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Entry version 181 (02 Jun 2021)
Sequence version 3 (26 May 2009)
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Protein

Pentafunctional AROM polypeptide

Gene

aromA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+Note: Binds 2 Zn2+ ions per subunit.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: chorismate biosynthesis

This protein is involved in step 2, 3, 4, 5 and 6 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.UniRule annotation This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei119NADUniRule annotation2 Publications1
Binding sitei130Substrate 11
Binding sitei146Substrate 21
Binding sitei152Substrate 21
Binding sitei161NADUniRule annotation2 Publications1
Binding sitei162Substrate 21
Binding sitei190NADUniRule annotation2 Publications1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi194Zinc; catalyticUniRule annotation2 Publications1
Binding sitei250Substrate 21
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei260Proton acceptor; for 3-dehydroquinate synthase activity1
Metal bindingi271Zinc; catalyticUniRule annotation2 Publications1
Binding sitei271Substrate 21
Active sitei275Proton acceptor; for 3-dehydroquinate synthase activity1
Metal bindingi287Zinc; catalyticUniRule annotation2 Publications1
Binding sitei287Substrate 21
Binding sitei356Substrate 21
Active sitei824For EPSP synthase activityUniRule annotation1
Active sitei1179Proton acceptor; for 3-dehydroquinate dehydratase activityUniRule annotation1
Active sitei1207Schiff-base intermediate with substrate; for 3-dehydroquinate dehydratase activityUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi44 – 46NADUniRule annotation2 Publications3
Nucleotide bindingi81 – 84NADUniRule annotation2 Publications4
Nucleotide bindingi114 – 116NADUniRule annotation2 Publications3
Nucleotide bindingi139 – 140NADUniRule annotation2 Publications2
Nucleotide bindingi179 – 182NADUniRule annotation2 Publications4
Nucleotide bindingi870 – 877ATPUniRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Lyase, Multifunctional enzyme, Oxidoreductase, Transferase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis
LigandATP-binding, Metal-binding, NADP, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.1.1.25, 517
4.2.3.4, 517

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P07547

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00053;UER00085
UPA00053;UER00086
UPA00053;UER00087
UPA00053;UER00088
UPA00053;UER00089

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pentafunctional AROM polypeptideUniRule annotation
Including the following 5 domains:
3-dehydroquinate synthaseUniRule annotation (EC:4.2.3.4UniRule annotation)
Short name:
DHQSUniRule annotation
3-phosphoshikimate 1-carboxyvinyltransferaseUniRule annotation (EC:2.5.1.19UniRule annotation)
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthaseUniRule annotation
Short name:
EPSP synthaseUniRule annotation
Short name:
EPSPSUniRule annotation
Shikimate kinaseUniRule annotation (EC:2.7.1.71UniRule annotation)
Short name:
SKUniRule annotation
3-dehydroquinate dehydrataseUniRule annotation (EC:4.2.1.10UniRule annotation)
Short name:
3-dehydroquinaseUniRule annotation
Shikimate dehydrogenaseUniRule annotation (EC:1.1.1.25UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:aromA
Synonyms:aroA, aroM
ORF Names:AN0708
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri227321 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillusAspergillus subgen. Nidulantes
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000560 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VIII
  • UP000005890 Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001408591 – 1583Pentafunctional AROM polypeptideAdd BLAST1583

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

UniRule annotation2 Publications

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
162425.CADANIAP00001961

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11583
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P07547

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P07547

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 3843-dehydroquinate synthaseAdd BLAST384
Regioni194 – 197Substrate binding 24
Regioni264 – 268Substrate binding 25
Regioni397 – 842EPSP synthaseAdd BLAST446
Regioni863 – 1055Shikimate kinaseAdd BLAST193
Regioni1056 – 12763-dehydroquinaseAdd BLAST221
Regioni1289 – 1583Shikimate dehydrogenaseAdd BLAST295

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.UniRule annotation
In the 2nd section; belongs to the EPSP synthase family.UniRule annotation
In the 3rd section; belongs to the shikimate kinase family.UniRule annotation
In the 4th section; belongs to the type-I 3-dehydroquinase family.UniRule annotation
In the C-terminal section; belongs to the shikimate dehydrogenase family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0692, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001201_0_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P07547

Identification of Orthologs from Complete Genome Data

More...
OMAi
LMFNMAL

Database of Orthologous Groups

More...
OrthoDBi
39786at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00502, DHQase_I, 1 hit
cd01556, EPSP_synthase, 1 hit
cd00464, SK, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.70, 1 hit
3.65.10.10, 2 hits

