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Protein

Kappa-casein

Gene

CSN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.

GO - Biological processi

  • lactation Source: UniProtKB
  • protein stabilization Source: UniProtKB
  • transmembrane transport Source: Reactome

Keywordsi

Molecular functionMilk protein

Enzyme and pathway databases

ReactomeiR-HSA-5223345 Miscellaneous transport and binding events

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-casein
Gene namesi
Name:CSN3
Synonyms:CASK, CSN10, CSNK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000171209.3
HGNCiHGNC:2446 CSN3
MIMi601695 gene
neXtProtiNX_P07498

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1448
OpenTargetsiENSG00000171209
PharmGKBiPA26949

Protein family/group databases

Allergomei1064 Hom s 8

Chemistry databases

ChEMBLiCHEMBL3621024

Polymorphism and mutation databases

BioMutaiCSN3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000000449821 – 182Kappa-caseinAdd BLAST162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi133O-linked (GalNAc...) threonine1 Publication1
Glycosylationi143O-linked (GalNAc...) threonine1 Publication1
Glycosylationi148O-linked (GalNAc...) threonine1 Publication1
Glycosylationi151O-linked (GalNAc...) threonine1 Publication1
Modified residuei157Phosphothreonine; alternateBy similarity1
Glycosylationi157O-linked (GalNAc...) threonine; alternate1 Publication1
Glycosylationi167O-linked (GalNAc...) threonine1 Publication1
Glycosylationi169O-linked (GalNAc...) threonine1 Publication1
Glycosylationi178O-linked (GalNAc...) threonineBy similarity1

Post-translational modificationi

The N-terminus is blocked.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei117 – 118Cleavage; by chymosin/rennin2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP07498
PeptideAtlasiP07498
PRIDEiP07498
ProteomicsDBi52011
TopDownProteomicsiP07498

PTM databases

GlyConnecti308
iPTMnetiP07498
PhosphoSitePlusiP07498
SwissPalmiP07498
UniCarbKBiP07498

Miscellaneous databases

PMAP-CutDBiP07498

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Gene expression databases

BgeeiENSG00000171209 Expressed in 38 organ(s), highest expression level in minor salivary gland
CleanExiHS_CASK
HS_CSN3
GenevisibleiP07498 HS

Organism-specific databases

HPAiHPA035953
HPA035954

Interactioni

Subunit structurei

Heteromultimers composed of alpha-s1 casein and kappa casein linked by disulfide bonds.

Binary interactionsi

WithEntry#Exp.IntActNotes
RBPMSQ930623EBI-2602175,EBI-740322

Protein-protein interaction databases

BioGridi107835, 8 interactors
IntActiP07498, 7 interactors
MINTiP07498
STRINGi9606.ENSP00000304822

Structurei

3D structure databases

ProteinModelPortaliP07498
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the kappa-casein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCVG Eukaryota
ENOG4111E7Q LUCA
GeneTreeiENSGT00390000009184
HOGENOMiHOG000111309
HOVERGENiHBG005246
InParanoidiP07498
KOiK17282
OMAiRPHAQIP
OrthoDBiEOG091G105X
PhylomeDBiP07498
TreeFamiTF338369

Family and domain databases

InterProiView protein in InterPro
IPR000117 Casein_kappa
PANTHERiPTHR11470 PTHR11470, 1 hit
PfamiView protein in Pfam
PF00997 Casein_kappa, 1 hit
PIRSFiPIRSF002374 Casein_kappa, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07498-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSFLLVVNA LALTLPFLAV EVQNQKQPAC HENDERPFYQ KTAPYVPMYY
60 70 80 90 100
VPNSYPYYGT NLYQRRPAIA INNPYVPRTY YANPAVVRPH AQIPQRQYLP
110 120 130 140 150
NSHPPTVVRR PNLHPSFIAI PPKKIQDKII IPTINTIATV EPTPAPATEP
160 170 180
TVDSVVTPEA FSESIITSTP ETTTVAVTPP TA
Length:182
Mass (Da):20,305
Last modified:October 1, 1996 - v3
Checksum:i8A1609D2D5C94895
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25 – 27QKQ → EQK AA sequence (PubMed:4018271).Curated3
Sequence conflicti153D → N AA sequence (PubMed:4018271).Curated1
Sequence conflicti161F → T AA sequence (PubMed:7460900).Curated1
Sequence conflicti162S → T AA sequence (PubMed:4018271).Curated1
Sequence conflicti162S → T AA sequence (PubMed:7460900).Curated1
Sequence conflicti173T → P AA sequence (PubMed:4018271).Curated1
Sequence conflicti173T → P AA sequence (PubMed:7460900).Curated1
Sequence conflicti178 – 181TPPT → PTTS AA sequence (PubMed:4018271).Curated4
Sequence conflicti178 – 181TPPT → PTTS AA sequence (PubMed:7460900).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02633875Y → C1 PublicationCorresponds to variant dbSNP:rs17850702Ensembl.1
Natural variantiVAR_026339110R → L1 PublicationCorresponds to variant dbSNP:rs1048152Ensembl.1
Natural variantiVAR_026340145A → T1 PublicationCorresponds to variant dbSNP:rs3775739Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73628 mRNA Translation: AAA59456.1
X66417 mRNA Translation: CAA47048.1
U51899 Genomic DNA Translation: AAC50772.1
BC010935 mRNA Translation: AAH10935.1
CCDSiCCDS3538.1
PIRiJC4957 KKHU
RefSeqiNP_005203.2, NM_005212.2
XP_011529922.1, XM_011531620.2
XP_016863250.1, XM_017007761.1
UniGeneiHs.54415

