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Protein

Cytochrome c oxidase subunit 6A2, mitochondrial

Gene

COX6A2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  • cytochrome-c oxidase activity Source: InterPro
  • enzyme regulator activity Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

BRENDAi1.9.3.1 908

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6A2, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIa-heart
Short name:
COXVIAH
Cytochrome c oxidase polypeptide VIb
Gene namesi
Name:COX6A2
Synonyms:COX6A
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Organism-specific databases

VGNCiVGNC:27637 COX6A2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini13 – 24Mitochondrial matrixAdd BLAST12
Transmembranei25 – 49HelicalAdd BLAST25
Topological domaini50 – 97Mitochondrial intermembraneAdd BLAST48

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 12Mitochondrion1 PublicationAdd BLAST12
ChainiPRO_000000611513 – 97Cytochrome c oxidase subunit 6A2, mitochondrialAdd BLAST85

Proteomic databases

PaxDbiP07471
PRIDEiP07471

Expressioni

Tissue specificityi

Heart/muscle specific isoform.

Gene expression databases

BgeeiENSBTAG00000019521 Expressed in 6 organ(s), highest expression level in heart

Interactioni

Protein-protein interaction databases

CORUMiP07471
DIPiDIP-39018N
IntActiP07471, 2 interactors
STRINGi9913.ENSBTAP00000026002

Structurei

Secondary structure

197
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP07471
SMRiP07471
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07471

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3469 Eukaryota
ENOG411253X LUCA
GeneTreeiENSGT00390000002756
HOGENOMiHOG000193965
HOVERGENiHBG060482
InParanoidiP07471
KOiK02266
OMAiREPFAKY
OrthoDBiEOG091G0C5F
TreeFamiTF105064

Family and domain databases

CDDicd00925 Cyt_c_Oxidase_VIa, 1 hit
Gene3Di4.10.95.10, 1 hit
InterProiView protein in InterPro
IPR001349 Cyt_c_oxidase_su6a
IPR018507 Cyt_c_oxidase_su6a_CS
IPR036418 Cyt_c_oxidase_su6a_sf
PANTHERiPTHR11504 PTHR11504, 1 hit
PfamiView protein in Pfam
PF02046 COX6A, 1 hit
PIRSFiPIRSF000277 COX6A1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD006036 Cyt_c_oxidase_su6a, 1 hit
SUPFAMiSSF81411 SSF81411, 1 hit
PROSITEiView protein in PROSITE
PS01329 COX6A, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07471-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALPLKSLSR GLASAAKGDH GGTGARTWRF LTFGLALPSV ALCTLNSWLH
60 70 80 90
SGHRERPAFI PYHHLRIRTK PFSWGDGNHT FFHNPRVNPL PTGYEKP
Length:97
Mass (Da):10,800
Last modified:May 1, 1992 - v2
Checksum:i59B408A1B9B6AF4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56857 mRNA Translation: CAA40183.1
S64127 Genomic DNA Translation: AAB27605.1
BC103117 mRNA Translation: AAI03118.1
PIRiS35702 OGBO6
RefSeqiNP_776947.1, NM_174522.3
UniGeneiBt.49093

Genome annotation databases

EnsembliENSBTAT00000026002; ENSBTAP00000026002; ENSBTAG00000019521
GeneIDi282200
KEGGibta:282200

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56857 mRNA Translation: CAA40183.1
S64127 Genomic DNA Translation: AAB27605.1
BC103117 mRNA Translation: AAI03118.1
PIRiS35702 OGBO6
RefSeqiNP_776947.1, NM_174522.3
UniGeneiBt.49093