HAMAP database of protein families

More...
HAMAPi
MF_00210, EPSP_synth, 1 hit
MF_03143, Pentafunct_AroM, 1 hit
MF_00109, Shikimate_kinase, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018508, 3-dehydroquinate_DH_AS
IPR013785, Aldolase_TIM
IPR016037, DHQ_synth_AroB
IPR030960, DHQS/DOIS
IPR001381, DHquinase_I
IPR001986, Enolpyruvate_Tfrase_dom
IPR036968, Enolpyruvate_Tfrase_sf
IPR006264, EPSP_synthase
IPR023193, EPSP_synthase_CS
IPR036291, NAD(P)-bd_dom_sf
IPR027417, P-loop_NTPase
IPR008289, Pentafunct_AroM
IPR013792, RNA3'P_cycl/enolpyr_Trfase_a/b
IPR041121, SDH_C
IPR031322, Shikimate/glucono_kinase
IPR013708, Shikimate_DH-bd_N
IPR010110, Shikimate_DH_AroM-type
IPR000623, Shikimate_kinase/TSH1
IPR023000, Shikimate_kinase_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01761, DHQ_synthase, 1 hit
PF01487, DHquinase_I, 1 hit
PF00275, EPSP_synthase, 1 hit
PF18317, SDH_C, 1 hit
PF08501, Shikimate_dh_N, 1 hit
PF01202, SKI, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000514, Pentafunct_AroM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735, SSF51735, 1 hit
SSF52540, SSF52540, 1 hit
SSF55205, SSF55205, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01356, aroA, 1 hit
TIGR01357, aroB, 1 hit
TIGR01093, aroD, 1 hit
TIGR01809, Shik-DH-AROM, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01028, DEHYDROQUINASE_I, 1 hit
PS00104, EPSP_SYNTHASE_1, 1 hit
PS00885, EPSP_SYNTHASE_2, 1 hit
PS01128, SHIKIMATE_KINASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P07547-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNPTKISIL GRESIIADFG LWRNYVAKDL ISDCSSTTYV LVTDTNIGSI
60 70 80 90 100
YTPSFEEAFR KAAAEITPSP RLLIYNAPPG EVSKSRQTKA DIEDWMLSQN
110 120 130 140 150
PPCGRDTVVI ALGGGVIGDL TGFVASTYMR GVRYVQVPTT LLAMVDSSIG
160 170 180 190 200
GKTAIDTPLG KNLIGAIWQP TKIYIDLEFL ETLPVREFIN GMAEVIKTAA
210 220 230 240 250
ISSEEEFTAL EENAETILKA VRREVRPGEH RFEGIEEILK ARILASARHK
260 270 280 290 300
AYVVSADERE GGLRNLLNWG HSIGHAIEAI LTPQILHGEC VAIGMVKEAE
310 320 330 340 350
LARHLGILKG VAVSRIVKCL AAYGLPTSLK DARIRKLTAG KHCSVDQLMF
360 370 380 390 400
NMALDKKNDG PKKKIVLLSA IGTPYETRAS VVANEDIRVV LAPSIEVHPG
410 420 430 440 450
VAQSSNVICA PPGSKSISNR ALVLAALGSG TCRIKNLLHS DDTEVMLNAL
460 470 480 490 500
ERLGAATFSW EEEGEVLVVN GKGGNLQASS SPLYLGNAGT ASRFLTTVAT
510 520 530 540 550
LANSSTVDSS VLTGNNRMKQ RPIGDLVDAL TANGASIEYV ERTGSLPLKI
560 570 580 590 600
AASGGFAGGN INLAAKVSSQ YVSSLLMCAP YAKEPVTLRL VGGKPISQPY
610 620 630 640 650
IDMTTAMMRS FGIDVQKSTT EEHTYHIPQG RYVNPAEYVI ESDASSATYP
660 670 680 690 700
LAVAAVTGTT CTVPNIGSAS LQGDARFAVE VLRPMGCTVE QTETSTTVTG
710 720 730 740 750
PSDGILRPLP NVDMEPMTDA FLGASVLAAI ARGKESNHTT RIYGIANQRV
760 770 780 790 800
KECNRIKAMK DELAKFGVIC REHDDGLEID GIDRSNLRQP VGGVFCYDDH
810 820 830 840 850
RVAFSFSVLS LVTPQPTLIL EKECVGKTWP GWWDTLRQLF KVKLEGKELE
860 870 880 890 900
EEPVAASGPD RANASIYIIG MRGAGKSTAG NWVSKALNRP FVDLDTELET
910 920 930 940 950
VEGMTIPDII KTRGWQGFRN AELEILKRTL KERSRGYVFA CGGGVVEMPE
960 970 980 990 1000
ARKLLTDYHK TKGNVLLLMR DIKKIMDFLS IDKTRPAYVE DMMGVWLRRK