Genome annotation databases

EnsembliENST00000304954; ENSP00000304822; ENSG00000171209
GeneIDi1448
KEGGihsa:1448
UCSCiuc003hfe.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Protein Spotlight

Of buttons, digestion and glue - Issue 16 of November 2001

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73628 mRNA Translation: AAA59456.1
X66417 mRNA Translation: CAA47048.1
U51899 Genomic DNA Translation: AAC50772.1
BC010935 mRNA Translation: AAH10935.1
CCDSiCCDS3538.1
PIRiJC4957 KKHU
RefSeqiNP_005203.2, NM_005212.2
XP_011529922.1, XM_011531620.2
XP_016863250.1, XM_017007761.1
UniGeneiHs.54415

3D structure databases

ProteinModelPortaliP07498
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107835, 8 interactors
IntActiP07498, 7 interactors
MINTiP07498
STRINGi9606.ENSP00000304822

Chemistry databases

ChEMBLiCHEMBL3621024

Protein family/group databases

Allergomei1064 Hom s 8

PTM databases

GlyConnecti308
iPTMnetiP07498
PhosphoSitePlusiP07498
SwissPalmiP07498
UniCarbKBiP07498

Polymorphism and mutation databases

BioMutaiCSN3

Proteomic databases

PaxDbiP07498
PeptideAtlasiP07498
PRIDEiP07498
ProteomicsDBi52011
TopDownProteomicsiP07498

Protocols and materials databases

DNASUi1448
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304954; ENSP00000304822; ENSG00000171209
GeneIDi1448
KEGGihsa:1448
UCSCiuc003hfe.5 human

Organism-specific databases

CTDi1448
DisGeNETi1448
EuPathDBiHostDB:ENSG00000171209.3
GeneCardsiCSN3
HGNCiHGNC:2446 CSN3
HPAiHPA035953
HPA035954
MIMi601695 gene
neXtProtiNX_P07498
OpenTargetsiENSG00000171209
PharmGKBiPA26949
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JCVG Eukaryota
ENOG4111E7Q LUCA
GeneTreeiENSGT00390000009184
HOGENOMiHOG000111309
HOVERGENiHBG005246
InParanoidiP07498
KOiK17282
OMAiRPHAQIP
OrthoDBiEOG091G105X
PhylomeDBiP07498
TreeFamiTF338369

Enzyme and pathway databases

ReactomeiR-HSA-5223345 Miscellaneous transport and binding events

Miscellaneous databases

GeneWikiiCSN3_(gene)
GenomeRNAii1448
PMAP-CutDBiP07498
PROiPR:P07498
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171209 Expressed in 38 organ(s), highest expression level in minor salivary gland
CleanExiHS_CASK
HS_CSN3
GenevisibleiP07498 HS

Family and domain databases

InterProiView protein in InterPro
IPR000117 Casein_kappa
PANTHERiPTHR11470 PTHR11470, 1 hit
PfamiView protein in Pfam
PF00997 Casein_kappa, 1 hit
PIRSFiPIRSF002374 Casein_kappa, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCASK_HUMAN
AccessioniPrimary (citable) accession number: P07498
Secondary accession number(s): Q13575
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 178 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
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Main funding by: National Institutes of Health

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