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Protein

Beta-2 adrenergic receptor

Gene

ADRB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei113Agonist or antagonist1
Binding sitei118Agonist or antagonist1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • adenylate cyclase binding Source: Ensembl
  • adrenergic receptor activity Source: GO_Central
  • amyloid-beta binding Source: ARUK-UCL
  • beta2-adrenergic receptor activity Source: HGNC
  • epinephrine binding Source: GO_Central
  • norepinephrine binding Source: HGNC
  • potassium channel regulator activity Source: BHF-UCL
  • protein-containing complex binding Source: ARUK-UCL
  • protein homodimerization activity Source: HGNC

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-390696 Adrenoceptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-5689880 Ub-specific processing proteases
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P07550

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P07550

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
P07550 Predicted

Transport Classification Database

More...
TCDBi
9.A.14.3.5 the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Beta-2 adrenergic receptor
Alternative name(s):
Beta-2 adrenoreceptor
Short name:
Beta-2 adrenoceptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADRB2
Synonyms:ADRB2R, B2AR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000169252.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:286 ADRB2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
109690 gene+phenotype

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P07550

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 34ExtracellularAdd BLAST34
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei35 – 58Helical; Name=1Add BLAST24
Topological domaini59 – 71CytoplasmicAdd BLAST13
Transmembranei72 – 95Helical; Name=2Add BLAST24
Topological domaini96 – 106ExtracellularAdd BLAST11
Transmembranei107 – 129Helical; Name=3Add BLAST23
Topological domaini130 – 150CytoplasmicAdd BLAST21
Transmembranei151 – 174Helical; Name=4Add BLAST24
Topological domaini175 – 196ExtracellularAdd BLAST22
Transmembranei197 – 220Helical; Name=5Add BLAST24
Topological domaini221 – 274CytoplasmicAdd BLAST54
Transmembranei275 – 298Helical; Name=6Add BLAST24
Topological domaini299 – 305Extracellular7
Transmembranei306 – 329Helical; Name=7Add BLAST24
Topological domaini330 – 413CytoplasmicAdd BLAST84

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi79D → N: Affects binding of catecholamines, and produces an uncoupling between the receptor and stimulatory G proteins. 1 Publication1
Mutagenesisi141Y → F: Abolishes insulin-induced tyrosine phosphorylation and insulin-induced receptor supersensitization. 1 Publication1
Mutagenesisi341C → G: Uncoupled receptor. 1 Publication1
Mutagenesisi345 – 346SS → AA: Delayed agonist-promoted desensitization. 1 Publication2
Mutagenesisi350Y → A: Does not affect insulin-induced tyrosine phosphorylation or insulin-induced receptor supersensitization. 1 Publication1
Mutagenesisi354Y → A: Does not affect insulin-induced tyrosine phosphorylation or insulin-induced receptor supersensitization. 1 Publication1
Mutagenesisi366Y → F: Does not affect insulin-induced tyrosine phosphorylation or insulin-induced receptor supersensitization. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
154

