UniProtKB - P07471 (CX6A2_BOVIN)
Cytochrome c oxidase subunit 6A2, mitochondrial
COX6A2
Functioni
: oxidative phosphorylation Pathwayi
This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.By similarityView all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.
GO - Molecular functioni
- cytochrome-c oxidase activity Source: InterPro
- enzyme regulator activity Source: GO_Central
GO - Biological processi
- mitochondrial electron transport, cytochrome c to oxygen Source: GO_Central
Keywordsi
Molecular function | Oxidoreductase |
Enzyme and pathway databases
BRENDAi | 1.9.3.1, 908 |
UniPathwayi | UPA00705 |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome c oxidase subunit 6A2, mitochondrialAlternative name(s): Cytochrome c oxidase polypeptide VIa-heart Short name: COXVIAH Cytochrome c oxidase polypeptide VIb |
Gene namesi | Name:COX6A2 Synonyms:COX6A |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:27637, COX6A2 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane 2 Publications; Single-pass membrane protein 2 Publications
Mitochondrion
- mitochondrial respiratory chain complex IV Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
- respiratory chain complex IV Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 13 – 24 | Mitochondrial matrix1 PublicationAdd BLAST | 12 | |
Transmembranei | 25 – 49 | Helical1 PublicationAdd BLAST | 25 | |
Topological domaini | 50 – 97 | Mitochondrial intermembrane1 PublicationAdd BLAST | 48 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 12 | Mitochondrion1 PublicationAdd BLAST | 12 | |
ChainiPRO_0000006115 | 13 – 97 | Cytochrome c oxidase subunit 6A2, mitochondrialAdd BLAST | 85 |
Proteomic databases
PaxDbi | P07471 |
PRIDEi | P07471 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSBTAG00000019521, Expressed in heart and 12 other tissues |
Interactioni
Subunit structurei
Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I1 (or COX4I2), COX5A, COX5B, COX6A2 (or COX6A1), COX6B1 (or COX6B2), COX6C, COX7A1 (or COX7A2), COX7B, COX7C, COX8B and NDUFA4, which are encoded in the nuclear genome (PubMed:8638158). The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI1III2IV1 and megacomplex MCI2III2IV2) (PubMed:26698328, PubMed:27830641).
3 PublicationsProtein-protein interaction databases
CORUMi | P07471 |
DIPi | DIP-39018N |
IntActi | P07471, 2 interactors |
STRINGi | 9913.ENSBTAP00000026002 |
Structurei
Secondary structure
3D structure databases
SMRi | P07471 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P07471 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptide, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3469, Eukaryota |
GeneTreei | ENSGT00940000162257 |
HOGENOMi | CLU_122515_1_1_1 |
InParanoidi | P07471 |
OMAi | WLHSGHH |
OrthoDBi | 1591077at2759 |
TreeFami | TF105064 |
Family and domain databases
CDDi | cd00925, Cyt_c_Oxidase_VIa, 1 hit |
Gene3Di | 4.10.95.10, 1 hit |
InterProi | View protein in InterPro IPR001349, Cyt_c_oxidase_su6a IPR018507, Cyt_c_oxidase_su6a_CS IPR036418, Cyt_c_oxidase_su6a_sf |
PANTHERi | PTHR11504, PTHR11504, 1 hit |
Pfami | View protein in Pfam PF02046, COX6A, 1 hit |
PIRSFi | PIRSF000277, COX6A1, 1 hit |
SUPFAMi | SSF81411, SSF81411, 1 hit |
PROSITEi | View protein in PROSITE PS01329, COX6A, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MALPLKSLSR GLASAAKGDH GGTGARTWRF LTFGLALPSV ALCTLNSWLH
60 70 80 90
SGHRERPAFI PYHHLRIRTK PFSWGDGNHT FFHNPRVNPL PTGYEKP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X56857 mRNA Translation: CAA40183.1 S64127 Genomic DNA Translation: AAB27605.1 BC103117 mRNA Translation: AAI03118.1 |
PIRi | S35702, OGBO6 |
RefSeqi | NP_776947.1, NM_174522.3 |
Genome annotation databases
Ensembli | ENSBTAT00000026002; ENSBTAP00000026002; ENSBTAG00000019521 |
GeneIDi | 282200 |
KEGGi | bta:282200 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X56857 mRNA Translation: CAA40183.1 S64127 Genomic DNA Translation: AAB27605.1 BC103117 mRNA Translation: AAI03118.1 |
PIRi | S35702, OGBO6 |
RefSeqi | NP_776947.1, NM_174522.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1OCC | X-ray | 2.80 | G/T | 13-96 | [»] | |
1OCO | X-ray | 2.80 | G/T | 13-96 | [»] | |
