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Protein

Gastrin-releasing peptide

Gene

GRP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity).By similarity

GO - Molecular functioni

  • neuropeptide hormone activity Source: MGI
  • signaling receptor binding Source: ProtInc

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
R-HSA-416476 G alpha (q) signalling events
SIGNORiP07492

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrin-releasing peptide
Short name:
GRP
Cleaved into the following chain:
Alternative name(s):
GRP-10
Gene namesi
Name:GRP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000134443.9
HGNCiHGNC:4605 GRP
MIMi137260 gene
neXtProtiNX_P07492

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2922
OpenTargetsiENSG00000134443
PharmGKBiPA28999

Polymorphism and mutation databases

BioMutaiGRP
DMDMi308153451

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Add BLAST23
PeptideiPRO_000000303524 – 50Gastrin-releasing peptideAdd BLAST27
PeptideiPRO_000000303641 – 50Neuromedin-C10
PropeptideiPRO_000000303754 – 148Add BLAST95

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei50Methionine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP07492
PeptideAtlasiP07492
PRIDEiP07492
ProteomicsDBi52008
52009 [P07492-2]
52010 [P07492-3]

PTM databases

iPTMnetiP07492
PhosphoSitePlusiP07492

Expressioni

Gene expression databases

BgeeiENSG00000134443 Expressed in 110 organ(s), highest expression level in lung
CleanExiHS_GRP
ExpressionAtlasiP07492 baseline and differential
GenevisibleiP07492 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109179, 13 interactors
IntActiP07492, 1 interactor
STRINGi9606.ENSP00000256857

Structurei

Secondary structure

1148
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP07492
SMRiP07492
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZ53 Eukaryota
ENOG4111D8H LUCA
GeneTreeiENSGT00390000017865
HOGENOMiHOG000112821
HOVERGENiHBG005912
InParanoidiP07492
KOiK05224
OMAiLTKMYPR
OrthoDBiEOG091G0VOZ
PhylomeDBiP07492
TreeFamiTF336391

Family and domain databases

InterProiView protein in InterPro
IPR000874 Bombesin
IPR015674 Gastrin-RP
PANTHERiPTHR16866:SF2 PTHR16866:SF2, 1 hit
PfamiView protein in Pfam
PF02044 Bombesin, 1 hit
PROSITEiView protein in PROSITE
PS00257 BOMBESIN, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P07492-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRGRELPLVL LALVLCLAPR GRAVPLPAGG GTVLTKMYPR GNHWAVGHLM
60 70 80 90 100
GKKSTGESSS VSERGSLKQQ LREYIRWEEA ARNLLGLIEA KENRNHQPPQ
110 120 130 140
PKALGNQQPS WDSEDSSNFK DVGSKGKVGR LSAPGSQREG RNPQLNQQ
Length:148
Mass (Da):16,213
Last modified:October 5, 2010 - v2
Checksum:i6A9ED9E2748255BD
GO
Isoform 2 (identifier: P07492-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-148: VGSKGKVGRLSAPGSQREGRNPQLNQQ → LVDSLLQVLNVKEGTPS

Show »
Length:138
Mass (Da):15,176
Checksum:iEDBB3BCB301A2FDD
GO
Isoform 3 (identifier: P07492-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     128-134: Missing.

Show »
Length:141
Mass (Da):15,533
Checksum:iE2564E75ADAFCFCD
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y5C5H0Y5C5_HUMAN
Gastrin-releasing peptide
GRP
96Annotation score:
H0YCH3H0YCH3_HUMAN
Gastrin-releasing peptide
GRP
35Annotation score:

Sequence cautioni

The sequence AAA52612 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0278344R → S1 PublicationCorresponds to variant dbSNP:rs1062557Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000549122 – 148VGSKG…QLNQQ → LVDSLLQVLNVKEGTPS in isoform 2. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_000550128 – 134Missing in isoform 3. Curated7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02054 mRNA Translation: AAA52613.1
M12550 mRNA No translation available.
M12512, M12511 Genomic DNA Translation: AAA52612.1 Sequence problems.
M12512, M12511 Genomic DNA Translation: AAA52611.1
BT006803 mRNA Translation: AAP35449.1
AC067859 Genomic DNA No translation available.
CH471096 Genomic DNA Translation: EAW63091.1
BC004488 mRNA Translation: AAH04488.1
CCDSiCCDS11971.1 [P07492-1]
CCDS45877.1 [P07492-3]
CCDS45878.1 [P07492-2]
PIRiA26182
B26182
RefSeqiNP_001012530.1, NM_001012512.2 [P07492-3]
NP_001012531.1, NM_001012513.2 [P07492-2]
NP_002082.2, NM_002091.4 [P07492-1]
UniGeneiHs.153444