MalaCards human disease database

More...
MalaCardsi
ADRB2
MIMi109690 gene+phenotype

Open Targets

More...
OpenTargetsi
ENSG00000169252

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA39

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL210

Drug and drug target database

More...
DrugBanki
DB07543 (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol
DB01193 Acebutolol
DB00866 Alprenolol
DB00321 Amitriptyline
DB00182 Amphetamine
DB01102 Arbutamine
DB01274 Arformoterol
DB06216 Asenapine
DB00335 Atenolol
DB01408 Bambuterol
DB00195 Betaxolol
DB00217 Bethanidine
DB01295 Bevantolol
DB00612 Bisoprolol
DB00901 Bitolterol
DB08807 Bopindolol
DB06726 Bufuralol
DB08808 Bupranolol
DB00248 Cabergoline
DB00521 Carteolol
DB01136 Carvedilol
DB04846 Celiprolol
DB01407 Clenbuterol
DB01151 Desipramine
DB00449 Dipivefrin
DB00841 Dobutamine
DB06262 Droxidopa
DB01363 Ephedra
DB00668 Epinephrine
DB01288 Fenoterol
DB00983 Formoterol
DB05039 Indacaterol
DB00221 Isoetarine
DB01064 Isoprenaline
DB00598 Labetalol
DB01210 Levobunolol
DB13139 Levosalbutamol
DB01365 Mephentermine
DB01214 Metipranolol
DB00264 Metoprolol
DB00370 Mirtazapine
DB01203 Nadolol
DB05849 NCX 950
DB04861 Nebivolol
DB00368 Norepinephrine
DB00540 Nortriptyline
DB00334 Olanzapine
DB09080 Olodaterol
DB00816 Orciprenaline
DB01580 Oxprenolol
DB01359 Penbutolol
DB00925 Phenoxybenzamine
DB00397 Phenylpropanolamine
DB00960 Pindolol
DB01291 Pirbuterol
DB01366 Procaterol
DB00571 Propranolol
DB00852 Pseudoephedrine
DB00867 Ritodrine
DB01001 Salbutamol
DB00938 Salmeterol
DB00489 Sotalol
DB00871 Terbutaline
DB00373 Timolol
DB00726 Trimipramine
DB09082 Vilanterol

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
29

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ADRB2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439450

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000691301 – 413Beta-2 adrenergic receptorAdd BLAST413

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi6N-linked (GlcNAc...) asparagineCurated1
Glycosylationi15N-linked (GlcNAc...) asparagineCurated1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi106 ↔ 191
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei141Phosphotyrosine1 Publication1
Disulfide bondi184 ↔ 190
Modified residuei246PhosphoserineCombined sources1
Modified residuei261Phosphoserine; by PKASequence analysis1
Modified residuei262Phosphoserine; by PKASequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi341S-palmitoyl cysteine3 Publications1
Modified residuei345Phosphoserine; by PKA1 Publication1
Modified residuei346Phosphoserine; by PKA1 Publication1
Modified residuei355Phosphoserine; by BARKCurated1
Modified residuei356Phosphoserine; by BARKCurated1
Modified residuei3824-hydroxyproline1 Publication1
Modified residuei3954-hydroxyproline1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation.4 Publications
Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK.
Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor.1 Publication
Polyubiquitinated. Agonist-induced ubiquitination leads to sort internalized receptors to the lysosomes for degradation (PubMed:19424180, PubMed:20559325). Deubiquitination by USP20 and USP33, leads to ADRB2 recycling and resensitization after prolonged agonist stimulation. USP20 and USP33 are constitutively associated and are dissociated immediately after agonist stimulation. Ubiquitination by the VHL-E3 ligase complex is oxygen-dependent.2 Publications
Hydroxylation by EGLN3 occurs only under normoxia and increases the interaction with VHL and the subsequent ubiquitination and degradation of ADRB2.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P07550

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P07550

PeptideAtlas

More...
PeptideAtlasi
P07550

PRoteomics IDEntifications database

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PRIDEi
P07550

ProteomicsDB human proteome resource

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ProteomicsDBi
52013

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P07550

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P07550

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P07550

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000169252 Expressed in 181 organ(s), highest expression level in squamous epithelium

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P07550 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P07550 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA003431
HPA075322

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds SLC9A3R1 and GPRASP1. Interacts with ARRB1 and ARRB2. Interacts with SRC, USP20 and USP33. Interacts with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to its degradation. Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated ubiquitination. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with CNIH4 (PubMed:24405750). Interacts with ARRDC3 (PubMed:20559325, PubMed:25220262).15 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106663, 246 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P07550

Database of interacting proteins

More...
DIPi
DIP-33948N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P07550

Protein interaction database and analysis system

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IntActi
P07550, 15 interactors

Molecular INTeraction database

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MINTi
P07550

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000305372

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P07550

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1413
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P07550

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P07550

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P07550

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni193 – 207Agonist and antagonist bindingAdd BLAST15
Regioni286 – 293Agonist and antagonist binding8
Regioni312 – 316Agonist and antagonist binding5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi410 – 413PDZ-binding4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3656 Eukaryota
ENOG410XRW9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159538

