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Protein

Beta-2 adrenergic receptor

Gene

ADRB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei113Agonist or antagonist1
Binding sitei118Agonist or antagonist1

GO - Molecular functioni

  • adenylate cyclase binding Source: Ensembl
  • adrenergic receptor activity Source: GO_Central
  • amyloid-beta binding Source: ARUK-UCL
  • beta2-adrenergic receptor activity Source: HGNC
  • epinephrine binding Source: GO_Central
  • norepinephrine binding Source: HGNC
  • potassium channel regulator activity Source: BHF-UCL
  • protein-containing complex binding Source: ARUK-UCL
  • protein homodimerization activity Source: HGNC

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-390696 Adrenoceptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-5689880 Ub-specific processing proteases
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
SignaLinkiP07550
SIGNORiP07550

Protein family/group databases

MoonDBiP07550 Predicted
TCDBi9.A.14.3.5 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-2 adrenergic receptor
Alternative name(s):
Beta-2 adrenoreceptor
Short name:
Beta-2 adrenoceptor
Gene namesi
Name:ADRB2
Synonyms:ADRB2R, B2AR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000169252.5
HGNCiHGNC:286 ADRB2
MIMi109690 gene+phenotype
neXtProtiNX_P07550

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularAdd BLAST34
Transmembranei35 – 58Helical; Name=1Add BLAST24
Topological domaini59 – 71CytoplasmicAdd BLAST13
Transmembranei72 – 95Helical; Name=2Add BLAST24
Topological domaini96 – 106ExtracellularAdd BLAST11
Transmembranei107 – 129Helical; Name=3Add BLAST23
Topological domaini130 – 150CytoplasmicAdd BLAST21
Transmembranei151 – 174Helical; Name=4Add BLAST24
Topological domaini175 – 196ExtracellularAdd BLAST22
Transmembranei197 – 220Helical; Name=5Add BLAST24
Topological domaini221 – 274CytoplasmicAdd BLAST54
Transmembranei275 – 298Helical; Name=6Add BLAST24
Topological domaini299 – 305Extracellular7
Transmembranei306 – 329Helical; Name=7Add BLAST24
Topological domaini330 – 413CytoplasmicAdd BLAST84

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi79D → N: Affects binding of catecholamines, and produces an uncoupling between the receptor and stimulatory G proteins. 1 Publication1
Mutagenesisi141Y → F: Abolishes insulin-induced tyrosine phosphorylation and insulin-induced receptor supersensitization. 1 Publication1
Mutagenesisi341C → G: Uncoupled receptor. 1 Publication1
Mutagenesisi345 – 346SS → AA: Delayed agonist-promoted desensitization. 1 Publication2
Mutagenesisi350Y → A: Does not affect insulin-induced tyrosine phosphorylation or insulin-induced receptor supersensitization. 1 Publication1
Mutagenesisi354Y → A: Does not affect insulin-induced tyrosine phosphorylation or insulin-induced receptor supersensitization. 1 Publication1
Mutagenesisi366Y → F: Does not affect insulin-induced tyrosine phosphorylation or insulin-induced receptor supersensitization. 1 Publication1

Organism-specific databases

DisGeNETi154
MalaCardsiADRB2
MIMi109690 gene+phenotype
OpenTargetsiENSG00000169252
PharmGKBiPA39