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80G/T13-96[»]
1OCOX-ray2.80G/T13-96[»]
1OCRX-ray2.35G/T13-96[»]
1OCZX-ray2.90G/T13-96[»]
1V54X-ray1.80G/T13-97[»]
1V55X-ray1.90G/T13-97[»]
2DYRX-ray1.80G/T13-97[»]
2DYSX-ray2.20G/T13-97[»]
2EIJX-ray1.90G/T13-97[»]
2EIKX-ray2.10G/T13-97[»]
2EILX-ray2.10G/T13-97[»]
2EIMX-ray2.60G/T13-97[»]
2EINX-ray2.70G/T13-97[»]
2OCCX-ray2.30G/T13-96[»]
2Y69X-ray1.95G/T1-97[»]
2YBBelectron microscopy19.00R13-96[»]
2ZXWX-ray2.50G/T13-97[»]
3ABKX-ray2.00G/T13-97[»]
3ABLX-ray2.10G/T13-97[»]
3ABMX-ray1.95G/T13-97[»]
3AG1X-ray2.20G/T13-97[»]
3AG2X-ray1.80G/T13-97[»]
3AG3X-ray1.80G/T13-97[»]
3AG4X-ray2.05G/T13-97[»]
3ASNX-ray3.00G/T13-97[»]
3ASOX-ray2.30G/T13-97[»]
3WG7X-ray1.90G/T13-97[»]
3X2QX-ray2.00G/T13-97[»]
5B1AX-ray1.50G/T13-97[»]
5B1BX-ray1.60G/T13-97[»]
5B3SX-ray1.68G/T13-97[»]
5GPNelectron microscopy5.40413-96[»]
5IY5X-ray2.00G/T13-96[»]
5LUFelectron microscopy9.10413-96[»]
5W97X-ray2.30G/g13-97[»]
5WAUX-ray1.95G/g13-97[»]
5X19X-ray2.20G/T13-97[»]
5X1BX-ray2.40G/T13-97[»]
5X1FX-ray2.20G/T13-97[»]
5XDQX-ray1.77G/T13-97[»]
5XDXX-ray1.99G/T13-97[»]
5XTHelectron microscopy3.90313-96[»]
5XTIelectron microscopy17.403/B313-96[»]
5Z84X-ray1.85G/T13-97[»]
5Z85X-ray1.85G/T13-97[»]
5Z86X-ray1.85G/T13-97[»]
5ZCOX-ray1.90G/T13-97[»]
5ZCPX-ray1.65G/T13-97[»]
5ZCQX-ray1.65G/T13-97[»]
ProteinModelPortaliP07471
SMRiP07471
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiP07471
DIPiDIP-39018N
IntActiP07471, 2 interactors
STRINGi9913.ENSBTAP00000026002

Proteomic databases

PaxDbiP07471
PRIDEiP07471

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000026002; ENSBTAP00000026002; ENSBTAG00000019521
GeneIDi282200
KEGGibta:282200

Organism-specific databases

CTDi1339
VGNCiVGNC:27637 COX6A2

Phylogenomic databases

eggNOGiKOG3469 Eukaryota
ENOG411253X LUCA
GeneTreeiENSGT00390000002756
HOGENOMiHOG000193965
HOVERGENiHBG060482
InParanoidiP07471
KOiK02266
OMAiREPFAKY
OrthoDBiEOG091G0C5F
TreeFamiTF105064

Enzyme and pathway databases

BRENDAi1.9.3.1 908

Miscellaneous databases

EvolutionaryTraceiP07471

Gene expression databases

BgeeiENSBTAG00000019521 Expressed in 6 organ(s), highest expression level in heart

Family and domain databases

CDDicd00925 Cyt_c_Oxidase_VIa, 1 hit
Gene3Di4.10.95.10, 1 hit
InterProiView protein in InterPro
IPR001349 Cyt_c_oxidase_su6a
IPR018507 Cyt_c_oxidase_su6a_CS
IPR036418 Cyt_c_oxidase_su6a_sf
PANTHERiPTHR11504 PTHR11504, 1 hit
PfamiView protein in Pfam
PF02046 COX6A, 1 hit
PIRSFiPIRSF000277 COX6A1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD006036 Cyt_c_oxidase_su6a, 1 hit
SUPFAMiSSF81411 SSF81411, 1 hit
PROSITEiView protein in PROSITE
PS01329 COX6A, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCX6A2_BOVIN
AccessioniPrimary (citable) accession number: P07471
Secondary accession number(s): Q3SZ61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: May 1, 1992
Last modified: October 10, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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