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG106962

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P07550

KEGG Orthology (KO)

More...
KOi
K04142

Identification of Orthologs from Complete Genome Data

More...
OMAi
KETCCDF

Database of Orthologous Groups

More...
OrthoDBi
EOG091G06VI

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P07550

TreeFam database of animal gene trees

More...
TreeFami
TF316350

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15957 7tmA_Beta2_AR, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002233 ADR_fam
IPR000332 ADRB2_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

The PANTHER Classification System

More...
PANTHERi
PTHR24248:SF21 PTHR24248:SF21, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01103 ADRENERGICR
PR00562 ADRENRGCB2AR
PR00237 GPCRRHODOPSN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P07550-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQPGNGSAF LLAPNGSHAP DHDVTQERDE VWVVGMGIVM SLIVLAIVFG
60 70 80 90 100
NVLVITAIAK FERLQTVTNY FITSLACADL VMGLAVVPFG AAHILMKMWT
110 120 130 140 150
FGNFWCEFWT SIDVLCVTAS IETLCVIAVD RYFAITSPFK YQSLLTKNKA
160 170 180 190 200
RVIILMVWIV SGLTSFLPIQ MHWYRATHQE AINCYANETC CDFFTNQAYA
210 220 230 240 250
IASSIVSFYV PLVIMVFVYS RVFQEAKRQL QKIDKSEGRF HVQNLSQVEQ
260 270 280 290 300
DGRTGHGLRR SSKFCLKEHK ALKTLGIIMG TFTLCWLPFF IVNIVHVIQD
310 320 330 340 350
NLIRKEVYIL LNWIGYVNSG FNPLIYCRSP DFRIAFQELL CLRRSSLKAY
360 370 380 390 400
GNGYSSNGNT GEQSGYHVEQ EKENKLLCED LPGTEDFVGH QGTVPSDNID
410
SQGRNCSTND SLL
Length:413
Mass (Da):46,459
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i408C22731C6EDFBE
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD96745 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti71F → L in BAG35969 (PubMed:14702039).Curated1
Sequence conflicti216V → A in AAN01267 (Ref. 8) Curated1
Sequence conflicti261S → P in BAD96745 (Ref. 10) Curated1
Sequence conflicti402Q → P in AAH12481 (PubMed:15489334).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The Gly-16 allele is overrepresented in individuals affected by nocturnal asthma as compared to controls, and appears to be an important genetic factor in the expression of this asthmatic phenotype.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04937315N → S. Corresponds to variant dbSNP:rs33973603Ensembl.1
Natural variantiVAR_00345216G → R Common polymorphism. 8 PublicationsCorresponds to variant dbSNP:rs1042713Ensembl.1
Natural variantiVAR_00345327E → Q13 PublicationsCorresponds to variant dbSNP:rs1042714Ensembl.1
Natural variantiVAR_00345434V → M1 PublicationCorresponds to variant dbSNP:rs990810566Ensembl.1
Natural variantiVAR_009125159I → F1 Publication1
Natural variantiVAR_009124159I → L1 Publication1
Natural variantiVAR_003455164T → I1 PublicationCorresponds to variant dbSNP:rs1800888EnsemblClinVar.1
Natural variantiVAR_025101220S → C1 PublicationCorresponds to variant dbSNP:rs3729943Ensembl.1
Natural variantiVAR_009394375K → R1 PublicationCorresponds to variant dbSNP:rs771585355Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X04827 mRNA Translation: CAA28511.1
Y00106 Genomic DNA Translation: CAA68289.1
M15169 mRNA Translation: AAA88015.1
J02960 Genomic DNA Translation: AAA88017.1
AF022953 Genomic DNA Translation: AAB82148.1
AF022954 Genomic DNA Translation: AAB82149.1
AF022955 Genomic DNA Translation: AAB82150.1
AF022956 Genomic DNA Translation: AAB82151.1
AF169225 Genomic DNA Translation: AAD48036.1
AF202305 Genomic DNA Translation: AAF17569.1
AF203386 Genomic DNA Translation: AAF20199.1
AY136741 mRNA Translation: AAN01267.1
AK313151 mRNA Translation: BAG35969.1
AK223025 mRNA Translation: BAD96745.1 Different initiation.
DQ094845 Genomic DNA Translation: AAY88739.1
EU332834 Genomic DNA Translation: ABY87523.1
CH471062 Genomic DNA Translation: EAW61798.1
BC012481 mRNA Translation: AAH12481.3
BC063486 mRNA Translation: AAH63486.2
BC073856 mRNA Translation: AAH73856.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS4292.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A27525 QRHUB2