Chemistry databases

ChEMBLiCHEMBL210
DrugBankiDB07543 (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol
DB01193 Acebutolol
DB00866 Alprenolol
DB00321 Amitriptyline
DB00182 Amphetamine
DB01102 Arbutamine
DB01274 Arformoterol
DB06216 Asenapine
DB00335 Atenolol
DB01408 Bambuterol
DB00195 Betaxolol
DB00217 Bethanidine
DB01295 Bevantolol
DB00612 Bisoprolol
DB00901 Bitolterol
DB08807 Bopindolol
DB06726 Bufuralol
DB08808 Bupranolol
DB00248 Cabergoline
DB00521 Carteolol
DB01136 Carvedilol
DB04846 Celiprolol
DB01407 Clenbuterol
DB01151 Desipramine
DB00449 Dipivefrin
DB00841 Dobutamine
DB06262 Droxidopa
DB01363 Ephedra
DB00668 Epinephrine
DB01288 Fenoterol
DB00983 Formoterol
DB05039 Indacaterol
DB00221 Isoetarine
DB01064 Isoprenaline
DB00598 Labetalol
DB01210 Levobunolol
DB13139 Levosalbutamol
DB01365 Mephentermine
DB01214 Metipranolol
DB00264 Metoprolol
DB00370 Mirtazapine
DB01203 Nadolol
DB05849 NCX 950
DB04861 Nebivolol
DB00368 Norepinephrine
DB00540 Nortriptyline
DB00334 Olanzapine
DB09080 Olodaterol
DB00816 Orciprenaline
DB01580 Oxprenolol
DB01359 Penbutolol
DB00925 Phenoxybenzamine
DB00397 Phenylpropanolamine
DB00960 Pindolol
DB01291 Pirbuterol
DB01366 Procaterol
DB00571 Propranolol
DB00852 Pseudoephedrine
DB00867 Ritodrine
DB01001 Salbutamol
DB00938 Salmeterol
DB00489 Sotalol
DB00871 Terbutaline
DB00373 Timolol
DB00726 Trimipramine
DB09082 Vilanterol
GuidetoPHARMACOLOGYi29

Polymorphism and mutation databases

BioMutaiADRB2
DMDMi296439450

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691301 – 413Beta-2 adrenergic receptorAdd BLAST413

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineCurated1
Glycosylationi15N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi106 ↔ 191
Modified residuei141Phosphotyrosine1 Publication1
Disulfide bondi184 ↔ 190
Modified residuei246PhosphoserineCombined sources1
Modified residuei261Phosphoserine; by PKASequence analysis1
Modified residuei262Phosphoserine; by PKASequence analysis1
Lipidationi341S-palmitoyl cysteine3 Publications1
Modified residuei345Phosphoserine; by PKA1 Publication1
Modified residuei346Phosphoserine; by PKA1 Publication1
Modified residuei355Phosphoserine; by BARKCurated1
Modified residuei356Phosphoserine; by BARKCurated1
Modified residuei3824-hydroxyproline1 Publication1
Modified residuei3954-hydroxyproline1 Publication1

Post-translational modificationi

Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation.4 Publications
Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK.
Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor.1 Publication
Polyubiquitinated. Agonist-induced ubiquitination leads to sort internalized receptors to the lysosomes for degradation (PubMed:19424180, PubMed:20559325). Deubiquitination by USP20 and USP33, leads to ADRB2 recycling and resensitization after prolonged agonist stimulation. USP20 and USP33 are constitutively associated and are dissociated immediately after agonist stimulation. Ubiquitination by the VHL-E3 ligase complex is oxygen-dependent.2 Publications
Hydroxylation by EGLN3 occurs only under normoxia and increases the interaction with VHL and the subsequent ubiquitination and degradation of ADRB2.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP07550
PaxDbiP07550
PeptideAtlasiP07550
PRIDEiP07550
ProteomicsDBi52013

PTM databases

iPTMnetiP07550
PhosphoSitePlusiP07550
SwissPalmiP07550

Expressioni

Gene expression databases

BgeeiENSG00000169252 Expressed in 181 organ(s), highest expression level in squamous epithelium
ExpressionAtlasiP07550 baseline and differential
GenevisibleiP07550 HS

Organism-specific databases

HPAiHPA003431
HPA075322

Interactioni

Subunit structurei

Binds SLC9A3R1 and GPRASP1. Interacts with ARRB1 and ARRB2. Interacts with SRC, USP20 and USP33. Interacts with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to its degradation. Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated ubiquitination. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with CNIH4 (PubMed:24405750). Interacts with ARRDC3 (PubMed:20559325, PubMed:25220262).15 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106663, 246 interactors
CORUMiP07550
DIPiDIP-33948N
ELMiP07550
IntActiP07550, 15 interactors
MINTiP07550
STRINGi9606.ENSP00000305372

Chemistry databases

BindingDBiP07550

Structurei

Secondary structure

1413
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP07550
SMRiP07550
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07550

