOGi | ENOG502S9FZ, Eukaryota |
GeneTreei | ENSGT00390000018299 |
HOGENOMi | CLU_211742_0_0_1 |
InParanoidi | P07552 |
OMAi | LGPRYLQ |
OrthoDBi | 1621371at2759 |
TreeFami | TF105034 |
Miscellaneous databases
EvolutionaryTracei | P07552 |
Gene expression databases
Bgeei | ENSBTAG00000008692, Expressed in heart and 98 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR029027, Single_a-helix_sf IPR015089, UQCR |
PANTHERi | PTHR15420, PTHR15420, 1 hit |
Pfami | View protein in Pfam PF08997, UCR_6-4kD, 1 hit |
SUPFAMi | SSF81518, SSF81518, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | QCR10_BOVIN | |
Accessioni | P07552Primary (citable) accession number: P07552 Secondary accession number(s): A1A4P1, O18996, Q3T176 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1988 |
Last sequence update: | December 15, 1998 | |
Last modified: | February 23, 2022 | |
This is version 155 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families