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Protein

Involucrin

Gene

IVL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein binding, bridging Source: UniProtKB
  • structural molecule activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processKeratinization

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6809371 Formation of the cornified envelope

SIGNOR Signaling Network Open Resource

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SIGNORi
P07476

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Involucrin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IVL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000163207.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6187 IVL

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
147360 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P07476

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3713

Open Targets

More...
OpenTargetsi
ENSG00000163207

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29985

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IVL

Domain mapping of disease mutations (DMDM)

More...
DMDMi
254763301

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001597361 – 585InvolucrinAdd BLAST585

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi79Omega-hydroxyceramide glutamate ester1 Publication1
Lipidationi118Omega-hydroxyceramide glutamate ester1 Publication1
Lipidationi133Omega-hydroxyceramide glutamate ester1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki496Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in other proteins)

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Substrate of transglutaminase. Some glutamines and lysines are cross-linked to other involucrin molecules, to other proteins such as keratin, desmoplakin, periplakin and envoplakin, and to lipids like omega-hydroxyceramide.

Keywords - PTMi

Isopeptide bond, Lipoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P07476

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P07476

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P07476

PeptideAtlas

More...
PeptideAtlasi
P07476

PRoteomics IDEntifications database

More...
PRIDEi
P07476

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52005

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P07476

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P07476

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Keratinocytes of epidermis and other stratified squamous epithelia.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163207 Expressed in 89 organ(s), highest expression level in ectocervix

CleanEx database of gene expression profiles

More...
CleanExi
HS_IVL

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P07476 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002243
HPA055211

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Directly or indirectly cross-linked to cornifelin (CNFN).

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ACDQ96AP02EBI-11307220,EBI-717666

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109917, 40 interactors

Protein interaction database and analysis system

More...
IntActi
P07476, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000357753

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of protein disorder

More...
DisProti
DP00221

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P07476

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati153 – 162110
Repeati163 – 172210
Repeati173 – 182310
Repeati183 – 192410
Repeati193 – 202510
Repeati203 – 212610
Repeati213 – 222710
Repeati223 – 232810
Repeati233 – 242910
Repeati243 – 2521010
Repeati253 – 2621110
Repeati263 – 2721210
Repeati273 – 2821310
Repeati283 – 2921410
Repeati293 – 3021510
Repeati303 – 3121610
Repeati313 – 3221710
Repeati323 – 3321810
Repeati333 – 3421910
Repeati343 – 3522010
Repeati353 – 3622110
Repeati363 – 3722210
Repeati373 – 3822310
Repeati383 – 39224; approximate10
Repeati393 – 4022510
Repeati403 – 4122610
Repeati413 – 4222710
Repeati423 – 4322810
Repeati433 – 4422910
Repeati443 – 4523010
Repeati453 – 4623110
Repeati463 – 4723210
Repeati473 – 4823310
Repeati483 – 4923410
Repeati493 – 5023510
Repeati503 – 51236; approximate10
Repeati513 – 5223710
Repeati523 – 5323810
Repeati533 – 54239; approximate10

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni153 – 54239 X 10 AA approximate tandem repeats of [LP]-[EKG]-[LHVYQEK]-[PLSQE]-[EQDV]-[QHEKRGA]-Q-[EMVQLP]-[GKLE]-[QHVNLD]Add BLAST390

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the involucrin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JDU1 Eukaryota
ENOG410Z08K LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164168

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006166

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P07476

Identification of Orthologs from Complete Genome Data

More...
OMAi
SHEPDMA

Database of Orthologous Groups

More...
OrthoDBi
EOG091G01GZ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P07476

