UniProtKB - P07538 (GP13_BPPZA)
Protein
Morphogenesis protein 1
Gene
13
Organism
Bacillus phage PZA (Bacteriophage PZA)
Status
Functioni
May serve as a plug to restrain the highly pressurized packaged genome and thus would be the first virion protein to contact the host cell wall, degrading the peptidoglycan layer and thereby facilitating viral genome entry into the host bacteria. Acts probably as a multifunctional enzyme that degrades N-acetylglucosamine polymers (in vitro) and cleaves the peptide cross-links of the host cell wall. Essential for the tail assembly.By similarity
Cofactori
Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 45 | For lysozyme-like glycosidase activityBy similarity | 1 | |
Binding sitei | 45 | SubstrateBy similarity | 1 | |
Binding sitei | 71 | SubstrateBy similarity | 1 | |
Binding sitei | 106 | SubstrateBy similarity | 1 | |
Metal bindingi | 188 | ZincBy similarity | 1 | |
Metal bindingi | 195 | ZincBy similarity | 1 | |
Metal bindingi | 280 | ZincBy similarity | 1 |
GO - Molecular functioni
- hydrolase activity, acting on glycosyl bonds Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- metallopeptidase activity Source: UniProtKB-KW
GO - Biological processi
- cell wall organization Source: UniProtKB-KW
- cytolysis Source: UniProtKB-KW
- defense response to bacterium Source: UniProtKB-KW
- disruption by virus of host cell wall peptidoglycan during virus entry Source: UniProtKB-KW
- viral tail assembly Source: UniProtKB-KW
Keywordsi
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:13 |
Organismi | Bacillus phage PZA (Bacteriophage PZA) |
Taxonomic identifieri | 10757 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Uroviricota › Caudoviricetes › Caudovirales › Podoviridae › Picovirinae › Salasvirus › |
Virus hosti | Bacillus subtilis [TaxID: 1423] |
Proteomesi |
|
Subcellular locationi
- Virion By similarity Note: Located at the distal tip of the tail knob.By similarity
Keywords - Cellular componenti
VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000106596 | 1 – 365 | Morphogenesis protein 1Add BLAST | 365 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 159 | Lysozyme-like glycosidaseBy similarityAdd BLAST | 159 | |
Regioni | 137 – 140 | Substrate-bindingBy similarity | 4 | |
Regioni | 160 – 165 | LinkerBy similarity | 6 | |
Regioni | 166 – 365 | Probable metalloendopeptidaseBy similarityAdd BLAST | 200 |
Sequence similaritiesi
In the N-terminal section; belongs to the glycosyl hydrolase 24 family.Curated
In the C-terminal section; belongs to the peptidase M23B family.Curated
Family and domain databases
Gene3Di | 2.70.70.10, 1 hit |
InterProi | View protein in InterPro IPR011055, Dup_hybrid_motif IPR041219, Phage_lysozyme2 |
Pfami | View protein in Pfam PF18013, Phage_lysozyme2, 1 hit |
SUPFAMi | SSF51261, SSF51261, 1 hit |
i Sequence
Sequence statusi: Complete.
P07538-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVYVSNKYLT MSEMKVNAQY ILNYLSNNGW TKQAICGMLG NMQSESTINP
60 70 80 90 100
GLWQNLDEGN TSLGFGLVQW TPASNYINWA NNQGIPYKNM DSELKRIIWE
110 120 130 140 150
VNNNAQWNNL RDMTFKEYIK STKTPRELAM IFLASYERPA NPNQPVRGDQ
160 170 180 190 200
AEYWYKNLSG GGGGGLQLAQ FPMDIINITQ GENGSFSHKG TLCIDFVGKT
210 220 230 240 250
EKYPYYAPCD CTCVWRGDAS AYLAWTSDKE VMCADGSVRY ITWVNVHESP
260 270 280 290 300
LPFDVGKKLK KGDLMGHTGI GGNVTGDHWH FNVIDGKEYQ GWTKKPDSCL
310 320 330 340 350
AGTELHIYDV FAVNNVEIIN GNGYDWKTSD WQDGDGGDGG DDNENNKTKD
360
LITLLLSDAL HGWKA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M11813 Genomic DNA Translation: AAA88490.1 |
PIRi | H24831, WMBP13 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M11813 Genomic DNA Translation: AAA88490.1 |
PIRi | H24831, WMBP13 |
3D structure databases
SMRi | P07538 |
ModBasei | Search... |
Family and domain databases
Gene3Di | 2.70.70.10, 1 hit |
InterProi | View protein in InterPro IPR011055, Dup_hybrid_motif IPR041219, Phage_lysozyme2 |
Pfami | View protein in Pfam PF18013, Phage_lysozyme2, 1 hit |
SUPFAMi | SSF51261, SSF51261, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GP13_BPPZA | |
Accessioni | P07538Primary (citable) accession number: P07538 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1988 |
Last sequence update: | April 1, 1988 | |
Last modified: | April 7, 2021 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Documents
- Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families