NCBI Reference Sequences

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RefSeqi
NP_000015.1, NM_000024.5

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.2551

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000305988; ENSP00000305372; ENSG00000169252

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
154

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:154

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04827 mRNA Translation: CAA28511.1
Y00106 Genomic DNA Translation: CAA68289.1
M15169 mRNA Translation: AAA88015.1
J02960 Genomic DNA Translation: AAA88017.1
AF022953 Genomic DNA Translation: AAB82148.1
AF022954 Genomic DNA Translation: AAB82149.1
AF022955 Genomic DNA Translation: AAB82150.1
AF022956 Genomic DNA Translation: AAB82151.1
AF169225 Genomic DNA Translation: AAD48036.1
AF202305 Genomic DNA Translation: AAF17569.1
AF203386 Genomic DNA Translation: AAF20199.1
AY136741 mRNA Translation: AAN01267.1
AK313151 mRNA Translation: BAG35969.1
AK223025 mRNA Translation: BAD96745.1 Different initiation.
DQ094845 Genomic DNA Translation: AAY88739.1
EU332834 Genomic DNA Translation: ABY87523.1
CH471062 Genomic DNA Translation: EAW61798.1
BC012481 mRNA Translation: AAH12481.3
BC063486 mRNA Translation: AAH63486.2
BC073856 mRNA Translation: AAH73856.1
CCDSiCCDS4292.1
PIRiA27525 QRHUB2
RefSeqiNP_000015.1, NM_000024.5
UniGeneiHs.2551

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GQ4X-ray1.90A409-413[»]
2R4RX-ray3.40A1-365[»]
2R4SX-ray3.40A24-365[»]
2RH1X-ray2.40A1-230[»]
A263-365[»]
3D4SX-ray2.80A1-230[»]
A263-348[»]
3KJ6X-ray3.40A2-365[»]
3NY8X-ray2.84A1-230[»]
A263-348[»]
3NY9X-ray2.84A1-230[»]
A263-348[»]
3NYAX-ray3.16A1-230[»]
A263-348[»]
3P0GX-ray3.50A1-230[»]
A263-365[»]
3PDSX-ray3.50A25-230[»]
A264-348[»]
3SN6X-ray3.20R29-365[»]
4GBRX-ray3.99A29-365[»]
4LDEX-ray2.79A29-348[»]
4LDLX-ray3.10A29-348[»]
4LDOX-ray3.20A29-348[»]
4QKXX-ray3.30A29-348[»]
5D5AX-ray2.48A1-230[»]
A263-365[»]
5D5BX-ray3.80A1-230[»]
A263-365[»]
5D6LX-ray3.20A1-223[»]
A264-365[»]
5JQHX-ray3.20A/B30-348[»]
5X7DX-ray2.70A1-230[»]
A264-365[»]
6CSYX-ray2.96A29-365[»]
ProteinModelPortaliP07550
SMRiP07550
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106663, 246 interactors
CORUMiP07550
DIPiDIP-33948N
ELMiP07550
IntActiP07550, 15 interactors
MINTiP07550
STRINGi9606.ENSP00000305372