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni193 – 207Agonist and antagonist bindingAdd BLAST15
Regioni286 – 293Agonist and antagonist binding8
Regioni312 – 316Agonist and antagonist binding5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi410 – 413PDZ-binding4

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139331
HOVERGENiHBG106962
InParanoidiP07550
KOiK04142
OMAiKETCCDF
OrthoDBiEOG091G06VI
PhylomeDBiP07550
TreeFamiTF316350

Family and domain databases

CDDicd15957 7tmA_Beta2_AR, 1 hit
InterProiView protein in InterPro
IPR002233 ADR_fam
IPR000332 ADRB2_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24248:SF21 PTHR24248:SF21, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00562 ADRENRGCB2AR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P07550-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQPGNGSAF LLAPNGSHAP DHDVTQERDE VWVVGMGIVM SLIVLAIVFG
60 70 80 90 100
NVLVITAIAK FERLQTVTNY FITSLACADL VMGLAVVPFG AAHILMKMWT
110 120 130 140 150
FGNFWCEFWT SIDVLCVTAS IETLCVIAVD RYFAITSPFK YQSLLTKNKA
160 170 180 190 200
RVIILMVWIV SGLTSFLPIQ MHWYRATHQE AINCYANETC CDFFTNQAYA
210 220 230 240 250
IASSIVSFYV PLVIMVFVYS RVFQEAKRQL QKIDKSEGRF HVQNLSQVEQ
260 270 280 290 300
DGRTGHGLRR SSKFCLKEHK ALKTLGIIMG TFTLCWLPFF IVNIVHVIQD
310 320 330 340 350
NLIRKEVYIL LNWIGYVNSG FNPLIYCRSP DFRIAFQELL CLRRSSLKAY
360 370 380 390 400
GNGYSSNGNT GEQSGYHVEQ EKENKLLCED LPGTEDFVGH QGTVPSDNID
410
SQGRNCSTND SLL
Length:413
Mass (Da):46,459
Last modified:May 18, 2010 - v3
Checksum:i408C22731C6EDFBE
GO

Sequence cautioni

The sequence BAD96745 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71F → L in BAG35969 (PubMed:14702039).Curated1
Sequence conflicti216V → A in AAN01267 (Ref. 8) Curated1
Sequence conflicti261S → P in BAD96745 (Ref. 10) Curated1
Sequence conflicti402Q → P in AAH12481 (PubMed:15489334).Curated1

Polymorphismi

The Gly-16 allele is overrepresented in individuals affected by nocturnal asthma as compared to controls, and appears to be an important genetic factor in the expression of this asthmatic phenotype.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04937315N → S. Corresponds to variant dbSNP:rs33973603Ensembl.1
Natural variantiVAR_00345216G → R Common polymorphism. 8 PublicationsCorresponds to variant dbSNP:rs1042713Ensembl.1
Natural variantiVAR_00345327E → Q13 PublicationsCorresponds to variant dbSNP:rs1042714Ensembl.1
Natural variantiVAR_00345434V → M1 PublicationCorresponds to variant dbSNP:rs990810566Ensembl.1
Natural variantiVAR_009125159I → F1 Publication1
Natural variantiVAR_009124159I → L1 Publication1
Natural variantiVAR_003455164T → I1 PublicationCorresponds to variant dbSNP:rs1800888EnsemblClinVar.1
Natural variantiVAR_025101220S → C1 PublicationCorresponds to variant dbSNP:rs3729943Ensembl.1
Natural variantiVAR_009394375K → R1 PublicationCorresponds to variant dbSNP:rs771585355Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04827 mRNA Translation: CAA28511.1
Y00106 Genomic DNA Translation: CAA68289.1
M15169 mRNA Translation: AAA88015.1
J02960 Genomic DNA Translation: AAA88017.1
AF022953 Genomic DNA Translation: AAB82148.1
AF022954 Genomic DNA Translation: AAB82149.1
AF022955 Genomic DNA Translation: AAB82150.1
AF022956 Genomic DNA Translation: AAB82151.1
AF169225 Genomic DNA Translation: AAD48036.1
AF202305 Genomic DNA Translation: AAF17569.1
AF203386 Genomic DNA Translation: AAF20199.1
AY136741 mRNA Translation: AAN01267.1
AK313151 mRNA Translation: BAG35969.1
AK223025 mRNA Translation: BAD96745.1 Different initiation.
DQ094845 Genomic DNA Translation: AAY88739.1
EU332834 Genomic DNA Translation: ABY87523.1
CH471062 Genomic DNA Translation: EAW61798.1
BC012481 mRNA Translation: AAH12481.3
BC063486 mRNA Translation: AAH63486.2
BC073856 mRNA Translation: AAH73856.1
CCDSiCCDS4292.1
PIRiA27525 QRHUB2
RefSeqiNP_000015.1, NM_000024.5
UniGeneiHs.2551

