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Protein

Cytochrome c oxidase subunit 7A1, mitochondrial

Gene

COX7A1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

  • mitochondrial respiratory chain supercomplex assembly Source: GO_Central
  • regulation of oxidative phosphorylation Source: GO_Central

Enzyme and pathway databases

BRENDAi1.9.3.1 908

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7A1, mitochondrial
Alternative name(s):
Cytochrome c oxidase subunit VIIIc
Short name:
VIIIC
Cytochrome c oxidase subunit VIIa-heart
Short name:
Cytochrome c oxidase subunit VIIa-H
Cytochrome c oxidase subunit VIIa-muscle
Short name:
Cytochrome c oxidase subunit VIIa-M
Gene namesi
Name:COX7A1
Synonyms:COX7A, COX7AH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Organism-specific databases

VGNCiVGNC:27639 COX7A1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 46Mitochondrial matrixAdd BLAST25
Transmembranei47 – 75HelicalAdd BLAST29
Topological domaini76 – 80Mitochondrial intermembrane5

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 21Mitochondrion1 PublicationAdd BLAST21
ChainiPRO_000000614822 – 80Cytochrome c oxidase subunit 7A1, mitochondrialAdd BLAST59

Proteomic databases

PaxDbiP07470
PRIDEiP07470

Expressioni

Gene expression databases

BgeeiENSBTAG00000014878 Expressed in 9 organ(s), highest expression level in heart

Interactioni

Protein-protein interaction databases

CORUMiP07470
DIPiDIP-38984N
IntActiP07470, 3 interactors
STRINGi9913.ENSBTAP00000019808

Structurei

Secondary structure

180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP07470
SMRiP07470
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07470

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIa family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JE1I Eukaryota
ENOG410ZCEG LUCA
GeneTreeiENSGT00400000022054
HOGENOMiHOG000264231
HOVERGENiHBG051095
InParanoidiP07470
KOiK02270
OMAiRVTMGLC
OrthoDBiEOG091G12UD
TreeFamiTF105067

Family and domain databases

CDDicd00928 Cyt_c_Oxidase_VIIa, 1 hit
Gene3Di4.10.91.10, 1 hit
InterProiView protein in InterPro
IPR039297 COX7a
IPR036539 Cyt_c_oxidase_su7a_sf
IPR003177 Cytc_oxidase_su7a_met
PANTHERiPTHR10510 PTHR10510, 1 hit
PfamiView protein in Pfam
PF02238 COX7a, 1 hit
SUPFAMiSSF81419 SSF81419, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07470-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRALRVSQAL VRSFSSTARN RFENRVAEKQ KLFQEDNGLP VHLKGGATDN
60 70 80
ILYRVTMTLC LGGTLYSLYC LGWASFPHKK
Length:80
Mass (Da):9,063
Last modified:December 1, 1992 - v2
Checksum:iA33FE89A867472A0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73W → H AA sequence (PubMed:3006725).Curated1
Sequence conflicti76 – 78Missing AA sequence (PubMed:3006725).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56739 mRNA Translation: CAA40063.1
M83299 Genomic DNA Translation: AAA30464.1
BC114907 mRNA Translation: AAI14908.1
PIRiA41852 OSBO7A
RefSeqiNP_788847.1, NM_176674.2
UniGeneiBt.76

Genome annotation databases

EnsembliENSBTAT00000019808; ENSBTAP00000019808; ENSBTAG00000014878
GeneIDi338086
KEGGibta:338086

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56739 mRNA Translation: CAA40063.1
M83299 Genomic DNA Translation: AAA30464.1
BC114907 mRNA Translation: AAI14908.1
PIRiA41852 OSBO7A
RefSeqiNP_788847.1, NM_176674.2
UniGeneiBt.76