Chemistry databases

BindingDBiP07550
ChEMBLiCHEMBL210
DrugBankiDB07543 (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol
DB01193 Acebutolol
DB00866 Alprenolol
DB00321 Amitriptyline
DB00182 Amphetamine
DB01102 Arbutamine
DB01274 Arformoterol
DB06216 Asenapine
DB00335 Atenolol
DB01408 Bambuterol
DB00195 Betaxolol
DB00217 Bethanidine
DB01295 Bevantolol
DB00612 Bisoprolol
DB00901 Bitolterol
DB08807 Bopindolol
DB06726 Bufuralol
DB08808 Bupranolol
DB00248 Cabergoline
DB00521 Carteolol
DB01136 Carvedilol
DB04846 Celiprolol
DB01407 Clenbuterol
DB01151 Desipramine
DB00449 Dipivefrin
DB00841 Dobutamine
DB06262 Droxidopa
DB01363 Ephedra
DB00668 Epinephrine
DB01288 Fenoterol
DB00983 Formoterol
DB05039 Indacaterol
DB00221 Isoetarine
DB01064 Isoprenaline
DB00598 Labetalol
DB01210 Levobunolol
DB13139 Levosalbutamol
DB01365 Mephentermine
DB01214 Metipranolol
DB00264 Metoprolol
DB00370 Mirtazapine
DB01203 Nadolol
DB05849 NCX 950
DB04861 Nebivolol
DB00368 Norepinephrine
DB00540 Nortriptyline
DB00334 Olanzapine
DB09080 Olodaterol
DB00816 Orciprenaline
DB01580 Oxprenolol
DB01359 Penbutolol
DB00925 Phenoxybenzamine
DB00397 Phenylpropanolamine
DB00960 Pindolol
DB01291 Pirbuterol
DB01366 Procaterol
DB00571 Propranolol
DB00852 Pseudoephedrine
DB00867 Ritodrine
DB01001 Salbutamol
DB00938 Salmeterol
DB00489 Sotalol
DB00871 Terbutaline
DB00373 Timolol
DB00726 Trimipramine
DB09082 Vilanterol
GuidetoPHARMACOLOGYi29

Protein family/group databases

MoonDBiP07550 Predicted
TCDBi9.A.14.3.5 the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
Search...

PTM databases

iPTMnetiP07550
PhosphoSitePlusiP07550
SwissPalmiP07550

Polymorphism and mutation databases

BioMutaiADRB2
DMDMi296439450

Proteomic databases

EPDiP07550
PaxDbiP07550
PeptideAtlasiP07550
PRIDEiP07550
ProteomicsDBi52013

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
154
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305988; ENSP00000305372; ENSG00000169252
GeneIDi154
KEGGihsa:154

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
154
DisGeNETi154
EuPathDBiHostDB:ENSG00000169252.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ADRB2
HGNCiHGNC:286 ADRB2
HPAiHPA003431
HPA075322
MalaCardsiADRB2
MIMi109690 gene+phenotype
neXtProtiNX_P07550
OpenTargetsiENSG00000169252
PharmGKBiPA39

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00940000159538
HOVERGENiHBG106962
InParanoidiP07550
KOiK04142
OMAiKETCCDF
OrthoDBiEOG091G06VI
PhylomeDBiP07550
TreeFamiTF316350

Enzyme and pathway databases

ReactomeiR-HSA-390696 Adrenoceptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-5689880 Ub-specific processing proteases
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
SignaLinkiP07550
SIGNORiP07550

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ADRB2 human
EvolutionaryTraceiP07550

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Beta-2_adrenergic_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
154

Protein Ontology

More...
PROi
PR:P07550

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000169252 Expressed in 181 organ(s), highest expression level in squamous epithelium
ExpressionAtlasiP07550 baseline and differential
GenevisibleiP07550 HS

Family and domain databases

CDDicd15957 7tmA_Beta2_AR, 1 hit
InterProiView protein in InterPro
IPR002233 ADR_fam
IPR000332 ADRB2_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24248:SF21 PTHR24248:SF21, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00562 ADRENRGCB2AR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADRB2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07550
Secondary accession number(s): B0LPE4
, B2R7X2, O14823, O14824, O14825, O14826, Q4JG18, Q53GA6, Q6GMT4, Q6P4D8, Q8NEQ9, Q96EC3, Q9UCZ0, Q9UCZ1, Q9UCZ2, Q9UCZ3, Q9UH95, Q9UHA1, Q9UMZ5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: May 18, 2010
Last modified: December 5, 2018
This is version 218 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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