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Protein

Involucrin

Gene

IVL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.

GO - Molecular functioni

  • protein binding, bridging Source: UniProtKB
  • structural molecule activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processKeratinization

Enzyme and pathway databases

ReactomeiR-HSA-6809371 Formation of the cornified envelope
SIGNORiP07476

Names & Taxonomyi

Protein namesi
Recommended name:
Involucrin
Gene namesi
Name:IVL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000163207.6
HGNCiHGNC:6187 IVL
MIMi147360 gene
neXtProtiNX_P07476

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi3713
OpenTargetsiENSG00000163207
PharmGKBiPA29985

Polymorphism and mutation databases

BioMutaiIVL
DMDMi254763301

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001597361 – 585InvolucrinAdd BLAST585

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi79Omega-hydroxyceramide glutamate ester1 Publication1
Lipidationi118Omega-hydroxyceramide glutamate ester1 Publication1
Lipidationi133Omega-hydroxyceramide glutamate ester1 Publication1
Cross-linki496Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in other proteins)

Post-translational modificationi

Substrate of transglutaminase. Some glutamines and lysines are cross-linked to other involucrin molecules, to other proteins such as keratin, desmoplakin, periplakin and envoplakin, and to lipids like omega-hydroxyceramide.

Keywords - PTMi

Isopeptide bond, Lipoprotein

Proteomic databases

EPDiP07476
MaxQBiP07476
PaxDbiP07476
PeptideAtlasiP07476
PRIDEiP07476
ProteomicsDBi52005

PTM databases

iPTMnetiP07476
PhosphoSitePlusiP07476

Expressioni

Tissue specificityi

Keratinocytes of epidermis and other stratified squamous epithelia.

Gene expression databases

BgeeiENSG00000163207 Expressed in 89 organ(s), highest expression level in ectocervix
CleanExiHS_IVL
GenevisibleiP07476 HS

Organism-specific databases

HPAiCAB002243
HPA055211

Interactioni

Subunit structurei

Directly or indirectly cross-linked to cornifelin (CNFN).

Binary interactionsi

WithEntry#Exp.IntActNotes
ACDQ96AP02EBI-11307220,EBI-717666

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109917, 40 interactors
IntActiP07476, 4 interactors
STRINGi9606.ENSP00000357753

Structurei

3D structure databases

DisProtiDP00221
ProteinModelPortaliP07476
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati153 – 162110
Repeati163 – 172210
Repeati173 – 182310
Repeati183 – 192410
Repeati193 – 202510
Repeati203 – 212610
Repeati213 – 222710
Repeati223 – 232810
Repeati233 – 242910
Repeati243 – 2521010
Repeati253 – 2621110
Repeati263 – 2721210
Repeati273 – 2821310
Repeati283 – 2921410
Repeati293 – 3021510
Repeati303 – 3121610
Repeati313 – 3221710
Repeati323 – 3321810
Repeati333 – 3421910
Repeati343 – 3522010
Repeati353 – 3622110
Repeati363 – 3722210
Repeati373 – 3822310
Repeati383 – 39224; approximate10
Repeati393 – 4022510
Repeati403 – 4122610
Repeati413 – 4222710
Repeati423 – 4322810
Repeati433 – 4422910
Repeati443 – 4523010
Repeati453 – 4623110
Repeati463 – 4723210
Repeati473 – 4823310
Repeati483 – 4923410
Repeati493 – 5023510
Repeati503 – 51236; approximate10
Repeati513 – 5223710
Repeati523 – 5323810
Repeati533 – 54239; approximate10

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni153 – 54239 X 10 AA approximate tandem repeats of [LP]-[EKG]-[LHVYQEK]-[PLSQE]-[EQDV]-[QHEKRGA]-Q-[EMVQLP]-[GKLE]-[QHVNLD]Add BLAST390

Sequence similaritiesi

Belongs to the involucrin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JDU1 Eukaryota
ENOG410Z08K LUCA
GeneTreeiENSGT00730000111623
HOVERGENiHBG006166
InParanoidiP07476
OMAiEKHMTAV
OrthoDBiEOG091G01GZ
PhylomeDBiP07476
TreeFamiTF340025

Family and domain databases

InterProiView protein in InterPro
IPR019743 Involucrin_CS
IPR019571 Involucrin_N
IPR000354 Involucrin_rpt
PfamiView protein in Pfam
PF00904 Involucrin, 40 hits
PF10583 Involucrin_N, 1 hit
PROSITEiView protein in PROSITE
PS00795 INVOLUCRIN, 1 hit

Sequencei

Sequence statusi: Complete.