TreeFam database of animal gene trees

More...
TreeFami
TF340025

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019743 Involucrin_CS
IPR019571 Involucrin_N
IPR000354 Involucrin_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00904 Involucrin, 40 hits
PF10583 Involucrin_N, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00795 INVOLUCRIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P07476-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQQHTLPVT LSPALSQELL KTVPPPVNTH QEQMKQPTPL PPPCQKVPVE
60 70 80 90 100
LPVEVPSKQE EKHMTAVKGL PEQECEQQQK EPQEQELQQQ HWEQHEEYQK
110 120 130 140 150
AENPEQQLKQ EKTQRDQQLN KQLEEEKKLL DQQLDQELVK RDEQLGMKKE
160 170 180 190 200
QLLELPEQQE GHLKHLEQQE GQLKHPEQQE GQLELPEQQE GQLELPEQQE
210 220 230 240 250
GQLELPEQQE GQLELPEQQE GQLELPEQQE GQLELPQQQE GQLELSEQQE
260 270 280 290 300
GQLELSEQQE GQLKHLEHQE GQLEVPEEQM GQLKYLEQQE GQLKHLDQQE
310 320 330 340 350
KQPELPEQQM GQLKHLEQQE GQPKHLEQQE GQLEQLEEQE GQLKHLEQQE
360 370 380 390 400
GQLEHLEHQE GQLGLPEQQV LQLKQLEKQQ GQPKHLEEEE GQLKHLVQQE
410 420 430 440 450
GQLKHLVQQE GQLEQQERQV EHLEQQVGQL KHLEEQEGQL KHLEQQQGQL
460 470 480 490 500
EVPEQQVGQP KNLEQEEKQL ELPEQQEGQV KHLEKQEAQL ELPEQQVGQP
510 520 530 540 550
KHLEQQEKHL EHPEQQDGQL KHLEQQEGQL KDLEQQKGQL EQPVFAPAPG
560 570 580
QVQDIQPALP TKGEVLLPVE HQQQKQEVQW PPKHK
Length:585
Mass (Da):68,479
Last modified:July 28, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i775D2AFB90F647E8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_029019113T → A. Corresponds to variant dbSNP:rs2229496Ensembl.1
Natural variantiVAR_029020166L → P. Corresponds to variant dbSNP:rs11205133Ensembl.1
Natural variantiVAR_029021174K → E. Corresponds to variant dbSNP:rs12035307Ensembl.1
Natural variantiVAR_058411227E → Q2 PublicationsCorresponds to variant dbSNP:rs11807064Ensembl.1
Natural variantiVAR_058412236P → S2 PublicationsCorresponds to variant dbSNP:rs17855670Ensembl.1
Natural variantiVAR_029022237Q → E2 PublicationsCorresponds to variant dbSNP:rs7520711Ensembl.1
Natural variantiVAR_029023312Q → K. Corresponds to variant dbSNP:rs11205137Ensembl.1
Natural variantiVAR_029024480V → L. Corresponds to variant dbSNP:rs7545520Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M13903 Genomic DNA Translation: AAA59186.1
AL162596 Genomic DNA No translation available.
BC046391 mRNA Translation: AAH46391.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1030.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A24168

NCBI Reference Sequences

More...
RefSeqi
NP_005538.2, NM_005547.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.516439

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000368764; ENSP00000357753; ENSG00000163207

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3713

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3713

UCSC genome browser

More...
UCSCi
uc001fau.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13903 Genomic DNA Translation: AAA59186.1
AL162596 Genomic DNA No translation available.
BC046391 mRNA Translation: AAH46391.1
CCDSiCCDS1030.1
PIRiA24168
RefSeqiNP_005538.2, NM_005547.2
UniGeneiHs.516439

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EU0model-A312-361[»]
DisProtiDP00221
ProteinModelPortaliP07476
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109917, 40 interactors
IntActiP07476, 5 interactors
STRINGi9606.ENSP00000357753

PTM databases

iPTMnetiP07476
PhosphoSitePlusiP07476

Polymorphism and mutation databases

BioMutaiIVL
DMDMi254763301

Proteomic databases

EPDiP07476
MaxQBiP07476
PaxDbiP07476
PeptideAtlasiP07476
PRIDEiP07476
ProteomicsDBi52005

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368764; ENSP00000357753; ENSG00000163207
GeneIDi3713
KEGGihsa:3713
UCSCiuc001fau.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3713
DisGeNETi3713
EuPathDBiHostDB:ENSG00000163207.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IVL

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0023860
HGNCiHGNC:6187 IVL
HPAiCAB002243
HPA055211
MIMi147360 gene
neXtProtiNX_P07476
OpenTargetsiENSG00000163207
PharmGKBiPA29985

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JDU1 Eukaryota
ENOG410Z08K LUCA
GeneTreeiENSGT00940000164168
HOVERGENiHBG006166
InParanoidiP07476
OMAiSHEPDMA
OrthoDBiEOG091G01GZ
PhylomeDBiP07476
TreeFamiTF340025

Enzyme and pathway databases

ReactomeiR-HSA-6809371 Formation of the cornified envelope
SIGNORiP07476

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IVL human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Involucrin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3713

Protein Ontology

More...
PROi
PR:P07476

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000163207 Expressed in 89 organ(s), highest expression level in ectocervix
CleanExiHS_IVL
GenevisibleiP07476 HS

Family and domain databases

InterProiView protein in InterPro
IPR019743 Involucrin_CS
IPR019571 Involucrin_N
IPR000354 Involucrin_rpt
PfamiView protein in Pfam
PF00904 Involucrin, 40 hits
PF10583 Involucrin_N, 1 hit
PROSITEiView protein in PROSITE
PS00795 INVOLUCRIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINVO_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07476
Secondary accession number(s): Q5T7P4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: July 28, 2009
Last modified: December 5, 2018
This is version 169 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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