1OCR | X-ray | 2.35 | G/T | 13-96 | [»] | |
1OCZ | X-ray | 2.90 | G/T | 13-96 | [»] | |
1V54 | X-ray | 1.80 | G/T | 13-97 | [»] | |
1V55 | X-ray | 1.90 | G/T | 13-97 | [»] | |
2DYR | X-ray | 1.80 | G/T | 13-97 | [»] | |
2DYS | X-ray | 2.20 | G/T | 13-97 | [»] | |
2EIJ | X-ray | 1.90 | G/T | 13-97 | [»] | |
2EIK | X-ray | 2.10 | G/T | 13-97 | [»] | |
2EIL | X-ray | 2.10 | G/T | 13-97 | [»] | |
2EIM | X-ray | 2.60 | G/T | 13-97 | [»] | |
2EIN | X-ray | 2.70 | G/T | 13-97 | [»] | |
2OCC | X-ray | 2.30 | G/T | 13-96 | [»] | |
2Y69 | X-ray | 1.95 | G/T | 1-97 | [»] | |
2YBB | electron microscopy | 19.00 | R | 13-96 | [»] | |
2ZXW | X-ray | 2.50 | G/T | 13-97 | [»] | |
3ABK | X-ray | 2.00 | G/T | 13-97 | [»] | |
3ABL | X-ray | 2.10 | G/T | 13-97 | [»] | |
3ABM | X-ray | 1.95 | G/T | 13-97 | [»] | |
3AG1 | X-ray | 2.20 | G/T | 13-97 | [»] | |
3AG2 | X-ray | 1.80 | G/T | 13-97 | [»] | |
3AG3 | X-ray | 1.80 | G/T | 13-97 | [»] | |
3AG4 | X-ray | 2.05 | G/T | 13-97 | [»] | |
3ASN | X-ray | 3.00 | G/T | 13-97 | [»] | |
3ASO | X-ray | 2.30 | G/T | 13-97 | [»] | |
3WG7 | X-ray | 1.90 | G/T | 13-97 | [»] | |
3X2Q | X-ray | 2.00 | G/T | 13-97 | [»] | |
5B1A | X-ray | 1.50 | G/T | 13-97 | [»] | |
5B1B | X-ray | 1.60 | G/T | 13-97 | [»] | |
5B3S | X-ray | 1.68 | G/T | 13-97 | [»] | |
5GPN | electron microscopy | 5.40 | 4 | 13-96 | [»] | |
5IY5 | X-ray | 2.00 | G/T | 13-96 | [»] | |
5LUF | electron microscopy | 9.10 | 4 | 13-96 | [»] | |
5W97 | X-ray | 2.30 | G/g | 13-97 | [»] | |
5WAU | X-ray | 1.95 | G/g | 13-97 | [»] | |
5X19 | X-ray | 2.20 | G/T | 13-97 | [»] | |
5X1B | X-ray | 2.40 | G/T | 13-97 | [»] | |
5X1F | X-ray | 2.20 | G/T | 13-97 | [»] | |
5XDQ | X-ray | 1.77 | G/T | 13-97 | [»] | |
5XDX | X-ray | 1.99 | G/T | 13-97 | [»] | |
5XTH | electron microscopy | 3.90 | 3 | 13-96 | [»] | |
5XTI | electron microscopy | 17.40 | 3/B3 | 13-96 | [»] | |
5Z84 | X-ray | 1.85 | G/T | 13-97 | [»] | |
5Z85 | X-ray | 1.85 | G/T | 13-97 | [»] | |
5Z86 | X-ray | 1.85 | G/T | 13-97 | [»] | |
5ZCO | X-ray | 1.90 | G/T | 13-97 | [»] | |
5ZCP | X-ray | 1.65 | G/T | 13-97 | [»] | |
5ZCQ | X-ray | 1.65 | G/T | 13-97 | [»] | |
6J8M | X-ray | 1.90 | G/T | 13-97 | [»] | |
6JUW | X-ray | 1.80 | G/T | 13-96 | [»] | |
6JY3 | X-ray | 1.85 | G | 13-97 | [»] | |
6JY4 | X-ray | 1.95 | G | 13-97 | [»] | |
6NKN | X-ray | 2.50 | G/T | 13-97 | [»] | |
6NMF | X-ray | 2.80 | G/T | 13-97 | [»] | |
6NMP | X-ray | 2.90 | G/T | 13-97 | [»] | |
SMRi | P07471 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
CORUMi | P07471 |
DIPi | DIP-39018N |
IntActi | P07471, 2 interactors |
STRINGi | 9913.ENSBTAP00000026002 |
Proteomic databases
PaxDbi | P07471 |
PRIDEi | P07471 |
Genome annotation databases
Ensembli | ENSBTAT00000026002; ENSBTAP00000026002; ENSBTAG00000019521 |
GeneIDi | 282200 |
KEGGi | bta:282200 |
Organism-specific databases
CTDi | 1339 |
VGNCi | VGNC:27637, COX6A2 |
Phylogenomic databases
eggNOGi | KOG3469, Eukaryota |
GeneTreei | ENSGT00940000162257 |
HOGENOMi | CLU_122515_1_1_1 |
InParanoidi | P07471 |
OMAi | WLHSGHH |
OrthoDBi | 1591077at2759 |
TreeFami | TF105064 |
Enzyme and pathway databases
UniPathwayi | UPA00705 |
BRENDAi | 1.9.3.1, 908 |
Miscellaneous databases
EvolutionaryTracei | P07471 |
Gene expression databases
Bgeei | ENSBTAG00000019521, Expressed in heart and 12 other tissues |
Family and domain databases
CDDi | cd00925, Cyt_c_Oxidase_VIa, 1 hit |
Gene3Di | 4.10.95.10, 1 hit |
InterProi | View protein in InterPro IPR001349, Cyt_c_oxidase_su6a IPR018507, Cyt_c_oxidase_su6a_CS IPR036418, Cyt_c_oxidase_su6a_sf |
PANTHERi | PTHR11504, PTHR11504, 1 hit |
Pfami | View protein in Pfam PF02046, COX6A, 1 hit |
PIRSFi | PIRSF000277, COX6A1, 1 hit |
SUPFAMi | SSF81411, SSF81411, 1 hit |
PROSITEi | View protein in PROSITE PS01329, COX6A, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CX6A2_BOVIN | |
Accessioni | P07471Primary (citable) accession number: P07471 Secondary accession number(s): Q3SZ61 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1988 |
Last sequence update: | May 1, 1992 | |
Last modified: | April 7, 2021 | |
This is version 163 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families