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80J/W22-80[»]
1OCOX-ray2.80J/W22-80[»]
1OCRX-ray2.35J/W22-80[»]
1OCZX-ray2.90J/W22-80[»]
1V54X-ray1.80J/W22-80[»]
1V55X-ray1.90J/W22-80[»]
2DYRX-ray1.80J/W22-80[»]
2DYSX-ray2.20J/W22-80[»]
2EIJX-ray1.90J/W22-80[»]
2EIKX-ray2.10J/W22-80[»]
2EILX-ray2.10J/W22-80[»]
2EIMX-ray2.60J/W22-80[»]
2EINX-ray2.70J/W22-80[»]
2OCCX-ray2.30J/W22-80[»]
2Y69X-ray1.95J/W1-80[»]
2YBBelectron microscopy19.00U22-80[»]
2ZXWX-ray2.50J/W22-80[»]
3ABKX-ray2.00J/W22-80[»]
3ABLX-ray2.10J/W22-80[»]
3ABMX-ray1.95J/W22-80[»]
3AG1X-ray2.20J/W22-80[»]
3AG2X-ray1.80J/W22-80[»]
3AG3X-ray1.80J/W22-80[»]
3AG4X-ray2.05J/W22-80[»]
3ASNX-ray3.00J/W22-80[»]
3ASOX-ray2.30J/W22-80[»]
3WG7X-ray1.90J/W22-80[»]
3X2QX-ray2.00J/W22-80[»]
5B1AX-ray1.50J/W22-80[»]
5B1BX-ray1.60J/W22-80[»]
5B3SX-ray1.68J/W22-80[»]
5GPNelectron microscopy5.40722-80[»]
5IY5X-ray2.00J/W22-79[»]
5LUFelectron microscopy9.10722-80[»]
5W97X-ray2.30J/j22-80[»]
5WAUX-ray1.95J/j22-80[»]
5X19X-ray2.20J/W22-80[»]
5X1BX-ray2.40J/W22-80[»]
5X1FX-ray2.20J/W22-80[»]
5XDQX-ray1.77J/W22-80[»]
5XDXX-ray1.99J/W22-80[»]
5XTHelectron microscopy3.90622-77[»]
5XTIelectron microscopy17.406/B622-77[»]
5Z84X-ray1.85J/W22-80[»]
5Z85X-ray1.85J/W22-80[»]
5Z86X-ray1.85J/W22-80[»]
5ZCOX-ray1.90J/W22-80[»]
5ZCPX-ray1.65J/W22-80[»]
5ZCQX-ray1.65J/W22-80[»]
ProteinModelPortaliP07470
SMRiP07470
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiP07470
DIPiDIP-38984N
IntActiP07470, 3 interactors
STRINGi9913.ENSBTAP00000019808

Proteomic databases

PaxDbiP07470
PRIDEiP07470

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000019808; ENSBTAP00000019808; ENSBTAG00000014878
GeneIDi338086
KEGGibta:338086

Organism-specific databases

CTDi1346
VGNCiVGNC:27639 COX7A1

Phylogenomic databases

eggNOGiENOG410JE1I Eukaryota
ENOG410ZCEG LUCA
GeneTreeiENSGT00400000022054
HOGENOMiHOG000264231
HOVERGENiHBG051095
InParanoidiP07470
KOiK02270
OMAiRVTMGLC
OrthoDBiEOG091G12UD
TreeFamiTF105067

Enzyme and pathway databases

BRENDAi1.9.3.1 908

Miscellaneous databases

EvolutionaryTraceiP07470

Gene expression databases

BgeeiENSBTAG00000014878 Expressed in 9 organ(s), highest expression level in heart

Family and domain databases

CDDicd00928 Cyt_c_Oxidase_VIIa, 1 hit
Gene3Di4.10.91.10, 1 hit
InterProiView protein in InterPro
IPR039297 COX7a
IPR036539 Cyt_c_oxidase_su7a_sf
IPR003177 Cytc_oxidase_su7a_met
PANTHERiPTHR10510 PTHR10510, 1 hit
PfamiView protein in Pfam
PF02238 COX7a, 1 hit
SUPFAMiSSF81419 SSF81419, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCX7A1_BOVIN
AccessioniPrimary (citable) accession number: P07470
Secondary accession number(s): A4FUH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: December 1, 1992
Last modified: November 7, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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