P07476-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQQHTLPVT LSPALSQELL KTVPPPVNTH QEQMKQPTPL PPPCQKVPVE
60 70 80 90 100
LPVEVPSKQE EKHMTAVKGL PEQECEQQQK EPQEQELQQQ HWEQHEEYQK
110 120 130 140 150
AENPEQQLKQ EKTQRDQQLN KQLEEEKKLL DQQLDQELVK RDEQLGMKKE
160 170 180 190 200
QLLELPEQQE GHLKHLEQQE GQLKHPEQQE GQLELPEQQE GQLELPEQQE
210 220 230 240 250
GQLELPEQQE GQLELPEQQE GQLELPEQQE GQLELPQQQE GQLELSEQQE
260 270 280 290 300
GQLELSEQQE GQLKHLEHQE GQLEVPEEQM GQLKYLEQQE GQLKHLDQQE
310 320 330 340 350
KQPELPEQQM GQLKHLEQQE GQPKHLEQQE GQLEQLEEQE GQLKHLEQQE
360 370 380 390 400
GQLEHLEHQE GQLGLPEQQV LQLKQLEKQQ GQPKHLEEEE GQLKHLVQQE
410 420 430 440 450
GQLKHLVQQE GQLEQQERQV EHLEQQVGQL KHLEEQEGQL KHLEQQQGQL
460 470 480 490 500
EVPEQQVGQP KNLEQEEKQL ELPEQQEGQV KHLEKQEAQL ELPEQQVGQP
510 520 530 540 550
KHLEQQEKHL EHPEQQDGQL KHLEQQEGQL KDLEQQKGQL EQPVFAPAPG
560 570 580
QVQDIQPALP TKGEVLLPVE HQQQKQEVQW PPKHK
Length:585
Mass (Da):68,479
Last modified:July 28, 2009 - v2
Checksum:i775D2AFB90F647E8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029019113T → A. Corresponds to variant dbSNP:rs2229496Ensembl.1
Natural variantiVAR_029020166L → P. Corresponds to variant dbSNP:rs11205133Ensembl.1
Natural variantiVAR_029021174K → E. Corresponds to variant dbSNP:rs12035307Ensembl.1
Natural variantiVAR_058411227E → Q2 PublicationsCorresponds to variant dbSNP:rs11807064Ensembl.1
Natural variantiVAR_058412236P → S2 PublicationsCorresponds to variant dbSNP:rs17855670Ensembl.1
Natural variantiVAR_029022237Q → E2 PublicationsCorresponds to variant dbSNP:rs7520711Ensembl.1
Natural variantiVAR_029023312Q → K. Corresponds to variant dbSNP:rs11205137Ensembl.1
Natural variantiVAR_029024480V → L. Corresponds to variant dbSNP:rs7545520Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13903 Genomic DNA Translation: AAA59186.1
AL162596 Genomic DNA No translation available.
BC046391 mRNA Translation: AAH46391.1
CCDSiCCDS1030.1
PIRiA24168
RefSeqiNP_005538.2, NM_005547.2
UniGeneiHs.516439

Genome annotation databases

EnsembliENST00000368764; ENSP00000357753; ENSG00000163207
GeneIDi3713
KEGGihsa:3713
UCSCiuc001fau.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13903 Genomic DNA Translation: AAA59186.1
AL162596 Genomic DNA No translation available.
BC046391 mRNA Translation: AAH46391.1
CCDSiCCDS1030.1
PIRiA24168
RefSeqiNP_005538.2, NM_005547.2
UniGeneiHs.516439

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EU0model-A312-361[»]
DisProtiDP00221
ProteinModelPortaliP07476
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109917, 40 interactors
IntActiP07476, 4 interactors
STRINGi9606.ENSP00000357753

PTM databases

iPTMnetiP07476
PhosphoSitePlusiP07476

Polymorphism and mutation databases

BioMutaiIVL
DMDMi254763301

Proteomic databases

EPDiP07476
MaxQBiP07476
PaxDbiP07476
PeptideAtlasiP07476
PRIDEiP07476
ProteomicsDBi52005

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368764; ENSP00000357753; ENSG00000163207
GeneIDi3713
KEGGihsa:3713
UCSCiuc001fau.4 human

Organism-specific databases

CTDi3713
DisGeNETi3713
EuPathDBiHostDB:ENSG00000163207.6
GeneCardsiIVL
H-InvDBiHIX0023860
HGNCiHGNC:6187 IVL
HPAiCAB002243
HPA055211
MIMi147360 gene
neXtProtiNX_P07476
OpenTargetsiENSG00000163207
PharmGKBiPA29985
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JDU1 Eukaryota
ENOG410Z08K LUCA
GeneTreeiENSGT00730000111623
HOVERGENiHBG006166
InParanoidiP07476
OMAiEKHMTAV
OrthoDBiEOG091G01GZ
PhylomeDBiP07476
TreeFamiTF340025

Enzyme and pathway databases

ReactomeiR-HSA-6809371 Formation of the cornified envelope
SIGNORiP07476

Miscellaneous databases

ChiTaRSiIVL human
GeneWikiiInvolucrin
GenomeRNAii3713
PROiPR:P07476
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163207 Expressed in 89 organ(s), highest expression level in ectocervix
CleanExiHS_IVL
GenevisibleiP07476 HS

Family and domain databases

InterProiView protein in InterPro
IPR019743 Involucrin_CS
IPR019571 Involucrin_N
IPR000354 Involucrin_rpt
PfamiView protein in Pfam
PF00904 Involucrin, 40 hits
PF10583 Involucrin_N, 1 hit
PROSITEiView protein in PROSITE
PS00795 INVOLUCRIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiINVO_HUMAN
AccessioniPrimary (citable) accession number: P07476
Secondary accession number(s): Q5T7P4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: July 28, 2009
Last modified: September 12, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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