Genome annotation databases

EnsembliENST00000256857; ENSP00000256857; ENSG00000134443 [P07492-1]
ENST00000420468; ENSP00000389696; ENSG00000134443 [P07492-3]
ENST00000529320; ENSP00000434101; ENSG00000134443 [P07492-2]
GeneIDi2922
KEGGihsa:2922
UCSCiuc002lhu.4 human [P07492-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Gastrin-releasing peptide entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02054 mRNA Translation: AAA52613.1
M12550 mRNA No translation available.
M12512, M12511 Genomic DNA Translation: AAA52612.1 Sequence problems.
M12512, M12511 Genomic DNA Translation: AAA52611.1
BT006803 mRNA Translation: AAP35449.1
AC067859 Genomic DNA No translation available.
CH471096 Genomic DNA Translation: EAW63091.1
BC004488 mRNA Translation: AAH04488.1
CCDSiCCDS11971.1 [P07492-1]
CCDS45877.1 [P07492-3]
CCDS45878.1 [P07492-2]
PIRiA26182
B26182
RefSeqiNP_001012530.1, NM_001012512.2 [P07492-3]
NP_001012531.1, NM_001012513.2 [P07492-2]
NP_002082.2, NM_002091.4 [P07492-1]
UniGeneiHs.153444

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N0BNMR-A41-50[»]
2N0CNMR-A41-50[»]
2N0DNMR-A41-50[»]
2N0ENMR-A41-50[»]
2N0FNMR-A41-50[»]
2N0GNMR-A41-50[»]
2N0HNMR-A41-50[»]
ProteinModelPortaliP07492
SMRiP07492
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109179, 13 interactors
IntActiP07492, 1 interactor
STRINGi9606.ENSP00000256857

PTM databases

iPTMnetiP07492
PhosphoSitePlusiP07492

Polymorphism and mutation databases

BioMutaiGRP
DMDMi308153451

Proteomic databases

PaxDbiP07492
PeptideAtlasiP07492
PRIDEiP07492
ProteomicsDBi52008
52009 [P07492-2]
52010 [P07492-3]

Protocols and materials databases

DNASUi2922
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256857; ENSP00000256857; ENSG00000134443 [P07492-1]
ENST00000420468; ENSP00000389696; ENSG00000134443 [P07492-3]
ENST00000529320; ENSP00000434101; ENSG00000134443 [P07492-2]
GeneIDi2922
KEGGihsa:2922
UCSCiuc002lhu.4 human [P07492-1]

Organism-specific databases

CTDi2922
DisGeNETi2922
EuPathDBiHostDB:ENSG00000134443.9
GeneCardsiGRP
HGNCiHGNC:4605 GRP
MIMi137260 gene
neXtProtiNX_P07492
OpenTargetsiENSG00000134443
PharmGKBiPA28999
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZ53 Eukaryota
ENOG4111D8H LUCA
GeneTreeiENSGT00390000017865
HOGENOMiHOG000112821
HOVERGENiHBG005912
InParanoidiP07492
KOiK05224
OMAiLTKMYPR
OrthoDBiEOG091G0VOZ
PhylomeDBiP07492
TreeFamiTF336391

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
R-HSA-416476 G alpha (q) signalling events
SIGNORiP07492

Miscellaneous databases

GeneWikiiGastrin-releasing_peptide
GenomeRNAii2922
PROiPR:P07492
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134443 Expressed in 110 organ(s), highest expression level in lung
CleanExiHS_GRP
ExpressionAtlasiP07492 baseline and differential
GenevisibleiP07492 HS

Family and domain databases

InterProiView protein in InterPro
IPR000874 Bombesin
IPR015674 Gastrin-RP
PANTHERiPTHR16866:SF2 PTHR16866:SF2, 1 hit
PfamiView protein in Pfam
PF02044 Bombesin, 1 hit
PROSITEiView protein in PROSITE
PS00257 BOMBESIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGRP_HUMAN
AccessioniPrimary (citable) accession number: P07492
Secondary accession number(s): P07491
, P81553, Q14454, Q53YA0, Q9BSY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: October 5, 2010
Last modified: November 7, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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