1010 1020 1030 1040 1050
PWFQECSNIQ YYSRDASPSG LARASEDFNR FLQVATGQID SLSIIKEKEH
1060 1070 1080 1090 1100
SFFASLTLPD LREAGDILEE VCVGSDAVEL RVDLLKDPAS NNDIPSVDYV
1110 1120 1130 1140 1150
VEQLSFLRSR VTLPIIFTIR TQSQGGRFPD NAHDAALELY RLAFRSGCEF
1160 1170 1180 1190 1200
VDLEIAFPED MLRAVTEMKG FSKIIASHHD PKGELSWANM SWIKFYNKAL
1210 1220 1230 1240 1250
EYGDIIKLVG VARNIDDNTA LRKFKNWAAE AHDVPLIAIN MGDQGQLSRI
1260 1270 1280 1290 1300
LNGFMTPVSH PSLPFKAAPG QLSATEIRKG LSLMGEIKPK KFAIFGSPIS
1310 1320 1330 1340 1350
QSRSPALHNT LFAQVGLPHN YTRLETTNAQ DVQEFIRSPD FGGASVTIPL
1360 1370 1380 1390 1400
KLDIMPLLDE VAAEAEIIGA VNTIIPVSTG KNTPSRLVGR NTDWQGMILS
1410 1420 1430 1440 1450
LRKAGVYGPK RKDQEQSALV VGGGGTARAA IYALHNMGYS PIYIVGRTPS
1460 1470 1480 1490 1500
KLENMVSTFP SSYNIRIVES PSSFESVPHV AIGTIPADQP IDPTMRETLC
1510 1520 1530 1540 1550
HMFERAQEAD AEAVKAIEHA PRILLEMAYK PQVTALMRLA SDSGWKTIPG
1560 1570 1580
LEVLVGQGWY QFKYWTGISP LYESARACSS PLI
Length:1,583
Mass (Da):172,664
Last modified:May 26, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFBC8610B961840D8
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA28836 differs from that shown. Reason: Frameshift.Curated
The sequence CAA28836 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAA65484 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti62A → R in CAA28836 (PubMed:3515316).Curated1
Sequence conflicti77A → R in CAA28836 (PubMed:3515316).Curated1
Sequence conflicti226R → T in CAA28836 (PubMed:3515316).Curated1
Sequence conflicti235I → T in CAA28836 (PubMed:3515316).Curated1
Sequence conflicti403Q → H in CAA28836 (PubMed:3515316).Curated1
Sequence conflicti535A → P in CAA28836 (PubMed:3515316).Curated1
Sequence conflicti646S → C in CAA28836 (PubMed:3515316).Curated1
Sequence conflicti862A → G in CAA28836 (PubMed:3515316).Curated1
Sequence conflicti862A → G no nucleotide entry (PubMed:3906567).Curated1
Sequence conflicti984T → S in CAA28836 (PubMed:3515316).Curated1
Sequence conflicti984T → S no nucleotide entry (PubMed:3906567).Curated1
Sequence conflicti1048K → G no nucleotide entry (PubMed:3906567).Curated1
Sequence conflicti1093D → N no nucleotide entry (PubMed:3906567).Curated1
Sequence conflicti1154E → D in CAA28836 (PubMed:3515316).Curated1
Sequence conflicti1154E → D no nucleotide entry (PubMed:3906567).Curated1
Sequence conflicti1345 – 1349SVTIP → FRNNS in CAA28836 (PubMed:3515316).Curated5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X05204 Genomic DNA Translation: CAA28836.1 Sequence problems.
AACD01000010 Genomic DNA Translation: EAA65484.1 Sequence problems.
AACD01000011 Genomic DNA No translation available.
BN001308 Genomic DNA Translation: CBF88944.1

Protein sequence database of the Protein Information Resource

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PIRi
A24962, BVASA1

NCBI Reference Sequences

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RefSeqi
XP_658312.1, XM_653220.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EAA65484; EAA65484; AN0708.2