Genome annotation databases

EnsembliENST00000305988; ENSP00000305372; ENSG00000169252
GeneIDi154
KEGGihsa:154

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04827 mRNA Translation: CAA28511.1
Y00106 Genomic DNA Translation: CAA68289.1
M15169 mRNA Translation: AAA88015.1
J02960 Genomic DNA Translation: AAA88017.1
AF022953 Genomic DNA Translation: AAB82148.1
AF022954 Genomic DNA Translation: AAB82149.1
AF022955 Genomic DNA Translation: AAB82150.1
AF022956 Genomic DNA Translation: AAB82151.1
AF169225 Genomic DNA Translation: AAD48036.1
AF202305 Genomic DNA Translation: AAF17569.1
AF203386 Genomic DNA Translation: AAF20199.1
AY136741 mRNA Translation: AAN01267.1
AK313151 mRNA Translation: BAG35969.1
AK223025 mRNA Translation: BAD96745.1 Different initiation.
DQ094845 Genomic DNA Translation: AAY88739.1
EU332834 Genomic DNA Translation: ABY87523.1
CH471062 Genomic DNA Translation: EAW61798.1
BC012481 mRNA Translation: AAH12481.3
BC063486 mRNA Translation: AAH63486.2
BC073856 mRNA Translation: AAH73856.1
CCDSiCCDS4292.1
PIRiA27525 QRHUB2
RefSeqiNP_000015.1, NM_000024.5
UniGeneiHs.2551

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GQ4X-ray1.90A409-413[»]
2R4RX-ray3.40A1-365[»]
2R4SX-ray3.40A24-365[»]
2RH1X-ray2.40A1-230[»]
A263-365[»]
3D4SX-ray2.80A1-230[»]
A263-348[»]
3KJ6X-ray3.40A2-365[»]
3NY8X-ray2.84A1-230[»]
A263-348[»]
3NY9X-ray2.84A1-230[»]
A263-348[»]
3NYAX-ray3.16A1-230[»]
A263-348[»]
3P0GX-ray3.50A1-230[»]
A263-365[»]
3PDSX-ray3.50A25-230[»]
A264-348[»]
3SN6X-ray3.20R29-365[»]
4GBRX-ray3.99A29-365[»]
4LDEX-ray2.79A29-348[»]
4LDLX-ray3.10A29-348[»]
4LDOX-ray3.20A29-348[»]
4QKXX-ray3.30A29-348[»]
5D5AX-ray2.48A1-230[»]
A263-365[»]
5D5BX-ray3.80A1-230[»]
A263-365[»]
5D6LX-ray3.20A1-223[»]
A264-365[»]
5JQHX-ray3.20A/B30-348[»]
5X7DX-ray2.70A1-230[»]
A264-365[»]
ProteinModelPortaliP07550
SMRiP07550
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106663, 246 interactors
CORUMiP07550
DIPiDIP-33948N
ELMiP07550
IntActiP07550, 15 interactors
MINTiP07550
STRINGi9606.ENSP00000305372

Chemistry databases

BindingDBiP07550
ChEMBLiCHEMBL210
DrugBankiDB07543 (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol
DB01193 Acebutolol
DB00866 Alprenolol
DB00321 Amitriptyline
DB00182 Amphetamine
DB01102 Arbutamine
DB01274 Arformoterol
DB06216 Asenapine
DB00335 Atenolol
DB01408 Bambuterol
DB00195 Betaxolol
DB00217 Bethanidine
DB01295 Bevantolol
DB00612 Bisoprolol
DB00901 Bitolterol
DB08807 Bopindolol
DB06726 Bufuralol
DB08808 Bupranolol
DB00248 Cabergoline
DB00521 Carteolol
DB01136 Carvedilol
DB04846 Celiprolol
DB01407 Clenbuterol
DB01151 Desipramine
DB00449 Dipivefrin
DB00841 Dobutamine
DB06262 Droxidopa
DB01363 Ephedra
DB00668 Epinephrine
DB01288 Fenoterol
DB00983 Formoterol
DB05039 Indacaterol
DB00221 Isoetarine
DB01064 Isoprenaline
DB00598 Labetalol
DB01210 Levobunolol
DB13139 Levosalbutamol
DB01365 Mephentermine
DB01214 Metipranolol
DB00264 Metoprolol
DB00370 Mirtazapine
DB01203 Nadolol
DB05849 NCX 950
DB04861 Nebivolol
DB00368 Norepinephrine
DB00540 Nortriptyline
DB00334 Olanzapine
DB09080 Olodaterol
DB00816 Orciprenaline
DB01580 Oxprenolol
DB01359 Penbutolol
DB00925 Phenoxybenzamine
DB00397 Phenylpropanolamine
DB00960 Pindolol
DB01291 Pirbuterol
DB01366 Procaterol
DB00571 Propranolol
DB00852 Pseudoephedrine
DB00867 Ritodrine
DB01001 Salbutamol
DB00938 Salmeterol
DB00489 Sotalol
DB00871 Terbutaline
DB00373 Timolol
DB00726 Trimipramine
DB09082 Vilanterol
GuidetoPHARMACOLOGYi29

Protein family/group databases

MoonDBiP07550 Predicted
TCDBi9.A.14.3.5 the g-protein-coupled receptor (gpcr) family
GPCRDBiSearch...

PTM databases

iPTMnetiP07550
PhosphoSitePlusiP07550
SwissPalmiP07550

Polymorphism and mutation databases

BioMutaiADRB2
DMDMi296439450

Proteomic databases

EPDiP07550
PaxDbiP07550
PeptideAtlasiP07550
PRIDEiP07550
ProteomicsDBi52013

Protocols and materials databases

DNASUi154
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305988; ENSP00000305372; ENSG00000169252
GeneIDi154
KEGGihsa:154

Organism-specific databases

CTDi154
DisGeNETi154
EuPathDBiHostDB:ENSG00000169252.5
GeneCardsiADRB2
HGNCiHGNC:286 ADRB2
HPAiHPA003431
HPA075322
MalaCardsiADRB2
MIMi109690 gene+phenotype
neXtProtiNX_P07550
OpenTargetsiENSG00000169252
PharmGKBiPA39
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139331
HOVERGENiHBG106962
InParanoidiP07550
KOiK04142
OMAiKETCCDF
OrthoDBiEOG091G06VI
PhylomeDBiP07550
TreeFamiTF316350

Enzyme and pathway databases

ReactomeiR-HSA-390696 Adrenoceptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-5689880 Ub-specific processing proteases
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
SignaLinkiP07550
SIGNORiP07550

Miscellaneous databases

ChiTaRSiADRB2 human
EvolutionaryTraceiP07550
GeneWikiiBeta-2_adrenergic_receptor
GenomeRNAii154
PROiPR:P07550
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169252 Expressed in 181 organ(s), highest expression level in squamous epithelium
ExpressionAtlasiP07550 baseline and differential
GenevisibleiP07550 HS

Family and domain databases

CDDicd15957 7tmA_Beta2_AR, 1 hit
InterProiView protein in InterPro
IPR002233 ADR_fam
IPR000332 ADRB2_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24248:SF21 PTHR24248:SF21, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00562 ADRENRGCB2AR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADRB2_HUMAN
AccessioniPrimary (citable) accession number: P07550
Secondary accession number(s): B0LPE4
, B2R7X2, O14823, O14824, O14825, O14826, Q4JG18, Q53GA6, Q6GMT4, Q6P4D8, Q8NEQ9, Q96EC3, Q9UCZ0, Q9UCZ1, Q9UCZ2, Q9UCZ3, Q9UH95, Q9UHA1, Q9UMZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 217 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  7. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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