Database of genes from NCBI RefSeq genomes

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GeneIDi
2876485

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ani:AN0708.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05204 Genomic DNA Translation: CAA28836.1 Sequence problems.
AACD01000010 Genomic DNA Translation: EAA65484.1 Sequence problems.
AACD01000011 Genomic DNA No translation available.
BN001308 Genomic DNA Translation: CBF88944.1
PIRiA24962, BVASA1
RefSeqiXP_658312.1, XM_653220.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DQSX-ray1.80A/B1-393[»]
1NR5X-ray2.10A/B1-393[»]
1NRXX-ray2.90A/B1-393[»]
1NUAX-ray2.85A/B1-393[»]
1NVAX-ray2.62A/B1-393[»]
1NVBX-ray2.70A/B1-393[»]
1NVDX-ray2.51A/B1-393[»]
1NVEX-ray2.58A/B/C/D1-393[»]
1NVFX-ray2.80A/B/C1-393[»]
1SG6X-ray1.70A/B1-393[»]
SMRiP07547
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi162425.CADANIAP00001961

Genome annotation databases

EnsemblFungiiEAA65484; EAA65484; AN0708.2
GeneIDi2876485
KEGGiani:AN0708.2

Phylogenomic databases

eggNOGiKOG0692, Eukaryota
HOGENOMiCLU_001201_0_2_1
InParanoidiP07547
OMAiLMFNMAL
OrthoDBi39786at2759

Enzyme and pathway databases

UniPathwayiUPA00053;UER00085
UPA00053;UER00086
UPA00053;UER00087
UPA00053;UER00088
UPA00053;UER00089
BRENDAi1.1.1.25, 517
4.2.3.4, 517
SABIO-RKiP07547

Miscellaneous databases

EvolutionaryTraceiP07547

Family and domain databases

CDDicd00502, DHQase_I, 1 hit
cd01556, EPSP_synthase, 1 hit
cd00464, SK, 1 hit
Gene3Di3.20.20.70, 1 hit
3.65.10.10, 2 hits
HAMAPiMF_00210, EPSP_synth, 1 hit
MF_03143, Pentafunct_AroM, 1 hit
MF_00109, Shikimate_kinase, 1 hit
InterProiView protein in InterPro
IPR018508, 3-dehydroquinate_DH_AS
IPR013785, Aldolase_TIM
IPR016037, DHQ_synth_AroB
IPR030960, DHQS/DOIS
IPR001381, DHquinase_I
IPR001986, Enolpyruvate_Tfrase_dom
IPR036968, Enolpyruvate_Tfrase_sf
IPR006264, EPSP_synthase
IPR023193, EPSP_synthase_CS
IPR036291, NAD(P)-bd_dom_sf
IPR027417, P-loop_NTPase
IPR008289, Pentafunct_AroM
IPR013792, RNA3'P_cycl/enolpyr_Trfase_a/b
IPR041121, SDH_C
IPR031322, Shikimate/glucono_kinase
IPR013708, Shikimate_DH-bd_N
IPR010110, Shikimate_DH_AroM-type
IPR000623, Shikimate_kinase/TSH1
IPR023000, Shikimate_kinase_CS
PfamiView protein in Pfam
PF01761, DHQ_synthase, 1 hit
PF01487, DHquinase_I, 1 hit
PF00275, EPSP_synthase, 1 hit
PF18317, SDH_C, 1 hit
PF08501, Shikimate_dh_N, 1 hit
PF01202, SKI, 1 hit
PIRSFiPIRSF000514, Pentafunct_AroM, 1 hit
SUPFAMiSSF51735, SSF51735, 1 hit
SSF52540, SSF52540, 1 hit
SSF55205, SSF55205, 1 hit
TIGRFAMsiTIGR01356, aroA, 1 hit
TIGR01357, aroB, 1 hit
TIGR01093, aroD, 1 hit
TIGR01809, Shik-DH-AROM, 1 hit
PROSITEiView protein in PROSITE
PS01028, DEHYDROQUINASE_I, 1 hit
PS00104, EPSP_SYNTHASE_1, 1 hit
PS00885, EPSP_SYNTHASE_2, 1 hit
PS01128, SHIKIMATE_KINASE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARO1_EMENI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07547
Secondary accession number(s): C8VRD2, Q5BFH2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: May 26, 2009
Last modified: June 2, 2021
This is version 181 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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